DE69824705T2 - Aminobenzophenones als inhibitoren von interleukin und tnf - Google Patents

Aminobenzophenones als inhibitoren von interleukin und tnf Download PDF

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Publication number
DE69824705T2
DE69824705T2 DE69824705T DE69824705T DE69824705T2 DE 69824705 T2 DE69824705 T2 DE 69824705T2 DE 69824705 T DE69824705 T DE 69824705T DE 69824705 T DE69824705 T DE 69824705T DE 69824705 T2 DE69824705 T2 DE 69824705T2
Authority
DE
Germany
Prior art keywords
starting compound
compound
nmr
aminophenylamino
general procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824705T
Other languages
German (de)
English (en)
Other versions
DE69824705D1 (de
Inventor
Rytter Erik OTTOSEN
Schneur Rachlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharma AS
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma AS, Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharma AS
Application granted granted Critical
Publication of DE69824705D1 publication Critical patent/DE69824705D1/de
Publication of DE69824705T2 publication Critical patent/DE69824705T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69824705T 1997-01-24 1998-01-08 Aminobenzophenones als inhibitoren von interleukin und tnf Expired - Lifetime DE69824705T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9701453 1997-01-24
GBGB9701453.4A GB9701453D0 (en) 1997-01-24 1997-01-24 Aminobenzophenones
PCT/DK1998/000008 WO1998032730A1 (en) 1997-01-24 1998-01-08 Aminobenzophenones as inhibitors of interleukin and tnf

Publications (2)

Publication Number Publication Date
DE69824705D1 DE69824705D1 (de) 2004-07-29
DE69824705T2 true DE69824705T2 (de) 2005-07-07

Family

ID=10806523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824705T Expired - Lifetime DE69824705T2 (de) 1997-01-24 1998-01-08 Aminobenzophenones als inhibitoren von interleukin und tnf

Country Status (19)

Country Link
US (1) US6313174B1 (enExample)
EP (1) EP0966424B1 (enExample)
JP (1) JP4250204B2 (enExample)
KR (1) KR100544046B1 (enExample)
CN (1) CN1188388C (enExample)
AT (1) ATE269844T1 (enExample)
AU (1) AU733561B2 (enExample)
CA (1) CA2278798C (enExample)
DE (1) DE69824705T2 (enExample)
DK (1) DK0966424T3 (enExample)
ES (1) ES2223116T3 (enExample)
GB (1) GB9701453D0 (enExample)
HU (1) HUP0000678A3 (enExample)
NZ (1) NZ336754A (enExample)
PL (1) PL334806A1 (enExample)
PT (1) PT966424E (enExample)
RO (1) RO120195B1 (enExample)
RU (1) RU2200153C2 (enExample)
WO (1) WO1998032730A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750253B1 (en) 1999-07-16 2004-06-15 Leo Pharmaceutical Products Ltd. A/S Aminobenzophenones as inhibitors of il-1β and tnf-α
NZ516824A (en) * 1999-07-16 2004-03-26 Leo Pharm Prod Ltd Novel aminobenzophenones
US6897236B1 (en) 1999-07-16 2005-05-24 Leo Pharmaceutical Products, Ltd. Aminobenzophenones as inhibitors of IL-1β and TNF-α
HUP0201846A3 (en) * 1999-07-16 2002-11-28 Leo Pharm Prod Ltd Amonobenzophenones as inhibitors of il-1betha and tnf-alpha and pharmaceutical compositions containing them
DE60014394T2 (de) * 1999-07-16 2005-12-22 Leo Pharma A/S Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
CA2379319A1 (en) * 1999-07-16 2001-01-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab) Aminobenzophenones as inhibitors of il-1.beta. and tnf-.alpha.
HUP0203813A3 (en) * 1999-12-06 2008-03-28 Leo Pharma As Aminobenzophenones as inhibitors of il-1betha and tnf-alpha, pharmaceutical compositions containing them and their use
BR0012502A (pt) * 1999-12-17 2003-06-24 Abbott Lab Inibidores da expressão do gene para interleucina 5
AU2457201A (en) * 1999-12-28 2001-07-09 Bristol-Myers Squibb Company Cytokine, especially tnf-alpha, inhibitors
CA2408727A1 (en) * 2000-05-22 2001-11-29 Leo Pharma A/S Benzophenones as inhibitors of il-1.beta. and tnf-.alpha.
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
SE0100569D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab New compounds
GB0107368D0 (en) * 2001-03-23 2001-05-16 Novartis Ag Organic compounds
AU2002338286A1 (en) * 2001-04-10 2002-10-28 Leo Pharma A/S Novel aminophenyl ketone derivatives
EP1423356A2 (en) * 2001-08-28 2004-06-02 Leo Pharma A/S Novel aminobenzoephenones
BR0317445A (pt) * 2002-12-20 2005-11-16 Leo Pharma As Composto, composição farmacêutica, método para o tratamento de doenças, e, uso de um composto
WO2005009940A1 (en) * 2003-07-24 2005-02-03 Leo Pharma A/S Novel aminobenzophenone compounds
AU2005316034B2 (en) 2004-12-13 2012-01-19 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
KR101057546B1 (ko) * 2007-06-05 2011-08-17 주식회사 엘지화학 광학 이방성 화합물 및 이를 포함하는 수지 조성물
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
WO2012167133A2 (en) * 2011-06-01 2012-12-06 The Regents Of The University Of California Inhibitors of anandamide transport and their therapeutic uses
WO2013028570A2 (en) 2011-08-19 2013-02-28 The Regents Of The University Of California Meta-substituted biphenyl peripherally restricted faah inhibitors
WO2015157313A1 (en) 2014-04-07 2015-10-15 The Regents Of The University Of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1535401A (en) 1977-07-28 1978-12-13 Holliday & Co Ltd L Nitrodiphenylamine carboxylic acid disperse dyes
SU790620A1 (ru) * 1979-06-01 1981-07-30 Ордена Трудового Красного Знамени Институт Медицинскойпаразитологии И Торпической Медицины Им.E.И.Марциновского Дихлор аминобензофенон как исходный продуктдл пОлучЕНи лЕКАРСТВЕННыХ пРЕпАРАТОВ C АНТигЕльМиНТНыМдЕйСТВиЕМ
JPH0776303B2 (ja) 1986-11-21 1995-08-16 株式会社リコー 呈色性フタリド化合物及びその製造法及びこのものを発色成分とした記録材料

Also Published As

Publication number Publication date
KR20000070437A (ko) 2000-11-25
KR100544046B1 (ko) 2006-01-23
ES2223116T3 (es) 2005-02-16
EP0966424B1 (en) 2004-06-23
RU2200153C2 (ru) 2003-03-10
JP2001511771A (ja) 2001-08-14
NZ336754A (en) 2001-03-30
HUP0000678A2 (hu) 2001-10-28
GB9701453D0 (en) 1997-03-12
DK0966424T3 (da) 2004-11-01
RO120195B1 (ro) 2005-10-28
PL334806A1 (en) 2000-03-13
PT966424E (pt) 2004-09-30
ATE269844T1 (de) 2004-07-15
HK1025306A1 (en) 2000-11-10
JP4250204B2 (ja) 2009-04-08
AU5478198A (en) 1998-08-18
EP0966424A1 (en) 1999-12-29
CA2278798C (en) 2007-07-03
CN1188388C (zh) 2005-02-09
AU733561B2 (en) 2001-05-17
WO1998032730A1 (en) 1998-07-30
US6313174B1 (en) 2001-11-06
HUP0000678A3 (en) 2001-11-28
CA2278798A1 (en) 1998-07-30
DE69824705D1 (de) 2004-07-29
CN1248966A (zh) 2000-03-29

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