HUP0000678A2 - Interleukin- és tnf-gátló hatással rendelkező aminobenzofenonszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Interleukin- és tnf-gátló hatással rendelkező aminobenzofenonszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0000678A2 HUP0000678A2 HU0000678A HUP0000678A HUP0000678A2 HU P0000678 A2 HUP0000678 A2 HU P0000678A2 HU 0000678 A HU0000678 A HU 0000678A HU P0000678 A HUP0000678 A HU P0000678A HU P0000678 A2 HUP0000678 A2 HU P0000678A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- atom
- carbamoyl
- alkoxycarbonyl
- Prior art date
Links
- MAOBFOXLCJIFLV-UHFFFAOYSA-N (2-aminophenyl)-phenylmethanone Chemical class NC1=CC=CC=C1C(=O)C1=CC=CC=C1 MAOBFOXLCJIFLV-UHFFFAOYSA-N 0.000 title 1
- 102000015696 Interleukins Human genes 0.000 title 1
- 108010063738 Interleukins Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány szerinti (I) általános képletű vegyületek - a képletben R1és R2 jelentése egymástól függetlenül egy vagy több, azonos vagyeltérő, hidrogénatom, halogénatom, hidroxilcsoport, merkaptocsoport,trifluormetilcsoport, aminocsoport; 1-5 szénatomos alkil-, alkoxi-,alkil-tio-, alkil-amino- vagy alkoxikarbonilcsoport, cianocsoport,karboxilcsoport, karbamoilcsoport, fenilcsoport és nitrocsoport közülválasztott szubsztituens; R3 jelentése hidrogénatom, halogénatom,hidroxilcsoport, merkaptocsoport, trifluormetilcsoport, 1-5 szénatomosalkil-, alkoxi-, alkiltio-, alkilamino- vagy alkoxikarbonilcsoport,cianocsoport, kar- boxilcsoport vagy karbamoilcsoport; R4, R5 és R6jelentése egymástól függetlenül hidrogénatom, trifluormetilcsoport, 1-5 szénatomos alkil-, karbamoil-, alkoxikarbonil- vagy alkanoilcsoport;X jelentése oxigénatom, N-OH, vagy 1-5 szénatomos N- -O-alkil,dialkoxi-, ciklikus dialkoxi-, dialkiltio-, vagy ciklikusdialkiltiocsoport - valamint gyógyászatilag elfogadható sóikgyógyszerkészítmények hatóanyagaként asztma, allergia, reumásarthritis, csigolyaízületi gyulladás, köszvény, atherosclerosis,krónikus gyulladásos bélbetegség, proliferatív és gyulladásosbőrrendellenességek, például psoriasis és atopiás dermatitiskezelésére alkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9701453.4A GB9701453D0 (en) | 1997-01-24 | 1997-01-24 | Aminobenzophenones |
| PCT/DK1998/000008 WO1998032730A1 (en) | 1997-01-24 | 1998-01-08 | Aminobenzophenones as inhibitors of interleukin and tnf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000678A2 true HUP0000678A2 (hu) | 2001-10-28 |
| HUP0000678A3 HUP0000678A3 (en) | 2001-11-28 |
Family
ID=10806523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000678A HUP0000678A3 (en) | 1997-01-24 | 1998-01-08 | Aminobenzophenones as inhibitors of interleukin and tnf, process for their preparation and pharmaceutical compositions containing the same |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6313174B1 (hu) |
| EP (1) | EP0966424B1 (hu) |
| JP (1) | JP4250204B2 (hu) |
| KR (1) | KR100544046B1 (hu) |
| CN (1) | CN1188388C (hu) |
| AT (1) | ATE269844T1 (hu) |
| AU (1) | AU733561B2 (hu) |
| CA (1) | CA2278798C (hu) |
| DE (1) | DE69824705T2 (hu) |
| DK (1) | DK0966424T3 (hu) |
| ES (1) | ES2223116T3 (hu) |
| GB (1) | GB9701453D0 (hu) |
| HK (1) | HK1025306A1 (hu) |
| HU (1) | HUP0000678A3 (hu) |
| NZ (1) | NZ336754A (hu) |
| PL (1) | PL334806A1 (hu) |
| PT (1) | PT966424E (hu) |
| RO (1) | RO120195B1 (hu) |
| RU (1) | RU2200153C2 (hu) |
| WO (1) | WO1998032730A1 (hu) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0201913A3 (en) * | 1999-07-16 | 2002-11-28 | Leo Pharm Prod Ltd | Aminobenzophenones as inhibitors of il-1 betha and tnf-alpha and pharmaceutical compositions containing them |
| US6897236B1 (en) | 1999-07-16 | 2005-05-24 | Leo Pharmaceutical Products, Ltd. | Aminobenzophenones as inhibitors of IL-1β and TNF-α |
| PL353646A1 (en) * | 1999-07-16 | 2003-12-01 | Leo Pharmaceutical Products Ltd.A/S (Lovens Kemiskleo Pharmaceutical Products Ltd.A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)E Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of il-1beta and tnf-alpha |
| PL353639A1 (en) * | 1999-07-16 | 2003-12-01 | Leo Pharma A/Sleo Pharma A/S | Aminobenzophenones as inhibitors of il-1beta and tnf-alpha |
| RU2239628C2 (ru) | 1999-07-16 | 2004-11-10 | Лео Фармасьютикал Продактс Лтд. А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) | АМИНОБЕНЗОФЕНОНЫ КАК ИНГИБИТОРЫ IL-1β И TNF-α |
| CA2379316A1 (en) * | 1999-07-16 | 2001-01-25 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab) | Novel aminobenzophenones |
| CN1193003C (zh) * | 1999-12-06 | 2005-03-16 | 里奥制药有限公司 | 作为IL－1β与TNF－α抑制剂的氨基二苯酮 |
| BR0012502A (pt) * | 1999-12-17 | 2003-06-24 | Abbott Lab | Inibidores da expressão do gene para interleucina 5 |
| ATE449764T1 (de) * | 1999-12-28 | 2009-12-15 | Pharmacopeia Inc | Cytokine, insbesondere tnf-alpha, hemmer |
| EP1289958A2 (en) | 2000-05-22 | 2003-03-12 | Leo Pharma A/S | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) |
| US20020165286A1 (en) * | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
| SE0100569D0 (sv) * | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | New compounds |
| GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
| WO2002083622A2 (en) * | 2001-04-10 | 2002-10-24 | Leo Pharma A/S | Novel aminophenyl ketone derivatives |
| JP4540984B2 (ja) * | 2001-08-28 | 2010-09-08 | レオ ファーマ アクティーゼルスカブ | 新規アミノベンゾフェノン |
| KR20050089056A (ko) * | 2002-12-20 | 2005-09-07 | 레오 파마 에이/에스 | 신규한 아미노벤조페논 화합물 |
| CN1826310B (zh) | 2003-07-24 | 2010-07-21 | 利奥制药有限公司 | 新的氨基二苯酮化合物 |
| UA90698C2 (en) * | 2004-12-13 | 2010-05-25 | Лео Фарма А/С | Triazole substituted aminobenzophenone compounds |
| DE102005022020A1 (de) * | 2005-05-12 | 2006-11-23 | Merckle Gmbh | Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten |
| KR101057546B1 (ko) * | 2007-06-05 | 2011-08-17 | 주식회사 엘지화학 | 광학 이방성 화합물 및 이를 포함하는 수지 조성물 |
| EP2206534A1 (de) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
| WO2012167133A2 (en) * | 2011-06-01 | 2012-12-06 | The Regents Of The University Of California | Inhibitors of anandamide transport and their therapeutic uses |
| CN104203906B (zh) | 2011-08-19 | 2018-03-13 | 加利福尼亚大学董事会 | 间位取代的联苯基外周限制性faah抑制剂 |
| WO2015157313A1 (en) | 2014-04-07 | 2015-10-15 | The Regents Of The University Of California | Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1535401A (en) * | 1977-07-28 | 1978-12-13 | Holliday & Co Ltd L | Nitrodiphenylamine carboxylic acid disperse dyes |
| JPH0776303B2 (ja) * | 1986-11-21 | 1995-08-16 | 株式会社リコー | 呈色性フタリド化合物及びその製造法及びこのものを発色成分とした記録材料 |
-
1997
- 1997-01-24 GB GBGB9701453.4A patent/GB9701453D0/en active Pending
-
1998
- 1998-01-08 PL PL98334806A patent/PL334806A1/xx not_active IP Right Cessation
- 1998-01-08 PT PT98900270T patent/PT966424E/pt unknown
- 1998-01-08 US US09/341,923 patent/US6313174B1/en not_active Expired - Fee Related
- 1998-01-08 AU AU54781/98A patent/AU733561B2/en not_active Ceased
- 1998-01-08 NZ NZ336754A patent/NZ336754A/xx not_active IP Right Cessation
- 1998-01-08 CN CNB988028301A patent/CN1188388C/zh not_active Expired - Fee Related
- 1998-01-08 RO RO99-00839A patent/RO120195B1/ro unknown
- 1998-01-08 KR KR1019997006672A patent/KR100544046B1/ko not_active IP Right Cessation
- 1998-01-08 ES ES98900270T patent/ES2223116T3/es not_active Expired - Lifetime
- 1998-01-08 DE DE69824705T patent/DE69824705T2/de not_active Expired - Lifetime
- 1998-01-08 HU HU0000678A patent/HUP0000678A3/hu unknown
- 1998-01-08 JP JP53149998A patent/JP4250204B2/ja not_active Expired - Fee Related
- 1998-01-08 CA CA002278798A patent/CA2278798C/en not_active Expired - Fee Related
- 1998-01-08 EP EP98900270A patent/EP0966424B1/en not_active Expired - Lifetime
- 1998-01-08 AT AT98900270T patent/ATE269844T1/de active
- 1998-01-08 RU RU99118221/04A patent/RU2200153C2/ru not_active IP Right Cessation
- 1998-01-08 WO PCT/DK1998/000008 patent/WO1998032730A1/en not_active Application Discontinuation
- 1998-01-08 DK DK98900270T patent/DK0966424T3/da active
-
2000
- 2000-07-21 HK HK00104495A patent/HK1025306A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE269844T1 (de) | 2004-07-15 |
| US6313174B1 (en) | 2001-11-06 |
| EP0966424B1 (en) | 2004-06-23 |
| KR20000070437A (ko) | 2000-11-25 |
| KR100544046B1 (ko) | 2006-01-23 |
| PT966424E (pt) | 2004-09-30 |
| CN1188388C (zh) | 2005-02-09 |
| GB9701453D0 (en) | 1997-03-12 |
| DE69824705T2 (de) | 2005-07-07 |
| JP2001511771A (ja) | 2001-08-14 |
| HUP0000678A3 (en) | 2001-11-28 |
| AU5478198A (en) | 1998-08-18 |
| DE69824705D1 (de) | 2004-07-29 |
| CN1248966A (zh) | 2000-03-29 |
| HK1025306A1 (en) | 2000-11-10 |
| PL334806A1 (en) | 2000-03-13 |
| EP0966424A1 (en) | 1999-12-29 |
| DK0966424T3 (da) | 2004-11-01 |
| WO1998032730A1 (en) | 1998-07-30 |
| NZ336754A (en) | 2001-03-30 |
| JP4250204B2 (ja) | 2009-04-08 |
| AU733561B2 (en) | 2001-05-17 |
| ES2223116T3 (es) | 2005-02-16 |
| RO120195B1 (ro) | 2005-10-28 |
| CA2278798A1 (en) | 1998-07-30 |
| CA2278798C (en) | 2007-07-03 |
| RU2200153C2 (ru) | 2003-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |