HUP0401644A2 - Aminobenzofenon-származékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Aminobenzofenon-származékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0401644A2
HUP0401644A2 HU0401644A HUP0401644A HUP0401644A2 HU P0401644 A2 HUP0401644 A2 HU P0401644A2 HU 0401644 A HU0401644 A HU 0401644A HU P0401644 A HUP0401644 A HU P0401644A HU P0401644 A2 HUP0401644 A2 HU P0401644A2
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Hungary
Prior art keywords
group
alkyl
olefinic
cyclic hydrocarbon
same
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HU0401644A
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English (en)
Inventor
Erik Rytter Ottosen
Anne Marie Horneman
Xifu Liang
Original Assignee
Leo Pharma A/S
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Publication date
Application filed by Leo Pharma A/S filed Critical Leo Pharma A/S
Publication of HUP0401644A2 publication Critical patent/HUP0401644A2/hu
Publication of HUP0401644A3 publication Critical patent/HUP0401644A3/hu

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    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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Abstract

A találmány az aminobenzofenon-származékok új körére vonatkozik,ezeket tartalmazó gyógyászati készítményekre, a készítményekegységdózisaira, és a vegyületek alkalmazására gyógyszerek, különösenasztma, allergia, artritisz, reumatoid artritisz, köszvény,ateroszklerózis, krónikus gyulladásos bélbetegség (Crohn-kór),proliferatív és gyulladásos bőrrendellenességek, pszoriázis, atopiásdermatitisz, uveitisz, szeptikus sokk, AIDS, oszteoporózis és aknekezelésére vagy megelőzésére szolgáló gyógyszer előállítására. Atalálmány szerinti vegyületek az (I) általános képletnek megfelelőek -a képletben X jelentése oxigénatom; R1 jelentése halogénatom,hidroxil-, merkapto-, trifluormetil-, amino-, alkil-, olefines-,alkoxi-, alkiltio-, alkilamino-, alkoxikarbonil-, ciano-, -CONH2,fenil vagy nitrocsoport; R2 jelentése egy vagy több, azonos vagykülönböző helyettesítő, amelyek jelentése hidrogénatom, halogénatom,hidroxil-, merkapto-, trifluormetil-, amino-, alkil-, olefines-,alkoxi-, alkiltio-, alkilamino-, alkoxikarbonil-, ciano-, -CONH2,fenil- és/vagy nitrocsoport; R3 jelentése egy vagy több, azonos vagykülönböző helyettesítő, amelyek jelentése hidrogénatom, halogénatom,hidroxil-, merkapto-, trifluormetil-, ciano-, karboxil-, karbamoil-,nitro-, alkil-, olefines-, gyűrűs szénhidrogén-, alkoxi-, alkiltio-,alkoxikarbonil- és/vagy fenilcsoport; R4 jelentése hidrogénatom,alkil-, olefines-, gyűrűs szénhidrogén-csoport vagy -C(O)O-C(Rd)(Re)(-O-C(O)-R14)-; ahol az R14 csoport adott esetben egy vagy több, azonosvagy különböző R8 helyettesítővel helyettesített; R5 jelentése egyvagy több, azonos vagy különböző helyettesítő, amelyek hidrogénatomés/vagy az R1 helyettesítőre magadott jelentések; R6 jelentése alkil-heterogyűrűs csoport, alkil(gyűrűs szénhidrogén)-csoport,alkilcsoport, olefines csoport, gyűrűs szénhidrogéncsoport,heterogyűrűs csoport alkinilcsoport, Y1, R21, Y2R22 vagy Y4R24; aholaz alkilcsoport, az olefines csoport és a gyűrűs szénhidrogéncsoportegy vagy több azonos vagy különböző helyettesítővel helyettesítettek,és ahol az (alkil)heterogyűrűs csoport, az (alkil)(gyűrűsszénhidrogén)-csoport, a hetero gyűrűs csoport és a alkinilcsoportadott esetben egy vagy több, azonos vagy különböző helyettesítővelhelyettesítettek; azzal a megkötéssel, hogy a 2-klór-4-(2-[1,1,1-trifluormetil)fenilamino-2'-metil-benzofenon kizárt; valamint a fentivegyületek gyógyászati szempontból elfogadható sói és szolvátjai,például hidrátja. Ó
HU0401644A 2001-08-28 2002-08-26 Aminobenzoephenones, pharmaceutical compositions containing them and use thereof HUP0401644A3 (en)

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