KR100544046B1 - 인터류킨 및 ｔｎｆ의 억제제로서의 아미노벤조페논, 이의 제조방법 및 이를 함유하는 약제학적 제제 - Google Patents

인터류킨 및 ｔｎｆ의 억제제로서의 아미노벤조페논, 이의 제조방법 및 이를 함유하는 약제학적 제제 Download PDF

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Publication number
KR100544046B1
KR100544046B1 KR1019997006672A KR19997006672A KR100544046B1 KR 100544046 B1 KR100544046 B1 KR 100544046B1 KR 1019997006672 A KR1019997006672 A KR 1019997006672A KR 19997006672 A KR19997006672 A KR 19997006672A KR 100544046 B1 KR100544046 B1 KR 100544046B1
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KR
South Korea
Prior art keywords
compound
nmr
aminophenylamino
starting compound
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019997006672A
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English (en)
Korean (ko)
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KR20000070437A (ko
Inventor
슈노이르 라흘린
Original Assignee
레오 파마 에이/에스
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Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019997006672A 1997-01-24 1998-01-08 인터류킨 및 ｔｎｆ의 억제제로서의 아미노벤조페논, 이의 제조방법 및 이를 함유하는 약제학적 제제 Expired - Fee Related KR100544046B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9701453.4A GB9701453D0 (en) 1997-01-24 1997-01-24 Aminobenzophenones
GB9701453.4 1997-01-24
PCT/DK1998/000008 WO1998032730A1 (en) 1997-01-24 1998-01-08 Aminobenzophenones as inhibitors of interleukin and tnf

Publications (2)

Publication Number Publication Date
KR20000070437A KR20000070437A (ko) 2000-11-25
KR100544046B1 true KR100544046B1 (ko) 2006-01-23

Family

ID=10806523

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997006672A Expired - Fee Related KR100544046B1 (ko) 1997-01-24 1998-01-08 인터류킨 및 ｔｎｆ의 억제제로서의 아미노벤조페논, 이의 제조방법 및 이를 함유하는 약제학적 제제

Country Status (19)

Country Link
US (1) US6313174B1 (enExample)
EP (1) EP0966424B1 (enExample)
JP (1) JP4250204B2 (enExample)
KR (1) KR100544046B1 (enExample)
CN (1) CN1188388C (enExample)
AT (1) ATE269844T1 (enExample)
AU (1) AU733561B2 (enExample)
CA (1) CA2278798C (enExample)
DE (1) DE69824705T2 (enExample)
DK (1) DK0966424T3 (enExample)
ES (1) ES2223116T3 (enExample)
GB (1) GB9701453D0 (enExample)
HU (1) HUP0000678A3 (enExample)
NZ (1) NZ336754A (enExample)
PL (1) PL334806A1 (enExample)
PT (1) PT966424E (enExample)
RO (1) RO120195B1 (enExample)
RU (1) RU2200153C2 (enExample)
WO (1) WO1998032730A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003505362A (ja) * 1999-07-16 2003-02-12 レオ・ファーマ・アクティーゼルスカブ ＩＬ−１βおよびＴＮＦ−αの抑制剤としてのアミノベンゾフェノン
DK1210320T3 (da) * 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa
US6897236B1 (en) 1999-07-16 2005-05-24 Leo Pharmaceutical Products, Ltd. Aminobenzophenones as inhibitors of IL-1β and TNF-α
US6750253B1 (en) 1999-07-16 2004-06-15 Leo Pharmaceutical Products Ltd. A/S Aminobenzophenones as inhibitors of il-1β and tnf-α
EP1202954B1 (en) * 1999-07-16 2003-10-01 Leo Pharma A/S Novel aminobenzophenones
AU768816B2 (en) * 1999-07-16 2004-01-08 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha
AU776395B2 (en) * 1999-12-06 2004-09-09 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha
EP1250332A1 (en) * 1999-12-17 2002-10-23 Abbott Laboratories Inhibitors of interleukin 5 gene expression
JP2003519143A (ja) * 1999-12-28 2003-06-17 ファーマコピーア，インコーポレーティッド ピリミジン及びトリアジン系キナーゼ阻害剤
CA2408727A1 (en) * 2000-05-22 2001-11-29 Leo Pharma A/S Benzophenones as inhibitors of il-1.beta. and tnf-.alpha.
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
SE0100569D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab New compounds
GB0107368D0 (en) * 2001-03-23 2001-05-16 Novartis Ag Organic compounds
AU2002338286A1 (en) * 2001-04-10 2002-10-28 Leo Pharma A/S Novel aminophenyl ketone derivatives
MXPA04001912A (es) * 2001-08-28 2004-07-23 Leo Pharma As Aminobenzofenonas novedosas.
CN1753861A (zh) * 2002-12-20 2006-03-29 利奥制药有限公司 新颖的氨基二苯酮化合物
WO2005009940A1 (en) * 2003-07-24 2005-02-03 Leo Pharma A/S Novel aminobenzophenone compounds
DK1828148T3 (da) * 2004-12-13 2010-05-17 Leo Pharma As Triazolsubstituerede aminobenzophenonforbindelser
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
KR101057546B1 (ko) * 2007-06-05 2011-08-17 주식회사 엘지화학 광학 이방성 화합물 및 이를 포함하는 수지 조성물
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
WO2012167133A2 (en) * 2011-06-01 2012-12-06 The Regents Of The University Of California Inhibitors of anandamide transport and their therapeutic uses
MX354772B (es) 2011-08-19 2018-03-21 Univ California Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.
EP3988540A1 (en) 2014-04-07 2022-04-27 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1535401A (en) * 1977-07-28 1978-12-13 Holliday & Co Ltd L Nitrodiphenylamine carboxylic acid disperse dyes
SU790620A1 (ru) * 1979-06-01 1981-07-30 Ордена Трудового Красного Знамени Институт Медицинскойпаразитологии И Торпической Медицины Им.E.И.Марциновского Дихлор аминобензофенон как исходный продуктдл пОлучЕНи лЕКАРСТВЕННыХ пРЕпАРАТОВ C АНТигЕльМиНТНыМдЕйСТВиЕМ
JPH0776303B2 (ja) * 1986-11-21 1995-08-16 株式会社リコー 呈色性フタリド化合物及びその製造法及びこのものを発色成分とした記録材料

Also Published As

Publication number Publication date
DK0966424T3 (da) 2004-11-01
ES2223116T3 (es) 2005-02-16
US6313174B1 (en) 2001-11-06
JP4250204B2 (ja) 2009-04-08
DE69824705T2 (de) 2005-07-07
RO120195B1 (ro) 2005-10-28
AU5478198A (en) 1998-08-18
NZ336754A (en) 2001-03-30
CN1188388C (zh) 2005-02-09
HUP0000678A2 (hu) 2001-10-28
CN1248966A (zh) 2000-03-29
EP0966424A1 (en) 1999-12-29
ATE269844T1 (de) 2004-07-15
JP2001511771A (ja) 2001-08-14
WO1998032730A1 (en) 1998-07-30
CA2278798A1 (en) 1998-07-30
HUP0000678A3 (en) 2001-11-28
KR20000070437A (ko) 2000-11-25
EP0966424B1 (en) 2004-06-23
RU2200153C2 (ru) 2003-03-10
PT966424E (pt) 2004-09-30
CA2278798C (en) 2007-07-03
GB9701453D0 (en) 1997-03-12
PL334806A1 (en) 2000-03-13
AU733561B2 (en) 2001-05-17
HK1025306A1 (en) 2000-11-10
DE69824705D1 (de) 2004-07-29

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Publication Publication Date Title
KR100544046B1 (ko) 인터류킨 및 ｔｎｆ의 억제제로서의 아미노벤조페논, 이의 제조방법 및 이를 함유하는 약제학적 제제
US6555710B1 (en) Aminobenzophenones as inhibitors of IL-1 β and TNF-α
JP4684515B2 (ja) ＩＬ−１βおよびＴＮＦ−αの抑制剤としてのアミノベンゾフェノン
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