CN1188388C - 作为白介素和肿瘤坏死因子tnf抑制剂的氨基二苯酮 - Google Patents

作为白介素和肿瘤坏死因子tnf抑制剂的氨基二苯酮 Download PDF

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Publication number
CN1188388C
CN1188388C CNB988028301A CN98802830A CN1188388C CN 1188388 C CN1188388 C CN 1188388C CN B988028301 A CNB988028301 A CN B988028301A CN 98802830 A CN98802830 A CN 98802830A CN 1188388 C CN1188388 C CN 1188388C
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CN
China
Prior art keywords
compound
nmr
starting compound
purification
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988028301A
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English (en)
Chinese (zh)
Other versions
CN1248966A (zh
Inventor
E·R·奥托森
S·拉克林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Publication of CN1248966A publication Critical patent/CN1248966A/zh
Application granted granted Critical
Publication of CN1188388C publication Critical patent/CN1188388C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB988028301A 1997-01-24 1998-01-08 作为白介素和肿瘤坏死因子tnf抑制剂的氨基二苯酮 Expired - Fee Related CN1188388C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9701453.4A GB9701453D0 (en) 1997-01-24 1997-01-24 Aminobenzophenones
GB9701453.4 1997-01-24

Publications (2)

Publication Number Publication Date
CN1248966A CN1248966A (zh) 2000-03-29
CN1188388C true CN1188388C (zh) 2005-02-09

Family

ID=10806523

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988028301A Expired - Fee Related CN1188388C (zh) 1997-01-24 1998-01-08 作为白介素和肿瘤坏死因子tnf抑制剂的氨基二苯酮

Country Status (19)

Country Link
US (1) US6313174B1 (enExample)
EP (1) EP0966424B1 (enExample)
JP (1) JP4250204B2 (enExample)
KR (1) KR100544046B1 (enExample)
CN (1) CN1188388C (enExample)
AT (1) ATE269844T1 (enExample)
AU (1) AU733561B2 (enExample)
CA (1) CA2278798C (enExample)
DE (1) DE69824705T2 (enExample)
DK (1) DK0966424T3 (enExample)
ES (1) ES2223116T3 (enExample)
GB (1) GB9701453D0 (enExample)
HU (1) HUP0000678A3 (enExample)
NZ (1) NZ336754A (enExample)
PL (1) PL334806A1 (enExample)
PT (1) PT966424E (enExample)
RO (1) RO120195B1 (enExample)
RU (1) RU2200153C2 (enExample)
WO (1) WO1998032730A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003505362A (ja) * 1999-07-16 2003-02-12 レオ・ファーマ・アクティーゼルスカブ ＩＬ−１βおよびＴＮＦ−αの抑制剤としてのアミノベンゾフェノン
DK1210320T3 (da) * 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa
US6897236B1 (en) 1999-07-16 2005-05-24 Leo Pharmaceutical Products, Ltd. Aminobenzophenones as inhibitors of IL-1β and TNF-α
US6750253B1 (en) 1999-07-16 2004-06-15 Leo Pharmaceutical Products Ltd. A/S Aminobenzophenones as inhibitors of il-1β and tnf-α
EP1202954B1 (en) * 1999-07-16 2003-10-01 Leo Pharma A/S Novel aminobenzophenones
AU768816B2 (en) * 1999-07-16 2004-01-08 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha
AU776395B2 (en) * 1999-12-06 2004-09-09 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha
EP1250332A1 (en) * 1999-12-17 2002-10-23 Abbott Laboratories Inhibitors of interleukin 5 gene expression
JP2003519143A (ja) * 1999-12-28 2003-06-17 ファーマコピーア，インコーポレーティッド ピリミジン及びトリアジン系キナーゼ阻害剤
CA2408727A1 (en) * 2000-05-22 2001-11-29 Leo Pharma A/S Benzophenones as inhibitors of il-1.beta. and tnf-.alpha.
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
SE0100569D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab New compounds
GB0107368D0 (en) * 2001-03-23 2001-05-16 Novartis Ag Organic compounds
AU2002338286A1 (en) * 2001-04-10 2002-10-28 Leo Pharma A/S Novel aminophenyl ketone derivatives
MXPA04001912A (es) * 2001-08-28 2004-07-23 Leo Pharma As Aminobenzofenonas novedosas.
CN1753861A (zh) * 2002-12-20 2006-03-29 利奥制药有限公司 新颖的氨基二苯酮化合物
WO2005009940A1 (en) * 2003-07-24 2005-02-03 Leo Pharma A/S Novel aminobenzophenone compounds
DK1828148T3 (da) * 2004-12-13 2010-05-17 Leo Pharma As Triazolsubstituerede aminobenzophenonforbindelser
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
KR101057546B1 (ko) * 2007-06-05 2011-08-17 주식회사 엘지화학 광학 이방성 화합물 및 이를 포함하는 수지 조성물
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
WO2012167133A2 (en) * 2011-06-01 2012-12-06 The Regents Of The University Of California Inhibitors of anandamide transport and their therapeutic uses
MX354772B (es) 2011-08-19 2018-03-21 Univ California Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.
EP3988540A1 (en) 2014-04-07 2022-04-27 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1535401A (en) * 1977-07-28 1978-12-13 Holliday & Co Ltd L Nitrodiphenylamine carboxylic acid disperse dyes
SU790620A1 (ru) * 1979-06-01 1981-07-30 Ордена Трудового Красного Знамени Институт Медицинскойпаразитологии И Торпической Медицины Им.E.И.Марциновского Дихлор аминобензофенон как исходный продуктдл пОлучЕНи лЕКАРСТВЕННыХ пРЕпАРАТОВ C АНТигЕльМиНТНыМдЕйСТВиЕМ
JPH0776303B2 (ja) * 1986-11-21 1995-08-16 株式会社リコー 呈色性フタリド化合物及びその製造法及びこのものを発色成分とした記録材料

Also Published As

Publication number Publication date
DK0966424T3 (da) 2004-11-01
ES2223116T3 (es) 2005-02-16
US6313174B1 (en) 2001-11-06
JP4250204B2 (ja) 2009-04-08
DE69824705T2 (de) 2005-07-07
RO120195B1 (ro) 2005-10-28
AU5478198A (en) 1998-08-18
NZ336754A (en) 2001-03-30
KR100544046B1 (ko) 2006-01-23
HUP0000678A2 (hu) 2001-10-28
CN1248966A (zh) 2000-03-29
EP0966424A1 (en) 1999-12-29
ATE269844T1 (de) 2004-07-15
JP2001511771A (ja) 2001-08-14
WO1998032730A1 (en) 1998-07-30
CA2278798A1 (en) 1998-07-30
HUP0000678A3 (en) 2001-11-28
KR20000070437A (ko) 2000-11-25
EP0966424B1 (en) 2004-06-23
RU2200153C2 (ru) 2003-03-10
PT966424E (pt) 2004-09-30
CA2278798C (en) 2007-07-03
GB9701453D0 (en) 1997-03-12
PL334806A1 (en) 2000-03-13
AU733561B2 (en) 2001-05-17
HK1025306A1 (en) 2000-11-10
DE69824705D1 (de) 2004-07-29

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PB01 Publication
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SE01 Entry into force of request for substantive examination
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Granted publication date: 20050209

Termination date: 20130108