DE69823344T2 - Substituierte benzimidazol-derivate und ihre verwendung zur behandlung retroviraler infektionen - Google Patents
Substituierte benzimidazol-derivate und ihre verwendung zur behandlung retroviraler infektionen Download PDFInfo
- Publication number
- DE69823344T2 DE69823344T2 DE69823344T DE69823344T DE69823344T2 DE 69823344 T2 DE69823344 T2 DE 69823344T2 DE 69823344 T DE69823344 T DE 69823344T DE 69823344 T DE69823344 T DE 69823344T DE 69823344 T2 DE69823344 T2 DE 69823344T2
- Authority
- DE
- Germany
- Prior art keywords
- bis
- benzimidazolyl
- alkyl
- pyrrole
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US808321 | 1997-02-28 | ||
| US08/808,321 US5935982A (en) | 1997-02-28 | 1997-02-28 | Methods of treating retroviral infection and compounds useful therefor |
| PCT/US1998/003830 WO1998038170A1 (en) | 1997-02-28 | 1998-02-27 | Substituted benzimidazoles and their use for treating retroviral infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69823344D1 DE69823344D1 (de) | 2004-05-27 |
| DE69823344T2 true DE69823344T2 (de) | 2005-05-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69823344T Expired - Fee Related DE69823344T2 (de) | 1997-02-28 | 1998-02-27 | Substituierte benzimidazol-derivate und ihre verwendung zur behandlung retroviraler infektionen |
Country Status (8)
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|---|---|
| US (1) | US5935982A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0973750B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2002513404A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE264846T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU738975B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2282552A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69823344T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998038170A1 (cg-RX-API-DMAC7.html) |
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| US6242461B1 (en) * | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
| EP1297834A4 (en) * | 2000-06-14 | 2007-05-09 | Shionogi & Co | ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS |
| WO2002002516A2 (en) * | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
| US20020124843A1 (en) * | 2001-02-01 | 2002-09-12 | Skiba Jeffry B. | Eye medication delivery system |
| AU2002254616B2 (en) * | 2001-04-11 | 2007-09-06 | Idenix (Cayman) Limited | Phenylindoles for the treatment of HIV |
| US6958211B2 (en) * | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| IL160208A0 (en) * | 2001-08-31 | 2004-07-25 | Neurochem Int Ltd | Amidine derivatives for treating amyloidosis |
| WO2004014364A1 (en) * | 2002-08-07 | 2004-02-19 | Idenix (Cayman) Limited | Substituted phenylindoles for the treatment of hiv |
| DE602004021211D1 (de) * | 2003-03-07 | 2009-07-09 | Merck Patent Gmbh | Fluorene und Arylgruppen enthaltende Mono-, Oligo- und Polymere |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
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| PT1799696E (pt) | 2004-09-17 | 2009-02-16 | Idenix Pharmaceuticals Inc | Fosfoindoles como inibidores de hiv |
| BRPI0717511A2 (pt) * | 2006-09-29 | 2013-11-19 | Idenix Pharmaceuticals Inc | Composto puro, composição farmacêutica, métodos para tratar uma infecção por hiv, para prevenir uma infecção por hiv, para inibir a replicação de hiv, e, uso de um composto |
| SG172353A1 (en) | 2008-12-23 | 2011-07-28 | Abbott Lab | Anti-viral compounds |
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| US8314135B2 (en) * | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
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| US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
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| CN102459165B (zh) * | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
| WO2010132538A1 (en) * | 2009-05-12 | 2010-11-18 | Schering Corporation | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| AU2010253790A1 (en) | 2009-05-29 | 2011-12-15 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as Hepatitis C |
| US8980920B2 (en) | 2009-05-29 | 2015-03-17 | Merck Sharp & Dohme Corp. | Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C |
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| WO2017223260A1 (en) * | 2016-06-23 | 2017-12-28 | Albert Einstein College Of Medicine, Inc. | Pu.1 inhibitors |
| CN109553608B (zh) * | 2017-09-26 | 2020-12-08 | 北京大学 | 一类五元六元杂环化合物及其制备方法和治疗肿瘤的用途 |
| CN113264925A (zh) * | 2020-02-14 | 2021-08-17 | 上海美悦生物科技发展有限公司 | 一种杂环化合物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2839989A1 (de) * | 1978-09-14 | 1980-04-03 | Hoechst Ag | Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung |
| US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| DE4212748A1 (de) * | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| IL111011A0 (en) * | 1993-09-22 | 1994-11-28 | Wellcome Found | Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them |
| US6815461B1 (en) * | 1994-01-20 | 2004-11-09 | The University Of North Carolina At Chapel Hill | Method of inhibiting retroviral integrase |
| DE59509233D1 (de) * | 1994-02-24 | 2001-06-13 | Haarmann & Reimer Gmbh | Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren |
| US5602172A (en) * | 1994-05-06 | 1997-02-11 | The University Of North Carolina At Chapel Hill | Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor |
| US5667975A (en) * | 1994-05-06 | 1997-09-16 | The University Of North Carolina | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans |
| US5668166A (en) * | 1995-06-07 | 1997-09-16 | Georgia State University Research Foundation, Inc. | Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor |
| US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
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1997
- 1997-02-28 US US08/808,321 patent/US5935982A/en not_active Expired - Fee Related
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1998
- 1998-02-27 AT AT98908758T patent/ATE264846T1/de not_active IP Right Cessation
- 1998-02-27 AU AU66707/98A patent/AU738975B2/en not_active Ceased
- 1998-02-27 DE DE69823344T patent/DE69823344T2/de not_active Expired - Fee Related
- 1998-02-27 EP EP98908758A patent/EP0973750B1/en not_active Expired - Lifetime
- 1998-02-27 CA CA002282552A patent/CA2282552A1/en not_active Abandoned
- 1998-02-27 WO PCT/US1998/003830 patent/WO1998038170A1/en not_active Ceased
- 1998-02-27 JP JP53787098A patent/JP2002513404A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998038170A1 (en) | 1998-09-03 |
| AU6670798A (en) | 1998-09-18 |
| EP0973750B1 (en) | 2004-04-21 |
| CA2282552A1 (en) | 1998-09-03 |
| HK1026691A1 (en) | 2000-12-22 |
| AU738975B2 (en) | 2001-10-04 |
| DE69823344D1 (de) | 2004-05-27 |
| JP2002513404A (ja) | 2002-05-08 |
| US5935982A (en) | 1999-08-10 |
| EP0973750A1 (en) | 2000-01-26 |
| ATE264846T1 (de) | 2004-05-15 |
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