JP2002513404A - 置換ベンズイミダゾール類とレトロウイルス感染の治療におけるそれらの使用 - Google Patents

置換ベンズイミダゾール類とレトロウイルス感染の治療におけるそれらの使用

Info

Publication number
JP2002513404A
JP2002513404A JP53787098A JP53787098A JP2002513404A JP 2002513404 A JP2002513404 A JP 2002513404A JP 53787098 A JP53787098 A JP 53787098A JP 53787098 A JP53787098 A JP 53787098A JP 2002513404 A JP2002513404 A JP 2002513404A
Authority
JP
Japan
Prior art keywords
hydrogen
alkyl
group
bis
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP53787098A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002513404A5 (cg-RX-API-DMAC7.html
Inventor
ダイクストラ，クリスティン・シー
ボイキン，デイヴィッド
ティドウェル，リチャード・アール
Original Assignee
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル
オーバーン・ユニヴァーシティ
ジョージア・ステイト・ユニヴァーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル, オーバーン・ユニヴァーシティ, ジョージア・ステイト・ユニヴァーシティ filed Critical ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル
Publication of JP2002513404A publication Critical patent/JP2002513404A/ja
Publication of JP2002513404A5 publication Critical patent/JP2002513404A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP53787098A 1997-02-28 1998-02-27 置換ベンズイミダゾール類とレトロウイルス感染の治療におけるそれらの使用 Ceased JP2002513404A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/808,321 1997-02-28
US08/808,321 US5935982A (en) 1997-02-28 1997-02-28 Methods of treating retroviral infection and compounds useful therefor
PCT/US1998/003830 WO1998038170A1 (en) 1997-02-28 1998-02-27 Substituted benzimidazoles and their use for treating retroviral infection

Publications (2)

Publication Number Publication Date
JP2002513404A true JP2002513404A (ja) 2002-05-08
JP2002513404A5 JP2002513404A5 (cg-RX-API-DMAC7.html) 2005-08-11

Family

ID=25198455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53787098A Ceased JP2002513404A (ja) 1997-02-28 1998-02-27 置換ベンズイミダゾール類とレトロウイルス感染の治療におけるそれらの使用

Country Status (8)

Country Link
US (1) US5935982A (cg-RX-API-DMAC7.html)
EP (1) EP0973750B1 (cg-RX-API-DMAC7.html)
JP (1) JP2002513404A (cg-RX-API-DMAC7.html)
AT (1) ATE264846T1 (cg-RX-API-DMAC7.html)
AU (1) AU738975B2 (cg-RX-API-DMAC7.html)
CA (1) CA2282552A1 (cg-RX-API-DMAC7.html)
DE (1) DE69823344T2 (cg-RX-API-DMAC7.html)
WO (1) WO1998038170A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339193A (ja) * 2003-03-07 2004-12-02 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2012526834A (ja) * 2009-05-12 2012-11-01 シェーリング コーポレイション ウイルス疾患治療に有用な縮合型三環式アリール化合物
JP2015520125A (ja) * 2012-04-13 2015-07-16 エルジー・ケム・リミテッド 新しい含窒素複素環式化合物およびこれを用いた有機電子素子

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6142163A (en) * 1996-03-29 2000-11-07 Lam Research Corporation Method and apparatus for pressure control in vacuum processors
EP1219607B1 (en) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
EP1231910B1 (en) * 1999-11-16 2009-05-20 Oncozyme Pharma Inc. Pentamidine for treating cancer
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
US6242461B1 (en) * 2000-01-25 2001-06-05 Pfizer Inc. Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases
EP1297834A4 (en) * 2000-06-14 2007-05-09 Shionogi & Co ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
US20020124843A1 (en) * 2001-02-01 2002-09-12 Skiba Jeffry B. Eye medication delivery system
AU2002254616B2 (en) * 2001-04-11 2007-09-06 Idenix (Cayman) Limited Phenylindoles for the treatment of HIV
US6958211B2 (en) * 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
IL160208A0 (en) * 2001-08-31 2004-07-25 Neurochem Int Ltd Amidine derivatives for treating amyloidosis
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
CA2561718A1 (en) 2004-04-13 2005-10-27 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
PT1799696E (pt) 2004-09-17 2009-02-16 Idenix Pharmaceuticals Inc Fosfoindoles como inibidores de hiv
BRPI0717511A2 (pt) * 2006-09-29 2013-11-19 Idenix Pharmaceuticals Inc Composto puro, composição farmacêutica, métodos para tratar uma infecção por hiv, para prevenir uma infecção por hiv, para inibir a replicação de hiv, e, uso de um composto
SG172353A1 (en) 2008-12-23 2011-07-28 Abbott Lab Anti-viral compounds
WO2010075376A2 (en) 2008-12-23 2010-07-01 Abbott Laboratories Anti-viral compounds
US8314135B2 (en) * 2009-02-09 2012-11-20 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole antivirals
WO2010091413A1 (en) * 2009-02-09 2010-08-12 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8242156B2 (en) * 2009-02-17 2012-08-14 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8188132B2 (en) * 2009-02-17 2012-05-29 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US9765087B2 (en) 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8101643B2 (en) * 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8673954B2 (en) 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
CN102459165B (zh) * 2009-04-15 2015-09-02 Abbvie公司 抗病毒化合物
AU2010253790A1 (en) 2009-05-29 2011-12-15 Merck Sharp & Dohme Corp. Antiviral compounds composed of three aligned aryl moieties to treat diseases such as Hepatitis C
US8980920B2 (en) 2009-05-29 2015-03-17 Merck Sharp & Dohme Corp. Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C
JP5530514B2 (ja) * 2009-06-11 2014-06-25 アッヴィ・バハマズ・リミテッド Ｈｃｖ感染を治療するための抗ウィルス化合物
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8221737B2 (en) 2009-06-16 2012-07-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
WO2010148006A1 (en) * 2009-06-16 2010-12-23 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US8609648B2 (en) 2009-07-02 2013-12-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
EP2475256A4 (en) * 2009-09-11 2013-06-05 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US8815928B2 (en) 2009-09-11 2014-08-26 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8822700B2 (en) * 2009-09-11 2014-09-02 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8759332B2 (en) * 2009-09-11 2014-06-24 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8703938B2 (en) * 2009-09-11 2014-04-22 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8927709B2 (en) * 2009-09-11 2015-01-06 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8653070B2 (en) * 2009-12-14 2014-02-18 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
CA2785488A1 (en) 2009-12-22 2011-07-21 Merck Sharp & Dohme Corp. Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
WO2011091417A1 (en) 2010-01-25 2011-07-28 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8178531B2 (en) * 2010-02-23 2012-05-15 Enanta Pharmaceuticals, Inc. Antiviral agents
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
EP2542074A4 (en) * 2010-03-04 2014-05-14 Enanta Pharm Inc PHARMACEUTICAL COMBINATION ACTIVE AGENTS AS HCV REPLICATION INHIBITORS
AR080676A1 (es) * 2010-03-09 2012-05-02 Schering Corp Compuestos de sililo triciclicos fusionados y metodos de uso de los mismos para el tratamiento de enfermedades virales
US9127021B2 (en) 2010-04-09 2015-09-08 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
EP2575819A4 (en) 2010-06-04 2013-11-27 Enanta Pharm Inc INHIBITORS OF HEPATITIS C VIRUS
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
WO2012021704A1 (en) 2010-08-12 2012-02-16 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
CN103687489A (zh) 2011-05-18 2014-03-26 埃南塔制药公司 制备5-氮杂螺[2.4]庚烷-6-甲酸及其衍生物的方法
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
WO2017223260A1 (en) * 2016-06-23 2017-12-28 Albert Einstein College Of Medicine, Inc. Pu.1 inhibitors
CN109553608B (zh) * 2017-09-26 2020-12-08 北京大学 一类五元六元杂环化合物及其制备方法和治疗肿瘤的用途
CN113264925A (zh) * 2020-02-14 2021-08-17 上海美悦生物科技发展有限公司 一种杂环化合物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2839989A1 (de) * 1978-09-14 1980-04-03 Hoechst Ag Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
IL111011A0 (en) * 1993-09-22 1994-11-28 Wellcome Found Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them
US6815461B1 (en) * 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
DE59509233D1 (de) * 1994-02-24 2001-06-13 Haarmann & Reimer Gmbh Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren
US5602172A (en) * 1994-05-06 1997-02-11 The University Of North Carolina At Chapel Hill Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
US5667975A (en) * 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans
US5668166A (en) * 1995-06-07 1997-09-16 Georgia State University Research Foundation, Inc. Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339193A (ja) * 2003-03-07 2004-12-02 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2011046711A (ja) * 2003-03-07 2011-03-10 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2011225575A (ja) * 2003-03-07 2011-11-10 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2012526834A (ja) * 2009-05-12 2012-11-01 シェーリング コーポレイション ウイルス疾患治療に有用な縮合型三環式アリール化合物
JP2015520125A (ja) * 2012-04-13 2015-07-16 エルジー・ケム・リミテッド 新しい含窒素複素環式化合物およびこれを用いた有機電子素子
US9666812B2 (en) 2012-04-13 2017-05-30 Lg Chem, Ltd. Nitrogen-containing heterocyclic compound and organic electronic device using same

Also Published As

Publication number Publication date
WO1998038170A1 (en) 1998-09-03
AU6670798A (en) 1998-09-18
EP0973750B1 (en) 2004-04-21
CA2282552A1 (en) 1998-09-03
HK1026691A1 (en) 2000-12-22
AU738975B2 (en) 2001-10-04
DE69823344D1 (de) 2004-05-27
US5935982A (en) 1999-08-10
DE69823344T2 (de) 2005-05-12
EP0973750A1 (en) 2000-01-26
ATE264846T1 (de) 2004-05-15

Similar Documents

Publication Publication Date Title
JP2002513404A (ja) 置換ベンズイミダゾール類とレトロウイルス感染の治療におけるそれらの使用
US5622955A (en) Methods of treating cryptosporidium parvum
EP0831832B1 (en) Methods of combatting infectious diseases using dicationic bis-benzimidazoles
JP4907082B2 (ja) ウイルス阻害剤
US5602172A (en) Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
CN101848909A (zh) 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶
JPH10501222A (ja) 破骨細胞仲介骨吸収を抑制するための化合物
EP0403535A1 (en) Coumarins to inhibit reverse transcriptase in humans
JP3306830B2 (ja) レトロウイルスインテグラーゼの阻害剤
JP3539926B2 (ja) 抗ウイルス性ピリミジンジオン誘導体及びそれらの製造方法
US7528161B2 (en) NF-kappaB inhibitors and uses thereof
KR100647386B1 (ko) ＮＦ-κＢ 억제제 및 그 용도
KR20050004227A (ko) ＮＦ-κＢ 억제제 및 그 용도
JP2004526712A (ja) ６−フェニルベンゾナフチリジン
US9359310B2 (en) Methanethione compounds having antiviral activity
JP4023753B2 (ja) Ｐｎｅｕｍｏｃｙｓｔｉｓ ｃａｒｉｎｉｉ肺炎、Ｇｉａｒｄｉａ ｌａｍｂｌｉａおよびＣｒｙｐｔｏｓｐｏｒｉｄｉｕｍ ｐａｒｖｕｍを阻止する方法およびそれらに有用な化合物
JP2005089298A (ja) ナフタレン化合物及びその医薬用途
CN119080751A (zh) 一种杂环并氮杂二酮类衍生物及其制备方法与应用
JPH10507446A (ja) ビス−２−アミノピリジン類、その製造方法及び寄生虫感染を制御するためのその用途
HK1026691B (en) Substituted benzimidazoles and their use for treating retroviral infection
JPH1149676A (ja) ピリジン系テロメラーゼ阻害剤
JPH0363275A (ja) ５，１１―ジヒドロ―６Ｈ―ピリド［２，３―ｂ］［１，４］ベンゾジアゼピン―６―オン及び―チオン並びに該化合物のＡＩＤＳの予防又は治療における使用法
EP0428105B1 (en) Use of quinolyl- and isoquinolyloxazole-2-ones for the production of a medicament for the prevention of glycoprotein enveloped virus infectivity
JP3805677B2 (ja) 新規な５−ピリミジンカルボキサミド誘導体及び該誘導体を含む製薬組成物
JP2003523952A (ja) 新規な３−ニトロピリジン誘導体及び該誘導体を含む製薬組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20041210

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080617

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20081111

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090113