DE69821508T2 - Verbrauchseinheit für laseranheftung-mikrodissektion - Google Patents
Verbrauchseinheit für laseranheftung-mikrodissektion Download PDFInfo
- Publication number
- DE69821508T2 DE69821508T2 DE69821508T DE69821508T DE69821508T2 DE 69821508 T2 DE69821508 T2 DE 69821508T2 DE 69821508 T DE69821508 T DE 69821508T DE 69821508 T DE69821508 T DE 69821508T DE 69821508 T2 DE69821508 T2 DE 69821508T2
- Authority
- DE
- Germany
- Prior art keywords
- transfer film
- laser microdissection
- laser
- cap
- microdissection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012546 transfer Methods 0.000 claims abstract description 161
- 238000000034 method Methods 0.000 claims abstract description 66
- 239000000758 substrate Substances 0.000 claims abstract description 46
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 238000001001 laser micro-dissection Methods 0.000 claims description 150
- 230000005540 biological transmission Effects 0.000 claims description 41
- 239000000463 material Substances 0.000 claims description 31
- 238000004519 manufacturing process Methods 0.000 claims description 28
- 239000011521 glass Substances 0.000 claims description 17
- 239000002904 solvent Substances 0.000 claims description 17
- 238000001531 micro-dissection Methods 0.000 claims description 10
- 239000005338 frosted glass Substances 0.000 claims description 9
- 230000002745 absorbent Effects 0.000 claims description 7
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- 229920001296 polysiloxane Polymers 0.000 claims description 7
- -1 polytetrafluoroethylene Polymers 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 6
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- 239000008273 gelatin Substances 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 238000009499 grossing Methods 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
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- 239000000126 substance Substances 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
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- 238000000370 laser capture micro-dissection Methods 0.000 abstract description 80
- 238000011109 contamination Methods 0.000 abstract description 7
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- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 18
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
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- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
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- 229920006225 ethylene-methyl acrylate Polymers 0.000 description 2
- 239000005043 ethylene-methyl acrylate Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
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- 238000010438 heat treatment Methods 0.000 description 2
- 239000012943 hotmelt Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
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- 238000000465 moulding Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
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- 238000000926 separation method Methods 0.000 description 2
- RWMKKWXZFRMVPB-UHFFFAOYSA-N silicon(4+) Chemical compound [Si+4] RWMKKWXZFRMVPB-UHFFFAOYSA-N 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000012876 topography Methods 0.000 description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical class C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 239000004134 Dicalcium diphosphate Substances 0.000 description 1
- 229920003345 Elvax® Polymers 0.000 description 1
- 241001643597 Evas Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
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- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- KYDACBKVLZCERN-UHFFFAOYSA-N ac1mpb82 Chemical compound [V+2]=O.[N-]1C(N=C2C3=CC4=CC=C(C=C4C=C3C(N=C3C4=CC5=CC=C(C=C5C=C4C(=N4)[N-]3)C(C)(C)C)=N2)C(C)(C)C)=C(C=C2C(C=CC(=C2)C(C)(C)C)=C2)C2=C1N=C1C2=CC3=CC(C(C)(C)C)=CC=C3C=C2C4=N1 KYDACBKVLZCERN-UHFFFAOYSA-N 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
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- 201000005389 breast carcinoma in situ Diseases 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
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- 238000004980 dosimetry Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 208000015355 drug-resistant tuberculosis Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- HGVPOWOAHALJHA-UHFFFAOYSA-N ethene;methyl prop-2-enoate Chemical compound C=C.COC(=O)C=C HGVPOWOAHALJHA-UHFFFAOYSA-N 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001650 focal adhesion Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
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- 210000003734 kidney Anatomy 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 201000009671 multidrug-resistant tuberculosis Diseases 0.000 description 1
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- 230000009871 nonspecific binding Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
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- 229920005989 resin Polymers 0.000 description 1
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- 238000007493 shaping process Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
- G01N2001/284—Collecting samples on a sticky, tacky, adhesive surface using local activation of adhesive, i.e. Laser Capture Microdissection
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Glass Compositions (AREA)
- Lasers (AREA)
- Laser Beam Processing (AREA)
- Gyroscopes (AREA)
- Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6073297P | 1997-10-01 | 1997-10-01 | |
| US60732P | 1997-10-01 | ||
| US08/984,983 US5985085A (en) | 1997-10-01 | 1997-12-04 | Method of manufacturing consumable for laser capture microdissection |
| US984983 | 1997-12-04 | ||
| US984979 | 1997-12-04 | ||
| US08/984,979 US7075640B2 (en) | 1997-10-01 | 1997-12-04 | Consumable for laser capture microdissection |
| PCT/US1998/020340 WO1999017094A2 (en) | 1997-10-01 | 1998-09-30 | Consumable for laser capture microdissection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69821508D1 DE69821508D1 (de) | 2004-03-11 |
| DE69821508T2 true DE69821508T2 (de) | 2004-12-16 |
Family
ID=27369893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69821508T Expired - Lifetime DE69821508T2 (de) | 1997-10-01 | 1998-09-30 | Verbrauchseinheit für laseranheftung-mikrodissektion |
| DE69842157T Expired - Lifetime DE69842157D1 (de) | 1997-10-01 | 1998-09-30 | Verfahren für laser-Anheftungs-Mikrodissektion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69842157T Expired - Lifetime DE69842157D1 (de) | 1997-10-01 | 1998-09-30 | Verfahren für laser-Anheftungs-Mikrodissektion |
Country Status (7)
| Country | Link |
|---|---|
| EP (3) | EP1260807B1 (enExample) |
| JP (2) | JP4125481B2 (enExample) |
| AT (2) | ATE259057T1 (enExample) |
| AU (1) | AU9671898A (enExample) |
| CA (1) | CA2306030C (enExample) |
| DE (2) | DE69821508T2 (enExample) |
| WO (1) | WO1999017094A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7075640B2 (en) | 1997-10-01 | 2006-07-11 | Arcturus Bioscience, Inc. | Consumable for laser capture microdissection |
| US6743601B1 (en) | 1998-12-10 | 2004-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Non-contact laser capture microdissection |
| JP4520642B2 (ja) * | 1998-12-10 | 2010-08-11 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， リプリゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 非接触レーザーキャプチャ顕微解剖のための設計 |
| AU4708600A (en) * | 1999-05-10 | 2000-11-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Surface coatings for hot-melt adhesive films |
| WO2001061311A1 (en) | 2000-02-16 | 2001-08-23 | Arcturus Engineering, Inc. | Transfer film for laser microcapture |
| DE10018251C2 (de) | 2000-04-13 | 2003-08-14 | Leica Microsystems | Laserschneid-Vorrichtung mit Mikroskop |
| US7776273B2 (en) | 2000-04-26 | 2010-08-17 | Life Technologies Corporation | Laser capture microdissection (LCM) extraction device and device carrier, and method for post-LCM fluid processing |
| US6699721B1 (en) | 2000-05-09 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Surface coatings for hot-melt adhesive film |
| JP3773831B2 (ja) * | 2000-10-31 | 2006-05-10 | 富士写真フイルム株式会社 | 生体試料の切断方法およびそれに用いる装置 |
| DE10058316A1 (de) * | 2000-11-24 | 2002-06-13 | P A L M Gmbh | Aufnahmeelement zum Aufnehmen eines mit einem Mikroskop zu betrachtenden Objekts, insbesondere eines biologischen Objekts |
| US7749388B2 (en) | 2001-06-15 | 2010-07-06 | Life Technologies Corporation | Low volume filtration column devices and methods of filtering therewith |
| US7556733B2 (en) | 2001-06-15 | 2009-07-07 | Mds Analytical Technologies (Us) Inc. | Low volume filtration column devices and methods of filtering therewith |
| US7229595B2 (en) | 2001-06-15 | 2007-06-12 | Molecular Devices Corporation | Filtration column devices and methods of filtering therewith |
| EP1651775A2 (en) * | 2003-06-18 | 2006-05-03 | Arcturus Bioscience, Inc. | Breast cancer survival and recurrence |
| US8012693B2 (en) | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| DE202010017281U1 (de) | 2010-04-15 | 2011-06-22 | Mmi Ag | Probengefäßträger für die Ablage von Einzelzellen unter einem Mikroskop |
| DE102011076238A1 (de) | 2011-05-20 | 2012-11-22 | Siemens Ag | Anordnung und Verfahren zur optischen Analyse und spezifischen Isolierung von biologischen Proben |
| WO2014053955A1 (en) * | 2012-10-03 | 2014-04-10 | Koninklijke Philips N.V. | Combined sample examinations |
| JP7356351B2 (ja) | 2016-12-12 | 2023-10-04 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム |
| US11085039B2 (en) | 2016-12-12 | 2021-08-10 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
| EP3562796B1 (en) | 2016-12-30 | 2023-04-19 | Xcella Biosciences, Inc. | Multi-stage sample recovery system |
| ES2987081T3 (es) | 2018-12-06 | 2024-11-13 | Xcella Biosciences Inc | Carga lateral de arreglos de microcapilares |
| JP7309140B1 (ja) * | 2022-04-07 | 2023-07-18 | 学校法人昭和大学 | 顕微鏡標本作製用平板及び顕微鏡標本の作製方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2801568A (en) * | 1954-11-15 | 1957-08-06 | Evelyn S Dakin | Microscope slide |
| CH566015A5 (en) * | 1973-04-12 | 1975-08-29 | Ciba Geigy Ag | Producing relief contrast in microscope image of phase object - including suppression of disturbing interference and refraction |
| US5170285A (en) * | 1988-11-09 | 1992-12-08 | Senko Medical Instruments Mfg. Co., Ltd. | Semitransparent slide and filter combination for a microscope |
| US5037613A (en) * | 1989-03-16 | 1991-08-06 | Eastman Kodak Company | Incubator |
| JP2906069B2 (ja) * | 1989-12-20 | 1999-06-14 | 泉工医科工業株式会社 | シール片およびスライド |
| US5843657A (en) * | 1994-03-01 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of cellular material under microscopic visualization |
| US5734498A (en) * | 1994-05-09 | 1998-03-31 | The Regents Of The University Of California | Illuminator elements for conventional light microscopes |
| US5859699A (en) * | 1997-02-07 | 1999-01-12 | Arcturus Engineering, Inc. | Laser capture microdissection analysis vessel |
| US6469779B2 (en) * | 1997-02-07 | 2002-10-22 | Arcturus Engineering, Inc. | Laser capture microdissection method and apparatus |
-
1998
- 1998-09-30 WO PCT/US1998/020340 patent/WO1999017094A2/en not_active Ceased
- 1998-09-30 DE DE69821508T patent/DE69821508T2/de not_active Expired - Lifetime
- 1998-09-30 EP EP02015774.9A patent/EP1260807B1/en not_active Expired - Lifetime
- 1998-09-30 AU AU96718/98A patent/AU9671898A/en not_active Abandoned
- 1998-09-30 AT AT98950746T patent/ATE259057T1/de not_active IP Right Cessation
- 1998-09-30 DE DE69842157T patent/DE69842157D1/de not_active Expired - Lifetime
- 1998-09-30 AT AT02027060T patent/ATE500496T1/de not_active IP Right Cessation
- 1998-09-30 CA CA002306030A patent/CA2306030C/en not_active Expired - Fee Related
- 1998-09-30 EP EP98950746A patent/EP1021700B1/en not_active Expired - Lifetime
- 1998-09-30 EP EP02027060A patent/EP1304556B1/en not_active Expired - Lifetime
- 1998-09-30 JP JP2000514115A patent/JP4125481B2/ja not_active Expired - Fee Related
-
2008
- 2008-02-20 JP JP2008039148A patent/JP4423482B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1021700A2 (en) | 2000-07-26 |
| EP1304556A2 (en) | 2003-04-23 |
| EP1021700B1 (en) | 2004-02-04 |
| WO1999017094A2 (en) | 1999-04-08 |
| DE69821508D1 (de) | 2004-03-11 |
| WO1999017094A3 (en) | 1999-07-22 |
| CA2306030A1 (en) | 1999-04-08 |
| ATE500496T1 (de) | 2011-03-15 |
| EP1304556B1 (en) | 2011-03-02 |
| AU9671898A (en) | 1999-04-23 |
| CA2306030C (en) | 2003-11-25 |
| ATE259057T1 (de) | 2004-02-15 |
| EP1260807B1 (en) | 2016-03-30 |
| EP1304556A3 (en) | 2003-06-04 |
| DE69842157D1 (de) | 2011-04-14 |
| JP2001518615A (ja) | 2001-10-16 |
| EP1260807A1 (en) | 2002-11-27 |
| HK1029623A1 (en) | 2001-04-06 |
| JP4423482B2 (ja) | 2010-03-03 |
| JP2008157967A (ja) | 2008-07-10 |
| JP4125481B2 (ja) | 2008-07-30 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ARCTURUS BIOSCIENCE, INC., MOUNTAIN VIEW, CALIF., |
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| 8327 | Change in the person/name/address of the patent owner |
Owner name: MDS ANALYTICAL TECHNOLOGIES (US) INC., SUNNYVA, US |