DE69812644T2 - Halbineinandergreifendes polymernetzwerk - Google Patents

Halbineinandergreifendes polymernetzwerk

Info

Publication number
DE69812644T2
DE69812644T2 DE69812644T DE69812644T DE69812644T2 DE 69812644 T2 DE69812644 T2 DE 69812644T2 DE 69812644 T DE69812644 T DE 69812644T DE 69812644 T DE69812644 T DE 69812644T DE 69812644 T2 DE69812644 T2 DE 69812644T2
Authority
DE
Germany
Prior art keywords
polymerized
compositions
polymer network
macromers
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812644T
Other languages
English (en)
Other versions
DE69812644D1 (de
Inventor
Venkatram R Shastri
S Langer
J Tarcha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE69812644D1 publication Critical patent/DE69812644D1/de
Publication of DE69812644T2 publication Critical patent/DE69812644T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30583—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with hardenable fluid, e.g. curable in-situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0085—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof hardenable in situ, e.g. epoxy resins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/903—Interpenetrating network
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/923—Bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
DE69812644T 1997-07-17 1998-07-10 Halbineinandergreifendes polymernetzwerk Expired - Lifetime DE69812644T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/895,762 US5837752A (en) 1997-07-17 1997-07-17 Semi-interpenetrating polymer networks
PCT/US1998/014390 WO1999003516A2 (en) 1997-07-17 1998-07-10 Semi-interpenetrating polymer networks

Publications (2)

Publication Number Publication Date
DE69812644D1 DE69812644D1 (de) 2003-04-30
DE69812644T2 true DE69812644T2 (de) 2003-12-18

Family

ID=25405044

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812644T Expired - Lifetime DE69812644T2 (de) 1997-07-17 1998-07-10 Halbineinandergreifendes polymernetzwerk

Country Status (7)

Country Link
US (1) US5837752A (de)
EP (1) EP1005378B1 (de)
JP (2) JP2001510078A (de)
AT (1) ATE235273T1 (de)
CA (1) CA2296374C (de)
DE (1) DE69812644T2 (de)
WO (1) WO1999003516A2 (de)

Families Citing this family (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
US7060287B1 (en) * 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
EP0842670A1 (de) * 1996-11-13 1998-05-20 Katsunari Nishihara Biomedizinische Materialien
WO1998030141A2 (en) * 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6486232B1 (en) * 1997-04-18 2002-11-26 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
US6309420B1 (en) * 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
SE9801901L (sv) * 1998-05-29 1999-08-02 Bone Support Ab Förfarande för framställning av pulverkomponent till cement för medicinskt bruk, användning av sådan pulverkomponent samt sådan pulverkomponent
US6300390B1 (en) 1998-06-09 2001-10-09 Kerr Corporation Dental restorative composite
US6121344A (en) * 1998-06-19 2000-09-19 Kerr Corporation Optimum particle sized hybrid composite
US6403672B1 (en) * 1998-11-30 2002-06-11 University Technology Corporation Preparation and use of photopolymerized microparticles
US6864301B2 (en) * 1998-11-30 2005-03-08 The Regents Of The University Of Colorado Preparation and use of photopolymerized microparticles
WO2000035511A1 (en) * 1998-12-17 2000-06-22 Cambridge Scientific, Inc. Sequenced incorporation of cortical bone allografts
US6506217B1 (en) * 1999-03-29 2003-01-14 Arnett Facial Reconstruction Courses, Inc. Moldable post-implantation bone filler and method
US6482427B2 (en) * 1999-04-23 2002-11-19 Unicare Biomedical, Inc. Compositions and methods for repair of osseous defects and accelerated wound healing
CA2372276C (en) * 1999-05-18 2012-01-10 Cryolife, Inc. Self-supporting, shaped, three-dimensional biopolymeric materials and methods
US20040110722A1 (en) * 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
ATE291446T1 (de) * 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
EP1202701A1 (de) * 1999-08-13 2002-05-08 JENERIC/PENTRON Incorporated Dentalzusammensetzungen mit abbaubaren polymeren
US6352667B1 (en) * 1999-08-24 2002-03-05 Absorbable Polymer Technologies, Inc. Method of making biodegradable polymeric implants
EP1142596A1 (de) * 2000-04-03 2001-10-10 Universiteit Gent Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
WO2001076514A2 (en) * 2000-04-05 2001-10-18 Kyphon Inc. Methods and devices for treating fractured and/or diseased bone
SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
US6875212B2 (en) 2000-06-23 2005-04-05 Vertelink Corporation Curable media for implantable medical device
US6964667B2 (en) 2000-06-23 2005-11-15 Sdgi Holdings, Inc. Formed in place fixation system with thermal acceleration
CA2414168C (en) 2000-06-23 2010-02-09 University Of Southern California Percutaneous vertebral fusion system
US6899713B2 (en) 2000-06-23 2005-05-31 Vertelink Corporation Formable orthopedic fixation system
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US6787584B2 (en) * 2000-08-11 2004-09-07 Pentron Corporation Dental/medical compositions comprising degradable polymers and methods of manufacture thereof
US20020045678A1 (en) * 2000-08-22 2002-04-18 Lopez Larry A. Dental restorative compositions and method of use thereof
US6770086B1 (en) * 2000-11-02 2004-08-03 Scimed Life Systems, Inc. Stent covering formed of porous polytetraflouroethylene
US7625580B1 (en) 2000-11-28 2009-12-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
AU2002245092A1 (en) * 2000-12-08 2002-07-30 Todd M. Boyce Implant for orthopedic applications
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6666870B2 (en) * 2001-01-05 2003-12-23 Robert A Dixon Method utilizing chemical bonding to improve the bone screw fixation interface
CA2438047A1 (en) * 2001-02-14 2002-08-22 Hildegard M. Kramer Biocompatible fleece for hemostasis and tissue engineering
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
US20070191964A1 (en) * 2001-04-04 2007-08-16 Arthrocare Corporation Enhanced visibility materials for implantation in hard tissue
US7122057B2 (en) 2001-04-12 2006-10-17 Therics, Llc Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications
US8740987B2 (en) 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
US7722894B2 (en) * 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
US6822033B2 (en) 2001-11-19 2004-11-23 United States Gypsum Company Compositions and methods for treating set gypsum
SE522098C2 (sv) 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
US20050019747A1 (en) * 2002-08-07 2005-01-27 Anderson Daniel G. Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
US20040028804A1 (en) * 2002-08-07 2004-02-12 Anderson Daniel G. Production of polymeric microarrays
JP2006501884A (ja) 2002-08-12 2006-01-19 オステオテック，インコーポレイテッド 骨−ポリマー複合材料の合成
EP1549359A2 (de) * 2002-10-08 2005-07-06 Osteotech, Inc. Kupplungsmittel für orthopädische biomaterialien
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
NZ540697A (en) * 2002-12-12 2008-05-30 Osteotech Inc Formable and settable polymer bone composite and method of production thereof
BR0317809A (pt) * 2003-02-13 2005-11-29 Synthes Ag Mistura de substituição de osso injetável
AU2004212942A1 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
US20060052471A1 (en) * 2003-02-27 2006-03-09 A Enterprises, Inc. Initiators and crosslinkable polymeric materials
US7393493B2 (en) * 2003-02-27 2008-07-01 A Enterprises, Inc. Crosslinkable polymeric materials and their applications
SE0300620D0 (sv) 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
US20050136536A1 (en) * 2003-09-15 2005-06-23 Anderson Daniel G. Embryonic epithelial cells
WO2005037137A2 (en) * 2003-10-17 2005-04-28 Therics, Inc. Spinal cage insert, filler piece and method of manufacturing
SE0302983D0 (sv) 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
GB0329907D0 (en) * 2003-12-23 2004-01-28 Innomed Ltd Compositions
US20060222677A1 (en) * 2004-01-14 2006-10-05 Bianca Baroli Method of protecting sensitive molecules from a photo-polymerizing environment
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
US20080249633A1 (en) * 2006-08-22 2008-10-09 Tim Wu Biodegradable Materials and Methods of Use
US7446131B1 (en) * 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
SE527528C2 (sv) * 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
JP4752047B2 (ja) * 2004-06-30 2011-08-17 国立大学法人北海道大学 細胞培養用基材の製造方法及び細胞培養方法
US20060074422A1 (en) * 2004-09-27 2006-04-06 Story Brooks J Suture anchor and void filler combination
US20060067971A1 (en) * 2004-09-27 2006-03-30 Story Brooks J Bone void filler
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
AT501700B1 (de) * 2005-04-14 2011-03-15 Univ Wien Tech Mit strahlung härtbare, biologisch abbaubare zusammensetzungen und deren verwendung als stützmaterialien für den knochenersatz
WO2006138542A2 (en) * 2005-06-15 2006-12-28 Surmodics, Inc. Macromer composition including light activated initiator
US7727235B2 (en) * 2005-06-29 2010-06-01 Ethicon, Inc. Medical fixation devices with improved torsional drive head
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
WO2007022348A2 (en) * 2005-08-18 2007-02-22 Massachusetts Institute Of Technology Amplification of cell polulations from embryonic stem cells
CA2626347A1 (en) * 2005-10-19 2007-04-26 A Enterprises, Inc. Curable bone substitute
US20070100449A1 (en) * 2005-10-31 2007-05-03 O'neil Michael Injectable soft tissue fixation technique
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
CA2634245C (en) * 2005-12-28 2013-12-10 Dentsply International Inc. Light-curable bone growth material for treating dental bone defects
AU2007204617A1 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
US20090011486A1 (en) * 2006-01-12 2009-01-08 Massachusetts Institute Of Technology Biodegradable Elastomers
WO2007084725A2 (en) 2006-01-19 2007-07-26 Osteotech, Inc. Injectable and moldable bone substitute materials
EP1976459A4 (de) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Poröses knochenimplantat
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
US20070212385A1 (en) * 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
JP2009534309A (ja) 2006-03-31 2009-09-24 マサチューセッツ インスティテュート オブ テクノロジー 治療剤の標的化送達のためのシステム
US20080069857A1 (en) * 2006-04-12 2008-03-20 Yoon Yeo Compositions And Methods For Inhibiting Adhesions
CA2649915A1 (en) * 2006-04-20 2007-11-01 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
EP2015789A1 (de) * 2006-04-27 2009-01-21 Queensland University of Technology Biologisch abbaubare implantate zur knochenfusion und zusammensetzungen dafür
WO2007133807A2 (en) 2006-05-15 2007-11-22 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
US20080193536A1 (en) * 2006-08-14 2008-08-14 Alireza Khademhosseini Cell-Laden Hydrogels
US8105382B2 (en) 2006-12-07 2012-01-31 Interventional Spine, Inc. Intervertebral implant
US7771476B2 (en) * 2006-12-21 2010-08-10 Warsaw Orthopedic Inc. Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion
US8758407B2 (en) 2006-12-21 2014-06-24 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing orthopedic implant device in vivo
US8480718B2 (en) 2006-12-21 2013-07-09 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to be hardened after placement in vivo
US8663328B2 (en) 2006-12-21 2014-03-04 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
PT2109641T (pt) * 2007-01-17 2017-05-25 Agrofresh Inc Entrega de agentes de bloqueio e/ou promotores de etileno
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US8070895B2 (en) 2007-02-12 2011-12-06 United States Gypsum Company Water resistant cementitious article and method for preparing same
EP2061875A1 (de) * 2007-03-09 2009-05-27 Corning Incorporated Gummibeschichtungen für eine zellkultur, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung
US8080418B2 (en) * 2007-03-09 2011-12-20 Corning Incorporated Method of making a three dimensional cell culture matrix
PT2136788E (pt) 2007-03-30 2012-02-03 Bind Biosciences Inc Direccionamento a células de cancro utilizando nanopartículas
WO2008124639A2 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2008144514A2 (en) * 2007-05-17 2008-11-27 Massachusetts Institute Of Technology Polyol-based polymers
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
WO2009002456A2 (en) * 2007-06-21 2008-12-31 Massachusetts Institute Of Technology Methods and compositions relating to progenitor cells
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US20090149569A1 (en) * 2007-07-19 2009-06-11 Shastri V Prasad Surface engineering of tissue graft materials for enhanced porosity and cell adhesion
US8062655B2 (en) * 2007-08-31 2011-11-22 Phillips Plastics Corporation Composite scaffold structure
MX2010003642A (es) 2007-10-12 2010-08-09 Massachusetts Inst Technology Nanotecnologia de vacuna.
WO2009069123A2 (en) 2007-11-26 2009-06-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions comprising fibrous polypeptides and polysaccharides
JP5441922B2 (ja) 2008-01-17 2014-03-12 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 膨張可能な椎間インプラント及び関連するその製造方法
CA2719798A1 (en) * 2008-03-28 2009-10-01 Osteotech, Inc. Bone anchors for orthopedic applications
KR20110003475A (ko) 2008-04-05 2011-01-12 신세스 게엠바하 팽창성 추간 임플란트
GB2459438B (en) * 2008-04-10 2010-10-06 Kythera Biopharmaceuticals Inc Systems and methods for transdermal photo-polymerization
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
US9198875B2 (en) 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
WO2010096704A2 (en) * 2009-02-19 2010-08-26 Alex Garfield Bonner Porous interpenetrating polymer network
EP2403964B1 (de) 2009-03-02 2021-09-08 Massachusetts Institute of Technology Verfahren und produkte zur in-vivo-profilerstellung von enzymen
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US8329308B2 (en) 2009-03-31 2012-12-11 United States Gypsum Company Cementitious article and method for preparing the same
EA022699B1 (ru) 2009-05-27 2016-02-29 Селекта Байосайенсиз, Инк. НАЦЕЛЕННЫЕ СИНТЕТИЧЕСКИЕ НАНОНОСИТЕЛИ С pH-ЧУВСТВИТЕЛЬНЫМ ВЫСВОБОЖДЕНИЕМ ИММУНОМОДУЛИРУЮЩИХ СРЕДСТВ
EP3311833A3 (de) 2009-08-26 2018-07-25 Selecta Biosciences, Inc. Zusammensetzungen zur induzierung von t-zellen-hilfe
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
EA023397B1 (ru) 2010-05-26 2016-05-31 Селекта Байосайенсиз, Инк. Комбинированные вакцины с синтетическими наноносителями
US8845733B2 (en) 2010-06-24 2014-09-30 DePuy Synthes Products, LLC Lateral spondylolisthesis reduction cage
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
EP2585541B1 (de) * 2010-06-25 2016-06-08 3M Innovative Properties Company Semiinterpenetrierendes polymernetzwerk
TW201215379A (en) 2010-06-29 2012-04-16 Synthes Gmbh Distractible intervertebral implant
US20130217829A1 (en) * 2010-08-27 2013-08-22 David Myung "hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same"
US9549901B2 (en) 2010-09-03 2017-01-24 The Brigham And Women's Hospital, Inc. Lipid-polymer hybrid particles
WO2012045013A2 (en) * 2010-10-01 2012-04-05 Skeletal Kinetics, Llc Porogen containing calcium phosphate cement compositions
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
WO2012149259A1 (en) 2011-04-29 2012-11-01 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers to reduce antibody responses
AU2012290306B2 (en) 2011-07-29 2017-08-17 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte (CTL) immune responses
EP2742134A2 (de) 2011-08-11 2014-06-18 Qiagen GmbH Zell- oder virussimulationsmittel mit eingekapselten markermolekülen
CA2885996A1 (en) 2011-10-03 2013-04-11 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
EP2841056A4 (de) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stabile schichtweise beschichtete teilchen
PL2958603T3 (pl) 2013-02-20 2018-10-31 Bone Support Ab Ulepszone zestalanie utwardzalnego materiału zastępczego kości
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9717601B2 (en) 2013-02-28 2017-08-01 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
EP3766516A1 (de) 2013-03-14 2021-01-20 President and Fellows of Harvard College Zusammensetzungen von nanopartikeln
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
EA201592103A3 (ru) 2013-05-03 2016-08-31 Селекта Байосайенсиз, Инк. Способы и композиции для усиления cd4+ регуляторных t-клеток
CN112933218A (zh) 2013-06-04 2021-06-11 西莱克塔生物科技公司 非免疫抑制性抗原特异性免疫治疗剂的重复施用
EA201692512A1 (ru) 2014-06-25 2017-07-31 Селекта Байосайенсиз, Инк. Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки
WO2016025786A1 (en) * 2014-08-15 2016-02-18 The Johns Hopkins University Post-surgical imaging marker
CN106714826A (zh) 2014-09-07 2017-05-24 西莱克塔生物科技公司 用于减弱基因表达调节抗病毒转移载体免疫应答的方法和组合物
SI3215133T1 (sl) 2014-11-05 2021-07-30 Selecta Biosciences, Inc. Postopki in sestavki v zvezi z uporabo površinsko aktivnih snovi z nizkim HLB v proizvodnji sintetičnih nanonosilcev, ki vsebujejo rapalog
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
EP3340982B1 (de) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Verbindungen zur behandlung von immun- und entzündungserkrankungen
WO2017117188A1 (en) 2015-12-29 2017-07-06 Massachusetts Institute Of Technology Biodegradable free-standing controlled drug release stickers
US11225520B2 (en) 2016-02-16 2022-01-18 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
EP3426285B1 (de) 2016-03-11 2024-05-29 Cartesian Therapeutics, Inc. Formulierungen und dosen von pegylierter uricase
WO2018005552A1 (en) 2016-06-27 2018-01-04 Achillion Pharmaceuticals, Inc. Quinazoline and indole compounds to treat medical disorders
US11596522B2 (en) 2016-06-28 2023-03-07 Eit Emerging Implant Technologies Gmbh Expandable and angularly adjustable intervertebral cages with articulating joint
US11510788B2 (en) 2016-06-28 2022-11-29 Eit Emerging Implant Technologies Gmbh Expandable, angularly adjustable intervertebral cages
US20180085319A1 (en) 2016-09-27 2018-03-29 Takashi Kei Kishimoto Methods and compositions for treating cancer
WO2018094227A1 (en) 2016-11-17 2018-05-24 The University Of North Carolina At Chapel Hill Alkyl pyrrolopyrimidine analogs and methods of making and using same
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
KR20190104194A (ko) 2017-01-07 2019-09-06 셀렉타 바이오사이언시즈, 인크. 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여
US10584201B2 (en) * 2017-01-10 2020-03-10 The Texas A&M University System Methanesulfonic acid mediated solvent free synthesis of conjugated porous polymer networks
CN110612122A (zh) 2017-03-11 2019-12-24 西莱克塔生物科技公司 与用抗炎剂和包含免疫抑制剂之合成纳米载体进行的组合治疗相关的方法和组合物
AU2018248327A1 (en) 2017-04-07 2019-10-17 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
EP3675897A1 (de) 2017-09-01 2020-07-08 Dana Farber Cancer Institute, Inc. Immunogene peptide spezifisch für bcma und taci-antigene zur behandlung von krebs
US20200249194A9 (en) 2017-10-12 2020-08-06 Massachusetts Institute Of Technology Prostate protease nanosensors and uses thereof
MX2020003838A (es) 2017-10-13 2020-08-06 Selecta Biosciences Inc Metodos y composiciones para atenuar las respuestas de inmunoglobulina m del vector de transferencia antiviral.
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
WO2019217661A1 (en) 2018-05-09 2019-11-14 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
US20200038462A1 (en) 2018-07-16 2020-02-06 Selecta Biosciences, Inc. Methods and compositions of otc constructs and vectors
CA3106640A1 (en) 2018-07-16 2020-01-23 Selecta Biosciences, Inc. Methods and compositions of mma constructs and vectors
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
JP2021535112A (ja) 2018-08-20 2021-12-16 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体ｄ因子の医学的障害の治療のための医薬化合物
WO2020068920A2 (en) 2018-09-25 2020-04-02 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
EP3866773A4 (de) 2018-10-16 2022-10-26 Georgia State University Research Foundation, Inc. Kohlenmonoxid-prodrugs zur behandlung von erkrankungen
WO2020081635A2 (en) 2018-10-16 2020-04-23 Massachusetts Institute Of Technology Renal clearable nanocatalysts for disease monitoring
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
MX2021013163A (es) 2019-04-28 2022-02-21 Selecta Biosciences Inc Métodos para el tratamiento de sujetos con inmunidad preexistente a vectores de transferencia viral.
MX2021014566A (es) 2019-05-28 2022-03-22 Selecta Biosciences Inc Métodos y composiciones para la respuesta inmune atenuada anti-vector de transferencia viral.
CN114207440A (zh) 2019-06-04 2022-03-18 西莱克塔生物科技公司 聚乙二醇化尿酸酶的制剂和剂量
AU2020370129A1 (en) 2019-10-21 2022-05-12 Selecta Biosciences, Inc. Methods and compositions for treating liver diseases and disorders
WO2021092354A1 (en) 2019-11-08 2021-05-14 Selecta Biosciences, Inc. Formulations and doses of pegylated uricase
US20210262025A1 (en) 2020-02-18 2021-08-26 Massachusetts Institute Of Technology Multiplexed in vivo disease sensing with nucleic acid-barcoded reporters
WO2021174013A1 (en) 2020-02-26 2021-09-02 Selecta Biosciences, Inc. Methods and compositions using synthetic nanocarriers comprising immunosuppressant
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
MX2022011248A (es) 2020-03-11 2022-12-15 Selecta Biosciences Inc Metodos y composiciones relacionados con nanoportadores sinteticos.
EP4135693A1 (de) 2020-04-14 2023-02-22 Selecta Biosciences, Inc. Verfahren und zusammensetzungen zur induktion von autophagie
US11855258B2 (en) 2020-06-08 2023-12-26 Cmc Materials, Inc. Secondary battery cell with solid polymer electrolyte
EP4240400A1 (de) 2020-11-04 2023-09-13 Selecta Biosciences, Inc. Zusammensetzungen zur verringerung der immunantworten gegen immunglobulinproteasen
WO2022150335A1 (en) 2021-01-05 2022-07-14 Selecta Biosciences, Inc. Viral vector dosing protocols
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
US20220323607A1 (en) 2021-04-09 2022-10-13 Selecta Biosciences, Inc. Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists to enhance immune tolerance
WO2022240741A1 (en) 2021-05-12 2022-11-17 Dana-Farber Cancer Institute, Inc. Lag3 and gal3 inhibitory agents, xbp1, cs1, and cd138 peptides, and methods of use thereof
WO2023064367A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
CA3235269A1 (en) 2021-10-12 2023-04-20 Cartesian Therapeutics, Inc. Viral vector dosing protocols
CA3237037A1 (en) 2021-11-14 2023-05-19 Cartesian Therapeutics, Inc. Multiple dosing with viral vectors
WO2023133319A1 (en) 2022-01-10 2023-07-13 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and synthetic nanocarrier dose sparing
WO2023172624A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2023172628A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressant in combination with high affinity il-2 receptor agonists and related dosing
US20230372535A1 (en) 2022-03-25 2023-11-23 Selecta Biosciences, Inc. Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists and anti-igm agents
US20230381277A1 (en) 2022-04-08 2023-11-30 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance
US20240148841A1 (en) 2022-08-11 2024-05-09 Selecta Biosciences Inc. Compositions and methods related to immunoglobulin proteases and fusions thereof
WO2024107889A1 (en) 2022-11-15 2024-05-23 Selecta Biosciences, Inc. Compositions and methods for treating primary biliary cholangitis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
DE246341T1 (de) * 1986-05-20 1989-03-30 Massachusetts Institute Of Technology, Cambridge, Mass., Us Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad.
AU2902289A (en) * 1987-12-08 1989-07-05 Mark Chasin Method of forming bioerodible implants for improved controlled drug release
US4888413A (en) * 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
DE69004245T2 (de) * 1990-02-23 1994-05-11 Minnesota Mining & Mfg Semi-thermoplastische Formmasse mit thermostabilem Formerinnerungsvermögen.
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
IT1259100B (it) * 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
ITPD940011A1 (it) * 1994-01-28 1995-07-28 Fidia Advanced Biopolymers Srl Rivestimento di oggetti biomedicali mediante microsfere ottenute da polimeri biocompatibili
CA2167455A1 (en) * 1995-01-19 1996-07-20 Kevin Cooper Absorbable polyalkylene diglycolates
ATE342295T1 (de) * 1995-07-28 2006-11-15 Genzyme Corp Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same

Also Published As

Publication number Publication date
JP2001510078A (ja) 2001-07-31
JP2010005426A (ja) 2010-01-14
EP1005378A2 (de) 2000-06-07
DE69812644D1 (de) 2003-04-30
EP1005378B1 (de) 2003-03-26
WO1999003516A2 (en) 1999-01-28
US5837752A (en) 1998-11-17
CA2296374A1 (en) 1999-01-28
ATE235273T1 (de) 2003-04-15
WO1999003516A3 (en) 1999-06-24
CA2296374C (en) 2006-04-25

Similar Documents

Publication Publication Date Title
DE69812644D1 (de) Halbineinandergreifendes polymernetzwerk
EP0613380B1 (de) Die Verwendung von monomerem/polymerem Material zur Herstellung einer härtbaren Zusammensetzung für die Reparatur von Knorpeln
EP0642363B1 (de) Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen
ATE273721T1 (de) Diferentiell bioabbaubare medizinische inplantate
CA2632120C (en) Methods of bonding or modifying hydrogels using irradiation
DK0959873T3 (da) Gelsammensætning og fremgangsmåder
CA2308721A1 (en) Radio-opaque polymer biomaterials
WO2001013819A3 (en) A method of making biodegradable polymeric implants
GB9814609D0 (en) Polymers
IT1243390B (it) Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
AU7486798A (en) Polyhydroxyalkanoates for (in vivo) applications
CY1107044T1 (el) Ιατρικες συσκευες και εφαρμογες πολυμερων πολυυδροξυαλκανοϊκου
BR9711241B8 (pt) processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento
EP0895785A3 (de) Füllmaterial für implantierbare Prothesen aus Weichgewebe und Implantate daraus
NO982703L (no) Lineµre blokkpolymerer som omfatter urea- og uretangrupper, fremgangsmÕte til fremstilling av lineµre blokkpolymerer og anvendelse av blokkpolymerene som implantater
DE69636989D1 (de) Bioaktive lasttragende zusammensetzungen zum knochenverbund
JP2010512223A (ja) 組織修復のための複合材料
DE59711402D1 (de) Injizierbare polymerzusammensetzung zur herstellung eines in-situ-implantats
ATE242636T1 (de) Methode zur sterilisation männlicher säugetiere
DE60019727D1 (de) Biologisch abbaures verbundmaterial für die gewebewiederherstellung
FI935509A (fi) Sampolymerer baserade pao cykliska estrar och deras anvaendning som kirurgiska implantat
BR9906034A (pt) Mistura de polìmero radiopaco
San Roman et al. Polymeric Biomaterials for Medical Applications. II. Porous and Biodegradable Carbon Fiber Reinforced Composites
ATE223723T1 (de) Sterilisation weiblicher säugetieren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition