SI3215133T1 - Postopki in sestavki v zvezi z uporabo površinsko aktivnih snovi z nizkim HLB v proizvodnji sintetičnih nanonosilcev, ki vsebujejo rapalog - Google Patents

Postopki in sestavki v zvezi z uporabo površinsko aktivnih snovi z nizkim HLB v proizvodnji sintetičnih nanonosilcev, ki vsebujejo rapalog

Info

Publication number
SI3215133T1
SI3215133T1 SI201531494T SI201531494T SI3215133T1 SI 3215133 T1 SI3215133 T1 SI 3215133T1 SI 201531494 T SI201531494 T SI 201531494T SI 201531494 T SI201531494 T SI 201531494T SI 3215133 T1 SI3215133 T1 SI 3215133T1
Authority
SI
Slovenia
Prior art keywords
rapalog
production
methods
synthetic nanocarriers
low hlb
Prior art date
Application number
SI201531494T
Other languages
English (en)
Inventor
Conlin O'neil
Aaron P. Griset
David H. Altreuter
Original Assignee
Selecta Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selecta Biosciences, Inc. filed Critical Selecta Biosciences, Inc.
Publication of SI3215133T1 publication Critical patent/SI3215133T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
SI201531494T 2014-11-05 2015-11-05 Postopki in sestavki v zvezi z uporabo površinsko aktivnih snovi z nizkim HLB v proizvodnji sintetičnih nanonosilcev, ki vsebujejo rapalog SI3215133T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462075866P 2014-11-05 2014-11-05
US201462075864P 2014-11-05 2014-11-05
EP15798601.9A EP3215133B1 (en) 2014-11-05 2015-11-05 Methods and compositions related to the use of low hlb surfactants in the production of synthetic nanocarriers comprising a rapalog
PCT/US2015/059349 WO2016073798A1 (en) 2014-11-05 2015-11-05 Methods and compositions related to the use of low hlb surfactants in the production of synthetic nanocarriers comprising a rapalog

Publications (1)

Publication Number Publication Date
SI3215133T1 true SI3215133T1 (sl) 2021-07-30

Family

ID=54697646

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531494T SI3215133T1 (sl) 2014-11-05 2015-11-05 Postopki in sestavki v zvezi z uporabo površinsko aktivnih snovi z nizkim HLB v proizvodnji sintetičnih nanonosilcev, ki vsebujejo rapalog

Country Status (23)

Country Link
US (2) US20160128986A1 (sl)
EP (6) EP4356910A3 (sl)
JP (5) JP6912377B2 (sl)
KR (2) KR102601922B1 (sl)
CN (5) CN115212187A (sl)
AU (4) AU2015342968B2 (sl)
BR (3) BR112017008720A2 (sl)
CA (2) CA2966850C (sl)
CY (1) CY1124418T1 (sl)
DK (4) DK3215192T3 (sl)
EA (2) EA201790977A1 (sl)
ES (4) ES2865375T3 (sl)
FI (2) FI3906918T3 (sl)
HR (1) HRP20210098T1 (sl)
HU (3) HUE054894T2 (sl)
IL (7) IL295292B2 (sl)
LT (1) LT3215133T (sl)
MX (4) MX2017005904A (sl)
PL (1) PL3215133T3 (sl)
PT (1) PT3215133T (sl)
RS (1) RS61359B1 (sl)
SI (1) SI3215133T1 (sl)
WO (2) WO2016073798A1 (sl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107252482A (zh) 2009-05-27 2017-10-17 西莱克塔生物科技公司 具有不同释放速率的纳米载体加工组分
US20110293701A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Multivalent synthetic nanocarrier vaccines
WO2012061717A1 (en) 2010-11-05 2012-05-10 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
MX2013012593A (es) 2011-04-29 2014-08-21 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos.
CN109172819A (zh) 2011-07-29 2019-01-11 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞（ctl）免疫应答的合成纳米载体
KR20220025907A (ko) 2013-05-03 2022-03-03 셀렉타 바이오사이언시즈, 인크. 비-알레르겐성 항원에 반응하는 아나필락시스를 감소시키거나 방지하기 위한 관용유발 합성 나노담체
WO2015025538A1 (ja) * 2013-08-20 2015-02-26 サンノプコ株式会社 バイオエタノール発酵工程用添加剤及びバイオエタノールの製造方法
MX2017002931A (es) 2014-09-07 2017-05-30 Selecta Biosciences Inc Metodos y composiciones para atenuar respuestas inmunes anti-vector de transferencia viral.
JP6774591B2 (ja) * 2015-02-17 2020-10-28 サンノプコ株式会社 バイオエタノール発酵工程用添加剤及びバイオエタノールの製造方法
US10973925B2 (en) * 2015-04-28 2021-04-13 University Of Central Florida Research Foundation Inc. Methods and compositions for theranostic nanoparticles
KR20180120753A (ko) 2016-03-11 2018-11-06 셀렉타 바이오사이언시즈, 인크. Peg화 우리카제의 제제 및 용량
KR102341902B1 (ko) * 2016-09-09 2021-12-21 카오카부시키가이샤 디카르복실산 결정 및 그 제조 방법
WO2018064215A1 (en) 2016-09-27 2018-04-05 Selecta Biosciences, Inc. Recombinant immunotoxins for use in the treatment of cancer
JP2020506890A (ja) 2017-01-07 2020-03-05 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリアにカップリングした免疫抑制剤のパターン化された投与
KR20190124295A (ko) 2017-03-11 2019-11-04 셀렉타 바이오사이언시즈, 인크. 항염증제, 및 면역억제제를 포함하는 합성 나노담체를 사용한 조합 치료와 관련된 방법 및 조성물
WO2019075360A1 (en) 2017-10-13 2019-04-18 Selecta Biosciences, Inc. METHODS AND COMPOSITIONS FOR MITIGATING ANTI-VECTOR VIRAL TRANSFER IGM RESPONSES
BR112021021566A2 (pt) 2019-04-28 2022-04-19 Selecta Biosciences Inc Métodos para tratamento de indivíduos com imunidade preexistente a vetores de transferência viral
CA3141863A1 (en) 2019-05-28 2020-12-03 Selecta Biosciences, Inc. Methods and compositions for attenuated anti-viral transfer vector immune response
CA3138071A1 (en) 2019-06-04 2020-12-10 Selecta Biosciences, Inc. Formulations and doses of pegylated uricase
IL292392A (en) 2019-10-21 2022-06-01 Selecta Biosciences Inc Methods and preparations for the treatment of liver diseases and disorders
CN118384281A (zh) 2019-11-08 2024-07-26 西莱克塔生物科技公司 聚乙二醇化尿酸酶的制剂和剂量
WO2021174013A1 (en) 2020-02-26 2021-09-02 Selecta Biosciences, Inc. Methods and compositions using synthetic nanocarriers comprising immunosuppressant
US20210308058A1 (en) * 2020-03-11 2021-10-07 Selecta Biosciences, Inc. Methods and compositions related to synthetic nanocarriers
CA3180166A1 (en) 2020-04-14 2021-10-21 Selecta Biosciences, Inc. Methods and compositions for inducing autophagy
CN116568329A (zh) 2020-11-04 2023-08-08 西莱克塔生物科技公司 用于降低针对免疫球蛋白蛋白酶的免疫应答的组合物
JP2024502115A (ja) 2021-01-05 2024-01-17 セレクタ バイオサイエンシーズ インコーポレーテッド ウイルスベクター投薬プロトコル
KR102304785B1 (ko) 2021-03-26 2021-09-24 (주)진성티앤피 정밀광학기기의 부품 제조 방법
MX2023011930A (es) 2021-04-09 2024-03-11 Selecta Biosciences Inc Nanoportadores sintéticos que comprenden un inmunosupresor en combinación con antagonistas del receptor de il-2 de alta afinidad para mejorar la tolerancia inmune.
CA3216491A1 (en) 2021-04-16 2022-10-20 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
US20230141563A1 (en) 2021-10-12 2023-05-11 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
US20230140196A1 (en) 2021-10-12 2023-05-04 Selecta Biosciences, Inc. Viral vector dosing protocols
WO2023086615A1 (en) 2021-11-14 2023-05-19 Selecta Biosciences, Inc. Multiple dosing with viral vectors
WO2023133319A1 (en) 2022-01-10 2023-07-13 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and synthetic nanocarrier dose sparing
US20230357437A1 (en) 2022-03-09 2023-11-09 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2023172628A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressant in combination with high affinity il-2 receptor agonists and related dosing
US20230381277A1 (en) 2022-04-08 2023-11-30 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance
WO2024036324A1 (en) 2022-08-11 2024-02-15 Selecta Biosciences, Inc. Compositions and methods related to immunoglobulin proteases and fusions thereof
WO2024107889A1 (en) 2022-11-15 2024-05-23 Selecta Biosciences, Inc. Compositions and methods for treating primary biliary cholangitis

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946929A (en) 1983-03-22 1990-08-07 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4638045A (en) 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4806621A (en) 1986-01-21 1989-02-21 Massachusetts Institute Of Technology Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5019379A (en) 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
US5010167A (en) 1989-03-31 1991-04-23 Massachusetts Institute Of Technology Poly(amide-and imide-co-anhydride) for biological application
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5565215A (en) 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US6095148A (en) 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
EP0937082A2 (en) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
US7288266B2 (en) 1996-08-19 2007-10-30 United States Of America As Represented By The Secretary, Department Of Health And Human Services Liposome complexes for increased systemic delivery
US5837752A (en) 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US6187335B1 (en) 1997-12-31 2001-02-13 Orasomal Technologies, Inc. Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
US6632922B1 (en) 1998-03-19 2003-10-14 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
US6506577B1 (en) 1998-03-19 2003-01-14 The Regents Of The University Of California Synthesis and crosslinking of catechol containing copolypeptides
US6686446B2 (en) 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
JP2002521423A (ja) 1998-07-31 2002-07-16 コリア インスティチュート オブ サイエンス アンド テクノロージ 遺伝子又は薬物運搬体としての脂質エマルジョン及び固形脂質微粒子
CA2341358C (en) * 1998-09-01 2011-04-26 David James Brayden Method for inducing a cell-mediated immune response and parenteral vaccine formulations therefor
CA2400172C (en) 2000-02-28 2010-04-20 Genesegues, Inc. Nanocapsule encapsulation system and method
US6818732B2 (en) 2001-08-30 2004-11-16 The Regents Of The University Of California Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
WO2004017943A2 (en) 2002-08-23 2004-03-04 Medigene Oncology Gmbh Non-vesicular cationic lipid formulations
CN1886100A (zh) * 2003-11-14 2006-12-27 阿尔萨公司 基于表面活性剂的凝胶作为可注射的持续药物递送载体
US20050260260A1 (en) 2004-05-19 2005-11-24 Edward Kisak Liposome compositions for the delivery of macromolecules
NZ592132A (en) * 2005-08-31 2012-12-21 Abraxis Bioscience Llc Composition comprising nanoparticles of docitaxel and a citrate
US8414910B2 (en) * 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
MX350501B (es) 2007-10-12 2017-09-07 Massachusetts Inst Technology Nanotecnologia de vacuna.
US8613951B2 (en) * 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
ES2765240T3 (es) * 2008-06-16 2020-06-08 Pfizer Nanopartículas poliméricas cargadas de fármaco y procedimientos de fabricación y uso de las mismas
CN101676291B (zh) 2008-09-18 2012-05-09 上海海和药物研究开发有限公司 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途
JP2012512175A (ja) * 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
KR101267813B1 (ko) * 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
EP2616050A1 (en) * 2010-09-14 2013-07-24 Nanologica AB Super-saturating delivery vehicles for poorly water-soluble pharmaceutical and cosmetic active ingredients
WO2012059936A1 (en) * 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
MX2013012593A (es) * 2011-04-29 2014-08-21 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos.
CN102793674B (zh) * 2011-05-26 2014-11-26 澳门科技大学 一种雷公藤甲素固体脂质纳米颗粒及其制备方法和应用
WO2013056132A2 (en) 2011-10-14 2013-04-18 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
CN102871966B (zh) * 2012-10-19 2013-11-20 东南大学 用于改善雷帕霉素生物利用度的纳米载药颗粒及其制备方法

Also Published As

Publication number Publication date
EP3834823A1 (en) 2021-06-16
ES2865375T3 (es) 2021-10-15
DK3834823T3 (da) 2024-04-08
HRP20210098T1 (hr) 2021-03-05
CN115212187A (zh) 2022-10-21
IL283699A (en) 2021-07-29
AU2021209202A1 (en) 2021-08-19
IL251620B (en) 2021-02-28
KR102656139B1 (ko) 2024-04-11
MX2021006698A (es) 2021-07-07
IL288609A (en) 2022-02-01
IL296246A (en) 2022-11-01
CN107072965B (zh) 2021-05-11
WO2016073798A1 (en) 2016-05-12
BR112017008720A2 (pt) 2017-12-19
EP3834823B1 (en) 2024-01-03
BR112017008499B1 (pt) 2023-10-03
DK3215192T3 (da) 2021-05-03
MX2017005903A (es) 2017-06-27
EP3906918A1 (en) 2021-11-10
US20160128987A1 (en) 2016-05-12
IL295292B2 (en) 2024-10-01
IL288609B (en) 2022-10-01
DK3906918T3 (da) 2024-04-08
IL283699B (en) 2022-09-01
ES2977158T3 (es) 2024-08-20
JP6912377B2 (ja) 2021-08-04
HUE066099T2 (hu) 2024-07-28
JP7218089B2 (ja) 2023-02-06
AU2015342968B2 (en) 2021-05-27
ES2977259T3 (es) 2024-08-21
JP2022173236A (ja) 2022-11-18
CA2966850A1 (en) 2016-05-12
JP2017537081A (ja) 2017-12-14
PL3215133T3 (pl) 2021-06-14
WO2016073799A9 (en) 2016-12-08
JP2021143180A (ja) 2021-09-24
CN113244191A (zh) 2021-08-13
KR20170081660A (ko) 2017-07-12
EA201790977A1 (ru) 2017-10-31
AU2015342968A1 (en) 2017-04-27
EP4360633A3 (en) 2024-05-22
EP3215192A4 (en) 2018-05-02
IL251622A0 (en) 2017-06-29
IL288609B2 (en) 2023-02-01
US20160128986A1 (en) 2016-05-12
EP4356910A3 (en) 2024-05-22
EP3906918B1 (en) 2024-01-03
CN107072964A (zh) 2017-08-18
CA2966852A1 (en) 2016-05-12
LT3215133T (lt) 2021-02-25
FI3906918T3 (fi) 2024-04-04
EP3215192B1 (en) 2021-02-17
IL251620A0 (en) 2017-06-29
ES2846809T3 (es) 2021-07-29
MX2017005904A (es) 2017-06-27
HUE053094T2 (hu) 2021-06-28
EP4360633A2 (en) 2024-05-01
PT3215133T (pt) 2021-01-29
HUE054894T2 (hu) 2021-10-28
CA2966850C (en) 2024-03-26
WO2016073799A1 (en) 2016-05-12
IL295292A (en) 2022-10-01
EP3215192A1 (en) 2017-09-13
FI3834823T3 (fi) 2024-04-02
EP4356910A2 (en) 2024-04-24
BR122021025344B1 (pt) 2024-02-20
AU2015342969B2 (en) 2021-05-27
IL280518A (en) 2021-03-01
CN115212186A (zh) 2022-10-21
EA201790978A1 (ru) 2017-09-29
AU2021209202B2 (en) 2023-11-30
AU2015342969A1 (en) 2017-04-27
JP2023169893A (ja) 2023-11-30
CN107072965A (zh) 2017-08-18
MX2021012273A (es) 2021-11-12
RS61359B1 (sr) 2021-02-26
KR20170081659A (ko) 2017-07-12
IL295292B1 (en) 2024-06-01
EP3215133B1 (en) 2020-10-28
IL280518B (en) 2022-01-01
CA2966852C (en) 2024-01-02
BR112017008499A2 (pt) 2017-12-26
AU2021209204A1 (en) 2021-08-19
KR102601922B1 (ko) 2023-11-15
EP3215133A1 (en) 2017-09-13
IL251622B (en) 2021-06-30
DK3215133T3 (da) 2021-02-01
CY1124418T1 (el) 2022-07-22
JP2017533243A (ja) 2017-11-09

Similar Documents

Publication Publication Date Title
IL288609B (en) Methods and compositions related to the use of surfactants with low hlb in the production of artificial nanocarriers containing Reflog
IL249011A0 (en) Methods and preparations related to exosomes
GB201415632D0 (en) Improvements in and relating to displays
GB201401066D0 (en) Improvements in and relating to screens
EP2951217A4 (en) SURFACTANTS AND METHODS OF MAKING AND USING THEM
ZA201804773B (en) Use of emulsifier in collector composition
IL245529A0 (en) Rapidly disintegrating formulations and methods of use
PL3229591T3 (pl) Surfaktanty cukrowe i ich zastosowanie w kompozycjach agrochemicznych
GB201400431D0 (en) Phospholipid compositions and their preparation
IL251957A0 (en) il-12 compositions and methods of use in stem cell therapy
PT3148517T (pt) Composições e métodos para promover a formação óssea
GB201421000D0 (en) Improvements in and relating to displays
GB201500715D0 (en) Improvements in and relating to zipwire trolleys
EP3096742C0 (en) COMPOSITIONS AND METHODS FOR MODIFYING THE SURFACE OF CELLS, AND METHODS OF USE
HK1243404A1 (zh) 色酰胺組合物和使用方法
GB201418071D0 (en) Improvement in or relation to fishing
GB201518802D0 (en) Improvements in and relating to nozzles
GB2517846B (en) Improvements in and relating to loudspeakers
GB201514431D0 (en) Improvements in and relating to materials
GB201410254D0 (en) Improvements in and relating to kettles
GB2530075B (en) Improvements in and relating to eyewashing
GB201417432D0 (en) Improvements in and relating to pipe-breaking
GB201417404D0 (en) Improvements in and relating to radar
GB201412345D0 (en) Improvements in and relating to devices
GB201404525D0 (en) Improvements in and relating to displays