DE69809967T2 - Genipin-derivate mit einer die leber schützenden aktivität - Google Patents

Genipin-derivate mit einer die leber schützenden aktivität

Info

Publication number
DE69809967T2
DE69809967T2 DE69809967T DE69809967T DE69809967T2 DE 69809967 T2 DE69809967 T2 DE 69809967T2 DE 69809967 T DE69809967 T DE 69809967T DE 69809967 T DE69809967 T DE 69809967T DE 69809967 T2 DE69809967 T2 DE 69809967T2
Authority
DE
Germany
Prior art keywords
protecting liver
activity protecting
genipin derivatives
genipin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69809967T
Other languages
English (en)
Other versions
DE69809967D1 (de
Inventor
Hwan Moon
Jin Choi
Jin Lee
Uk Chung
Ryul Ha
June Lee
Woong Oh
Won Jeong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choongwae Pharmaceutical Co Ltd
Original Assignee
Choongwae Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019970058131A external-priority patent/KR100248329B1/ko
Priority claimed from KR1019970066389A external-priority patent/KR100240779B1/ko
Priority claimed from KR1019970067407A external-priority patent/KR100240778B1/ko
Application filed by Choongwae Pharmaceutical Co Ltd filed Critical Choongwae Pharmaceutical Co Ltd
Publication of DE69809967D1 publication Critical patent/DE69809967D1/de
Application granted granted Critical
Publication of DE69809967T2 publication Critical patent/DE69809967T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69809967T 1997-11-05 1998-09-04 Genipin-derivate mit einer die leber schützenden aktivität Expired - Fee Related DE69809967T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019970058131A KR100248329B1 (ko) 1997-11-05 1997-11-05 신규한 제니핀 유도체 및 이를 유효성분으로 하는 간질환치료제조성물
KR1019970066389A KR100240779B1 (ko) 1997-12-05 1997-12-05 신규한 제니핀 유도체 및 이를 유효성분으로 하는 간질환치료제조성물
KR1019970067407A KR100240778B1 (ko) 1997-12-10 1997-12-10 신규한 제니핀 유도체 및 이를 유효성분으로 하는 간질환치료제조성물
PCT/KR1998/000273 WO1999023090A1 (en) 1997-11-05 1998-09-04 Novel genipin derivative having liver protection activity

Publications (2)

Publication Number Publication Date
DE69809967D1 DE69809967D1 (de) 2003-01-16
DE69809967T2 true DE69809967T2 (de) 2003-09-11

Family

ID=27349627

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809967T Expired - Fee Related DE69809967T2 (de) 1997-11-05 1998-09-04 Genipin-derivate mit einer die leber schützenden aktivität

Country Status (6)

Country Link
US (1) US6262083B1 (de)
EP (1) EP1045841B1 (de)
AU (1) AU9188698A (de)
DE (1) DE69809967T2 (de)
ES (1) ES2189238T3 (de)
WO (1) WO1999023090A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998418B1 (en) 1996-11-05 2006-02-14 Gp Medical, Inc. Acellular biological material chemically treated with genipin
US7101857B2 (en) * 1996-11-05 2006-09-05 Gp Medical, Inc. Crosslinkable biological material and medical uses
US6545042B2 (en) 1996-11-05 2003-04-08 Gp Medical Acellular biological material chemically treated with genipin
US7282220B1 (en) 1996-11-05 2007-10-16 Hsing-Wen Sung Genipin-crosslinked gelatin microspheres as drug carrier
US6624138B1 (en) 2001-09-27 2003-09-23 Gp Medical Drug-loaded biological material chemically treated with genipin
US7351421B2 (en) * 1996-11-05 2008-04-01 Hsing-Wen Sung Drug-eluting stent having collagen drug carrier chemically treated with genipin
US20050163818A1 (en) * 1996-11-05 2005-07-28 Hsing-Wen Sung Drug-eluting device chemically treated with genipin
US20050019404A1 (en) * 2003-06-30 2005-01-27 Hsing-Wen Sung Drug-eluting biodegradable stent
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
EP1615878B1 (de) * 2003-01-14 2012-04-04 Cytokinetics, Inc. Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz
WO2004089926A2 (en) * 2003-03-31 2004-10-21 Beth Israel Deaconess Medical Center, Inc. Genipin derivatives and uses thereof
JP5080970B2 (ja) * 2004-06-17 2012-11-21 サイトキネティクス・インコーポレーテッド 心疾患を治療するための置換尿素誘導体
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
EP1959960B1 (de) * 2005-12-15 2013-04-10 Cytokinetics, Inc. Bestimmte chemische entitäten, zusammensetzungen und verfahren
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
WO2007075377A2 (en) * 2005-12-15 2007-07-05 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US7718657B2 (en) * 2005-12-16 2010-05-18 Cytokinetics, Inc. Certain indanyl urea modulators of the cardiac sarcomere
JP5178526B2 (ja) * 2005-12-19 2013-04-10 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
KR101494031B1 (ko) * 2010-09-08 2015-02-17 성균관대학교산학협력단 제니핀 또는 이의 유도체를 포함하는 패혈증 예방 또는 치료용 약학적 조성물
EP2967824B1 (de) 2013-03-12 2020-11-04 Carnegie Mellon University Beschichtete vasookklusive vorrichtung zur behandlung von aneurysmen
CN105440048A (zh) * 2014-09-28 2016-03-30 复旦大学 1,3-苯并二噁茂类化合物山芝麻素及其药物用途
CN104892562B (zh) * 2015-06-16 2017-03-15 吴虹 抑制环氧化酶‑2的化合物及其制备方法和应用
CN107400128B (zh) * 2017-07-27 2020-03-31 贵州省中国科学院天然产物化学重点实验室 拟单萜吲哚生物碱及其制备方法和应用
CN107602523B (zh) * 2017-09-11 2020-08-18 安徽中医药大学 京尼平类似物、制备方法及其应用
CN113831316B (zh) * 2021-10-13 2023-04-04 陕西中医药大学 一种1-o-烷基京尼平及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0366682A (ja) * 1989-08-04 1991-03-22 Tsumura & Co 新規イリドイド誘導体
KR100218052B1 (ko) 1992-07-15 1999-09-01 이병언 B형 간염 바이러스의 복제를 억제하는 약학적 제제
KR100197744B1 (ko) 1996-10-18 1999-06-15 이병언 항 b형 간염 바이러스 활성을 갖는 신규한 제니핀 유도체

Also Published As

Publication number Publication date
DE69809967D1 (de) 2003-01-16
AU9188698A (en) 1999-05-24
EP1045841A1 (de) 2000-10-25
EP1045841B1 (de) 2002-12-04
WO1999023090A1 (en) 1999-05-14
ES2189238T3 (es) 2003-07-01
US6262083B1 (en) 2001-07-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee