DE69806925T2 - Ligand-aminodextran-markierungsubstanzkonjugate und deren verwendung - Google Patents
Ligand-aminodextran-markierungsubstanzkonjugate und deren verwendungInfo
- Publication number
- DE69806925T2 DE69806925T2 DE69806925T DE69806925T DE69806925T2 DE 69806925 T2 DE69806925 T2 DE 69806925T2 DE 69806925 T DE69806925 T DE 69806925T DE 69806925 T DE69806925 T DE 69806925T DE 69806925 T2 DE69806925 T2 DE 69806925T2
- Authority
- DE
- Germany
- Prior art keywords
- ligand
- aminodextran
- phycobiliprotein
- amdex
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
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- Zoology (AREA)
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- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
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| US08/857,941 US5891741A (en) | 1997-05-16 | 1997-05-16 | Antibody-aminodextran-phycobiliprotein conjugates |
| US08/976,031 US5994089A (en) | 1997-05-16 | 1997-11-21 | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
| PCT/US1998/009774 WO1998052040A1 (en) | 1997-05-16 | 1998-05-14 | Ligand-aminodextran-marker conjugates and uses thereof |
Publications (2)
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| DE69806925D1 DE69806925D1 (de) | 2002-09-05 |
| DE69806925T2 true DE69806925T2 (de) | 2003-02-27 |
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| DE69806925T Expired - Fee Related DE69806925T2 (de) | 1997-05-16 | 1998-05-14 | Ligand-aminodextran-markierungsubstanzkonjugate und deren verwendung |
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| US (2) | US5994089A (https=) |
| EP (1) | EP0981747B1 (https=) |
| JP (1) | JP4005146B2 (https=) |
| DE (1) | DE69806925T2 (https=) |
| WO (1) | WO1998052040A1 (https=) |
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| US5994089A (en) | 1997-05-16 | 1999-11-30 | Coulter International Corp. | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
| ATE268905T1 (de) | 1998-07-30 | 2004-06-15 | Oakville Trading Hong Kong Ltd | Verfahren zur herstellung von wasserlöslichen vernetzten conjugate |
| US6696243B2 (en) * | 2001-01-23 | 2004-02-24 | Coulter International Corp. | Method for the analysis of soluble analytes |
| ES2747357T3 (es) * | 2001-03-14 | 2020-03-10 | Dako Denmark As | Construcciones de moléculas MHC y sus usos para el diagnóstico y terapia |
| US8323903B2 (en) * | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| WO2004102201A1 (en) * | 2003-05-07 | 2004-11-25 | Novasite Pharmaceuticals, Inc. | Gain of function sorting for drug discovery and development |
| US20050009060A1 (en) * | 2003-05-07 | 2005-01-13 | Andrew Beernink | Multiplexed multitarget screening method |
| US7083936B2 (en) * | 2003-08-01 | 2006-08-01 | Beckman Coulter, Inc. | Aminodextran compositions and conjugates and method of making and using them |
| US7326577B2 (en) * | 2003-10-20 | 2008-02-05 | Esoterix, Inc. | Cell fixation and use in phospho-proteome screening |
| US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
| US7612871B2 (en) * | 2004-09-01 | 2009-11-03 | Honeywell International Inc | Frequency-multiplexed detection of multiple wavelength light for flow cytometry |
| EP1982176A1 (en) * | 2006-01-30 | 2008-10-22 | Dako Denmark A/S | High-speed quantification of antigen specific t-cells in whole blood by flow cytometry |
| EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
| ATE538377T1 (de) | 2007-04-02 | 2012-01-15 | Acoustic Cytometry Systems Inc | Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln |
| EP3620465B1 (en) * | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
| CN101349644B (zh) | 2007-07-20 | 2012-06-27 | 深圳迈瑞生物医疗电子股份有限公司 | 一种白细胞分类试剂和其使用方法 |
| US8102161B2 (en) * | 2007-09-25 | 2012-01-24 | Tdk Corporation | Stable output in a switching power supply by smoothing the output of the secondary coil |
| US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US8266950B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, LLP | Particle analysis in an acoustic cytometer |
| US8491870B2 (en) | 2007-12-21 | 2013-07-23 | Lers Surgical, Llc | Method for detection and treatment of aneurysms |
| CN105440725A (zh) | 2008-01-04 | 2016-03-30 | 深圳迈瑞生物医疗电子股份有限公司 | 不对称菁类荧光染料，组合物及在生物样品染色中的用途 |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| US8679764B2 (en) | 2008-03-11 | 2014-03-25 | Becton, Dickinson And Company | Density-based cell detection system |
| CN101602762B (zh) | 2008-06-10 | 2013-10-16 | 深圳迈瑞生物医疗电子股份有限公司 | 不对称菁类化合物、其制备方法及应用 |
| US10722562B2 (en) * | 2008-07-23 | 2020-07-28 | Immudex Aps | Combinatorial analysis and repair |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| CN101726579B (zh) | 2008-10-17 | 2014-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 血液检测试剂和方法 |
| EP2356456B1 (en) * | 2008-12-12 | 2016-05-18 | Beckman Coulter, Inc. | Multicolor flow cytometry compositions containing unconjugated phycobiliproteins |
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| US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
| CA1279008C (en) * | 1985-10-11 | 1991-01-15 | Smith Kline & French Canada Ltd. | Methods and reagents for performing subset analysis |
| US5206143A (en) * | 1985-11-01 | 1993-04-27 | Smithkline Beecham Corporation | Method and reagents for performing subset analysis using quantitative differences in fluorescence intensity |
| US5171846A (en) | 1990-05-21 | 1992-12-15 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use |
| EP0594772B1 (en) * | 1991-07-04 | 1996-08-28 | Immunodex K/S | Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone |
| ES2051651B1 (es) * | 1992-12-10 | 1995-01-01 | Univ Salamanca | Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones. |
| CA2164646A1 (en) | 1993-06-11 | 1994-12-22 | Wade E. Bolton | Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation |
| EP0752097A4 (en) | 1994-03-07 | 1997-12-10 | Coulter Corp | COVALENTLY IMMOBILIZED ANTIBODIES ON POLYMER PEARLS |
| US5891741A (en) | 1997-05-16 | 1999-04-06 | Coulter International Corp. | Antibody-aminodextran-phycobiliprotein conjugates |
| US5994089A (en) | 1997-05-16 | 1999-11-30 | Coulter International Corp. | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
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- 1998-05-14 US US09/403,919 patent/US6387622B1/en not_active Expired - Fee Related
- 1998-05-14 JP JP54949998A patent/JP4005146B2/ja not_active Expired - Fee Related
- 1998-05-14 WO PCT/US1998/009774 patent/WO1998052040A1/en not_active Ceased
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|---|---|
| JP2002504992A (ja) | 2002-02-12 |
| EP0981747A1 (en) | 2000-03-01 |
| JP4005146B2 (ja) | 2007-11-07 |
| US6387622B1 (en) | 2002-05-14 |
| US5994089A (en) | 1999-11-30 |
| WO1998052040A1 (en) | 1998-11-19 |
| DE69806925D1 (de) | 2002-09-05 |
| EP0981747B1 (en) | 2002-07-31 |
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