DE69332884T2 - Direkte auswahl von zellen durch ein aussheidungsprodukt - Google Patents
Direkte auswahl von zellen durch ein aussheidungsproduktInfo
- Publication number
- DE69332884T2 DE69332884T2 DE69332884T DE69332884T DE69332884T2 DE 69332884 T2 DE69332884 T2 DE 69332884T2 DE 69332884 T DE69332884 T DE 69332884T DE 69332884 T DE69332884 T DE 69332884T DE 69332884 T2 DE69332884 T2 DE 69332884T2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- product
- direct selection
- exhaust product
- labelled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Massaging Devices (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96593492A | 1992-10-21 | 1992-10-21 | |
PCT/US1993/010126 WO1994009117A1 (en) | 1992-10-21 | 1993-10-21 | Direct selection of cells by secretion product |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69332884D1 DE69332884D1 (de) | 2003-05-22 |
DE69332884T2 true DE69332884T2 (de) | 2003-11-20 |
Family
ID=25510696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332884T Expired - Lifetime DE69332884T2 (de) | 1992-10-21 | 1993-10-21 | Direkte auswahl von zellen durch ein aussheidungsprodukt |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060141540A1 (de) |
EP (2) | EP0667896B1 (de) |
JP (1) | JP3731891B2 (de) |
KR (1) | KR100306635B1 (de) |
AT (1) | ATE237808T1 (de) |
AU (1) | AU679949B2 (de) |
CA (1) | CA2146974C (de) |
DE (1) | DE69332884T2 (de) |
ES (1) | ES2191677T3 (de) |
WO (1) | WO1994009117A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08510325A (ja) * | 1993-05-28 | 1996-10-29 | カイロン コーポレイション | 生物学的に活性なペプチド配列の選択方法 |
US7119248B1 (en) | 1994-04-12 | 2006-10-10 | Miltenyi Biotec Gmbh | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof |
CA2330678C (en) * | 1998-05-11 | 2009-04-07 | Miltenyi Biotec Gmbh | Method of direct selection of antigen-specific t cells |
EP1147416B1 (de) * | 1999-01-23 | 2013-05-29 | Minerva Biotechnologies Corporation | Assays unter verwendung von kolloiden sowie nicht-kolloidalen strukturen |
DE60026729T2 (de) * | 1999-09-03 | 2006-12-14 | Miltenyi Biotec Gmbh | Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule |
EP1392859B1 (de) * | 2001-01-16 | 2006-05-10 | Regeneron Pharmaceuticals, Inc. | Isolierung von sezernierte proteine exprimierenden zellen |
US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
WO2002093172A1 (en) * | 2001-05-17 | 2002-11-21 | Miltenyi Biotec Gmbh | Antigen binding fragments for dendritic cell subset and use thereof |
EP1570267B1 (de) | 2002-12-03 | 2011-10-12 | UCB Pharma, S.A. | Verfahren zum nachweis antikörper-herstellender zellen |
US7771969B2 (en) | 2003-08-20 | 2010-08-10 | Celltech R&D Limited | Methods for obtaining antibodies |
EP1658500B1 (de) | 2003-08-20 | 2012-04-18 | UCB Pharma, S.A. | Verfahren zur gewinnung von antikörpern |
GB0412973D0 (en) * | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
EA014182B1 (ru) | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
EP1982176A1 (de) * | 2006-01-30 | 2008-10-22 | Dako Denmark A/S | Quantifizierung antigenspezifischer t-zellen in vollblut mit hoher geschwindigkeit mittels durchflusszytometrie |
GB0605965D0 (en) * | 2006-03-24 | 2006-05-03 | Univ East Anglia | Fluorescence based detection of substances |
WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
WO2008118476A2 (en) | 2007-03-26 | 2008-10-02 | Codon Devices, Inc. | Cell surface display, screening and production of proteins of interest |
EP3023436A1 (de) | 2007-07-03 | 2016-05-25 | Dako Denmark A/S | Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren |
EP2197908A2 (de) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc-multimere in tuberkulose-diagnostika, -impfstoff und therapeutika |
US10968269B1 (en) | 2008-02-28 | 2021-04-06 | Agilent Technologies, Inc. | MHC multimers in borrelia diagnostics and disease |
US8067339B2 (en) | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
WO2010009735A2 (en) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
GB0817244D0 (en) * | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
EP2700713B1 (de) | 2012-08-21 | 2016-07-13 | Miltenyi Biotec GmbH | Untersuchungs- und Anreicherungssystem für die Proteinexpression in eukaryotischen Zellen unter Verwendung einer trizistronischen Expressionskassette |
TWI675044B (zh) | 2012-11-14 | 2019-10-21 | 美商再生元醫藥公司 | 重組細胞表面捕捉蛋白質 |
WO2015161835A1 (de) | 2014-04-20 | 2015-10-29 | New / Era / Mabs Gmbh | Biomoleküle freisetzende zelle und deren selektion mittels eines oberflächenproteins |
JP6740906B2 (ja) * | 2015-02-12 | 2020-08-19 | コニカミノルタ株式会社 | 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット |
WO2016180948A1 (en) | 2015-05-12 | 2016-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for labeling, detection and isolation of foxp3+ regulatory t cells, isolated population of foxp3+ regulatory t cells thus obtained and uses thereof |
WO2017056844A1 (ja) | 2015-09-28 | 2017-04-06 | コニカミノルタ株式会社 | 前立腺癌の病理組織診断結果(グリーソンスコア)の推定方法 |
WO2022256839A1 (en) * | 2021-06-03 | 2022-12-08 | Georgia Tech Research Corporation | Isolation and analysis of single cells secreting molecules using heterofunctional particles |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
US4557979A (en) * | 1984-02-17 | 1985-12-10 | Monsanto Company | Process for deposition of resin dispersions on metal substrates |
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5238811A (en) * | 1988-04-26 | 1993-08-24 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same |
US5256532A (en) * | 1988-05-02 | 1993-10-26 | Zynaxis Technologies, Inc. | Methods, reagents and test kits for determination of subpopulations of biological entities |
US6020145A (en) * | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
CA2330678C (en) * | 1998-05-11 | 2009-04-07 | Miltenyi Biotec Gmbh | Method of direct selection of antigen-specific t cells |
-
1993
- 1993-10-21 AT AT94900375T patent/ATE237808T1/de not_active IP Right Cessation
- 1993-10-21 CA CA002146974A patent/CA2146974C/en not_active Expired - Lifetime
- 1993-10-21 JP JP51039694A patent/JP3731891B2/ja not_active Expired - Lifetime
- 1993-10-21 ES ES94900375T patent/ES2191677T3/es not_active Expired - Lifetime
- 1993-10-21 AU AU55385/94A patent/AU679949B2/en not_active Expired
- 1993-10-21 EP EP94900375A patent/EP0667896B1/de not_active Expired - Lifetime
- 1993-10-21 EP EP03007897A patent/EP1324040A3/de not_active Withdrawn
- 1993-10-21 WO PCT/US1993/010126 patent/WO1994009117A1/en active IP Right Grant
- 1993-10-21 DE DE69332884T patent/DE69332884T2/de not_active Expired - Lifetime
- 1993-10-21 KR KR1019950701547A patent/KR100306635B1/ko not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/359,328 patent/US20060141540A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0667896B1 (de) | 2003-04-16 |
EP0667896A1 (de) | 1995-08-23 |
KR100306635B1 (ko) | 2001-11-30 |
AU679949B2 (en) | 1997-07-17 |
CA2146974A1 (en) | 1994-04-28 |
EP1324040A3 (de) | 2007-06-20 |
DE69332884D1 (de) | 2003-05-22 |
ATE237808T1 (de) | 2003-05-15 |
AU5538594A (en) | 1994-05-09 |
WO1994009117A1 (en) | 1994-04-28 |
EP0667896A4 (de) | 1996-09-04 |
JP3731891B2 (ja) | 2006-01-05 |
ES2191677T3 (es) | 2003-09-16 |
EP1324040A2 (de) | 2003-07-02 |
US20060141540A1 (en) | 2006-06-29 |
KR950704475A (ko) | 1995-11-20 |
CA2146974C (en) | 2010-02-02 |
JPH08504574A (ja) | 1996-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |