ES2191677T3 - Seleccion directa de celulas mediante un producto de secrecion. - Google Patents

Seleccion directa de celulas mediante un producto de secrecion.

Info

Publication number
ES2191677T3
ES2191677T3 ES94900375T ES94900375T ES2191677T3 ES 2191677 T3 ES2191677 T3 ES 2191677T3 ES 94900375 T ES94900375 T ES 94900375T ES 94900375 T ES94900375 T ES 94900375T ES 2191677 T3 ES2191677 T3 ES 2191677T3
Authority
ES
Spain
Prior art keywords
cells
product
direct selection
secretion product
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900375T
Other languages
English (en)
Inventor
Stefan Miltenyi
Andreas Radbruch
Rudi Manz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2191677T3 publication Critical patent/ES2191677T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Abstract

UNAS CELULAS PUEDEN SER CLASIFICADAS CON PRODUCTOS QUE SECRETAN Y LIBERAN DE UNA MANERA EFICAZ POR ACOPLAMIENTO DE LAS CELULAS EN SU SUPERFICIE A UN LIGANDO DE UNION ESPECIFICO PARA EL PRODUCTO Y PERMITIENDO AL PRODUCTO QUE SEA CAPTURADO POR EL LIGANDO DE UNION ESPECIFICO A MEDIDA QUE ES SECRETADO Y LIBERADO. LAS CELULAS CLASIFICADAS CON EL PRODUCTO PUEDEN SER ACOPLADAS A CONTINUACION A CLASES APROPIADAS, SI SE DESEA, Y SEPARADAS DE ACUERDO CON LA PRESENCIA, AUSENCIA, O CANTIDAD DE PRODUCTO.
ES94900375T 1992-10-21 1993-10-21 Seleccion directa de celulas mediante un producto de secrecion. Expired - Lifetime ES2191677T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96593492A 1992-10-21 1992-10-21

Publications (1)

Publication Number Publication Date
ES2191677T3 true ES2191677T3 (es) 2003-09-16

Family

ID=25510696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900375T Expired - Lifetime ES2191677T3 (es) 1992-10-21 1993-10-21 Seleccion directa de celulas mediante un producto de secrecion.

Country Status (10)

Country Link
US (1) US20060141540A1 (es)
EP (2) EP0667896B1 (es)
JP (1) JP3731891B2 (es)
KR (1) KR100306635B1 (es)
AT (1) ATE237808T1 (es)
AU (1) AU679949B2 (es)
CA (1) CA2146974C (es)
DE (1) DE69332884T2 (es)
ES (1) ES2191677T3 (es)
WO (1) WO1994009117A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510325A (ja) * 1993-05-28 1996-10-29 カイロン コーポレイション 生物学的に活性なペプチド配列の選択方法
US7119248B1 (en) 1994-04-12 2006-10-10 Miltenyi Biotec Gmbh Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
EP1078263B1 (en) * 1998-05-11 2009-07-22 Miltenyi Biotec GmbH Method of direct selection of antigen-specific t cells
AU3347900A (en) * 1999-01-23 2000-08-07 Minerva Biotechnologies Corporation Interaction of colloid-immobilized species with species on non-colloidal structures
US6468432B1 (en) * 1999-09-03 2002-10-22 Miltenyi Biotec Gmbh Methods of modification of selected cells in a magnetic cell separation column
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
DE60211329T2 (de) * 2001-01-16 2007-05-24 Regeneron Pharmaceuticals, Inc. Isolierung von sezernierte proteine exprimierenden zellen
EP1395826A4 (en) * 2001-05-17 2005-11-09 Miltenyi Biotec Gmbh ANTIGEN-BINDING FRAGMENTS FOR A SUB-GROUP OF DENDRITIC CELLS AND USE THEREOF
EP1570267B1 (en) 2002-12-03 2011-10-12 UCB Pharma, S.A. Assay for identifying antibody producing cells
ATE554390T1 (de) 2003-08-20 2012-05-15 Ucb Pharma Sa Verfahren zur gewinnung von antikörpern
US7771969B2 (en) 2003-08-20 2010-08-10 Celltech R&D Limited Methods for obtaining antibodies
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
AU2005263331B8 (en) 2004-07-20 2011-06-16 Symphogen A/S Anti-Rhesus D recombinant polyclonal antibody and methods of manufacture
US20090061478A1 (en) * 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
WO2008118476A2 (en) 2007-03-26 2008-10-02 Codon Devices, Inc. Cell surface display, screening and production of proteins of interest
EP2361930A3 (en) 2007-03-26 2011-10-26 Dako Denmark A/S Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases
EP2167536A1 (en) * 2007-07-03 2010-03-31 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
EP2700713B1 (en) 2012-08-21 2016-07-13 Miltenyi Biotec GmbH Screening and enrichment system for protein expression in eukaryotic cells using a tricistronic expression cassette
TW202206465A (zh) 2012-11-14 2022-02-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
DE112014006603A5 (de) 2014-04-20 2017-01-19 new/era/mabs GmbH Biomoleküle freisetzende Zelle und deren Selektion mittels eines Oberflächenproteins sowie für dieses codierende Nukleinsäure, deren Expressionsvektor und dessen Empfängerzelle
JP6740906B2 (ja) * 2015-02-12 2020-08-19 コニカミノルタ株式会社 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット
EP3295171A1 (en) 2015-05-12 2018-03-21 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and kits for labeling, detection and isolation of foxp3+ regulatory t cells, isolated population of foxp3+ regulatory t cells thus obtained and uses thereof
EP3358352B1 (en) * 2015-09-28 2019-11-20 Konica Minolta, Inc. Method for estimating pathological tissue diagnosis result (gleason score) of prostate cancer
WO2022256839A1 (en) * 2021-06-03 2022-12-08 Georgia Tech Research Corporation Isolation and analysis of single cells secreting molecules using heterofunctional particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4557979A (en) * 1984-02-17 1985-12-10 Monsanto Company Process for deposition of resin dispersions on metal substrates
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US6020145A (en) * 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
EP1078263B1 (en) * 1998-05-11 2009-07-22 Miltenyi Biotec GmbH Method of direct selection of antigen-specific t cells

Also Published As

Publication number Publication date
AU679949B2 (en) 1997-07-17
KR950704475A (ko) 1995-11-20
CA2146974A1 (en) 1994-04-28
ATE237808T1 (de) 2003-05-15
AU5538594A (en) 1994-05-09
EP0667896B1 (en) 2003-04-16
EP1324040A2 (en) 2003-07-02
JPH08504574A (ja) 1996-05-21
EP0667896A1 (en) 1995-08-23
US20060141540A1 (en) 2006-06-29
JP3731891B2 (ja) 2006-01-05
KR100306635B1 (ko) 2001-11-30
WO1994009117A1 (en) 1994-04-28
EP0667896A4 (en) 1996-09-04
CA2146974C (en) 2010-02-02
DE69332884D1 (de) 2003-05-22
DE69332884T2 (de) 2003-11-20
EP1324040A3 (en) 2007-06-20

Similar Documents

Publication Publication Date Title
ES2191677T3 (es) Seleccion directa de celulas mediante un producto de secrecion.
FI834039A (fi) Straolningshaerdbara bindemedelkompositioner
EP0494608A3 (en) Arrangement to control the slip in an automated friction clutch
EP1591462A3 (en) Temperature-responsive polymer compound and process for producing the same
GB2265151B (en) Binding composition for the preparation of an agglomerate based on finely divided material, process using the said composition and thus obtained agglomerate
DE69011001T2 (de) Presse mit Steuerschaltungsanordnung.
EP0354185A3 (en) Piperidine-triazine compounds for use as stabilizers for organic materials
AU541049B2 (en) Cyclopropane carboxylates and their use as insectides
DE69108881T2 (de) Mechanismus zur Reduzierung von Druckverlusten in Rohrkrümmern.
IL57363A0 (en) Abrasion-resistant decorative laminate and its production
NZ335867A (en) Mobile ladder including a goods lift
DE2963189D1 (en) 9-alpha-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester and methods for the microbiological production thereof
AU7254381A (en) Press for/drying garbage and the like
IT8124640A0 (it) Sganciatore di accoppiamento in particolare per accoppiamenti azionabili per trazione.
IL58431A (en) Process for working up biomasses,the products obtained and their use
CA2001782A1 (en) 3-(3-propan-2-ylphenyl) butanal and 3-(3-propen-2-ylphenyl) butanal and their use as odorants
FR2657345B1 (fr) Procede de c-alkylation de l'hydroquinone et de ses monoethers.
JPS52133683A (en) Device for picking up and conveying material
DE59104325D1 (de) Handwerkzeugmaschine mit Bremskupplung.
JPS53129268A (en) Classification of mixture of paper and plastic
JPS5270024A (en) Fungicidal composition for industrial use
JPS5724479A (en) Protective device for power interruption
JPS55132766A (en) Oxidative size removing agent and method
JPS5412167A (en) Garbage collecting container with push-in apparatus
青木眞則 My Concern for Agricultural Machinery Issues in Present Agricultual Methods