DE69739121D1 - Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren - Google Patents

Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Info

Publication number
DE69739121D1
DE69739121D1 DE69739121T DE69739121T DE69739121D1 DE 69739121 D1 DE69739121 D1 DE 69739121D1 DE 69739121 T DE69739121 T DE 69739121T DE 69739121 T DE69739121 T DE 69739121T DE 69739121 D1 DE69739121 D1 DE 69739121D1
Authority
DE
Germany
Prior art keywords
promotive
libraries
promoters
artificial
selected organisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739121T
Other languages
German (de)
English (en)
Inventor
Peter Ruhdal Jensen
Karin Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69739121D1 publication Critical patent/DE69739121D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69739121T 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren Expired - Lifetime DE69739121D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK88696 1996-08-23
PCT/DK1997/000342 WO1998007846A1 (en) 1996-08-23 1997-08-25 Artificial promoter libraries for selected organisms and promoters derived from such libraries

Publications (1)

Publication Number Publication Date
DE69739121D1 true DE69739121D1 (de) 2009-01-02

Family

ID=8098645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739121T Expired - Lifetime DE69739121D1 (de) 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Country Status (8)

Country Link
US (1) US7199233B1 (enExample)
EP (2) EP2034021A1 (enExample)
JP (2) JP2001503249A (enExample)
CN (1) CN1243827C (enExample)
AU (1) AU3938397A (enExample)
DE (1) DE69739121D1 (enExample)
DK (1) DK0934406T3 (enExample)
WO (1) WO1998007846A1 (enExample)

Families Citing this family (47)

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JP2001509395A (ja) 1997-07-14 2001-07-24 バレンティス・インコーポレーテッド 細胞又は組織特異的な人工転写調節領域の同定方法
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
RU2214456C2 (ru) 1998-09-25 2003-10-20 Адзиномото Ко., Инк. Способ конструирования бактериальных штаммов, продуцирующих аминокислоты (варианты), и способ получения аминокислоты путем ферментации с использованием сконструированных бактериальных штаммов, продуцирующих аминокислоты
US6555674B2 (en) 2000-08-09 2003-04-29 Nsgene A/S JeT promoter
DE60143959D1 (de) 2000-08-25 2011-03-10 Basf Plant Science Gmbh En kodieren
US20040166566A1 (en) * 2001-06-06 2004-08-26 Takashi Ito Novel promoter
WO2003087149A2 (en) 2002-04-10 2003-10-23 Novozymes A/S Bacillus licheniformis mutant host cell
US7521204B2 (en) 2002-04-10 2009-04-21 Novozymes A/S Bacillus host cell
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
EP1499709B1 (en) * 2002-04-22 2012-01-04 E.I. Du Pont De Nemours And Company Promoter and plasmid system for genetic engineering
US20080076678A1 (en) 2005-06-15 2008-03-27 Philippe Soucaille Method of creating a library of bacterial clones with varying levels of gene expression
JP2006513692A (ja) * 2002-04-22 2006-04-27 ジェネンコー・インターナショナル・インク 様々なレベルの遺伝子発現を生じる修飾プロモーターを作成する方法
ATE401422T1 (de) * 2002-04-22 2008-08-15 Genencor Int Verfahren zur erzeugung einer bibliothek aus bakterienklonen mit unterschiedlichen genexpressionsniveaus
EP1546304B1 (en) 2002-10-04 2013-05-08 Danisco US Inc. Improved production of bacterial strains
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
WO2004046387A1 (en) * 2002-11-15 2004-06-03 Sangamo Biosciences, Inc. Methods and compositions for analysis of regulatory sequences
JP4821606B2 (ja) * 2003-03-12 2011-11-24 味の素株式会社 効率的にＬ−グルタミン酸を生産するためのプロモーター変異による細菌のｓｕｃＡＢ発現の最適化
WO2006116400A2 (en) 2005-04-27 2006-11-02 Massachusetts Institute Of Technology Promoter engineering and genetic control
US20070294785A1 (en) * 2006-06-13 2007-12-20 Athenix Corporation Methods for generating genetic diversity by permutational mutagenesis
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
CN101600800B (zh) 2006-11-29 2013-08-28 埃塞尼克斯公司 改良的grg23 epsp合酶：组合物和使用方法
US7618801B2 (en) 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
NZ587540A (en) 2008-03-28 2012-06-29 Danisco Us Inc Method for amplifying locus in bacterial cell
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
EP2311961A1 (en) * 2009-10-15 2011-04-20 DKFZ Deutsches Krebsforschungszentrum Model-guided random assembly PCR for the synthesis of eukaryotic promoters
WO2011053957A2 (en) 2009-11-02 2011-05-05 Gen9, Inc. Compositions and methods for the regulation of multiple genes of interest in a cell
CA2817697C (en) 2010-11-12 2021-11-16 Gen9, Inc. Methods and devices for nucleic acids synthesis
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
CN102286517B (zh) * 2011-06-10 2016-08-03 中国科学院天津工业生物技术研究所 利用人工调控元件及其文库调控微生物染色体上基因表达强度的方法
JP2014526899A (ja) 2011-08-26 2014-10-09 ジェン９・インコーポレイテッド 核酸の高忠実度アセンブリのための組成物および方法
EP2573172A1 (en) 2011-09-21 2013-03-27 Heinrich-Heine-Universität Düsseldorf Means and methods for rhamnolipid production
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
CA2871505C (en) 2012-04-24 2021-10-12 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
WO2014004393A1 (en) 2012-06-25 2014-01-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
EP2970869A4 (en) 2013-03-14 2016-08-03 Codexis Inc REPRESSIBLE PROMOTER WITH LOW PHOSPHATE CONTENT
US10907180B2 (en) 2015-07-08 2021-02-02 Rheinisch-Westfaelische Technische Hochshule Aachen (RWTH) Extracellular production of designer hydroxyalkanoyloxy alkanoic acids with recombinant bacteria
CN105296486B (zh) * 2015-11-18 2019-04-26 湖北大学 一种启动子文库构建方法和强启动子
US9988624B2 (en) * 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CN105603537A (zh) * 2016-03-11 2016-05-25 南京工业大学 一种启动子文库的构建方法及其应用
CN110869504A (zh) * 2017-06-07 2020-03-06 齐默尔根公司 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途
CN108118058B (zh) 2017-12-29 2021-06-29 苏州金唯智生物科技有限公司 一种改进的启动子及其应用
CN108118059B (zh) * 2017-12-30 2021-03-19 苏州金唯智生物科技有限公司 一种改进的启动子及其组成的载体和应用
EP3546582A1 (en) * 2018-03-26 2019-10-02 KWS SAAT SE & Co. KGaA Promoter activating elements
CN110317807A (zh) * 2018-03-29 2019-10-11 中国科学院天津工业生物技术研究所 一种谷氨酸棒杆菌人工启动子文库
CN113260626B (zh) * 2018-11-05 2024-09-13 豪夫迈·罗氏有限公司 在原核宿主细胞中产生双链蛋白质的方法
CN109486847B (zh) * 2018-12-17 2021-03-02 江南大学 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统
CA3163686A1 (en) * 2019-12-16 2021-06-24 Ginkgo Bioworks, Inc. Enhanced production of histidine, purine pathway metabolites, and plasmid dna

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215550D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
WO1994025609A1 (en) * 1993-04-28 1994-11-10 Hybritech Incorporated Method for creating optimized regulatory regions affecting protein expression and protein trafficking

Also Published As

Publication number Publication date
EP0934406B1 (en) 2008-11-19
CN1243827C (zh) 2006-03-01
DK0934406T3 (da) 2009-01-26
JP4469005B2 (ja) 2010-05-26
AU3938397A (en) 1998-03-06
EP0934406A2 (en) 1999-08-11
EP2034021A1 (en) 2009-03-11
WO1998007846A1 (en) 1998-02-26
JP2001503249A (ja) 2001-03-13
JP2009022293A (ja) 2009-02-05
CN1233287A (zh) 1999-10-27
US7199233B1 (en) 2007-04-03

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