DE69739121D1 - Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren - Google Patents

Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Info

Publication number
DE69739121D1
DE69739121D1 DE69739121T DE69739121T DE69739121D1 DE 69739121 D1 DE69739121 D1 DE 69739121D1 DE 69739121 T DE69739121 T DE 69739121T DE 69739121 T DE69739121 T DE 69739121T DE 69739121 D1 DE69739121 D1 DE 69739121D1
Authority
DE
Germany
Prior art keywords
promotive
libraries
promoters
artificial
selected organisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739121T
Other languages
German (de)
English (en)
Inventor
Peter Ruhdal Jensen
Karin Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69739121D1 publication Critical patent/DE69739121D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69739121T 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren Expired - Lifetime DE69739121D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK88696 1996-08-23
PCT/DK1997/000342 WO1998007846A1 (en) 1996-08-23 1997-08-25 Artificial promoter libraries for selected organisms and promoters derived from such libraries

Publications (1)

Publication Number Publication Date
DE69739121D1 true DE69739121D1 (de) 2009-01-02

Family

ID=8098645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739121T Expired - Lifetime DE69739121D1 (de) 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Country Status (8)

Country Link
US (1) US7199233B1 (enExample)
EP (2) EP2034021A1 (enExample)
JP (2) JP2001503249A (enExample)
CN (1) CN1243827C (enExample)
AU (1) AU3938397A (enExample)
DE (1) DE69739121D1 (enExample)
DK (1) DK0934406T3 (enExample)
WO (1) WO1998007846A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002737A1 (en) 1997-07-14 1999-01-21 Valentis, Inc. Method for the identification of synthetic cell- or tissue-specific transcriptional regulatory regions
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
BRPI9909409B1 (pt) 1998-09-25 2016-03-22 Ajinomoto Kk processos para produzir um ácido l-glutâmico
US6555674B2 (en) 2000-08-09 2003-04-29 Nsgene A/S JeT promoter
US20040219525A1 (en) 2000-08-25 2004-11-04 Heiko Haertel Plant polynucleotides encoding novel prenyl proteases
EP1400593A4 (en) * 2001-06-06 2005-04-06 Takeda Pharmaceutical NEW PROMOTER
EP1497429B1 (en) 2002-04-10 2008-07-02 Novozymes A/S Improved bacillus host cell
AU2003214036A1 (en) 2002-04-10 2003-10-27 Novozymes A/S Bacillus licheniformis mutant host cell
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
EP1499709B1 (en) * 2002-04-22 2012-01-04 E.I. Du Pont De Nemours And Company Promoter and plasmid system for genetic engineering
WO2003089604A2 (en) * 2002-04-22 2003-10-30 Genencor International, Inc. Methods of creating modified promoters resulting in varying levels of gene expression
US20080076678A1 (en) 2005-06-15 2008-03-27 Philippe Soucaille Method of creating a library of bacterial clones with varying levels of gene expression
ATE401422T1 (de) * 2002-04-22 2008-08-15 Genencor Int Verfahren zur erzeugung einer bibliothek aus bakterienklonen mit unterschiedlichen genexpressionsniveaus
EP2428573A3 (en) 2002-10-04 2012-06-27 Genecor International, Inc. Improved production of bacterial strains cross reference to related applications
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
EP1579005A4 (en) * 2002-11-15 2007-07-25 Sangamo Biosciences Inc METHOD AND COMPOSITIONS FOR THE ANALYSIS OF REGULATORY SEQUENCES
JP4821606B2 (ja) 2003-03-12 2011-11-24 味の素株式会社 効率的にＬ−グルタミン酸を生産するためのプロモーター変異による細菌のｓｕｃＡＢ発現の最適化
WO2006116400A2 (en) 2005-04-27 2006-11-02 Massachusetts Institute Of Technology Promoter engineering and genetic control
WO2007146975A2 (en) * 2006-06-13 2007-12-21 Athenix Corporation Methods for generating genetic diversity by permutational mutagenesis
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
CN101600800B (zh) 2006-11-29 2013-08-28 埃塞尼克斯公司 改良的grg23 epsp合酶：组合物和使用方法
US7618801B2 (en) 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
CN101981193B (zh) 2008-03-28 2016-05-11 丹尼斯科美国公司 在细菌细胞中扩增基因座的方法
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
EP2311961A1 (en) * 2009-10-15 2011-04-20 DKFZ Deutsches Krebsforschungszentrum Model-guided random assembly PCR for the synthesis of eukaryotic promoters
US20120315670A1 (en) 2009-11-02 2012-12-13 Gen9, Inc. Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell
CN103502448B (zh) 2010-11-12 2017-03-29 Gen9股份有限公司 核酸合成的方法和设备
EP4039363A1 (en) 2010-11-12 2022-08-10 Gen9, Inc. Protein arrays and methods of using and making the same
CN102286517B (zh) * 2011-06-10 2016-08-03 中国科学院天津工业生物技术研究所 利用人工调控元件及其文库调控微生物染色体上基因表达强度的方法
IL302248A (en) 2011-08-26 2023-06-01 Gen9 Inc Compositions and methods for high fidelity assembly of nucleic acids
EP2573172A1 (en) 2011-09-21 2013-03-27 Heinrich-Heine-Universität Düsseldorf Means and methods for rhamnolipid production
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013163263A2 (en) 2012-04-24 2013-10-31 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
EP3483311B8 (en) 2012-06-25 2025-10-29 Ginkgo Bioworks, Inc. Methods for nucleic acid assembly and high throughput sequencing
WO2014159850A2 (en) 2013-03-14 2014-10-02 Codexis, Inc. Low-phosphate repressible promoter
US10907180B2 (en) 2015-07-08 2021-02-02 Rheinisch-Westfaelische Technische Hochshule Aachen (RWTH) Extracellular production of designer hydroxyalkanoyloxy alkanoic acids with recombinant bacteria
CN105296486B (zh) * 2015-11-18 2019-04-26 湖北大学 一种启动子文库构建方法和强启动子
US9988624B2 (en) * 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) * 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
CN105603537A (zh) * 2016-03-11 2016-05-25 南京工业大学 一种启动子文库的构建方法及其应用
CA3064777A1 (en) * 2017-06-07 2018-12-13 Zach Serber Promoters from corynebacterium glutamicum and uses thereof in regulating ancillary gene expression
CN108118059B (zh) 2017-12-30 2021-03-19 苏州金唯智生物科技有限公司 一种改进的启动子及其组成的载体和应用
EP3546582A1 (en) * 2018-03-26 2019-10-02 KWS SAAT SE & Co. KGaA Promoter activating elements
CN110317807A (zh) * 2018-03-29 2019-10-11 中国科学院天津工业生物技术研究所 一种谷氨酸棒杆菌人工启动子文库
AU2019375413A1 (en) * 2018-11-05 2021-05-27 Genentech, Inc. Methods of producing two chain proteins in prokaryotic host cells
CN109486847B (zh) * 2018-12-17 2021-03-02 江南大学 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统
CN115175994A (zh) * 2019-12-16 2022-10-11 银杏生物制品公司 组氨酸、嘌呤途径代谢物和质粒dna的增强的产生

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215550D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
WO1994025609A1 (en) * 1993-04-28 1994-11-10 Hybritech Incorporated Method for creating optimized regulatory regions affecting protein expression and protein trafficking

Also Published As

Publication number Publication date
EP0934406A2 (en) 1999-08-11
JP4469005B2 (ja) 2010-05-26
JP2001503249A (ja) 2001-03-13
EP0934406B1 (en) 2008-11-19
CN1243827C (zh) 2006-03-01
DK0934406T3 (da) 2009-01-26
JP2009022293A (ja) 2009-02-05
CN1233287A (zh) 1999-10-27
US7199233B1 (en) 2007-04-03
EP2034021A1 (en) 2009-03-11
AU3938397A (en) 1998-03-06
WO1998007846A1 (en) 1998-02-26

Similar Documents

Publication Publication Date Title
DE69739121D1 (de) Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren
DE69729137D1 (de) Stent zur Implantation
ATE256442T1 (de) Künstliche zwischenwirbelscheibe
DE59712110D1 (de) Stent
FR2751867B1 (fr) Prothese collerette
DE69731164D1 (de) Stent
DE59710859D1 (de) Implantat
DK0821920T4 (da) Stent
DE69723791D1 (de) Rohrmolch
DE69732373D1 (de) Intraluminaler stent
NO991676D0 (no) FremgangsmÕter og sammensetninger for immunmodulering
DE69713295D1 (de) Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung
FR2744357B1 (fr) Prothese de hanche non luxable et peu usable
DE69715264D1 (de) Knochenprothese
DE69701239D1 (de) Aufzeichnungsmaterial und Verfahren zu dessen Herstellung
DE69621432D1 (de) Bettvorrichtung
DE69602217D1 (de) Elektrisch gesteuertes Expansionsventil und Verfahren zu dessen Herstellung
DE59501603D1 (de) Platzhalter für Wirbel
DE69631886D1 (de) Reformierungsanlage
DE19782204T1 (de) Verlängerungseinrichtung und Verfahren
DE69732460D1 (de) Thermokopf und verfahren zu seiner herstellung
ID18300A (id) Metoda penemperan
DE69734152D1 (de) Thermokopf und verfahren zu seiner herstellung
DE69718378D1 (de) Analoge FIFO-Speicher
NO990764D0 (no) Bioreaktor

Legal Events

Date Code Title Description
8364 No opposition during term of opposition