DE69739121D1 - Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren - Google Patents

Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Info

Publication number
DE69739121D1
DE69739121D1 DE69739121T DE69739121T DE69739121D1 DE 69739121 D1 DE69739121 D1 DE 69739121D1 DE 69739121 T DE69739121 T DE 69739121T DE 69739121 T DE69739121 T DE 69739121T DE 69739121 D1 DE69739121 D1 DE 69739121D1
Authority
DE
Germany
Prior art keywords
promotive
libraries
promoters
artificial
selected organisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739121T
Other languages
English (en)
Inventor
Peter Ruhdal Jensen
Karin Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69739121D1 publication Critical patent/DE69739121D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1051Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69739121T 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren Expired - Lifetime DE69739121D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK88696 1996-08-23
PCT/DK1997/000342 WO1998007846A1 (en) 1996-08-23 1997-08-25 Artificial promoter libraries for selected organisms and promoters derived from such libraries

Publications (1)

Publication Number Publication Date
DE69739121D1 true DE69739121D1 (de) 2009-01-02

Family

ID=8098645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739121T Expired - Lifetime DE69739121D1 (de) 1996-08-23 1997-08-25 Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren

Country Status (8)

Country Link
US (1) US7199233B1 (de)
EP (2) EP2034021A1 (de)
JP (2) JP2001503249A (de)
CN (1) CN1243827C (de)
AU (1) AU3938397A (de)
DE (1) DE69739121D1 (de)
DK (1) DK0934406T3 (de)
WO (1) WO1998007846A1 (de)

Families Citing this family (47)

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EP1003911A1 (de) 1997-07-14 2000-05-31 Valentis Inc. Verfahren zur identifizierung von synthetischen zell-oder gewebsspezifischen transkriptions-regulierten regionen
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
BR9917880B1 (pt) 1998-09-25 2014-02-18 Processo para produzir um ácido l-glutâmico
US6555674B2 (en) 2000-08-09 2003-04-29 Nsgene A/S JeT promoter
US20040219525A1 (en) 2000-08-25 2004-11-04 Heiko Haertel Plant polynucleotides encoding novel prenyl proteases
US20040166566A1 (en) * 2001-06-06 2004-08-26 Takashi Ito Novel promoter
EP1696035A3 (de) 2002-04-10 2008-04-02 Novozymes A/S Verbesserte Bacillus-Wirtszelle
DE60321901D1 (de) 2002-04-10 2008-08-14 Novozymes As Verbesserte bacillus-wirtszelle
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
EP1576094B1 (de) * 2002-04-22 2011-09-28 Danisco US Inc. Verfahren zur erzeugung zu variierenden genexpressionsniveaus führender modifizierter promotoren
MXPA04010366A (es) * 2002-04-22 2005-02-17 Du Pont Sistema promotor y plasmido para ingenieria genetica.
DK1501947T3 (da) * 2002-04-22 2008-11-17 Genencor Int Fremgangsmåde til at skabe et bibliotek af bakterielle kloner med varierende niveauer af genekspression
US20080076678A1 (en) 2005-06-15 2008-03-27 Philippe Soucaille Method of creating a library of bacterial clones with varying levels of gene expression
WO2004033421A2 (en) 2002-10-04 2004-04-22 Genencor International, Inc. Improved production of bacterial strains
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
EP1579005A4 (de) * 2002-11-15 2007-07-25 Sangamo Biosciences Inc Verfahren und zusammensetzungen zur analyse regulatorischer sequenzen
JP4821606B2 (ja) * 2003-03-12 2011-11-24 味の素株式会社 効率的にL−グルタミン酸を生産するためのプロモーター変異による細菌のsucAB発現の最適化
US8110672B2 (en) 2005-04-27 2012-02-07 Massachusetts Institute Of Technology Promoter engineering and genetic control
AR061365A1 (es) * 2006-06-13 2008-08-20 Athenix Corp Metodos para generar diversidad genetica mediante mutagenesis con permutaciones
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
PT2087124E (pt) 2006-11-29 2011-07-29 Athenix Corp Epsp sintases grg23 melhoradas: composições e processos de utilização
US7618801B2 (en) 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
CA2719314A1 (en) 2008-03-28 2009-10-01 Danisco Us Inc. Method for amplifying locus in bacterial cell
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina
EP2311961A1 (de) * 2009-10-15 2011-04-20 DKFZ Deutsches Krebsforschungszentrum Modellgeführte Zufallszusammenlagerungs-Polymerase-Kettenreaktion für die Synthese von eukaryotischen Promotern
US20120315670A1 (en) 2009-11-02 2012-12-13 Gen9, Inc. Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell
EP2638157B1 (de) 2010-11-12 2015-07-22 Gen9, Inc. Verfahren und vorrichtungen für nukleinsäuresynthese
EP4039363A1 (de) 2010-11-12 2022-08-10 Gen9, Inc. Proteinanordnungen und verfahren zu ihrer herstellung und verwendung
CN102286517B (zh) * 2011-06-10 2016-08-03 中国科学院天津工业生物技术研究所 利用人工调控元件及其文库调控微生物染色体上基因表达强度的方法
LT2944693T (lt) 2011-08-26 2019-08-26 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
EP2573172A1 (de) 2011-09-21 2013-03-27 Heinrich-Heine-Universität Düsseldorf Mittel und Verfahren zur Rhamnolipidherstellung
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP4001427A1 (de) 2012-04-24 2022-05-25 Gen9, Inc. Verfahren zum sortieren von nukleinsäuren und zur multiplexierten, vorbereitenden in-vitro-klonung
CN104685116A (zh) 2012-06-25 2015-06-03 Gen9股份有限公司 用于核酸组装和高通量测序的方法
US9670493B2 (en) 2013-03-14 2017-06-06 Codexis, Inc. Low-phosphate repressible promoter
BR112018000257A2 (pt) 2015-07-08 2018-09-04 Rheinisch Westfaelische Technische Hochschule Aachen Rwth célula hospedeira, método para produzir um haa, uso de uma célula hospedeira, método para produzir uma célula hospedeira, célula, preparação de haa, método para produzir uma composição de ácido graxo e composição de ácido graxo
CN105296486B (zh) * 2015-11-18 2019-04-26 湖北大学 一种启动子文库构建方法和强启动子
US9988624B2 (en) * 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) * 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
CN105603537A (zh) * 2016-03-11 2016-05-25 南京工业大学 一种启动子文库的构建方法及其应用
KR20200026881A (ko) * 2017-06-07 2020-03-11 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도
CN108118059B (zh) * 2017-12-30 2021-03-19 苏州金唯智生物科技有限公司 一种改进的启动子及其组成的载体和应用
EP3546582A1 (de) * 2018-03-26 2019-10-02 KWS SAAT SE & Co. KGaA Promoter-aktivierende elemente
CN110317807A (zh) * 2018-03-29 2019-10-11 中国科学院天津工业生物技术研究所 一种谷氨酸棒杆菌人工启动子文库
CA3117051A1 (en) * 2018-11-05 2020-05-14 Genentech, Inc. Methods of producing two chain proteins in prokaryotic host cells
CN109486847B (zh) * 2018-12-17 2021-03-02 江南大学 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统
US20230065419A1 (en) * 2019-12-16 2023-03-02 Ginkgo Bioworks, Inc. Enhanced production of histidine, purine pathway metabolites, and plasmid dna

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215550D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
AU6776194A (en) * 1993-04-28 1994-11-21 Hybritech Incorporated Method for creating optimized regulatory regions affecting protein expression and protein trafficking

Also Published As

Publication number Publication date
CN1243827C (zh) 2006-03-01
EP0934406B1 (de) 2008-11-19
EP0934406A2 (de) 1999-08-11
JP4469005B2 (ja) 2010-05-26
EP2034021A1 (de) 2009-03-11
WO1998007846A1 (en) 1998-02-26
JP2009022293A (ja) 2009-02-05
AU3938397A (en) 1998-03-06
JP2001503249A (ja) 2001-03-13
CN1233287A (zh) 1999-10-27
US7199233B1 (en) 2007-04-03
DK0934406T3 (da) 2009-01-26

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