DE69739121D1 - Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren - Google Patents
Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotorenInfo
- Publication number
- DE69739121D1 DE69739121D1 DE69739121T DE69739121T DE69739121D1 DE 69739121 D1 DE69739121 D1 DE 69739121D1 DE 69739121 T DE69739121 T DE 69739121T DE 69739121 T DE69739121 T DE 69739121T DE 69739121 D1 DE69739121 D1 DE 69739121D1
- Authority
- DE
- Germany
- Prior art keywords
- promotive
- libraries
- promoters
- artificial
- selected organisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK88696 | 1996-08-23 | ||
PCT/DK1997/000342 WO1998007846A1 (en) | 1996-08-23 | 1997-08-25 | Artificial promoter libraries for selected organisms and promoters derived from such libraries |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739121D1 true DE69739121D1 (de) | 2009-01-02 |
Family
ID=8098645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69739121T Expired - Lifetime DE69739121D1 (de) | 1996-08-23 | 1997-08-25 | Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren |
Country Status (8)
Country | Link |
---|---|
US (1) | US7199233B1 (de) |
EP (2) | EP2034021A1 (de) |
JP (2) | JP2001503249A (de) |
CN (1) | CN1243827C (de) |
AU (1) | AU3938397A (de) |
DE (1) | DE69739121D1 (de) |
DK (1) | DK0934406T3 (de) |
WO (1) | WO1998007846A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1003911A1 (de) | 1997-07-14 | 2000-05-31 | Valentis Inc. | Verfahren zur identifizierung von synthetischen zell-oder gewebsspezifischen transkriptions-regulierten regionen |
US6475183B1 (en) | 1998-06-03 | 2002-11-05 | Baxter International Inc. | Direct dual filling device for sealing agents |
BR9917880B1 (pt) | 1998-09-25 | 2014-02-18 | Processo para produzir um ácido l-glutâmico | |
US6555674B2 (en) | 2000-08-09 | 2003-04-29 | Nsgene A/S | JeT promoter |
US20040219525A1 (en) | 2000-08-25 | 2004-11-04 | Heiko Haertel | Plant polynucleotides encoding novel prenyl proteases |
US20040166566A1 (en) * | 2001-06-06 | 2004-08-26 | Takashi Ito | Novel promoter |
EP1696035A3 (de) | 2002-04-10 | 2008-04-02 | Novozymes A/S | Verbesserte Bacillus-Wirtszelle |
DE60321901D1 (de) | 2002-04-10 | 2008-08-14 | Novozymes As | Verbesserte bacillus-wirtszelle |
US6644365B1 (en) | 2002-04-19 | 2003-11-11 | Baxter International, Inc. | Tilting direct dual filling device |
EP1576094B1 (de) * | 2002-04-22 | 2011-09-28 | Danisco US Inc. | Verfahren zur erzeugung zu variierenden genexpressionsniveaus führender modifizierter promotoren |
MXPA04010366A (es) * | 2002-04-22 | 2005-02-17 | Du Pont | Sistema promotor y plasmido para ingenieria genetica. |
DK1501947T3 (da) * | 2002-04-22 | 2008-11-17 | Genencor Int | Fremgangsmåde til at skabe et bibliotek af bakterielle kloner med varierende niveauer af genekspression |
US20080076678A1 (en) | 2005-06-15 | 2008-03-27 | Philippe Soucaille | Method of creating a library of bacterial clones with varying levels of gene expression |
WO2004033421A2 (en) | 2002-10-04 | 2004-04-22 | Genencor International, Inc. | Improved production of bacterial strains |
US20050079617A1 (en) | 2003-10-03 | 2005-04-14 | Cervin Marguerite A. | Glucose transport mutants for production of biomaterial |
EP1579005A4 (de) * | 2002-11-15 | 2007-07-25 | Sangamo Biosciences Inc | Verfahren und zusammensetzungen zur analyse regulatorischer sequenzen |
JP4821606B2 (ja) * | 2003-03-12 | 2011-11-24 | 味の素株式会社 | 効率的にL−グルタミン酸を生産するためのプロモーター変異による細菌のsucAB発現の最適化 |
US8110672B2 (en) | 2005-04-27 | 2012-02-07 | Massachusetts Institute Of Technology | Promoter engineering and genetic control |
AR061365A1 (es) * | 2006-06-13 | 2008-08-20 | Athenix Corp | Metodos para generar diversidad genetica mediante mutagenesis con permutaciones |
WO2008027558A2 (en) | 2006-08-31 | 2008-03-06 | Codon Devices, Inc. | Iterative nucleic acid assembly using activation of vector-encoded traits |
PT2087124E (pt) | 2006-11-29 | 2011-07-29 | Athenix Corp | Epsp sintases grg23 melhoradas: composições e processos de utilização |
US7618801B2 (en) | 2007-10-30 | 2009-11-17 | Danison US Inc. | Streptomyces protease |
CA2719314A1 (en) | 2008-03-28 | 2009-10-01 | Danisco Us Inc. | Method for amplifying locus in bacterial cell |
AR076941A1 (es) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
EP2311961A1 (de) * | 2009-10-15 | 2011-04-20 | DKFZ Deutsches Krebsforschungszentrum | Modellgeführte Zufallszusammenlagerungs-Polymerase-Kettenreaktion für die Synthese von eukaryotischen Promotern |
US20120315670A1 (en) | 2009-11-02 | 2012-12-13 | Gen9, Inc. | Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell |
EP2638157B1 (de) | 2010-11-12 | 2015-07-22 | Gen9, Inc. | Verfahren und vorrichtungen für nukleinsäuresynthese |
EP4039363A1 (de) | 2010-11-12 | 2022-08-10 | Gen9, Inc. | Proteinanordnungen und verfahren zu ihrer herstellung und verwendung |
CN102286517B (zh) * | 2011-06-10 | 2016-08-03 | 中国科学院天津工业生物技术研究所 | 利用人工调控元件及其文库调控微生物染色体上基因表达强度的方法 |
LT2944693T (lt) | 2011-08-26 | 2019-08-26 | Gen9, Inc. | Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai |
EP2573172A1 (de) | 2011-09-21 | 2013-03-27 | Heinrich-Heine-Universität Düsseldorf | Mittel und Verfahren zur Rhamnolipidherstellung |
US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
EP4001427A1 (de) | 2012-04-24 | 2022-05-25 | Gen9, Inc. | Verfahren zum sortieren von nukleinsäuren und zur multiplexierten, vorbereitenden in-vitro-klonung |
CN104685116A (zh) | 2012-06-25 | 2015-06-03 | Gen9股份有限公司 | 用于核酸组装和高通量测序的方法 |
US9670493B2 (en) | 2013-03-14 | 2017-06-06 | Codexis, Inc. | Low-phosphate repressible promoter |
BR112018000257A2 (pt) | 2015-07-08 | 2018-09-04 | Rheinisch Westfaelische Technische Hochschule Aachen Rwth | célula hospedeira, método para produzir um haa, uso de uma célula hospedeira, método para produzir uma célula hospedeira, célula, preparação de haa, método para produzir uma composição de ácido graxo e composição de ácido graxo |
CN105296486B (zh) * | 2015-11-18 | 2019-04-26 | 湖北大学 | 一种启动子文库构建方法和强启动子 |
US9988624B2 (en) * | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
US11208649B2 (en) * | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
CN105603537A (zh) * | 2016-03-11 | 2016-05-25 | 南京工业大学 | 一种启动子文库的构建方法及其应用 |
KR20200026881A (ko) * | 2017-06-07 | 2020-03-11 | 지머젠 인코포레이티드 | 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도 |
CN108118059B (zh) * | 2017-12-30 | 2021-03-19 | 苏州金唯智生物科技有限公司 | 一种改进的启动子及其组成的载体和应用 |
EP3546582A1 (de) * | 2018-03-26 | 2019-10-02 | KWS SAAT SE & Co. KGaA | Promoter-aktivierende elemente |
CN110317807A (zh) * | 2018-03-29 | 2019-10-11 | 中国科学院天津工业生物技术研究所 | 一种谷氨酸棒杆菌人工启动子文库 |
CA3117051A1 (en) * | 2018-11-05 | 2020-05-14 | Genentech, Inc. | Methods of producing two chain proteins in prokaryotic host cells |
CN109486847B (zh) * | 2018-12-17 | 2021-03-02 | 江南大学 | 基于人工串联启动子的枯草芽孢杆菌高效诱导表达系统 |
US20230065419A1 (en) * | 2019-12-16 | 2023-03-02 | Ginkgo Bioworks, Inc. | Enhanced production of histidine, purine pathway metabolites, and plasmid dna |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9215550D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
AU6776194A (en) * | 1993-04-28 | 1994-11-21 | Hybritech Incorporated | Method for creating optimized regulatory regions affecting protein expression and protein trafficking |
-
1997
- 1997-08-25 DE DE69739121T patent/DE69739121D1/de not_active Expired - Lifetime
- 1997-08-25 CN CNB971987033A patent/CN1243827C/zh not_active Expired - Lifetime
- 1997-08-25 AU AU39383/97A patent/AU3938397A/en not_active Abandoned
- 1997-08-25 EP EP08169178A patent/EP2034021A1/de not_active Ceased
- 1997-08-25 WO PCT/DK1997/000342 patent/WO1998007846A1/en active Application Filing
- 1997-08-25 US US09/242,657 patent/US7199233B1/en not_active Expired - Fee Related
- 1997-08-25 DK DK97936613T patent/DK0934406T3/da active
- 1997-08-25 JP JP51028798A patent/JP2001503249A/ja not_active Withdrawn
- 1997-08-25 EP EP97936613A patent/EP0934406B1/de not_active Expired - Lifetime
-
2008
- 2008-09-10 JP JP2008232486A patent/JP4469005B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1243827C (zh) | 2006-03-01 |
EP0934406B1 (de) | 2008-11-19 |
EP0934406A2 (de) | 1999-08-11 |
JP4469005B2 (ja) | 2010-05-26 |
EP2034021A1 (de) | 2009-03-11 |
WO1998007846A1 (en) | 1998-02-26 |
JP2009022293A (ja) | 2009-02-05 |
AU3938397A (en) | 1998-03-06 |
JP2001503249A (ja) | 2001-03-13 |
CN1233287A (zh) | 1999-10-27 |
US7199233B1 (en) | 2007-04-03 |
DK0934406T3 (da) | 2009-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |