DE69738138T2 - Induktion von immunologischer Toleranz gegen einen therapeutischen Antikörper durch Varianten des therapeutischen Antikörpers - Google Patents
Induktion von immunologischer Toleranz gegen einen therapeutischen Antikörper durch Varianten des therapeutischen Antikörpers Download PDFInfo
- Publication number
- DE69738138T2 DE69738138T2 DE69738138T DE69738138T DE69738138T2 DE 69738138 T2 DE69738138 T2 DE 69738138T2 DE 69738138 T DE69738138 T DE 69738138T DE 69738138 T DE69738138 T DE 69738138T DE 69738138 T2 DE69738138 T2 DE 69738138T2
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- therapeutic antibody
- antigen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9603507.6A GB9603507D0 (en) | 1996-02-20 | 1996-02-20 | Antibody variants |
| GB9603507 | 1996-02-20 | ||
| PCT/GB1997/000472 WO1997031024A1 (en) | 1996-02-20 | 1997-02-20 | Antibody variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69738138D1 DE69738138D1 (de) | 2007-10-25 |
| DE69738138T2 true DE69738138T2 (de) | 2008-06-05 |
Family
ID=10789047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69738138T Expired - Lifetime DE69738138T2 (de) | 1996-02-20 | 1997-02-20 | Induktion von immunologischer Toleranz gegen einen therapeutischen Antikörper durch Varianten des therapeutischen Antikörpers |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20020048578A1 (enExample) |
| EP (1) | EP0970127B1 (enExample) |
| JP (1) | JP4574750B2 (enExample) |
| AT (1) | ATE373016T1 (enExample) |
| AU (1) | AU723366B2 (enExample) |
| CA (1) | CA2246715C (enExample) |
| DE (1) | DE69738138T2 (enExample) |
| ES (1) | ES2294793T3 (enExample) |
| GB (1) | GB9603507D0 (enExample) |
| NZ (1) | NZ331299A (enExample) |
| WO (1) | WO1997031024A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69621940T2 (de) * | 1995-08-18 | 2003-01-16 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| US6037454A (en) | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| WO2000029584A1 (en) | 1998-11-18 | 2000-05-25 | Genentech, Inc. | Antibody variants with higher binding affinity compared to parent antibodies |
| AU2001293995B2 (en) * | 2000-10-09 | 2005-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| US20040109855A1 (en) * | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| EP1618891A1 (en) * | 2003-03-31 | 2006-01-25 | Kirin Beer Kabushiki Kaisha | Method of inducing differentiation and proliferating regulatory t cell by anti-cd52 antibody and medicinal composition therefor |
| JP4972549B2 (ja) * | 2004-05-19 | 2012-07-11 | イムノコア リミテッド | Ｔ細胞レセプターを改善する方法 |
| EP2481424A1 (en) * | 2005-03-19 | 2012-08-01 | Medical Research Council | Improvements in or relating to treatment and prevention of hepatitis C viral infections |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| EP2152300A4 (en) * | 2007-05-16 | 2012-12-05 | Sinomab Bioscience Ltd | FUNCTIONAL HUMANIZATION OF COMPLEMENTARITY-REGULATING REGIONS |
| JP6035009B2 (ja) | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| BRPI1006141B8 (pt) | 2009-01-12 | 2021-05-25 | Cytomx Therapeutics Llc | composições de anticorpo modificado, métodos para preparar e usar as mesmas |
| CA2753294A1 (en) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Inc. | Proproteins and methods of use thereof |
| CN104231084B (zh) | 2009-05-13 | 2019-04-23 | 基酶有限公司 | 抗人cd52免疫球蛋白 |
| CN102449149B (zh) | 2009-05-29 | 2014-04-23 | 莫佛塞斯公司 | 集合及其使用方法 |
| JP6253986B2 (ja) | 2010-11-19 | 2017-12-27 | モルフォシス・アーゲー | コレクション及びその使用方法 |
| GB201109238D0 (en) * | 2011-06-01 | 2011-07-13 | Antitope Ltd | Antibodies |
| US9494597B2 (en) * | 2012-04-02 | 2016-11-15 | Ab Biosciences, Inc. | Human control antibodies and uses therefor |
| RU2713121C2 (ru) | 2012-04-27 | 2020-02-03 | Сайтомкс Терапьютикс, Инк. | Активируемые антитела, которые связываются с рецептором эпидермального фактора роста, и способы их применения |
| SG11201508358RA (en) | 2013-04-09 | 2015-11-27 | Boston Biomedical Inc | 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer |
| WO2015066279A2 (en) | 2013-10-30 | 2015-05-07 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| US9737623B2 (en) | 2013-12-11 | 2017-08-22 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
| US20160120158A1 (en) * | 2014-11-03 | 2016-05-05 | The Johns Hopkins University | Compositions and methods for the study and treatment of acute kidney injury |
| MX2017015618A (es) | 2015-06-03 | 2018-08-15 | Boston Biomedical Inc | Composiciones que comprenden un inhibidor de la autorrenovación y diferenciación de células madre cancerosas y un agente inmunoterapéutico para su uso en el tratamiento del cáncer. |
| JP7106563B2 (ja) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | ナフトフラン誘導体、その調製、および使用方法 |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| US12465637B2 (en) | 2019-04-30 | 2025-11-11 | Institute For Cancer Research | Compositions and methods for modulation of antibody activity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU618989B2 (en) * | 1988-02-12 | 1992-01-16 | British Technology Group Limited | Improvements in or relating to antibodies |
| US5846534A (en) * | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
| US5858725A (en) * | 1990-10-10 | 1999-01-12 | Glaxo Wellcome Inc. | Preparation of chimaeric antibodies using the recombinant PCR strategy |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| ATE174515T1 (de) * | 1991-10-15 | 1999-01-15 | Btg Int Ltd | Verwendung eines cdw52-spezifischen antikörpers zur behandlung von durch t-zellen vermittelten gelenkentzündungen |
| GB9125768D0 (en) * | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
-
1996
- 1996-02-20 GB GBGB9603507.6A patent/GB9603507D0/en active Pending
-
1997
- 1997-02-20 AU AU18851/97A patent/AU723366B2/en not_active Ceased
- 1997-02-20 US US09/125,460 patent/US20020048578A1/en not_active Abandoned
- 1997-02-20 DE DE69738138T patent/DE69738138T2/de not_active Expired - Lifetime
- 1997-02-20 ES ES97905226T patent/ES2294793T3/es not_active Expired - Lifetime
- 1997-02-20 WO PCT/GB1997/000472 patent/WO1997031024A1/en not_active Ceased
- 1997-02-20 AT AT97905226T patent/ATE373016T1/de not_active IP Right Cessation
- 1997-02-20 CA CA002246715A patent/CA2246715C/en not_active Expired - Fee Related
- 1997-02-20 EP EP97905226A patent/EP0970127B1/en not_active Expired - Lifetime
- 1997-02-20 NZ NZ331299A patent/NZ331299A/xx not_active IP Right Cessation
- 1997-02-20 JP JP52989397A patent/JP4574750B2/ja not_active Expired - Lifetime
-
2005
- 2005-07-14 US US11/180,631 patent/US8440190B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20060018898A1 (en) | 2006-01-26 |
| CA2246715A1 (en) | 1997-08-28 |
| ES2294793T3 (es) | 2008-04-01 |
| WO1997031024A1 (en) | 1997-08-28 |
| NZ331299A (en) | 2000-05-26 |
| CA2246715C (en) | 2008-08-05 |
| AU723366B2 (en) | 2000-08-24 |
| GB9603507D0 (en) | 1996-04-17 |
| US8440190B2 (en) | 2013-05-14 |
| EP0970127B1 (en) | 2007-09-12 |
| ATE373016T1 (de) | 2007-09-15 |
| AU1885197A (en) | 1997-09-10 |
| JP4574750B2 (ja) | 2010-11-04 |
| US20020048578A1 (en) | 2002-04-25 |
| JP2000506723A (ja) | 2000-06-06 |
| DE69738138D1 (de) | 2007-10-25 |
| EP0970127A1 (en) | 2000-01-12 |
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