DE69737531T2 - Vorrichtung zur Anwendung einer Mischung von zwei oder mehreren flüssigen Komponenten zur Bildung eines Biomaterials - Google Patents
Vorrichtung zur Anwendung einer Mischung von zwei oder mehreren flüssigen Komponenten zur Bildung eines Biomaterials Download PDFInfo
- Publication number
- DE69737531T2 DE69737531T2 DE69737531T DE69737531T DE69737531T2 DE 69737531 T2 DE69737531 T2 DE 69737531T2 DE 69737531 T DE69737531 T DE 69737531T DE 69737531 T DE69737531 T DE 69737531T DE 69737531 T2 DE69737531 T2 DE 69737531T2
- Authority
- DE
- Germany
- Prior art keywords
- liquids
- liquid
- openings
- diameter
- spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 110
- 239000012620 biological material Substances 0.000 title claims abstract description 12
- 239000000203 mixture Substances 0.000 title claims description 5
- 239000007921 spray Substances 0.000 claims abstract description 85
- 238000002156 mixing Methods 0.000 claims abstract description 39
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims abstract description 21
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical group CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 23
- 239000012530 fluid Substances 0.000 claims description 20
- 108010073651 fibrinmonomer Proteins 0.000 claims description 15
- 108010049003 Fibrinogen Proteins 0.000 claims description 9
- 102000008946 Fibrinogen Human genes 0.000 claims description 9
- 229940012952 fibrinogen Drugs 0.000 claims description 9
- 108010073385 Fibrin Proteins 0.000 claims description 8
- 102000009123 Fibrin Human genes 0.000 claims description 8
- 229950003499 fibrin Drugs 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 24
- 239000000443 aerosol Substances 0.000 abstract description 6
- 239000003894 surgical glue Substances 0.000 abstract description 3
- -1 e.g. Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 56
- 239000000306 component Substances 0.000 description 49
- 239000000853 adhesive Substances 0.000 description 22
- 230000001070 adhesive effect Effects 0.000 description 22
- 239000000243 solution Substances 0.000 description 18
- 239000000463 material Substances 0.000 description 8
- 239000003292 glue Substances 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 239000003106 tissue adhesive Substances 0.000 description 7
- 108090000190 Thrombin Proteins 0.000 description 6
- 229960004072 thrombin Drugs 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000002028 premature Effects 0.000 description 4
- 229920001169 thermoplastic Polymers 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 229920001222 biopolymer Polymers 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000012815 thermoplastic material Substances 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 2
- 239000011545 carbonate/bicarbonate buffer Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 238000009760 electrical discharge machining Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
- B05B7/0876—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form parallel jets constituted by a liquid or a mixture containing a liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
- Nozzles (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3094296P | 1996-11-15 | 1996-11-15 | |
| US30942P | 1996-11-15 | ||
| US08/970,291 US6454786B1 (en) | 1996-11-15 | 1997-11-14 | Devices and methods for applying a mixture of two or more liquid components to form a biomaterial |
| PCT/US1997/020653 WO1998020931A1 (en) | 1996-11-15 | 1997-11-14 | Devices and methods for applying a mixture of two or more liquid components to form a biomaterial |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69737531D1 DE69737531D1 (de) | 2007-05-10 |
| DE69737531T2 true DE69737531T2 (de) | 2008-01-31 |
Family
ID=26706614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737531T Expired - Lifetime DE69737531T2 (de) | 1996-11-15 | 1997-11-14 | Vorrichtung zur Anwendung einer Mischung von zwei oder mehreren flüssigen Komponenten zur Bildung eines Biomaterials |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6454786B1 (https=) |
| EP (1) | EP0951311B1 (https=) |
| JP (2) | JP4116083B2 (https=) |
| AT (1) | ATE357946T1 (https=) |
| AU (1) | AU721371B2 (https=) |
| BR (1) | BR9713070A (https=) |
| CA (2) | CA2583144C (https=) |
| DE (1) | DE69737531T2 (https=) |
| DK (1) | DK0951311T3 (https=) |
| ES (1) | ES2284186T3 (https=) |
| IL (1) | IL129916A0 (https=) |
| NO (1) | NO992342L (https=) |
| NZ (1) | NZ335751A (https=) |
| PT (1) | PT951311E (https=) |
| WO (1) | WO1998020931A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| WO1997040864A1 (en) * | 1996-04-30 | 1997-11-06 | Medtronic, Inc. | Method for making autologous fibrin sealant |
| AU6151799A (en) | 1998-09-17 | 2000-04-03 | Focal, Inc. | Self-cleaning fluid delivery device for medical applications |
| US6921380B1 (en) * | 1998-10-01 | 2005-07-26 | Baxter International Inc. | Component mixing catheter |
| US6479052B1 (en) * | 1998-12-02 | 2002-11-12 | Bristol-Myers Squibb Company | Spray delivery of cells |
| EP1185278A4 (en) * | 1999-06-01 | 2002-09-18 | Bristol Myers Squibb Co | FIBRINPOLYMERSTRUKTUR |
| CA2316554C (en) | 1999-08-25 | 2007-10-23 | Bristol-Myers Squibb Company | Applicator and electro-mechanical applicator drive system |
| US7544177B2 (en) | 2002-01-24 | 2009-06-09 | The Regents Of The University Of California | Aerosol device to deliver bioactive agent |
| US7217254B2 (en) * | 2002-09-20 | 2007-05-15 | Genzyme Corporation | Multi-pressure biocompatible agent delivery device and method |
| US7077339B2 (en) * | 2003-02-03 | 2006-07-18 | Biomet, Inc. | Spray applicator |
| US20040254528A1 (en) * | 2003-06-12 | 2004-12-16 | Adams Daniel O. | Catheter with removable wire lumen segment |
| US7490738B2 (en) * | 2004-10-01 | 2009-02-17 | Angiotech Pharmaceuticals (Us), Inc. | Mixing and dispensing fluid components of a multicomponent composition |
| BRPI0606642B8 (pt) * | 2005-01-12 | 2021-06-22 | Baxter Healthcare Sa | conjunto de aplicador de selante |
| US7611494B2 (en) * | 2005-02-08 | 2009-11-03 | Confluent Surgical, Inc. | Spray for fluent materials |
| EP2433590B1 (en) | 2005-02-18 | 2020-05-06 | Covidien LP | Rapid exchange catheter with embolic filter |
| US7766900B2 (en) * | 2005-02-21 | 2010-08-03 | Biomet Manufacturing Corp. | Method and apparatus for application of a fluid |
| US8603138B2 (en) * | 2006-10-04 | 2013-12-10 | Ethicon Endo-Surgery, Inc. | Use of an adhesive to treat intraluminal bleeding |
| US7914511B2 (en) * | 2006-10-18 | 2011-03-29 | Ethicon Endo-Surgery, Inc. | Use of biosurgical adhesive as bulking agent |
| US7749235B2 (en) * | 2006-10-20 | 2010-07-06 | Ethicon Endo-Surgery, Inc. | Stomach invagination method and apparatus |
| US7441973B2 (en) * | 2006-10-20 | 2008-10-28 | Ethicon Endo-Surgery, Inc. | Adhesive applicator |
| US7658305B2 (en) * | 2006-10-25 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | Adhesive applier with articulating tip |
| US8876844B2 (en) * | 2006-11-01 | 2014-11-04 | Ethicon Endo-Surgery, Inc. | Anastomosis reinforcement using biosurgical adhesive and device |
| US7892250B2 (en) | 2006-11-01 | 2011-02-22 | Ethicon Endo-Surgery, Inc. | Use of biosurgical adhesive on inflatable device for gastric restriction |
| US7833216B2 (en) * | 2006-11-08 | 2010-11-16 | Ethicon Endo-Surgery, Inc. | Fluid plunger adhesive dispenser |
| WO2008102340A2 (en) * | 2007-02-20 | 2008-08-28 | Svip 1 Llc | Kits and methods for determining colon cleanliness |
| US20100099944A1 (en) * | 2007-02-20 | 2010-04-22 | Tidhar Shalon | Fecal incontinence device, kit and method |
| US8287566B2 (en) * | 2007-10-26 | 2012-10-16 | Cohera Medical, Inc. | Spray devices and methods |
| US8518272B2 (en) | 2008-04-04 | 2013-08-27 | Biomet Biologics, Llc | Sterile blood separating system |
| US8182769B2 (en) | 2008-04-04 | 2012-05-22 | Biomet Biologics, Llc | Clean transportation system |
| AU2009244462B2 (en) | 2008-05-06 | 2013-04-11 | Cook Medical Technologies Llc | Apparatus and methods for delivering therapeutic agents |
| JP5631332B2 (ja) | 2008-12-23 | 2014-11-26 | クック メディカル テクノロジーズ エルエルシーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 治療薬を収容及び送達するための器械及び方法 |
| RU2406153C2 (ru) * | 2009-02-25 | 2010-12-10 | Армен Арменакович Акопян | Торговый аппарат аэрозольных смесей |
| US8118777B2 (en) | 2009-05-29 | 2012-02-21 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| US9101744B2 (en) | 2009-05-29 | 2015-08-11 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| US8608642B2 (en) * | 2010-02-25 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Methods and devices for treating morbid obesity using hydrogel |
| US20120000935A1 (en) * | 2010-06-30 | 2012-01-05 | E. I. Du Pont De Nemours And Company | Self-contained hand held yoke-connected device for dispensng a two-part adhesive aerosol |
| US8678238B2 (en) * | 2010-06-30 | 2014-03-25 | Actamax Surgical Materials, Llc | Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol |
| US20130245576A1 (en) * | 2012-03-13 | 2013-09-19 | Nordson Corporation | Applicator spray nozzles with pressure relief |
| EP2722008B1 (de) | 2012-10-16 | 2018-01-17 | Erbe Elektromedizin GmbH | Düse zur Zufuhr von biologischem Material, insbesondere Zellen, medizinische Vorrichtung mit einer derartigen Düse, Verwendung einer Düse, Verfahren zum Mischen von Fluiden und Gerät |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| US9867931B2 (en) | 2013-10-02 | 2018-01-16 | Cook Medical Technologies Llc | Therapeutic agents for delivery using a catheter and pressure source |
| IL230151A0 (en) * | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
| EP2907582B1 (de) * | 2014-02-17 | 2017-09-06 | Erbe Elektromedizin GmbH | Verfahren und Düse zum Mischen und Versprühen von medizinischen Fluiden |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
| US10952709B2 (en) | 2014-04-04 | 2021-03-23 | Hyperbranch Medical Technology, Inc. | Extended tip spray applicator for two-component surgical sealant, and methods of use thereof |
| US10912859B2 (en) | 2017-03-08 | 2021-02-09 | Baxter International Inc. | Additive able to provide underwater adhesion |
| US11202848B2 (en) | 2017-03-08 | 2021-12-21 | Baxter International Inc. | Surgical adhesive able to glue in wet conditions |
| BR102017008027B1 (pt) * | 2017-04-18 | 2022-04-19 | Cristália Produtos Químicos Farmacêuticos Ltda | Processo de obtenção de biopolímero de fibrina, meios de aplicação do referido biopolímero de fibrina, e processo de aplicação do referido biopolímero de fibrina |
| CN115697176A (zh) | 2020-06-05 | 2023-02-03 | 库克医学技术有限责任公司 | 用于递送治疗剂的医疗窥镜 |
| US20240082857A1 (en) * | 2021-01-18 | 2024-03-14 | Bonsens Ab | A swirl nozzle and methods of fabricating the same |
| EP4337107A1 (en) * | 2021-05-10 | 2024-03-20 | Boston Scientific Scimed, Inc. | Agent delivery devices and methods of using the same |
| WO2023287654A1 (en) | 2021-07-14 | 2023-01-19 | Cook Medical Technologies, LLC | Systems and methods for preventing clogging of a delivery system |
| US12496429B2 (en) | 2022-10-18 | 2025-12-16 | Cook Medical Technologies Llc | Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents |
| EP4434474A1 (de) | 2023-03-23 | 2024-09-25 | Erbe Elektromedizin GmbH | Instrument, system und verfahren zum versprühen von flüssigkeiten |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223083A (en) | 1960-09-09 | 1965-12-14 | President And Directors Of Geo | Method for adhesively securing together skin and other soft tissue and bone |
| GB1162790A (en) * | 1968-07-19 | 1969-08-27 | Andre Passe | Atomizing Apparatus for the Treatment of Wounds |
| US3577516A (en) | 1969-12-02 | 1971-05-04 | Nat Patent Dev Corp | Preparation of spray on bandage |
| JPS5413975U (https=) * | 1977-06-30 | 1979-01-29 | ||
| US4381008A (en) * | 1978-09-08 | 1983-04-26 | Johnson & Johnson | Methods of improving surface characteristics of extruded thermoplastic tubing and products produced thereby |
| AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| AT379311B (de) * | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| JPS6135236A (ja) * | 1984-07-27 | 1986-02-19 | Minoru Atake | 異径部を有する管状体の製造方法 |
| AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| JPH0430147Y2 (https=) * | 1985-10-08 | 1992-07-21 | ||
| DE3725553A1 (de) | 1987-08-01 | 1989-02-09 | Hoechst Ag | Spruehkopf zum applizieren eines mehrkomponentenmaterials |
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| US4874368A (en) | 1988-07-25 | 1989-10-17 | Micromedics, Inc. | Fibrin glue delivery system |
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| NZ233609A (en) * | 1989-05-17 | 1992-10-28 | Critikon Inc | Over-the-needle catheter assembly; restriction in catheter tube to limit liquid backflow |
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| US5116315A (en) | 1989-10-03 | 1992-05-26 | Hemaedics, Inc. | Biological syringe system |
| US5368563A (en) * | 1991-12-18 | 1994-11-29 | Micromedics, Inc. | Sprayer assembly for physiologic glue |
| US5336170A (en) | 1992-07-29 | 1994-08-09 | Research Medical, Inc. | Surgical site visualization wand |
| ES2130412T5 (es) | 1992-09-26 | 2005-03-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Aplicador de adhesivo destinado para tejidos. |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| JP2741323B2 (ja) * | 1992-12-21 | 1998-04-15 | 株式会社石川製作所 | 生体組織接着剤塗布用チューブ |
| JP3408295B2 (ja) * | 1993-10-05 | 2003-05-19 | 日本炭酸瓦斯株式会社 | 処置剤の自動押圧噴霧供給装置 |
| CA2112093C (en) | 1993-12-21 | 1995-02-21 | John A. Burgener | Parallel path induction nebulizer |
| EP0748240A4 (en) * | 1994-03-18 | 1998-04-29 | St Jude Medical | INTRA-AORTIC BALLOON CATHETERS |
| WO1995031137A1 (de) | 1994-05-18 | 1995-11-23 | Omrix Biopharmaceuticals S.A. | Vorrichtung zum ausgeben eines mehrkomponenten-gewebeklebstoffes |
| PT689874E (pt) | 1994-06-28 | 2002-03-28 | Aventis Behring Gmbh | Dispositivo para a pulverizacao de uma mistura de dois componentes |
| JP2789298B2 (ja) * | 1994-07-08 | 1998-08-20 | 株式会社石川製作所 | 生体組織接着剤塗布用チューブ |
| US5605541A (en) * | 1994-12-07 | 1997-02-25 | E. R. Squibb And Sons, Inc. | Fibrin sealant applicatoor |
| AU4434396A (en) * | 1994-12-28 | 1996-07-19 | Opperbas Holding B.V. | Device for applying one or several fluids |
| WO1996039212A2 (en) | 1995-06-06 | 1996-12-12 | Quantic Biomedical Partners | Wound sealant preparation and application device and method |
| JP3024765U (ja) * | 1995-11-17 | 1996-05-31 | 株式会社八光電機製作所 | 二薬液混合噴霧ノズル |
| WO1997020585A1 (en) * | 1995-12-07 | 1997-06-12 | Bristol-Myers Squibb Company | A method of applying a mixture of two liquid components |
| US5759169A (en) | 1996-03-13 | 1998-06-02 | New York Blood Center Inc. | Fibrin sealant glue-gun |
| US5759171A (en) | 1996-09-27 | 1998-06-02 | Thermogenesis Corp. | Sprayer for fibrin glue |
-
1997
- 1997-11-14 NZ NZ335751A patent/NZ335751A/xx unknown
- 1997-11-14 DE DE69737531T patent/DE69737531T2/de not_active Expired - Lifetime
- 1997-11-14 EP EP97946656A patent/EP0951311B1/en not_active Expired - Lifetime
- 1997-11-14 BR BR9713070-2A patent/BR9713070A/pt not_active Application Discontinuation
- 1997-11-14 AT AT97946656T patent/ATE357946T1/de not_active IP Right Cessation
- 1997-11-14 CA CA002583144A patent/CA2583144C/en not_active Expired - Fee Related
- 1997-11-14 US US08/970,291 patent/US6454786B1/en not_active Expired - Lifetime
- 1997-11-14 WO PCT/US1997/020653 patent/WO1998020931A1/en not_active Ceased
- 1997-11-14 IL IL12991697A patent/IL129916A0/xx unknown
- 1997-11-14 ES ES97946656T patent/ES2284186T3/es not_active Expired - Lifetime
- 1997-11-14 DK DK97946656T patent/DK0951311T3/da active
- 1997-11-14 AU AU51782/98A patent/AU721371B2/en not_active Ceased
- 1997-11-14 JP JP52279398A patent/JP4116083B2/ja not_active Expired - Fee Related
- 1997-11-14 PT PT97946656T patent/PT951311E/pt unknown
- 1997-11-14 CA CA002271738A patent/CA2271738C/en not_active Expired - Fee Related
-
1999
- 1999-05-14 NO NO19992342A patent/NO992342L/no not_active Application Discontinuation
- 1999-07-21 US US09/358,078 patent/US6206905B1/en not_active Expired - Fee Related
-
2007
- 2007-05-21 JP JP2007134424A patent/JP2007307385A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK0951311T3 (da) | 2007-07-09 |
| EP0951311B1 (en) | 2007-03-28 |
| EP0951311A4 (en) | 2000-11-08 |
| JP2001505787A (ja) | 2001-05-08 |
| CA2583144C (en) | 2009-03-10 |
| AU5178298A (en) | 1998-06-03 |
| AU721371B2 (en) | 2000-06-29 |
| EP0951311A1 (en) | 1999-10-27 |
| NO992342L (no) | 1999-07-06 |
| US6206905B1 (en) | 2001-03-27 |
| IL129916A0 (en) | 2000-02-29 |
| BR9713070A (pt) | 2000-04-11 |
| PT951311E (pt) | 2007-06-05 |
| US6454786B1 (en) | 2002-09-24 |
| ES2284186T3 (es) | 2007-11-01 |
| JP2007307385A (ja) | 2007-11-29 |
| JP4116083B2 (ja) | 2008-07-09 |
| ATE357946T1 (de) | 2007-04-15 |
| CA2271738C (en) | 2008-06-03 |
| WO1998020931A1 (en) | 1998-05-22 |
| CA2271738A1 (en) | 1998-05-22 |
| DE69737531D1 (de) | 2007-05-10 |
| CA2583144A1 (en) | 1998-05-22 |
| NO992342D0 (no) | 1999-05-14 |
| NZ335751A (en) | 2001-01-26 |
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Owner name: VIVOLUTION A/S, BIRKEROD, DK |