JP4116083B2 - 生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 - Google Patents
生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 Download PDFInfo
- Publication number
- JP4116083B2 JP4116083B2 JP52279398A JP52279398A JP4116083B2 JP 4116083 B2 JP4116083 B2 JP 4116083B2 JP 52279398 A JP52279398 A JP 52279398A JP 52279398 A JP52279398 A JP 52279398A JP 4116083 B2 JP4116083 B2 JP 4116083B2
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- Expired - Fee Related
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
- B05B7/0876—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form parallel jets constituted by a liquid or a mixture containing a liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
- Nozzles (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3094296P | 1996-11-15 | 1996-11-15 | |
| US60/030,942 | 1996-11-15 | ||
| US08/970,291 US6454786B1 (en) | 1996-11-15 | 1997-11-14 | Devices and methods for applying a mixture of two or more liquid components to form a biomaterial |
| PCT/US1997/020653 WO1998020931A1 (en) | 1996-11-15 | 1997-11-14 | Devices and methods for applying a mixture of two or more liquid components to form a biomaterial |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007134424A Division JP2007307385A (ja) | 1996-11-15 | 2007-05-21 | 生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001505787A JP2001505787A (ja) | 2001-05-08 |
| JP2001505787A5 JP2001505787A5 (https=) | 2005-07-14 |
| JP4116083B2 true JP4116083B2 (ja) | 2008-07-09 |
Family
ID=26706614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52279398A Expired - Fee Related JP4116083B2 (ja) | 1996-11-15 | 1997-11-14 | 生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 |
| JP2007134424A Withdrawn JP2007307385A (ja) | 1996-11-15 | 2007-05-21 | 生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007134424A Withdrawn JP2007307385A (ja) | 1996-11-15 | 2007-05-21 | 生体適合材料を形成する二つ又はそれ以上の液体成分の混合物を塗布するための装置及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6454786B1 (https=) |
| EP (1) | EP0951311B1 (https=) |
| JP (2) | JP4116083B2 (https=) |
| AT (1) | ATE357946T1 (https=) |
| AU (1) | AU721371B2 (https=) |
| BR (1) | BR9713070A (https=) |
| CA (2) | CA2583144C (https=) |
| DE (1) | DE69737531T2 (https=) |
| DK (1) | DK0951311T3 (https=) |
| ES (1) | ES2284186T3 (https=) |
| IL (1) | IL129916A0 (https=) |
| NO (1) | NO992342L (https=) |
| NZ (1) | NZ335751A (https=) |
| PT (1) | PT951311E (https=) |
| WO (1) | WO1998020931A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| WO1997040864A1 (en) * | 1996-04-30 | 1997-11-06 | Medtronic, Inc. | Method for making autologous fibrin sealant |
| AU6151799A (en) | 1998-09-17 | 2000-04-03 | Focal, Inc. | Self-cleaning fluid delivery device for medical applications |
| US6921380B1 (en) * | 1998-10-01 | 2005-07-26 | Baxter International Inc. | Component mixing catheter |
| US6479052B1 (en) * | 1998-12-02 | 2002-11-12 | Bristol-Myers Squibb Company | Spray delivery of cells |
| EP1185278A4 (en) * | 1999-06-01 | 2002-09-18 | Bristol Myers Squibb Co | FIBRINPOLYMERSTRUKTUR |
| CA2316554C (en) | 1999-08-25 | 2007-10-23 | Bristol-Myers Squibb Company | Applicator and electro-mechanical applicator drive system |
| US7544177B2 (en) | 2002-01-24 | 2009-06-09 | The Regents Of The University Of California | Aerosol device to deliver bioactive agent |
| US7217254B2 (en) * | 2002-09-20 | 2007-05-15 | Genzyme Corporation | Multi-pressure biocompatible agent delivery device and method |
| US7077339B2 (en) * | 2003-02-03 | 2006-07-18 | Biomet, Inc. | Spray applicator |
| US20040254528A1 (en) * | 2003-06-12 | 2004-12-16 | Adams Daniel O. | Catheter with removable wire lumen segment |
| US7490738B2 (en) * | 2004-10-01 | 2009-02-17 | Angiotech Pharmaceuticals (Us), Inc. | Mixing and dispensing fluid components of a multicomponent composition |
| BRPI0606642B8 (pt) * | 2005-01-12 | 2021-06-22 | Baxter Healthcare Sa | conjunto de aplicador de selante |
| US7611494B2 (en) * | 2005-02-08 | 2009-11-03 | Confluent Surgical, Inc. | Spray for fluent materials |
| EP2433590B1 (en) | 2005-02-18 | 2020-05-06 | Covidien LP | Rapid exchange catheter with embolic filter |
| US7766900B2 (en) * | 2005-02-21 | 2010-08-03 | Biomet Manufacturing Corp. | Method and apparatus for application of a fluid |
| US8603138B2 (en) * | 2006-10-04 | 2013-12-10 | Ethicon Endo-Surgery, Inc. | Use of an adhesive to treat intraluminal bleeding |
| US7914511B2 (en) * | 2006-10-18 | 2011-03-29 | Ethicon Endo-Surgery, Inc. | Use of biosurgical adhesive as bulking agent |
| US7749235B2 (en) * | 2006-10-20 | 2010-07-06 | Ethicon Endo-Surgery, Inc. | Stomach invagination method and apparatus |
| US7441973B2 (en) * | 2006-10-20 | 2008-10-28 | Ethicon Endo-Surgery, Inc. | Adhesive applicator |
| US7658305B2 (en) * | 2006-10-25 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | Adhesive applier with articulating tip |
| US8876844B2 (en) * | 2006-11-01 | 2014-11-04 | Ethicon Endo-Surgery, Inc. | Anastomosis reinforcement using biosurgical adhesive and device |
| US7892250B2 (en) | 2006-11-01 | 2011-02-22 | Ethicon Endo-Surgery, Inc. | Use of biosurgical adhesive on inflatable device for gastric restriction |
| US7833216B2 (en) * | 2006-11-08 | 2010-11-16 | Ethicon Endo-Surgery, Inc. | Fluid plunger adhesive dispenser |
| WO2008102340A2 (en) * | 2007-02-20 | 2008-08-28 | Svip 1 Llc | Kits and methods for determining colon cleanliness |
| US20100099944A1 (en) * | 2007-02-20 | 2010-04-22 | Tidhar Shalon | Fecal incontinence device, kit and method |
| US8287566B2 (en) * | 2007-10-26 | 2012-10-16 | Cohera Medical, Inc. | Spray devices and methods |
| US8518272B2 (en) | 2008-04-04 | 2013-08-27 | Biomet Biologics, Llc | Sterile blood separating system |
| US8182769B2 (en) | 2008-04-04 | 2012-05-22 | Biomet Biologics, Llc | Clean transportation system |
| AU2009244462B2 (en) | 2008-05-06 | 2013-04-11 | Cook Medical Technologies Llc | Apparatus and methods for delivering therapeutic agents |
| JP5631332B2 (ja) | 2008-12-23 | 2014-11-26 | クック メディカル テクノロジーズ エルエルシーCook Medical Technologies Llc | 治療薬を収容及び送達するための器械及び方法 |
| RU2406153C2 (ru) * | 2009-02-25 | 2010-12-10 | Армен Арменакович Акопян | Торговый аппарат аэрозольных смесей |
| US8118777B2 (en) | 2009-05-29 | 2012-02-21 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| US9101744B2 (en) | 2009-05-29 | 2015-08-11 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| US8608642B2 (en) * | 2010-02-25 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Methods and devices for treating morbid obesity using hydrogel |
| US20120000935A1 (en) * | 2010-06-30 | 2012-01-05 | E. I. Du Pont De Nemours And Company | Self-contained hand held yoke-connected device for dispensng a two-part adhesive aerosol |
| US8678238B2 (en) * | 2010-06-30 | 2014-03-25 | Actamax Surgical Materials, Llc | Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol |
| US20130245576A1 (en) * | 2012-03-13 | 2013-09-19 | Nordson Corporation | Applicator spray nozzles with pressure relief |
| EP2722008B1 (de) | 2012-10-16 | 2018-01-17 | Erbe Elektromedizin GmbH | Düse zur Zufuhr von biologischem Material, insbesondere Zellen, medizinische Vorrichtung mit einer derartigen Düse, Verwendung einer Düse, Verfahren zum Mischen von Fluiden und Gerät |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| US9867931B2 (en) | 2013-10-02 | 2018-01-16 | Cook Medical Technologies Llc | Therapeutic agents for delivery using a catheter and pressure source |
| IL230151A0 (en) * | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
| EP2907582B1 (de) * | 2014-02-17 | 2017-09-06 | Erbe Elektromedizin GmbH | Verfahren und Düse zum Mischen und Versprühen von medizinischen Fluiden |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
| US10952709B2 (en) | 2014-04-04 | 2021-03-23 | Hyperbranch Medical Technology, Inc. | Extended tip spray applicator for two-component surgical sealant, and methods of use thereof |
| US10912859B2 (en) | 2017-03-08 | 2021-02-09 | Baxter International Inc. | Additive able to provide underwater adhesion |
| US11202848B2 (en) | 2017-03-08 | 2021-12-21 | Baxter International Inc. | Surgical adhesive able to glue in wet conditions |
| BR102017008027B1 (pt) * | 2017-04-18 | 2022-04-19 | Cristália Produtos Químicos Farmacêuticos Ltda | Processo de obtenção de biopolímero de fibrina, meios de aplicação do referido biopolímero de fibrina, e processo de aplicação do referido biopolímero de fibrina |
| CN115697176A (zh) | 2020-06-05 | 2023-02-03 | 库克医学技术有限责任公司 | 用于递送治疗剂的医疗窥镜 |
| US20240082857A1 (en) * | 2021-01-18 | 2024-03-14 | Bonsens Ab | A swirl nozzle and methods of fabricating the same |
| EP4337107A1 (en) * | 2021-05-10 | 2024-03-20 | Boston Scientific Scimed, Inc. | Agent delivery devices and methods of using the same |
| WO2023287654A1 (en) | 2021-07-14 | 2023-01-19 | Cook Medical Technologies, LLC | Systems and methods for preventing clogging of a delivery system |
| US12496429B2 (en) | 2022-10-18 | 2025-12-16 | Cook Medical Technologies Llc | Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents |
| EP4434474A1 (de) | 2023-03-23 | 2024-09-25 | Erbe Elektromedizin GmbH | Instrument, system und verfahren zum versprühen von flüssigkeiten |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223083A (en) | 1960-09-09 | 1965-12-14 | President And Directors Of Geo | Method for adhesively securing together skin and other soft tissue and bone |
| GB1162790A (en) * | 1968-07-19 | 1969-08-27 | Andre Passe | Atomizing Apparatus for the Treatment of Wounds |
| US3577516A (en) | 1969-12-02 | 1971-05-04 | Nat Patent Dev Corp | Preparation of spray on bandage |
| JPS5413975U (https=) * | 1977-06-30 | 1979-01-29 | ||
| US4381008A (en) * | 1978-09-08 | 1983-04-26 | Johnson & Johnson | Methods of improving surface characteristics of extruded thermoplastic tubing and products produced thereby |
| AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| AT379311B (de) * | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| JPS6135236A (ja) * | 1984-07-27 | 1986-02-19 | Minoru Atake | 異径部を有する管状体の製造方法 |
| AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| JPH0430147Y2 (https=) * | 1985-10-08 | 1992-07-21 | ||
| DE3725553A1 (de) | 1987-08-01 | 1989-02-09 | Hoechst Ag | Spruehkopf zum applizieren eines mehrkomponentenmaterials |
| US4978336A (en) | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| US4874368A (en) | 1988-07-25 | 1989-10-17 | Micromedics, Inc. | Fibrin glue delivery system |
| US4902281A (en) | 1988-08-16 | 1990-02-20 | Corus Medical Corporation | Fibrinogen dispensing kit |
| NZ233609A (en) * | 1989-05-17 | 1992-10-28 | Critikon Inc | Over-the-needle catheter assembly; restriction in catheter tube to limit liquid backflow |
| US5226877A (en) | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
| US5116315A (en) | 1989-10-03 | 1992-05-26 | Hemaedics, Inc. | Biological syringe system |
| US5368563A (en) * | 1991-12-18 | 1994-11-29 | Micromedics, Inc. | Sprayer assembly for physiologic glue |
| US5336170A (en) | 1992-07-29 | 1994-08-09 | Research Medical, Inc. | Surgical site visualization wand |
| ES2130412T5 (es) | 1992-09-26 | 2005-03-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Aplicador de adhesivo destinado para tejidos. |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| JP2741323B2 (ja) * | 1992-12-21 | 1998-04-15 | 株式会社石川製作所 | 生体組織接着剤塗布用チューブ |
| JP3408295B2 (ja) * | 1993-10-05 | 2003-05-19 | 日本炭酸瓦斯株式会社 | 処置剤の自動押圧噴霧供給装置 |
| CA2112093C (en) | 1993-12-21 | 1995-02-21 | John A. Burgener | Parallel path induction nebulizer |
| EP0748240A4 (en) * | 1994-03-18 | 1998-04-29 | St Jude Medical | INTRA-AORTIC BALLOON CATHETERS |
| WO1995031137A1 (de) | 1994-05-18 | 1995-11-23 | Omrix Biopharmaceuticals S.A. | Vorrichtung zum ausgeben eines mehrkomponenten-gewebeklebstoffes |
| PT689874E (pt) | 1994-06-28 | 2002-03-28 | Aventis Behring Gmbh | Dispositivo para a pulverizacao de uma mistura de dois componentes |
| JP2789298B2 (ja) * | 1994-07-08 | 1998-08-20 | 株式会社石川製作所 | 生体組織接着剤塗布用チューブ |
| US5605541A (en) * | 1994-12-07 | 1997-02-25 | E. R. Squibb And Sons, Inc. | Fibrin sealant applicatoor |
| AU4434396A (en) * | 1994-12-28 | 1996-07-19 | Opperbas Holding B.V. | Device for applying one or several fluids |
| WO1996039212A2 (en) | 1995-06-06 | 1996-12-12 | Quantic Biomedical Partners | Wound sealant preparation and application device and method |
| JP3024765U (ja) * | 1995-11-17 | 1996-05-31 | 株式会社八光電機製作所 | 二薬液混合噴霧ノズル |
| WO1997020585A1 (en) * | 1995-12-07 | 1997-06-12 | Bristol-Myers Squibb Company | A method of applying a mixture of two liquid components |
| US5759169A (en) | 1996-03-13 | 1998-06-02 | New York Blood Center Inc. | Fibrin sealant glue-gun |
| US5759171A (en) | 1996-09-27 | 1998-06-02 | Thermogenesis Corp. | Sprayer for fibrin glue |
-
1997
- 1997-11-14 NZ NZ335751A patent/NZ335751A/xx unknown
- 1997-11-14 DE DE69737531T patent/DE69737531T2/de not_active Expired - Lifetime
- 1997-11-14 EP EP97946656A patent/EP0951311B1/en not_active Expired - Lifetime
- 1997-11-14 BR BR9713070-2A patent/BR9713070A/pt not_active Application Discontinuation
- 1997-11-14 AT AT97946656T patent/ATE357946T1/de not_active IP Right Cessation
- 1997-11-14 CA CA002583144A patent/CA2583144C/en not_active Expired - Fee Related
- 1997-11-14 US US08/970,291 patent/US6454786B1/en not_active Expired - Lifetime
- 1997-11-14 WO PCT/US1997/020653 patent/WO1998020931A1/en not_active Ceased
- 1997-11-14 IL IL12991697A patent/IL129916A0/xx unknown
- 1997-11-14 ES ES97946656T patent/ES2284186T3/es not_active Expired - Lifetime
- 1997-11-14 DK DK97946656T patent/DK0951311T3/da active
- 1997-11-14 AU AU51782/98A patent/AU721371B2/en not_active Ceased
- 1997-11-14 JP JP52279398A patent/JP4116083B2/ja not_active Expired - Fee Related
- 1997-11-14 PT PT97946656T patent/PT951311E/pt unknown
- 1997-11-14 CA CA002271738A patent/CA2271738C/en not_active Expired - Fee Related
-
1999
- 1999-05-14 NO NO19992342A patent/NO992342L/no not_active Application Discontinuation
- 1999-07-21 US US09/358,078 patent/US6206905B1/en not_active Expired - Fee Related
-
2007
- 2007-05-21 JP JP2007134424A patent/JP2007307385A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK0951311T3 (da) | 2007-07-09 |
| EP0951311B1 (en) | 2007-03-28 |
| EP0951311A4 (en) | 2000-11-08 |
| JP2001505787A (ja) | 2001-05-08 |
| CA2583144C (en) | 2009-03-10 |
| AU5178298A (en) | 1998-06-03 |
| AU721371B2 (en) | 2000-06-29 |
| DE69737531T2 (de) | 2008-01-31 |
| EP0951311A1 (en) | 1999-10-27 |
| NO992342L (no) | 1999-07-06 |
| US6206905B1 (en) | 2001-03-27 |
| IL129916A0 (en) | 2000-02-29 |
| BR9713070A (pt) | 2000-04-11 |
| PT951311E (pt) | 2007-06-05 |
| US6454786B1 (en) | 2002-09-24 |
| ES2284186T3 (es) | 2007-11-01 |
| JP2007307385A (ja) | 2007-11-29 |
| ATE357946T1 (de) | 2007-04-15 |
| CA2271738C (en) | 2008-06-03 |
| WO1998020931A1 (en) | 1998-05-22 |
| CA2271738A1 (en) | 1998-05-22 |
| DE69737531D1 (de) | 2007-05-10 |
| CA2583144A1 (en) | 1998-05-22 |
| NO992342D0 (no) | 1999-05-14 |
| NZ335751A (en) | 2001-01-26 |
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