DE69737126T2 - Hbv mutanten und methoden für deren nachweis - Google Patents
Hbv mutanten und methoden für deren nachweis Download PDFInfo
- Publication number
- DE69737126T2 DE69737126T2 DE69737126T DE69737126T DE69737126T2 DE 69737126 T2 DE69737126 T2 DE 69737126T2 DE 69737126 T DE69737126 T DE 69737126T DE 69737126 T DE69737126 T DE 69737126T DE 69737126 T2 DE69737126 T2 DE 69737126T2
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- Prior art keywords
- hbv
- mutation
- polymerase
- amino acid
- dna
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- 229940104230 thymidine Drugs 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO351996 | 1996-11-08 | ||
| AUPO3519A AUPO351996A0 (en) | 1996-11-08 | 1996-11-08 | Viral variants and methods for detecting same |
| PCT/AU1997/000520 WO1998021317A1 (en) | 1996-11-08 | 1997-08-15 | Viral variants and methods for detecting same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69737126D1 DE69737126D1 (de) | 2007-02-01 |
| DE69737126T2 true DE69737126T2 (de) | 2007-10-04 |
Family
ID=3797830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737126T Expired - Lifetime DE69737126T2 (de) | 1996-11-08 | 1997-08-15 | Hbv mutanten und methoden für deren nachweis |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6555311B1 (enExample) |
| EP (1) | EP0964916B1 (enExample) |
| JP (4) | JP2001503277A (enExample) |
| AT (1) | ATE348880T1 (enExample) |
| AU (1) | AUPO351996A0 (enExample) |
| CA (1) | CA2270178C (enExample) |
| DE (1) | DE69737126T2 (enExample) |
| ES (1) | ES2279542T3 (enExample) |
| WO (1) | WO1998021317A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA973367B (en) * | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
| USRE40233E1 (en) | 1996-11-08 | 2008-04-08 | Melbourne Health | Viral variants and methods for detecting same |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
| AUPP706098A0 (en) * | 1998-11-11 | 1998-12-03 | North Western Health Care Network | Biological compositions, components thereof and uses therefor |
| AUPP967999A0 (en) * | 1999-04-09 | 1999-05-06 | North Western Health Care Network | Viral variants |
| AR028149A1 (es) * | 1999-07-08 | 2003-04-30 | Innogenetics Nv | Deteccion de la resistencia a los farmacos contra la hepatitis b |
| AUPQ810900A0 (en) | 2000-06-09 | 2000-07-06 | Austin and Repatriation Medical Centre, The | Viral variants and methods of using same |
| SG90149A1 (en) * | 2000-07-18 | 2002-07-23 | Government Of The Republic Of | Diagnostic assay |
| US6697858B1 (en) * | 2000-08-14 | 2004-02-24 | Telephony@Work | Call center |
| US7405039B2 (en) | 2002-02-07 | 2008-07-29 | Austin Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
| CN100497604C (zh) * | 2002-02-07 | 2009-06-10 | 墨尔本保健公司 | 对核苷类似物具有改变的敏感性的病毒变体及其应用 |
| US8278432B2 (en) | 2002-03-29 | 2012-10-02 | Innogenetics N.V. | HBV drug resistance methods |
| EP1499712A4 (en) | 2002-04-12 | 2008-04-16 | Melbourne Health | HEPATITIS B VIRUS VARIANTS WITH REDUCED SENSITIVITY TO NUCLEOSIDANALOGES AND USE THEREOF |
| AU2003213874B2 (en) * | 2002-04-12 | 2008-12-04 | Austin Health | Hepatitis B viral variants with redused susceptibility to nucleoside analogs and uses thereof |
| CA2486420C (en) | 2002-06-14 | 2014-04-15 | Gen-Probe Incorporated | Compositions and methods for detecting hepatitis b virus |
| US20050053916A1 (en) * | 2002-10-01 | 2005-03-10 | Korba Brent E. | Diagnostic for long term response of HBV carrier to 3TC therapy |
| ES2494840T3 (es) | 2005-03-15 | 2014-09-16 | Fujirebio Europe N.V. | Variantes víricas de la hepatitis B con susceptibilidad reducida a análogos de nucleósidos y usos de las mismas |
| PT1858915E (pt) | 2005-03-15 | 2014-06-11 | Justus Liebig Universität Giessen | Variantes do vírus de hepatite b resistentes contra alguns análogos de nucleósido, mas sensíveis a outros, e suas utilizações |
| EP1874923A4 (en) | 2005-04-08 | 2010-08-04 | Melbourne Health | VARIANTS OF THE HEPATITIS B VIRUS WITH RESISTANCE TO ANTIVIRAL NUCLEOSIDAGENTS AND APPLICATIONS THEREOF |
| US8211443B2 (en) | 2005-04-08 | 2012-07-03 | Melbourne Health | Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof |
| KR100790226B1 (ko) | 2005-11-03 | 2008-01-02 | 연세대학교 산학협력단 | 독성 간염 유발 감수성을 검출하는 방법 |
| US12527665B2 (en) | 2008-12-11 | 2026-01-20 | Pacific Biosciences Of California, Inc. | Methods for identifying modified bases in nucleic acid templates |
| AU2009325069B2 (en) * | 2008-12-11 | 2015-03-19 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
| US9175338B2 (en) | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
| EP2694686B2 (en) | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
| WO2013163207A1 (en) | 2012-04-24 | 2013-10-31 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-c in nucleic acid templates |
| EP4069271A1 (en) * | 2019-12-07 | 2022-10-12 | ISA Pharmaceuticals B.V. | Treatment of diseases related to hepatitis b virus |
| US12442821B2 (en) * | 2021-07-01 | 2025-10-14 | National Cheng Kung University | Kit of in vitro quantifying large surface protein of hepatitis B virus (HBV), biomarker set for analyzing phases of HBV infection and hepatoma prognosis, and set of monoclonal antibodies for predicting, diagnosing or treating chronic liver disease |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595739A (en) * | 1993-05-07 | 1997-01-21 | Abbott Laboratories | Hepatitis B virus mutants, reagents and methods for detection |
| ZA973367B (en) * | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
| USRE40233E1 (en) * | 1996-11-08 | 2008-04-08 | Melbourne Health | Viral variants and methods for detecting same |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
| AUPP967999A0 (en) * | 1999-04-09 | 1999-05-06 | North Western Health Care Network | Viral variants |
| AUPQ810900A0 (en) * | 2000-06-09 | 2000-07-06 | Austin and Repatriation Medical Centre, The | Viral variants and methods of using same |
| US7405039B2 (en) * | 2002-02-07 | 2008-07-29 | Austin Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
| US8278432B2 (en) * | 2002-03-29 | 2012-10-02 | Innogenetics N.V. | HBV drug resistance methods |
| EP1499712A4 (en) * | 2002-04-12 | 2008-04-16 | Melbourne Health | HEPATITIS B VIRUS VARIANTS WITH REDUCED SENSITIVITY TO NUCLEOSIDANALOGES AND USE THEREOF |
| KR101326612B1 (ko) * | 2003-10-21 | 2013-11-12 | 멜버른 헬스 | Ｈｂｖ 변이체 검출 및 응용 |
| PT1858915E (pt) * | 2005-03-15 | 2014-06-11 | Justus Liebig Universität Giessen | Variantes do vírus de hepatite b resistentes contra alguns análogos de nucleósido, mas sensíveis a outros, e suas utilizações |
| ES2494840T3 (es) * | 2005-03-15 | 2014-09-16 | Fujirebio Europe N.V. | Variantes víricas de la hepatitis B con susceptibilidad reducida a análogos de nucleósidos y usos de las mismas |
| US8211443B2 (en) * | 2005-04-08 | 2012-07-03 | Melbourne Health | Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof |
| EP1874923A4 (en) * | 2005-04-08 | 2010-08-04 | Melbourne Health | VARIANTS OF THE HEPATITIS B VIRUS WITH RESISTANCE TO ANTIVIRAL NUCLEOSIDAGENTS AND APPLICATIONS THEREOF |
| EP2029747A4 (en) * | 2006-06-06 | 2011-01-05 | Melbourne Health | PROOF AND USE OF ANTIVIRAL RESISTANCE MUTATIONS |
-
1996
- 1996-11-08 AU AUPO3519A patent/AUPO351996A0/en not_active Abandoned
-
1997
- 1997-08-15 JP JP52194498A patent/JP2001503277A/ja not_active Withdrawn
- 1997-08-15 ES ES97934385T patent/ES2279542T3/es not_active Expired - Lifetime
- 1997-08-15 WO PCT/AU1997/000520 patent/WO1998021317A1/en not_active Ceased
- 1997-08-15 AT AT97934385T patent/ATE348880T1/de active
- 1997-08-15 CA CA2270178A patent/CA2270178C/en not_active Expired - Lifetime
- 1997-08-15 EP EP97934385A patent/EP0964916B1/en not_active Expired - Lifetime
- 1997-08-15 DE DE69737126T patent/DE69737126T2/de not_active Expired - Lifetime
-
1999
- 1999-05-06 US US09/306,420 patent/US6555311B1/en not_active Ceased
-
2002
- 2002-10-01 US US10/260,451 patent/US20030124096A1/en not_active Abandoned
-
2008
- 2008-01-24 JP JP2008014075A patent/JP2008154590A/ja active Pending
- 2008-05-09 US US12/117,869 patent/US20100203506A1/en not_active Abandoned
-
2011
- 2011-12-16 JP JP2011276121A patent/JP2012055322A/ja active Pending
-
2012
- 2012-07-12 US US13/547,392 patent/US20130171620A1/en not_active Abandoned
-
2015
- 2015-02-02 JP JP2015018686A patent/JP2015107127A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998021317A1 (en) | 1998-05-22 |
| EP0964916B1 (en) | 2006-12-20 |
| US20030124096A1 (en) | 2003-07-03 |
| AUPO351996A0 (en) | 1996-12-05 |
| ES2279542T3 (es) | 2007-08-16 |
| CA2270178A1 (en) | 1998-05-22 |
| US6555311B1 (en) | 2003-04-29 |
| JP2001503277A (ja) | 2001-03-13 |
| US20100203506A1 (en) | 2010-08-12 |
| ATE348880T1 (de) | 2007-01-15 |
| EP0964916A1 (en) | 1999-12-22 |
| HK1027374A1 (en) | 2001-01-12 |
| JP2008154590A (ja) | 2008-07-10 |
| EP0964916A4 (en) | 2001-09-26 |
| US20130171620A1 (en) | 2013-07-04 |
| JP2012055322A (ja) | 2012-03-22 |
| JP2015107127A (ja) | 2015-06-11 |
| CA2270178C (en) | 2012-06-12 |
| DE69737126D1 (de) | 2007-02-01 |
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| 8364 | No opposition during term of opposition |