ES2279542T3 - Mutantes de hbv y metodos para deteccion de los mismos. - Google Patents

Mutantes de hbv y metodos para deteccion de los mismos. Download PDF

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Publication number
ES2279542T3
ES2279542T3 ES97934385T ES97934385T ES2279542T3 ES 2279542 T3 ES2279542 T3 ES 2279542T3 ES 97934385 T ES97934385 T ES 97934385T ES 97934385 T ES97934385 T ES 97934385T ES 2279542 T3 ES2279542 T3 ES 2279542T3
Authority
ES
Spain
Prior art keywords
baselineskip
hbv
xaa
leu
variante
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97934385T
Other languages
English (en)
Spanish (es)
Inventor
Stephen Alister Locarnini
Angeline Ingrid Bartholomeusz
Thein Thein Aye
Robert A. De Man
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melbourne Health
Original Assignee
Melbourne Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melbourne Health filed Critical Melbourne Health
Application granted granted Critical
Publication of ES2279542T3 publication Critical patent/ES2279542T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES97934385T 1996-11-08 1997-08-15 Mutantes de hbv y metodos para deteccion de los mismos. Expired - Lifetime ES2279542T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO3519/96 1996-11-08
AUPO3519A AUPO351996A0 (en) 1996-11-08 1996-11-08 Viral variants and methods for detecting same

Publications (1)

Publication Number Publication Date
ES2279542T3 true ES2279542T3 (es) 2007-08-16

Family

ID=3797830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97934385T Expired - Lifetime ES2279542T3 (es) 1996-11-08 1997-08-15 Mutantes de hbv y metodos para deteccion de los mismos.

Country Status (9)

Country Link
US (4) US6555311B1 (enExample)
EP (1) EP0964916B1 (enExample)
JP (4) JP2001503277A (enExample)
AT (1) ATE348880T1 (enExample)
AU (1) AUPO351996A0 (enExample)
CA (1) CA2270178C (enExample)
DE (1) DE69737126T2 (enExample)
ES (1) ES2279542T3 (enExample)
WO (1) WO1998021317A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
USRE40233E1 (en) 1996-11-08 2008-04-08 Melbourne Health Viral variants and methods for detecting same
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same
AUPP706098A0 (en) * 1998-11-11 1998-12-03 North Western Health Care Network Biological compositions, components thereof and uses therefor
AUPP967999A0 (en) * 1999-04-09 1999-05-06 North Western Health Care Network Viral variants
AR028149A1 (es) * 1999-07-08 2003-04-30 Innogenetics Nv Deteccion de la resistencia a los farmacos contra la hepatitis b
AUPQ810900A0 (en) 2000-06-09 2000-07-06 Austin and Repatriation Medical Centre, The Viral variants and methods of using same
SG90149A1 (en) * 2000-07-18 2002-07-23 Government Of The Republic Of Diagnostic assay
US6697858B1 (en) * 2000-08-14 2004-02-24 Telephony@Work Call center
US7405039B2 (en) 2002-02-07 2008-07-29 Austin Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
CN100497604C (zh) * 2002-02-07 2009-06-10 墨尔本保健公司 对核苷类似物具有改变的敏感性的病毒变体及其应用
US8278432B2 (en) 2002-03-29 2012-10-02 Innogenetics N.V. HBV drug resistance methods
EP1499712A4 (en) 2002-04-12 2008-04-16 Melbourne Health HEPATITIS B VIRUS VARIANTS WITH REDUCED SENSITIVITY TO NUCLEOSIDANALOGES AND USE THEREOF
AU2003213874B2 (en) * 2002-04-12 2008-12-04 Austin Health Hepatitis B viral variants with redused susceptibility to nucleoside analogs and uses thereof
CA2486420C (en) 2002-06-14 2014-04-15 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
US20050053916A1 (en) * 2002-10-01 2005-03-10 Korba Brent E. Diagnostic for long term response of HBV carrier to 3TC therapy
ES2494840T3 (es) 2005-03-15 2014-09-16 Fujirebio Europe N.V. Variantes víricas de la hepatitis B con susceptibilidad reducida a análogos de nucleósidos y usos de las mismas
PT1858915E (pt) 2005-03-15 2014-06-11 Justus Liebig Universität Giessen Variantes do vírus de hepatite b resistentes contra alguns análogos de nucleósido, mas sensíveis a outros, e suas utilizações
EP1874923A4 (en) 2005-04-08 2010-08-04 Melbourne Health VARIANTS OF THE HEPATITIS B VIRUS WITH RESISTANCE TO ANTIVIRAL NUCLEOSIDAGENTS AND APPLICATIONS THEREOF
US8211443B2 (en) 2005-04-08 2012-07-03 Melbourne Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
KR100790226B1 (ko) 2005-11-03 2008-01-02 연세대학교 산학협력단 독성 간염 유발 감수성을 검출하는 방법
US12527665B2 (en) 2008-12-11 2026-01-20 Pacific Biosciences Of California, Inc. Methods for identifying modified bases in nucleic acid templates
AU2009325069B2 (en) * 2008-12-11 2015-03-19 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
US9175338B2 (en) 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
EP2694686B2 (en) 2011-04-06 2023-07-19 The University of Chicago COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC)
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
WO2013163207A1 (en) 2012-04-24 2013-10-31 Pacific Biosciences Of California, Inc. Identification of 5-methyl-c in nucleic acid templates
EP4069271A1 (en) * 2019-12-07 2022-10-12 ISA Pharmaceuticals B.V. Treatment of diseases related to hepatitis b virus
US12442821B2 (en) * 2021-07-01 2025-10-14 National Cheng Kung University Kit of in vitro quantifying large surface protein of hepatitis B virus (HBV), biomarker set for analyzing phases of HBV infection and hepatoma prognosis, and set of monoclonal antibodies for predicting, diagnosing or treating chronic liver disease

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595739A (en) * 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
USRE40233E1 (en) * 1996-11-08 2008-04-08 Melbourne Health Viral variants and methods for detecting same
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same
AUPP967999A0 (en) * 1999-04-09 1999-05-06 North Western Health Care Network Viral variants
AUPQ810900A0 (en) * 2000-06-09 2000-07-06 Austin and Repatriation Medical Centre, The Viral variants and methods of using same
US7405039B2 (en) * 2002-02-07 2008-07-29 Austin Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
US8278432B2 (en) * 2002-03-29 2012-10-02 Innogenetics N.V. HBV drug resistance methods
EP1499712A4 (en) * 2002-04-12 2008-04-16 Melbourne Health HEPATITIS B VIRUS VARIANTS WITH REDUCED SENSITIVITY TO NUCLEOSIDANALOGES AND USE THEREOF
KR101326612B1 (ko) * 2003-10-21 2013-11-12 멜버른 헬스 Ｈｂｖ 변이체 검출 및 응용
PT1858915E (pt) * 2005-03-15 2014-06-11 Justus Liebig Universität Giessen Variantes do vírus de hepatite b resistentes contra alguns análogos de nucleósido, mas sensíveis a outros, e suas utilizações
ES2494840T3 (es) * 2005-03-15 2014-09-16 Fujirebio Europe N.V. Variantes víricas de la hepatitis B con susceptibilidad reducida a análogos de nucleósidos y usos de las mismas
US8211443B2 (en) * 2005-04-08 2012-07-03 Melbourne Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
EP1874923A4 (en) * 2005-04-08 2010-08-04 Melbourne Health VARIANTS OF THE HEPATITIS B VIRUS WITH RESISTANCE TO ANTIVIRAL NUCLEOSIDAGENTS AND APPLICATIONS THEREOF
EP2029747A4 (en) * 2006-06-06 2011-01-05 Melbourne Health PROOF AND USE OF ANTIVIRAL RESISTANCE MUTATIONS

Also Published As

Publication number Publication date
WO1998021317A1 (en) 1998-05-22
EP0964916B1 (en) 2006-12-20
US20030124096A1 (en) 2003-07-03
AUPO351996A0 (en) 1996-12-05
CA2270178A1 (en) 1998-05-22
DE69737126T2 (de) 2007-10-04
US6555311B1 (en) 2003-04-29
JP2001503277A (ja) 2001-03-13
US20100203506A1 (en) 2010-08-12
ATE348880T1 (de) 2007-01-15
EP0964916A1 (en) 1999-12-22
HK1027374A1 (en) 2001-01-12
JP2008154590A (ja) 2008-07-10
EP0964916A4 (en) 2001-09-26
US20130171620A1 (en) 2013-07-04
JP2012055322A (ja) 2012-03-22
JP2015107127A (ja) 2015-06-11
CA2270178C (en) 2012-06-12
DE69737126D1 (de) 2007-02-01

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