DE69735996T2 - Menschlicher bikunin - Google Patents

Menschlicher bikunin Download PDF

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Publication number
DE69735996T2
DE69735996T2 DE69735996T DE69735996T DE69735996T2 DE 69735996 T2 DE69735996 T2 DE 69735996T2 DE 69735996 T DE69735996 T DE 69735996T DE 69735996 T DE69735996 T DE 69735996T DE 69735996 T2 DE69735996 T2 DE 69735996T2
Authority
DE
Germany
Prior art keywords
protein
bikunin
placental bikunin
amino acid
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69735996T
Other languages
German (de)
English (en)
Other versions
DE69735996D1 (de
Inventor
P. Paul Kensington TAMBURINI
Gary Milford DAVIS
A. Katherine West Haven DELARIA
W. Christopher Bethany MARLOR
K. Daniel Orange MULLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aerovance Inc
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of DE69735996D1 publication Critical patent/DE69735996D1/de
Application granted granted Critical
Publication of DE69735996T2 publication Critical patent/DE69735996T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • C07K14/8117Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
DE69735996T 1996-03-11 1997-03-10 Menschlicher bikunin Expired - Fee Related DE69735996T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US725251 1985-04-19
US1310696P 1996-03-11 1996-03-11
US13106P 1996-03-11
US1979396P 1996-06-14 1996-06-14
US19793P 1996-06-14
US72525196A 1996-10-04 1996-10-04
PCT/US1997/003894 WO1997033996A2 (en) 1996-03-11 1997-03-10 Human bikunin

Publications (2)

Publication Number Publication Date
DE69735996D1 DE69735996D1 (de) 2006-07-06
DE69735996T2 true DE69735996T2 (de) 2007-02-15

Family

ID=27359773

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735996T Expired - Fee Related DE69735996T2 (de) 1996-03-11 1997-03-10 Menschlicher bikunin

Country Status (27)

Country Link
US (3) US6583108B1 (enrdf_load_stackoverflow)
EP (1) EP0891426B1 (enrdf_load_stackoverflow)
JP (2) JP3469584B2 (enrdf_load_stackoverflow)
KR (1) KR100356956B1 (enrdf_load_stackoverflow)
AR (3) AR006188A1 (enrdf_load_stackoverflow)
AT (1) ATE328083T1 (enrdf_load_stackoverflow)
AU (1) AU716923B2 (enrdf_load_stackoverflow)
BR (1) BR9708021A (enrdf_load_stackoverflow)
CA (1) CA2247888A1 (enrdf_load_stackoverflow)
CO (1) CO4600683A1 (enrdf_load_stackoverflow)
DE (1) DE69735996T2 (enrdf_load_stackoverflow)
DK (1) DK0891426T3 (enrdf_load_stackoverflow)
ES (1) ES2263174T3 (enrdf_load_stackoverflow)
HR (1) HRP970144B1 (enrdf_load_stackoverflow)
HU (1) HU226419B1 (enrdf_load_stackoverflow)
ID (1) ID16224A (enrdf_load_stackoverflow)
IL (1) IL126115A (enrdf_load_stackoverflow)
IN (1) IN192874B (enrdf_load_stackoverflow)
MY (1) MY120693A (enrdf_load_stackoverflow)
NZ (1) NZ331540A (enrdf_load_stackoverflow)
PA (1) PA8426301A1 (enrdf_load_stackoverflow)
PL (1) PL188387B1 (enrdf_load_stackoverflow)
PT (1) PT891426E (enrdf_load_stackoverflow)
SV (1) SV1997000018A (enrdf_load_stackoverflow)
TR (1) TR199801794T2 (enrdf_load_stackoverflow)
WO (1) WO1997033996A2 (enrdf_load_stackoverflow)
YU (1) YU8997A (enrdf_load_stackoverflow)

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Also Published As

Publication number Publication date
CA2247888A1 (en) 1997-09-18
DE69735996D1 (de) 2006-07-06
HUP9902698A2 (hu) 1999-11-29
NZ331540A (en) 1999-10-28
WO1997033996A2 (en) 1997-09-18
PT891426E (pt) 2006-10-31
AR053063A2 (es) 2007-04-18
IL126115A0 (en) 1999-05-09
CO4600683A1 (es) 1998-05-08
JP3469584B2 (ja) 2003-11-25
PL328822A1 (en) 1999-02-15
EP0891426A2 (en) 1999-01-20
JP2001521367A (ja) 2001-11-06
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US20030194398A1 (en) 2003-10-16
WO1997033996A3 (en) 1997-11-13
US20060172946A1 (en) 2006-08-03
PA8426301A1 (es) 2000-05-24
ATE328083T1 (de) 2006-06-15
AR058982A1 (es) 2008-03-05
IN192874B (enrdf_load_stackoverflow) 2004-05-29
DK0891426T3 (da) 2006-10-02
YU8997A (sh) 1999-09-27
MY120693A (en) 2005-11-30
AR006188A1 (es) 1999-08-11
ES2263174T3 (es) 2006-12-01
JP2004000208A (ja) 2004-01-08
EP0891426B1 (en) 2006-05-31
BR9708021A (pt) 1999-07-27
IL126115A (en) 2007-03-08
US6583108B1 (en) 2003-06-24
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AU716923B2 (en) 2000-03-09
ID16224A (id) 1997-09-11
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HRP970144A2 (en) 1998-04-30
US7452859B2 (en) 2008-11-18
HRP970144B1 (en) 2004-10-31
TR199801794T2 (xx) 2000-07-21
US7019123B2 (en) 2006-03-28
KR19990087697A (ko) 1999-12-27
KR100356956B1 (ko) 2003-03-15
HU226419B1 (en) 2008-12-29
PL188387B1 (pl) 2005-01-31

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