DE69734653T2 - Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz - Google Patents
Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz Download PDFInfo
- Publication number
- DE69734653T2 DE69734653T2 DE69734653T DE69734653T DE69734653T2 DE 69734653 T2 DE69734653 T2 DE 69734653T2 DE 69734653 T DE69734653 T DE 69734653T DE 69734653 T DE69734653 T DE 69734653T DE 69734653 T2 DE69734653 T2 DE 69734653T2
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- Germany
- Prior art keywords
- growth hormone
- hgh
- formulation
- amount
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK49096 | 1996-04-24 | ||
| DK49096 | 1996-04-24 | ||
| PCT/DK1997/000184 WO1997039768A1 (en) | 1996-04-24 | 1997-04-24 | A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69734653D1 DE69734653D1 (de) | 2005-12-22 |
| DE69734653T2 true DE69734653T2 (de) | 2006-08-10 |
Family
ID=8094154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69734653T Expired - Lifetime DE69734653T2 (de) | 1996-04-24 | 1997-04-24 | Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020077461A1 (enExample) |
| EP (2) | EP0904099B1 (enExample) |
| JP (2) | JP4176834B2 (enExample) |
| KR (1) | KR20000010630A (enExample) |
| CN (1) | CN1130223C (enExample) |
| AT (1) | ATE309819T1 (enExample) |
| AU (1) | AU733592B2 (enExample) |
| BR (1) | BR9708858A (enExample) |
| CA (1) | CA2252535C (enExample) |
| CZ (1) | CZ298292B6 (enExample) |
| DE (1) | DE69734653T2 (enExample) |
| DK (1) | DK0904099T3 (enExample) |
| ES (1) | ES2253774T3 (enExample) |
| HU (1) | HU229868B1 (enExample) |
| IL (2) | IL126463A0 (enExample) |
| NO (1) | NO323360B1 (enExample) |
| PL (1) | PL188222B1 (enExample) |
| RU (1) | RU2236250C2 (enExample) |
| UA (1) | UA66758C2 (enExample) |
| WO (1) | WO1997039768A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| ES2230727T3 (es) * | 1997-11-12 | 2005-05-01 | Alza Corporation | Procedimiento de administracion dermal de polipeptidos. |
| GB9803448D0 (en) * | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| CA2418960A1 (en) | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP4949828B2 (ja) * | 2003-03-18 | 2012-06-13 | アレス トレーディング ソシエテ アノニム | 溶液中での成長ホルモンの安定化 |
| AU2004224439B2 (en) | 2003-03-24 | 2010-07-15 | Genzyme Corporation | Temporary embolization using inverse thermosensitive polymers |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| US7700086B2 (en) * | 2003-11-06 | 2010-04-20 | Pluromed, Inc. | Internal clamp for surgical procedures |
| WO2005063298A1 (en) * | 2003-12-23 | 2005-07-14 | Pharmacia Corporation | Stable growth hormone liquid formulation |
| BRPI0508798A (pt) * | 2004-04-07 | 2007-09-04 | Ares Trading Sa | formulação lìquida de hormÈnio de crescimento, composição farmacêutica, forma de apresentação da formulação lìquida de hormÈnio de crescimento e uso da formulação lìquida de hormÈnio de crescimento |
| CN101090980A (zh) * | 2004-12-22 | 2007-12-19 | Ambrx公司 | 经修饰的人类生长激素 |
| CN103520735B (zh) * | 2004-12-22 | 2015-11-25 | Ambrx公司 | 包含非天然编码的氨基酸的人生长激素配方 |
| BRPI0519430A2 (pt) * | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
| US8293708B2 (en) | 2005-08-30 | 2012-10-23 | Novo Nordisk Health Care A/G | Liquid formulations N-terminal serine of pegylated growth hormone |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| CN1939534B (zh) * | 2005-09-27 | 2010-12-01 | 长春金赛药业股份有限公司 | 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂 |
| BRPI0621841B8 (pt) | 2006-07-06 | 2021-05-25 | Daewoong Co Ltd | formulação líquida |
| BRPI0713963A2 (pt) | 2006-07-07 | 2012-11-27 | Novo Nordisk Healthcare Ag | conjugados de proteìna e métodos para sua preparação |
| CA2672284C (en) * | 2006-12-18 | 2014-08-26 | Altus Pharmaceuticals Inc. | Human growth hormone formulations |
| MX338357B (es) | 2010-01-22 | 2016-04-13 | Novo Nordisk Healthcare Ag | Compuestos estables de la hormona de crecimiento. |
| RS59459B1 (sr) | 2010-01-22 | 2019-11-29 | Novo Nordisk Healthcare Ag | Hormoni rasta sa produženom in-vivo efikasnošću |
| KR101337797B1 (ko) * | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
| BR112013008103B1 (pt) * | 2010-09-21 | 2021-01-26 | Ferring B.V. | processo para a produção do hormônio de crescimento humano (hgh) e método para reduzir a quantidade de formas poliméricas do hgh durante um processo para a produção de hgh |
| US9216219B2 (en) * | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| EP3689335A1 (en) | 2013-09-27 | 2020-08-05 | Hanmi Pharm. Co., Ltd. | Sustained type human growth hormone preparation |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| KR102483020B1 (ko) | 2016-03-28 | 2023-01-04 | 인사이트 코포레이션 | Tam 저해제로서의 피롤로트리아진 화합물 |
| CN111278453A (zh) | 2017-09-07 | 2020-06-12 | Jcr制药股份有限公司 | 水性药物组合物 |
| MA50655B1 (fr) | 2017-09-27 | 2021-11-30 | Incyte Corp | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
| AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
| WO2021178779A1 (en) | 2020-03-06 | 2021-09-10 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN115634284B (zh) * | 2022-10-31 | 2025-02-11 | 景泽生物医药(合肥)股份有限公司 | 一种促性腺激素冻干制剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| DE69232847T2 (de) * | 1991-12-20 | 2003-09-11 | Novo Nordisk A/S, Bagsvaerd | Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| DK0955062T3 (da) * | 1992-07-31 | 2007-09-17 | Genentech Inc | Vandig formulering indeholdende humant væksthormon |
-
1997
- 1997-04-23 US US08/842,293 patent/US20020077461A1/en not_active Abandoned
- 1997-04-24 EP EP97918073A patent/EP0904099B1/en not_active Expired - Lifetime
- 1997-04-24 PL PL97329386A patent/PL188222B1/pl unknown
- 1997-04-24 EP EP05110701A patent/EP1629832A1/en not_active Withdrawn
- 1997-04-24 HU HU9902476A patent/HU229868B1/hu unknown
- 1997-04-24 AT AT97918073T patent/ATE309819T1/de active
- 1997-04-24 DE DE69734653T patent/DE69734653T2/de not_active Expired - Lifetime
- 1997-04-24 AU AU26343/97A patent/AU733592B2/en not_active Expired
- 1997-04-24 RU RU98121135/15A patent/RU2236250C2/ru active
- 1997-04-24 WO PCT/DK1997/000184 patent/WO1997039768A1/en not_active Ceased
- 1997-04-24 CZ CZ0320798A patent/CZ298292B6/cs not_active IP Right Cessation
- 1997-04-24 JP JP53762297A patent/JP4176834B2/ja not_active Expired - Lifetime
- 1997-04-24 BR BR9708858A patent/BR9708858A/pt not_active Application Discontinuation
- 1997-04-24 CN CN97194040A patent/CN1130223C/zh not_active Expired - Lifetime
- 1997-04-24 IL IL12646397A patent/IL126463A0/xx active IP Right Grant
- 1997-04-24 UA UA98105593A patent/UA66758C2/xx unknown
- 1997-04-24 ES ES97918073T patent/ES2253774T3/es not_active Expired - Lifetime
- 1997-04-24 DK DK97918073T patent/DK0904099T3/da active
- 1997-04-24 KR KR1019980708535A patent/KR20000010630A/ko not_active Ceased
- 1997-04-24 CA CA002252535A patent/CA2252535C/en not_active Expired - Lifetime
-
1998
- 1998-10-04 IL IL126463A patent/IL126463A/en not_active IP Right Cessation
- 1998-10-23 NO NO19984951A patent/NO323360B1/no not_active IP Right Cessation
-
2008
- 2008-06-03 JP JP2008145780A patent/JP2008231124A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HU229868B1 (en) | 2014-10-28 |
| BR9708858A (pt) | 1999-08-03 |
| CN1130223C (zh) | 2003-12-10 |
| CN1216472A (zh) | 1999-05-12 |
| EP0904099A1 (en) | 1999-03-31 |
| NO984951D0 (no) | 1998-10-23 |
| AU733592B2 (en) | 2001-05-17 |
| JP2000508665A (ja) | 2000-07-11 |
| CA2252535C (en) | 2009-06-23 |
| HUP9902476A3 (en) | 2000-12-28 |
| HUP9902476A2 (hu) | 2000-11-28 |
| DE69734653D1 (de) | 2005-12-22 |
| US20020077461A1 (en) | 2002-06-20 |
| KR20000010630A (ko) | 2000-02-25 |
| WO1997039768A1 (en) | 1997-10-30 |
| NO984951L (no) | 1998-10-23 |
| NO323360B1 (no) | 2007-04-10 |
| PL329386A1 (en) | 1999-03-29 |
| PL188222B1 (pl) | 2004-12-31 |
| EP0904099B1 (en) | 2005-11-16 |
| ES2253774T3 (es) | 2006-06-01 |
| JP2008231124A (ja) | 2008-10-02 |
| DK0904099T3 (da) | 2006-03-06 |
| AU2634397A (en) | 1997-11-12 |
| UA66758C2 (en) | 2004-06-15 |
| CZ320798A3 (cs) | 1999-03-17 |
| CA2252535A1 (en) | 1997-10-30 |
| IL126463A (en) | 2007-06-17 |
| CZ298292B6 (cs) | 2007-08-15 |
| ATE309819T1 (de) | 2005-12-15 |
| IL126463A0 (en) | 1999-08-17 |
| JP4176834B2 (ja) | 2008-11-05 |
| RU2236250C2 (ru) | 2004-09-20 |
| EP1629832A1 (en) | 2006-03-01 |
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