DE69734653T2 - Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz - Google Patents
Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz Download PDFInfo
- Publication number
- DE69734653T2 DE69734653T2 DE69734653T DE69734653T DE69734653T2 DE 69734653 T2 DE69734653 T2 DE 69734653T2 DE 69734653 T DE69734653 T DE 69734653T DE 69734653 T DE69734653 T DE 69734653T DE 69734653 T2 DE69734653 T2 DE 69734653T2
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- Germany
- Prior art keywords
- growth hormone
- hgh
- formulation
- amount
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK49096 | 1996-04-24 | ||
| DK49096 | 1996-04-24 | ||
| PCT/DK1997/000184 WO1997039768A1 (en) | 1996-04-24 | 1997-04-24 | A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69734653D1 DE69734653D1 (de) | 2005-12-22 |
| DE69734653T2 true DE69734653T2 (de) | 2006-08-10 |
Family
ID=8094154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69734653T Expired - Lifetime DE69734653T2 (de) | 1996-04-24 | 1997-04-24 | Pharmazeutische formulierung, bestehend aus menschlichem wachstumshormon, histidine und einem nichtionischen detergenz |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020077461A1 (2) |
| EP (2) | EP1629832A1 (2) |
| JP (2) | JP4176834B2 (2) |
| KR (1) | KR20000010630A (2) |
| CN (1) | CN1130223C (2) |
| AT (1) | ATE309819T1 (2) |
| AU (1) | AU733592B2 (2) |
| BR (1) | BR9708858A (2) |
| CA (1) | CA2252535C (2) |
| CZ (1) | CZ298292B6 (2) |
| DE (1) | DE69734653T2 (2) |
| DK (1) | DK0904099T3 (2) |
| ES (1) | ES2253774T3 (2) |
| HU (1) | HU229868B1 (2) |
| IL (2) | IL126463A0 (2) |
| NO (1) | NO323360B1 (2) |
| PL (1) | PL188222B1 (2) |
| RU (1) | RU2236250C2 (2) |
| UA (1) | UA66758C2 (2) |
| WO (1) | WO1997039768A1 (2) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| CA2309955A1 (en) * | 1997-11-12 | 1999-05-20 | Alza Corporation | Method for decreasing self-association of polypeptides |
| GB9803448D0 (en) * | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP4949828B2 (ja) * | 2003-03-18 | 2012-06-13 | アレス トレーディング ソシエテ アノニム | 溶液中での成長ホルモンの安定化 |
| JP4909071B2 (ja) | 2003-03-24 | 2012-04-04 | プルーローメッド， インコーポレイテッド | 逆感熱性ポリマーを使用する一時的な塞栓形成 |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US8338374B2 (en) * | 2003-12-23 | 2012-12-25 | Pharmacia Corporation | Stable growth hormone liquid formulation |
| US7662393B2 (en) * | 2004-04-07 | 2010-02-16 | Ares Trading S.A. | Liquid growth hormone formulation and method of use |
| US7816320B2 (en) * | 2004-12-22 | 2010-10-19 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 |
| JP2008525473A (ja) * | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 修飾されたヒト成長ホルモン |
| CN101356269A (zh) * | 2004-12-22 | 2009-01-28 | Ambrx公司 | 表达和纯化重组人类生长激素的方法 |
| CN101268098A (zh) | 2005-08-30 | 2008-09-17 | 诺沃-诺迪斯克保健股份有限公司 | 聚乙二醇化生长激素的液体制剂 |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| CN1939534B (zh) * | 2005-09-27 | 2010-12-01 | 长春金赛药业股份有限公司 | 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂 |
| EP2049148B1 (en) * | 2006-07-06 | 2016-09-28 | Daewoong Co., Ltd. | A stable liquid formulation of human growth hormone |
| BRPI0713963A2 (pt) | 2006-07-07 | 2012-11-27 | Novo Nordisk Healthcare Ag | conjugados de proteìna e métodos para sua preparação |
| AU2007333959A1 (en) * | 2006-12-18 | 2008-06-26 | Altus Pharmaceuticals Inc. | Human growth hormone formulations |
| JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| CN118767117A (zh) | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| KR101337797B1 (ko) * | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
| MX339605B (es) * | 2010-09-21 | 2016-06-02 | Ferring Bv | Proceso mejorado para produccion de la hormona de crecimiento humano recombinante. |
| US9216219B2 (en) | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| TW201605468A (zh) * | 2013-09-27 | 2016-02-16 | 韓美藥品股份有限公司 | 長效人類生長激素接合物之製劑 |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| KR102655498B1 (ko) | 2017-09-07 | 2024-04-11 | 제이씨알 파마 가부시키가이샤 | 수성 의약 조성물 |
| SI3687996T1 (sl) | 2017-09-27 | 2022-04-29 | Incyte Corporation | Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM |
| MD3813800T2 (ro) | 2018-06-29 | 2025-10-31 | Incyte Corp | Formulări de inhibitor al AXL/MER |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN115634284B (zh) * | 2022-10-31 | 2025-02-11 | 景泽生物医药(合肥)股份有限公司 | 一种促性腺激素冻干制剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| DK0618807T3 (da) * | 1991-12-20 | 2003-03-03 | Novo Nordisk As | Stabiliseret farmaceutisk formulering omfattende human væksthormon og histidin |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| ES2153385T5 (es) * | 1992-07-31 | 2008-09-01 | Genentech, Inc. | Composicion acuosa a base de hormona del crecimiento humana. |
-
1997
- 1997-04-23 US US08/842,293 patent/US20020077461A1/en not_active Abandoned
- 1997-04-24 CN CN97194040A patent/CN1130223C/zh not_active Expired - Lifetime
- 1997-04-24 DK DK97918073T patent/DK0904099T3/da active
- 1997-04-24 KR KR1019980708535A patent/KR20000010630A/ko not_active Ceased
- 1997-04-24 HU HU9902476A patent/HU229868B1/hu unknown
- 1997-04-24 CA CA002252535A patent/CA2252535C/en not_active Expired - Lifetime
- 1997-04-24 RU RU98121135/15A patent/RU2236250C2/ru active
- 1997-04-24 EP EP05110701A patent/EP1629832A1/en not_active Withdrawn
- 1997-04-24 JP JP53762297A patent/JP4176834B2/ja not_active Expired - Lifetime
- 1997-04-24 EP EP97918073A patent/EP0904099B1/en not_active Expired - Lifetime
- 1997-04-24 ES ES97918073T patent/ES2253774T3/es not_active Expired - Lifetime
- 1997-04-24 BR BR9708858A patent/BR9708858A/pt not_active Application Discontinuation
- 1997-04-24 PL PL97329386A patent/PL188222B1/pl unknown
- 1997-04-24 UA UA98105593A patent/UA66758C2/xx unknown
- 1997-04-24 CZ CZ0320798A patent/CZ298292B6/cs not_active IP Right Cessation
- 1997-04-24 AU AU26343/97A patent/AU733592B2/en not_active Expired
- 1997-04-24 IL IL12646397A patent/IL126463A0/xx active IP Right Grant
- 1997-04-24 WO PCT/DK1997/000184 patent/WO1997039768A1/en not_active Ceased
- 1997-04-24 DE DE69734653T patent/DE69734653T2/de not_active Expired - Lifetime
- 1997-04-24 AT AT97918073T patent/ATE309819T1/de active
-
1998
- 1998-10-04 IL IL126463A patent/IL126463A/en not_active IP Right Cessation
- 1998-10-23 NO NO19984951A patent/NO323360B1/no not_active IP Right Cessation
-
2008
- 2008-06-03 JP JP2008145780A patent/JP2008231124A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2253774T3 (es) | 2006-06-01 |
| DE69734653D1 (de) | 2005-12-22 |
| CA2252535C (en) | 2009-06-23 |
| NO984951D0 (no) | 1998-10-23 |
| EP1629832A1 (en) | 2006-03-01 |
| PL329386A1 (en) | 1999-03-29 |
| CN1216472A (zh) | 1999-05-12 |
| EP0904099B1 (en) | 2005-11-16 |
| JP2008231124A (ja) | 2008-10-02 |
| IL126463A (en) | 2007-06-17 |
| RU2236250C2 (ru) | 2004-09-20 |
| AU2634397A (en) | 1997-11-12 |
| HU229868B1 (en) | 2014-10-28 |
| IL126463A0 (en) | 1999-08-17 |
| NO323360B1 (no) | 2007-04-10 |
| HUP9902476A3 (en) | 2000-12-28 |
| PL188222B1 (pl) | 2004-12-31 |
| JP4176834B2 (ja) | 2008-11-05 |
| CA2252535A1 (en) | 1997-10-30 |
| WO1997039768A1 (en) | 1997-10-30 |
| CZ320798A3 (cs) | 1999-03-17 |
| CZ298292B6 (cs) | 2007-08-15 |
| HUP9902476A2 (hu) | 2000-11-28 |
| AU733592B2 (en) | 2001-05-17 |
| JP2000508665A (ja) | 2000-07-11 |
| US20020077461A1 (en) | 2002-06-20 |
| UA66758C2 (en) | 2004-06-15 |
| ATE309819T1 (de) | 2005-12-15 |
| DK0904099T3 (da) | 2006-03-06 |
| EP0904099A1 (en) | 1999-03-31 |
| KR20000010630A (ko) | 2000-02-25 |
| BR9708858A (pt) | 1999-08-03 |
| NO984951L (no) | 1998-10-23 |
| CN1130223C (zh) | 2003-12-10 |
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