DE69733942T2 - Mcbi analoge von cc-1065 und die duocarmycine - Google Patents

Mcbi analoge von cc-1065 und die duocarmycine Download PDF

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Publication number
DE69733942T2
DE69733942T2 DE69733942T DE69733942T DE69733942T2 DE 69733942 T2 DE69733942 T2 DE 69733942T2 DE 69733942 T DE69733942 T DE 69733942T DE 69733942 T DE69733942 T DE 69733942T DE 69733942 T2 DE69733942 T2 DE 69733942T2
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DE
Germany
Prior art keywords
mcbi
hours
alkylation
dna
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69733942T
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German (de)
English (en)
Other versions
DE69733942D1 (de
Inventor
L. Dale BOGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of DE69733942D1 publication Critical patent/DE69733942D1/de
Application granted granted Critical
Publication of DE69733942T2 publication Critical patent/DE69733942T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Polymers (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Dc Digital Transmission (AREA)
  • Electrotherapy Devices (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69733942T 1996-03-08 1997-03-07 Mcbi analoge von cc-1065 und die duocarmycine Expired - Fee Related DE69733942T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
US13024P 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (2)

Publication Number Publication Date
DE69733942D1 DE69733942D1 (de) 2005-09-15
DE69733942T2 true DE69733942T2 (de) 2006-06-08

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733942T Expired - Fee Related DE69733942T2 (de) 1996-03-08 1997-03-07 Mcbi analoge von cc-1065 und die duocarmycine

Country Status (9)

Country Link
US (1) US5985908A (enExample)
EP (1) EP0888301B1 (enExample)
JP (1) JP2000506168A (enExample)
AT (1) ATE301639T1 (enExample)
AU (1) AU711974B2 (enExample)
CA (1) CA2246783C (enExample)
DE (1) DE69733942T2 (enExample)
ES (1) ES2244991T3 (enExample)
WO (1) WO1997032850A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934269A4 (en) * 1996-05-31 2000-01-12 Scripps Research Inst ANALOGS OF CC-1065 AND DUOCARMYCINE
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
AU721037B2 (en) * 1996-09-12 2000-06-22 Auckland Uniservices Limited Condensed N-acylindoles as antitumor agents
WO1998025900A1 (en) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Compounds having antitumor activity
JP3649617B2 (ja) * 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 ２本鎖ｄｎａを切断できる化合物及びその使用方法
WO2002030894A2 (en) * 2000-09-19 2002-04-18 Taiho Pharmaceutical Co., Ltd. Compositions and methods of the use thereof achiral analogues of cc-1065 and the duocarmycins
EP1408960B1 (en) 2001-02-22 2006-05-31 School Of Pharmacy, University Of London Benz-indole and benzo-quinoline derivatives as prodrugs for tumour treatment
ES2299560T3 (es) 2001-02-22 2008-06-01 University Of Bradford Derivados de pirrolindol y de pirroloquinolina como profarmacos para el tratamiento de tumores.
US6989452B2 (en) * 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
CN100519555C (zh) * 2004-03-13 2009-07-29 Tmrc株式会社 将dna的特定碱基序列烷基化的新吲哚衍生物和使用其的烷基化剂以及药剂
US7691962B2 (en) 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
JP4806680B2 (ja) 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
RS52100B (sr) * 2005-10-26 2012-06-30 Medarex, Inc. Postupci i jedinjenja za pripremu analoga cc-1065
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
AR065404A1 (es) 2007-02-21 2009-06-03 Medarex Inc Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
ES2647317T3 (es) 2008-11-03 2017-12-20 Syntarga B.V. Análogos de CC-1065 y sus conjugados
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
CN103906742A (zh) * 2011-09-28 2014-07-02 世宗大学校产学协力团 硒吩稠合芳族化合物和其制备方法
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US9089614B2 (en) 2012-12-21 2015-07-28 Bioalliance C.V. Hydrophilic self-immolative linkers and conjugates thereof
RU2680404C2 (ru) 2014-01-10 2019-02-21 Синтон Байофармасьютикалс Б. В. Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
US9950077B2 (en) 2014-06-20 2018-04-24 Bioalliance C.V. Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
IL260289B (en) 2016-01-08 2022-08-01 Bioalliance Cv Tetravalent anti-psgl-1 antibodies and uses thereof
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
JP7726628B2 (ja) 2020-01-30 2025-08-20 エイムドバイオ株式会社 ベンゾセレノフェン系化合物、これを含む薬学的組成物及び抗体－薬物複合体
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Also Published As

Publication number Publication date
AU1990297A (en) 1997-09-22
JP2000506168A (ja) 2000-05-23
ES2244991T3 (es) 2005-12-16
AU711974B2 (en) 1999-10-28
DE69733942D1 (de) 2005-09-15
WO1997032850A1 (en) 1997-09-12
US5985908A (en) 1999-11-16
EP0888301B1 (en) 2005-08-10
CA2246783C (en) 2006-07-11
ATE301639T1 (de) 2005-08-15
CA2246783A1 (en) 1997-09-12
EP0888301A1 (en) 1999-01-07
EP0888301A4 (en) 2002-05-08

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee