DE69730251T2 - Anwendung von scherflussbeanspruchung auf chondrozyten - Google Patents

Anwendung von scherflussbeanspruchung auf chondrozyten Download PDF

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Publication number
DE69730251T2
DE69730251T2 DE69730251T DE69730251T DE69730251T2 DE 69730251 T2 DE69730251 T2 DE 69730251T2 DE 69730251 T DE69730251 T DE 69730251T DE 69730251 T DE69730251 T DE 69730251T DE 69730251 T2 DE69730251 T2 DE 69730251T2
Authority
DE
Germany
Prior art keywords
cells
substrate
shear flow
chondrocytes
cartilage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730251T
Other languages
German (de)
English (en)
Other versions
DE69730251D1 (de
Inventor
Dror Seliktar
Noushin Dunkelman
E. Alvin PETERSON
E. Rhonda SCHREIBER
Jane Willoughby
K. Gail NAUGHTON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Original Assignee
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew PLC, TJ Smith and Nephew Ltd filed Critical Smith and Nephew PLC
Application granted granted Critical
Publication of DE69730251D1 publication Critical patent/DE69730251D1/de
Publication of DE69730251T2 publication Critical patent/DE69730251T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Excavating Of Shafts Or Tunnels (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Materials For Medical Uses (AREA)
DE69730251T 1996-11-20 1997-11-18 Anwendung von scherflussbeanspruchung auf chondrozyten Expired - Lifetime DE69730251T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US753104 1996-11-20
US08/753,104 US5928945A (en) 1996-11-20 1996-11-20 Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
PCT/US1997/021088 WO1998022573A1 (en) 1996-11-20 1997-11-18 Application of shear flow stress to chondrocytes

Publications (2)

Publication Number Publication Date
DE69730251D1 DE69730251D1 (de) 2004-09-16
DE69730251T2 true DE69730251T2 (de) 2005-09-15

Family

ID=25029173

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69730251T Expired - Lifetime DE69730251T2 (de) 1996-11-20 1997-11-18 Anwendung von scherflussbeanspruchung auf chondrozyten

Country Status (11)

Country Link
US (1) US5928945A (cg-RX-API-DMAC7.html)
EP (1) EP1019489B1 (cg-RX-API-DMAC7.html)
JP (1) JP4014645B2 (cg-RX-API-DMAC7.html)
KR (1) KR20000057136A (cg-RX-API-DMAC7.html)
AT (1) ATE273382T1 (cg-RX-API-DMAC7.html)
AU (1) AU744686B2 (cg-RX-API-DMAC7.html)
CA (1) CA2272547A1 (cg-RX-API-DMAC7.html)
DE (1) DE69730251T2 (cg-RX-API-DMAC7.html)
ES (1) ES2225999T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ335991A (cg-RX-API-DMAC7.html)
WO (1) WO1998022573A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
US5928945A (en) 1999-07-27
JP4014645B2 (ja) 2007-11-28
CA2272547A1 (en) 1998-05-28
ES2225999T3 (es) 2005-03-16
KR20000057136A (ko) 2000-09-15
AU5445198A (en) 1998-06-10
EP1019489A4 (en) 2002-08-28
NZ335991A (en) 2000-07-28
DE69730251D1 (de) 2004-09-16
AU744686B2 (en) 2002-02-28
WO1998022573A1 (en) 1998-05-28
EP1019489B1 (en) 2004-08-11
JP2001504697A (ja) 2001-04-10
EP1019489A1 (en) 2000-07-19
ATE273382T1 (de) 2004-08-15

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