DE69729007D1 - Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung - Google Patents

Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung

Info

Publication number
DE69729007D1
DE69729007D1 DE69729007T DE69729007T DE69729007D1 DE 69729007 D1 DE69729007 D1 DE 69729007D1 DE 69729007 T DE69729007 T DE 69729007T DE 69729007 T DE69729007 T DE 69729007T DE 69729007 D1 DE69729007 D1 DE 69729007D1
Authority
DE
Germany
Prior art keywords
mmp
inhibiting effect
acid derivatives
tnf inhibiting
hydroxamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69729007T
Other languages
English (en)
Other versions
DE69729007T2 (de
Inventor
Alan Owen
Gary Montana
Fraser Keily
John Watson
Douglas Baxter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9616599.8A external-priority patent/GB9616599D0/en
Priority claimed from GBGB9707427.2A external-priority patent/GB9707427D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of DE69729007D1 publication Critical patent/DE69729007D1/de
Application granted granted Critical
Publication of DE69729007T2 publication Critical patent/DE69729007T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69729007T 1996-08-07 1997-08-07 Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung Expired - Fee Related DE69729007T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9616599.8A GB9616599D0 (en) 1996-08-07 1996-08-07 Compounds
GB9616599 1996-08-07
GB9707427 1997-04-11
GBGB9707427.2A GB9707427D0 (en) 1997-04-11 1997-04-11 Compounds having mmp and tnf inhibitory activity
PCT/GB1997/002129 WO1998005635A1 (en) 1996-08-07 1997-08-07 Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

Publications (2)

Publication Number Publication Date
DE69729007D1 true DE69729007D1 (de) 2004-06-09
DE69729007T2 DE69729007T2 (de) 2005-04-07

Family

ID=26309836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729007T Expired - Fee Related DE69729007T2 (de) 1996-08-07 1997-08-07 Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung

Country Status (17)

Country Link
US (1) US6118001A (de)
EP (1) EP0968182B1 (de)
JP (1) JP2000517297A (de)
KR (1) KR20000029858A (de)
CN (1) CN1227540A (de)
AT (1) ATE266000T1 (de)
AU (1) AU730464B2 (de)
BR (1) BR9711027A (de)
CA (1) CA2263154A1 (de)
CZ (1) CZ297278B6 (de)
DE (1) DE69729007T2 (de)
DK (1) DK0968182T3 (de)
ES (1) ES2217425T3 (de)
NO (1) NO314452B1 (de)
PL (1) PL193829B1 (de)
PT (1) PT968182E (de)
WO (1) WO1998005635A1 (de)

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US6794511B2 (en) * 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6476027B1 (en) 1997-03-04 2002-11-05 Monsanto Company N-hydroxy 4-sulfonyl butanamide compounds
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EP1037868B1 (de) 1997-11-21 2003-02-05 PHARMACIA & UPJOHN COMPANY Alpha-hydroxy, -amino und -fluoro derivate von beta-sulfonylhydroxamsäuren als matrixmetalloproteinasen-inhibitoren
DE69939190D1 (de) 1998-06-18 2008-09-04 Hoffmann La Roche Verfahren für Arylalkylsulfid
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US6479502B1 (en) 1998-08-29 2002-11-12 British Biotech Pharmaceuticals Hydroxamic acid derivatives as proteinase inhibitors
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Also Published As

Publication number Publication date
PL193829B1 (pl) 2007-03-30
WO1998005635A1 (en) 1998-02-12
ES2217425T3 (es) 2004-11-01
NO990543D0 (no) 1999-02-05
CN1227540A (zh) 1999-09-01
CZ297278B6 (cs) 2006-10-11
CA2263154A1 (en) 1998-02-12
EP0968182B1 (de) 2004-05-06
DK0968182T3 (da) 2004-08-16
CZ36899A3 (cs) 1999-07-14
BR9711027A (pt) 1999-08-17
DE69729007T2 (de) 2005-04-07
PL331598A1 (en) 1999-08-02
EP0968182A1 (de) 2000-01-05
JP2000517297A (ja) 2000-12-26
AU730464B2 (en) 2001-03-08
NO990543L (no) 1999-04-06
ATE266000T1 (de) 2004-05-15
NO314452B1 (no) 2003-03-24
PT968182E (pt) 2004-08-31
KR20000029858A (ko) 2000-05-25
US6118001A (en) 2000-09-12
AU3856497A (en) 1998-02-25

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