GEP20012440B - Biphenylsulfonamide Matrix Metalloproteinase Inhibitors - Google Patents

Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

Info

Publication number
GEP20012440B
GEP20012440B GEAP19974608A GEAP1997004608A GEP20012440B GE P20012440 B GEP20012440 B GE P20012440B GE AP19974608 A GEAP19974608 A GE AP19974608A GE AP1997004608 A GEAP1997004608 A GE AP1997004608A GE P20012440 B GEP20012440 B GE P20012440B
Authority
GE
Georgia
Prior art keywords
matrix metalloproteinase
metalloproteinase inhibitors
biphenylsulfonamide
biphenylsulfonamide matrix
biphenylsulfonamides
Prior art date
Application number
GEAP19974608A
Inventor
Patrick Michael O’Brien
Drago Robert Sliskovic
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GEP20012440B publication Critical patent/GEP20012440B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Abstract

1. Technical Result Increase in inhibitory activity. 2. Essence Biphenylsulfonamides, which represent metalloproteinase enzymes inhibitors of formula (I) (meanings R1, R2 and R3 are defined in the description), pharmaceutical compositions on their base and methods for treatment. 3. Field of Application Chemistry, medicine.
GEAP19974608A 1999-02-16 1997-04-24 Biphenylsulfonamide Matrix Metalloproteinase Inhibitors GEP20012440B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1746099P 1999-02-16 1999-02-16

Publications (1)

Publication Number Publication Date
GEP20012440B true GEP20012440B (en) 2001-05-25

Family

ID=82787058

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19974608A GEP20012440B (en) 1999-02-16 1997-04-24 Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

Country Status (1)

Country Link
GE (1) GEP20012440B (en)

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