DE69722388T2 - Nichtpolymere epoxyverbindungen zur vernetzung von biologischem gewebe und daraus hergestellte bioprothesen - Google Patents

Nichtpolymere epoxyverbindungen zur vernetzung von biologischem gewebe und daraus hergestellte bioprothesen Download PDF

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Publication number
DE69722388T2
DE69722388T2 DE69722388T DE69722388T DE69722388T2 DE 69722388 T2 DE69722388 T2 DE 69722388T2 DE 69722388 T DE69722388 T DE 69722388T DE 69722388 T DE69722388 T DE 69722388T DE 69722388 T2 DE69722388 T2 DE 69722388T2
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DE
Germany
Prior art keywords
collagen
compound
group
tissue
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722388T
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German (de)
English (en)
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DE69722388D1 (de
Inventor
B. Can HU
E. Keith MYERS
Diana Nguyen-Thien-Nhon
Ralph Kafesjian
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Edwards Lifesciences Corp
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Edwards Lifesciences Corp
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Publication date
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Publication of DE69722388D1 publication Critical patent/DE69722388D1/de
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Publication of DE69722388T2 publication Critical patent/DE69722388T2/de
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
DE69722388T 1996-03-04 1997-03-03 Nichtpolymere epoxyverbindungen zur vernetzung von biologischem gewebe und daraus hergestellte bioprothesen Expired - Lifetime DE69722388T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60801496A 1996-03-04 1996-03-04
US608014 1996-03-04
PCT/US1997/003249 WO1997032615A1 (en) 1996-03-04 1997-03-03 Nonpolymeric epoxy compounds for cross-linking biological tissue and bioprosthetic grafts prepared thereby

Publications (2)

Publication Number Publication Date
DE69722388D1 DE69722388D1 (de) 2003-07-03
DE69722388T2 true DE69722388T2 (de) 2004-04-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722388T Expired - Lifetime DE69722388T2 (de) 1996-03-04 1997-03-03 Nichtpolymere epoxyverbindungen zur vernetzung von biologischem gewebe und daraus hergestellte bioprothesen

Country Status (6)

Country Link
US (1) US5880242A (cg-RX-API-DMAC10.html)
EP (1) EP0888142B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000506050A (cg-RX-API-DMAC10.html)
CA (1) CA2247199A1 (cg-RX-API-DMAC10.html)
DE (1) DE69722388T2 (cg-RX-API-DMAC10.html)
WO (1) WO1997032615A1 (cg-RX-API-DMAC10.html)

Cited By (10)

* Cited by examiner, † Cited by third party
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WO2019015792A1 (de) 2017-07-20 2019-01-24 Continental Reifen Deutschland Gmbh Verfahren zur herstellung eines fahrzeugreifens und fahrzeugreifen hergestellt nach dem verfahren und verwendung von behandelten festigkeitsträgern
US10611822B2 (en) 2011-07-28 2020-04-07 Harbor Medtech, Inc. Crosslinked human or animal tissue products and their methods of manufacture and use
EP3702523A1 (en) 2019-03-01 2020-09-02 Continental Reifen Deutschland GmbH Aqueous dipping composition
EP3702522A1 (en) 2019-03-01 2020-09-02 Continental Reifen Deutschland GmbH Aqueous dipping composition
EP3702524A1 (en) 2019-03-01 2020-09-02 Continental Reifen Deutschland GmbH Aqueous dipping composition
EP3702521A1 (en) 2019-03-01 2020-09-02 Continental Reifen Deutschland GmbH Aqueous dipping composition
EP4144513A1 (de) 2021-09-03 2023-03-08 Continental Reifen Deutschland GmbH Verbundmaterial als scheuerschutz für fahrzeugreifen und verfahren zur herstellung
WO2023030989A1 (de) 2021-09-03 2023-03-09 Continental Reifen Deutschland Gmbh Verbundmaterial für fahrzeugreifen und verfahren zur herstellung
WO2023155989A1 (de) 2022-02-17 2023-08-24 Continental Reifen Deutschland Gmbh Verbundmaterial für elastomere erzeugnisse, insbesondere fahrzeugreifen, und verfahren zur herstellung
US12102731B2 (en) 2020-05-01 2024-10-01 Harbor Medtech, Inc. Port-accessible multidirectional reinforced minimally invasive collagen device for soft tissue repair

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US6106555A (en) * 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10060660A1 (de) * 2000-12-06 2002-06-20 Frey Rainer Verfahren zur Konservierung von biologischen Prothesen, konservierte biologische Prothese und Konservierungslösung
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US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
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Publication number Priority date Publication date Assignee Title
US10611822B2 (en) 2011-07-28 2020-04-07 Harbor Medtech, Inc. Crosslinked human or animal tissue products and their methods of manufacture and use
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WO2019015792A1 (de) 2017-07-20 2019-01-24 Continental Reifen Deutschland Gmbh Verfahren zur herstellung eines fahrzeugreifens und fahrzeugreifen hergestellt nach dem verfahren und verwendung von behandelten festigkeitsträgern
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JP2000506050A (ja) 2000-05-23
WO1997032615A1 (en) 1997-09-12
CA2247199A1 (en) 1997-09-12
EP0888142A1 (en) 1999-01-07
US5880242A (en) 1999-03-09
EP0888142B1 (en) 2003-05-28

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