DE69801517T2 - Verfahren zur verhinderung der verkalkung von aldehyd-fixierten bioprothesenmaterialien - Google Patents

Verfahren zur verhinderung der verkalkung von aldehyd-fixierten bioprothesenmaterialien

Info

Publication number
DE69801517T2
DE69801517T2 DE69801517T DE69801517T DE69801517T2 DE 69801517 T2 DE69801517 T2 DE 69801517T2 DE 69801517 T DE69801517 T DE 69801517T DE 69801517 T DE69801517 T DE 69801517T DE 69801517 T2 DE69801517 T2 DE 69801517T2
Authority
DE
Germany
Prior art keywords
tissue
bioprothesis
aldehyd
materials
fixed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69801517T
Other languages
English (en)
Other versions
DE69801517D1 (de
Inventor
Ting Lee
Jun Yang
Thanh Dinh
H Pfadenhauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Publication of DE69801517D1 publication Critical patent/DE69801517D1/de
Application granted granted Critical
Publication of DE69801517T2 publication Critical patent/DE69801517T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
DE69801517T 1997-12-02 1998-11-23 Verfahren zur verhinderung der verkalkung von aldehyd-fixierten bioprothesenmaterialien Expired - Lifetime DE69801517T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/982,846 US6008292A (en) 1997-12-02 1997-12-02 Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
PCT/US1998/024900 WO1999027979A1 (en) 1997-12-02 1998-11-23 Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials

Publications (2)

Publication Number Publication Date
DE69801517D1 DE69801517D1 (de) 2001-10-04
DE69801517T2 true DE69801517T2 (de) 2002-04-11

Family

ID=25529556

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69801517T Expired - Lifetime DE69801517T2 (de) 1997-12-02 1998-11-23 Verfahren zur verhinderung der verkalkung von aldehyd-fixierten bioprothesenmaterialien

Country Status (11)

Country Link
US (1) US6008292A (de)
EP (1) EP1035877B1 (de)
JP (1) JP4460764B2 (de)
AT (1) ATE204767T1 (de)
AU (1) AU1466799A (de)
CA (1) CA2312376C (de)
DE (1) DE69801517T2 (de)
DK (1) DK1035877T3 (de)
ES (1) ES2163898T3 (de)
PT (1) PT1035877E (de)
WO (1) WO1999027979A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004028A1 (en) * 1994-07-29 1996-02-15 Baxter International Inc. Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6391538B1 (en) * 2000-02-09 2002-05-21 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic tissue
US20030050276A1 (en) * 2001-08-15 2003-03-13 Cunanan Crystal M. Treatment of tissue, instruments and work surfaces to remove infectious agents
EP1335751A2 (de) * 2000-11-01 2003-08-20 Edwards Lifesciences Corporation Methoden zur herstellung von bioprothetischen gewebe und implantierbare vorrichtungen, die derartiges gewebe enthaldend
AU2002320182B2 (en) * 2001-06-29 2008-02-21 Cook Biotech Incorporated Porous sponge matrix medical devices and methods
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
CN1903143A (zh) * 2005-07-29 2007-01-31 广东冠昊生物科技有限公司 生物型人工血管及其制备方法
CN1903144A (zh) * 2005-07-29 2007-01-31 广东冠昊生物科技有限公司 生物型人工韧带及其制备方法
CN100482178C (zh) * 2005-08-04 2009-04-29 广东冠昊生物科技有限公司 带生物膜的血管瘤夹
CN1986007B (zh) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 生物型外科补片
CN1986006A (zh) * 2005-12-20 2007-06-27 广州知光生物科技有限公司 生物型神经导管
CN1985778B (zh) * 2005-12-20 2010-10-13 广东冠昊生物科技股份有限公司 生物型人工角膜
CN1986001B (zh) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 生物护创膜
US20070237802A1 (en) * 2006-04-11 2007-10-11 Medtronic Vascular, Inc. Inhibition of Calcification on an Endovascular Device
CN101332316B (zh) * 2008-07-22 2012-12-26 广东冠昊生物科技股份有限公司 生物型鼻梁植入体
CN101332314B (zh) * 2008-07-22 2012-11-14 广东冠昊生物科技股份有限公司 生物型关节软骨修补件
US20100023129A1 (en) * 2008-07-22 2010-01-28 Guo-Feng Xu Jawbone prosthesis and method of manufacture
CN103933612B (zh) 2006-10-27 2016-06-22 爱德华兹生命科学公司 用于外科植入的生物组织
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
US9211361B2 (en) * 2010-03-15 2015-12-15 Kemal Schankereli Thin collagen tissue for medical device applications
EP2549957B1 (de) 2010-03-23 2019-01-30 Edwards Lifesciences Corporation Verfahren zur bearbeitung eines scheibenförmigen bioprothese-gewebes
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
WO2013016571A1 (en) 2011-07-28 2013-01-31 Harbor Medtech, Inc. Crosslinked human or animal tissue products and their methods of manufacture and use
EP2760494B1 (de) 2011-09-30 2017-04-19 Sofradim Production Umkehrbare versteifung aus leichtgewichtigen maschen
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
AU2013322268B2 (en) 2012-09-28 2017-08-31 Sofradim Production Packaging for a hernia repair device
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
EP3398554A1 (de) 2017-05-02 2018-11-07 Sofradim Production Prothese zur leistenbruch-reparatur
US11517428B2 (en) 2018-11-01 2022-12-06 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve
EP3653171A1 (de) 2018-11-16 2020-05-20 Sofradim Production Implantate zur weichgewebereparatur
CN114209886B (zh) * 2021-11-09 2022-12-02 江苏臻亿医疗科技有限公司 一种生物组织材料及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL47062A (en) * 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
US4405327A (en) * 1982-08-25 1983-09-20 Extracorporeal Medical Specialties, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4885005A (en) * 1982-11-12 1989-12-05 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
JP2529112B2 (ja) * 1987-08-31 1996-08-28 株式会社 高研 生体弁
US4976733A (en) * 1988-02-03 1990-12-11 Biomedical Design, Inc. Prevention of prosthesis calcification
US5002566A (en) * 1989-02-17 1991-03-26 Baxter International Inc. Calcification mitigation of bioprosthetic implants
EP0571527B1 (de) * 1991-02-14 1996-04-24 Baxter International Inc. Herstellungsverfahren für biegsame biologische Gewebeverpflanzungsmaterialen
WO1994017841A1 (en) * 1993-02-01 1994-08-18 Baxter International Inc. Biological grafts having regionalized differences in cross-link density and their methods of manufacture
US5549666A (en) * 1994-09-02 1996-08-27 Baxter International Inc. Natural tissue valve prostheses having variably complaint leaflets
US5674298A (en) * 1994-10-21 1997-10-07 The Board Of Regents Of The University Of Michigan Calcification-resistant bioprosthetic tissue and methods of making same

Also Published As

Publication number Publication date
JP2001524358A (ja) 2001-12-04
DE69801517D1 (de) 2001-10-04
JP4460764B2 (ja) 2010-05-12
CA2312376C (en) 2007-02-20
US6008292A (en) 1999-12-28
ATE204767T1 (de) 2001-09-15
EP1035877B1 (de) 2001-08-29
PT1035877E (pt) 2001-12-28
ES2163898T3 (es) 2002-02-01
EP1035877A1 (de) 2000-09-20
AU1466799A (en) 1999-06-16
DK1035877T3 (da) 2001-12-03
CA2312376A1 (en) 1999-06-10
WO1999027979A1 (en) 1999-06-10

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