DE69720809T2 - Durch gruppen erweiterte fluorophore polymere, die eine hydrophobe und konformativ eingeschrankte mikroumgebung schaffen - Google Patents

Durch gruppen erweiterte fluorophore polymere, die eine hydrophobe und konformativ eingeschrankte mikroumgebung schaffen Download PDF

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Publication number
DE69720809T2
DE69720809T2 DE69720809T DE69720809T DE69720809T2 DE 69720809 T2 DE69720809 T2 DE 69720809T2 DE 69720809 T DE69720809 T DE 69720809T DE 69720809 T DE69720809 T DE 69720809T DE 69720809 T2 DE69720809 T2 DE 69720809T2
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DE
Germany
Prior art keywords
dye
polymeric
polymeric dye
aniline
signal
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69720809T
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German (de)
English (en)
Other versions
DE69720809D1 (de
Inventor
Christopher Bieniarz
B. Jeffrey HUFF
J. Michael CORNWELL
R. Seshagiri TATA VENKATA
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Abbott Laboratories
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Abbott Laboratories
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Publication of DE69720809D1 publication Critical patent/DE69720809D1/de
Application granted granted Critical
Publication of DE69720809T2 publication Critical patent/DE69720809T2/de
Anticipated expiration legal-status Critical
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    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00Dyes not provided for by a single group of this subclass
    • C09B69/10Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/18Sulfur containing

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69720809T 1996-02-01 1997-01-30 Durch gruppen erweiterte fluorophore polymere, die eine hydrophobe und konformativ eingeschrankte mikroumgebung schaffen Expired - Fee Related DE69720809T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US595092 1996-02-01
US08/595,092 US5994143A (en) 1996-02-01 1996-02-01 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
PCT/US1997/001429 WO1997028447A1 (en) 1996-02-01 1997-01-30 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment

Publications (2)

Publication Number Publication Date
DE69720809D1 DE69720809D1 (de) 2003-05-15
DE69720809T2 true DE69720809T2 (de) 2004-04-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720809T Expired - Fee Related DE69720809T2 (de) 1996-02-01 1997-01-30 Durch gruppen erweiterte fluorophore polymere, die eine hydrophobe und konformativ eingeschrankte mikroumgebung schaffen

Country Status (7)

Country Link
US (1) US5994143A (cg-RX-API-DMAC7.html)
EP (1) EP1019722B1 (cg-RX-API-DMAC7.html)
JP (1) JP4255514B2 (cg-RX-API-DMAC7.html)
AT (1) ATE237138T1 (cg-RX-API-DMAC7.html)
DE (1) DE69720809T2 (cg-RX-API-DMAC7.html)
ES (1) ES2197332T3 (cg-RX-API-DMAC7.html)
WO (1) WO1997028447A1 (cg-RX-API-DMAC7.html)

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DE10331093A1 (de) * 2003-07-09 2005-02-10 Schering Ag Vorrichtung und Verfahren zur direkten quantitativen in vitro-Bestimmung einer in einer Probe enthaltenen Substanz
DE102004033050A1 (de) * 2004-07-08 2006-01-26 International University Bremen Gmbh Photostabilisierung von Fluoreszenzfarbstoffen

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US6437099B1 (en) * 1998-01-07 2002-08-20 Hamamatsu Photonics K.K. Fluorescene—activating antisera and IgG fraction therefrom
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050233465A1 (en) * 2004-04-14 2005-10-20 Bioprocessors Corp. Compositions of matter useful as pH indicators and related methods
WO2007053594A2 (en) * 2005-10-31 2007-05-10 Clontech Laboratories, Inc. Large dynamic range proteomic analysis methods and compositions for practicing the same
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
GB2437545B (en) * 2006-04-28 2011-07-06 Novexin Ltd Dextrin-containing reagents for detecting and quantifying proteins
JP2013040136A (ja) * 2011-08-17 2013-02-28 Tosoh Corp 4−アルコキシ−2−(4−アミノスチリル)ベンゾチアゾリウム塩、その製造方法およびそれを用いる核酸の検出方法
CN105377994B (zh) 2013-08-22 2018-03-02 索尼公司 水溶性荧光染料或有色染料及其使用方法
CN103525117A (zh) * 2013-10-30 2014-01-22 苏州大学 一种半花菁荧光染料、制备方法及应用
WO2016021883A1 (ko) * 2014-08-02 2016-02-11 주식회사 엘지화학 염료 복합체, 광전환 필름, 및 이를 포함하는 전자소자
EP3262055A4 (en) 2015-02-26 2018-09-05 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
CN104788991B (zh) * 2015-03-04 2017-01-25 苏州大学 一种二氯三嗪反应基半花菁荧光活性染料及其制备方法
EP3436528B1 (en) 2016-04-01 2025-07-02 Sony Group Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
KR20250029292A (ko) 2016-04-01 2025-03-04 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
US11390754B2 (en) * 2016-05-10 2022-07-19 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
KR102526802B1 (ko) * 2016-05-11 2023-05-02 소니그룹주식회사 초고명도 이량체성 또는 중합체성 염료
EP3464477A1 (en) 2016-06-06 2019-04-10 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
US12145956B2 (en) 2017-10-05 2024-11-19 Sony Group Corporation Programmable polymeric drugs
WO2019099789A1 (en) 2017-11-16 2019-05-23 Sony Corporation Programmable polymeric drugs
WO2019140227A1 (en) 2018-01-12 2019-07-18 Sony Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
WO2019182765A1 (en) 2018-03-19 2019-09-26 Sony Corporation Use of divalent metals for enhancement of fluorescent signals
JP7515786B2 (ja) 2018-03-21 2024-07-16 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
WO2020006285A1 (en) 2018-06-27 2020-01-02 Sony Corporation Polymeric dyes with linker groups comprising deoxyribose
KR102718543B1 (ko) 2019-09-26 2024-10-18 소니그룹주식회사 링커 그룹을 갖는 중합체성 탠덤 염료
CN111500110B (zh) * 2020-04-28 2022-09-06 陕西大风印务科技有限公司 烟用包装纸用透明油墨及其涂层、烟用包装纸
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

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US4619990A (en) * 1985-03-11 1986-10-28 Minnesota Mining And Manufacturing Company Polymeric dyes with pendent chromophore groups capable of undergoing thermoplastic deformation
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
DE3921498A1 (de) * 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
US5401469A (en) * 1989-04-19 1995-03-28 Ibiden Co., Ltd. Plastic optical biomaterials assay device
EP0439182B1 (en) * 1990-01-26 1996-04-24 Abbott Laboratories Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
DE4114482A1 (de) * 1991-05-03 1992-11-05 Bayer Ag Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung
WO1992020746A1 (en) * 1991-05-14 1992-11-26 Hybritech, Incorporated Polymeric compositions having bound antibodies
WO1995002700A1 (en) * 1993-07-13 1995-01-26 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10331093A1 (de) * 2003-07-09 2005-02-10 Schering Ag Vorrichtung und Verfahren zur direkten quantitativen in vitro-Bestimmung einer in einer Probe enthaltenen Substanz
DE102004033050A1 (de) * 2004-07-08 2006-01-26 International University Bremen Gmbh Photostabilisierung von Fluoreszenzfarbstoffen
US7511284B2 (en) 2004-07-08 2009-03-31 International University Bremen Gmbh Photostabilisation of fluorescent dyes

Also Published As

Publication number Publication date
JP2000509412A (ja) 2000-07-25
ATE237138T1 (de) 2003-04-15
DE69720809D1 (de) 2003-05-15
JP4255514B2 (ja) 2009-04-15
EP1019722B1 (en) 2003-04-09
US5994143A (en) 1999-11-30
WO1997028447A1 (en) 1997-08-07
EP1019722A1 (en) 2000-07-19
ES2197332T3 (es) 2004-01-01

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