DE69714590T2 - Vitamin d analoge verbindungen - Google Patents
Vitamin d analoge verbindungenInfo
- Publication number
- DE69714590T2 DE69714590T2 DE69714590T DE69714590T DE69714590T2 DE 69714590 T2 DE69714590 T2 DE 69714590T2 DE 69714590 T DE69714590 T DE 69714590T DE 69714590 T DE69714590 T DE 69714590T DE 69714590 T2 DE69714590 T2 DE 69714590T2
- Authority
- DE
- Germany
- Prior art keywords
- compound
- ether
- compounds
- formula
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 229930003231 vitamin Natural products 0.000 title 1
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- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims description 6
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9611603.3A GB9611603D0 (en) | 1996-06-04 | 1996-06-04 | Chemical compounds |
| PCT/DK1997/000225 WO1997046522A1 (en) | 1996-06-04 | 1997-05-15 | Novel vitamin d analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69714590D1 DE69714590D1 (de) | 2002-09-12 |
| DE69714590T2 true DE69714590T2 (de) | 2003-04-24 |
Family
ID=10794707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69714590T Expired - Lifetime DE69714590T2 (de) | 1996-06-04 | 1997-05-15 | Vitamin d analoge verbindungen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6197982B1 (enExample) |
| EP (1) | EP0906276B1 (enExample) |
| JP (1) | JP2000511894A (enExample) |
| CN (1) | CN1217926C (enExample) |
| AT (1) | ATE221875T1 (enExample) |
| AU (1) | AU714223B2 (enExample) |
| CZ (1) | CZ296255B6 (enExample) |
| DE (1) | DE69714590T2 (enExample) |
| DK (1) | DK0906276T3 (enExample) |
| ES (1) | ES2179343T3 (enExample) |
| GB (1) | GB9611603D0 (enExample) |
| NZ (1) | NZ332237A (enExample) |
| PL (1) | PL186804B1 (enExample) |
| PT (1) | PT906276E (enExample) |
| RO (1) | RO120133B1 (enExample) |
| RU (1) | RU2165413C2 (enExample) |
| WO (1) | WO1997046522A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098065A1 (en) * | 2000-01-11 | 2009-04-16 | Avikam Harel | Composition and methods for the treatment of skin disorders |
| EP1458678A1 (en) * | 2002-11-18 | 2004-09-22 | Teva Pharmaceutical Industries Limited | A crystallization method for purification of calcipotriene |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| KR20110113664A (ko) * | 2006-08-29 | 2011-10-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 비타민 ｄ 및 코르티코스테로이드를 포함하는 약학 조성물 |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| AU2010208323B2 (en) | 2009-01-27 | 2016-03-10 | Berg Llc | Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy |
| EP2464357B1 (en) | 2009-08-14 | 2019-05-22 | Berg LLC | Vitamin d3 and analogs thereof for treating alopecia |
| US20120322776A1 (en) * | 2009-12-22 | 2012-12-20 | Leo Pharma A/S | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
| CN102770121B (zh) * | 2009-12-22 | 2014-10-15 | 利奥制药有限公司 | 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 |
| PT2360145E (pt) * | 2010-01-26 | 2012-06-27 | Hybrigenics Sa | Novo processo para isomerização de estruturas bicíclicas condensadas e preparação de análogos de vitamina d que as contêm |
| HUE025554T2 (en) * | 2010-10-25 | 2016-02-29 | Teijin Pharma Ltd | Vitamin D3-23-in derivative |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| AU2016234990B2 (en) | 2015-10-02 | 2018-12-06 | Lg Electronics Inc. | Washing machine and method for controlling the same |
| AU2016234988B2 (en) | 2015-10-02 | 2018-08-02 | Lg Electronics Inc. | Washing machine |
| US20170096769A1 (en) | 2015-10-02 | 2017-04-06 | Lg Electronics Inc. | Method for controlling washing machine |
| US12351551B2 (en) * | 2019-11-27 | 2025-07-08 | Yonsung Fine Chemical Co., Ltd. | Method for producing maxacalcitol, and intermediate therefor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU688125A3 (ru) * | 1974-12-09 | 1979-09-25 | Тейдзин Лимитед (Фирма) | Способ получени 1 , 24/ /диокси-холекальциферола или 1 , 24 / /-диоксихолекальциферола или их производных |
| EP0296800B1 (en) | 1987-06-23 | 1991-10-16 | Yamanouchi Pharmaceutical Co. Ltd. | Vitamin d3 derivatives |
| GB9206648D0 (en) | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| US5552392A (en) | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
-
1996
- 1996-06-04 GB GBGB9611603.3A patent/GB9611603D0/en active Pending
-
1997
- 1997-05-15 CZ CZ0397198A patent/CZ296255B6/cs not_active IP Right Cessation
- 1997-05-15 RU RU98121401/04A patent/RU2165413C2/ru not_active IP Right Cessation
- 1997-05-15 ES ES97924929T patent/ES2179343T3/es not_active Expired - Lifetime
- 1997-05-15 DE DE69714590T patent/DE69714590T2/de not_active Expired - Lifetime
- 1997-05-15 DK DK97924929T patent/DK0906276T3/da active
- 1997-05-15 US US09/202,200 patent/US6197982B1/en not_active Expired - Fee Related
- 1997-05-15 PL PL97329941A patent/PL186804B1/pl not_active IP Right Cessation
- 1997-05-15 WO PCT/DK1997/000225 patent/WO1997046522A1/en not_active Ceased
- 1997-05-15 AU AU30256/97A patent/AU714223B2/en not_active Ceased
- 1997-05-15 RO RO98-01607A patent/RO120133B1/ro unknown
- 1997-05-15 CN CN971950202A patent/CN1217926C/zh not_active Expired - Fee Related
- 1997-05-15 EP EP97924929A patent/EP0906276B1/en not_active Expired - Lifetime
- 1997-05-15 PT PT97924929T patent/PT906276E/pt unknown
- 1997-05-15 NZ NZ332237A patent/NZ332237A/xx not_active IP Right Cessation
- 1997-05-15 AT AT97924929T patent/ATE221875T1/de active
- 1997-05-15 JP JP10500106A patent/JP2000511894A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0906276B1 (en) | 2002-08-07 |
| PL329941A1 (en) | 1999-04-26 |
| RU2165413C2 (ru) | 2001-04-20 |
| GB9611603D0 (en) | 1996-08-07 |
| CN1217926C (zh) | 2005-09-07 |
| RO120133B1 (ro) | 2005-09-30 |
| EP0906276A1 (en) | 1999-04-07 |
| WO1997046522A1 (en) | 1997-12-11 |
| AU714223B2 (en) | 1999-12-23 |
| CZ296255B6 (cs) | 2006-02-15 |
| AU3025697A (en) | 1998-01-05 |
| ES2179343T3 (es) | 2003-01-16 |
| ATE221875T1 (de) | 2002-08-15 |
| CZ397198A3 (cs) | 1999-03-17 |
| JP2000511894A (ja) | 2000-09-12 |
| DE69714590D1 (de) | 2002-09-12 |
| PL186804B1 (pl) | 2004-02-27 |
| CN1219928A (zh) | 1999-06-16 |
| DK0906276T3 (da) | 2002-12-02 |
| HK1019733A1 (en) | 2000-02-25 |
| PT906276E (pt) | 2002-12-31 |
| NZ332237A (en) | 2000-07-28 |
| US6197982B1 (en) | 2001-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LEO PHARMA A/S ZWEITNAME: LEO PHARMACEUTICAL PRODU |
|
| 8364 | No opposition during term of opposition |