DE69709618T2 - Synergistisches immunosuppressives eine 2, 2'-bi-1h-pyrrolverbindung enthaltendes mittel - Google Patents

Synergistisches immunosuppressives eine 2, 2'-bi-1h-pyrrolverbindung enthaltendes mittel

Info

Publication number
DE69709618T2
DE69709618T2 DE69709618T DE69709618T DE69709618T2 DE 69709618 T2 DE69709618 T2 DE 69709618T2 DE 69709618 T DE69709618 T DE 69709618T DE 69709618 T DE69709618 T DE 69709618T DE 69709618 T2 DE69709618 T2 DE 69709618T2
Authority
DE
Germany
Prior art keywords
compound container
immunosuppressive
synergistic
pyrrol compound
pyrrol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709618T
Other languages
English (en)
Other versions
DE69709618D1 (de
Inventor
Mario Ferrari
Paola Gnocchi
Chiara Fornasiero
Francesco Colotta
Alessio Roberto D
Maria Isetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of DE69709618D1 publication Critical patent/DE69709618D1/de
Application granted granted Critical
Publication of DE69709618T2 publication Critical patent/DE69709618T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69709618T 1996-09-20 1997-09-02 Synergistisches immunosuppressives eine 2, 2'-bi-1h-pyrrolverbindung enthaltendes mittel Expired - Fee Related DE69709618T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9619706.6A GB9619706D0 (en) 1996-09-20 1996-09-20 Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole comp und
PCT/EP1997/004884 WO1998011894A1 (en) 1996-09-20 1997-09-02 Synergistic immunosuppressant composition containing a 2,2'-bi-1h-pyrrole compound

Publications (2)

Publication Number Publication Date
DE69709618D1 DE69709618D1 (de) 2002-02-21
DE69709618T2 true DE69709618T2 (de) 2002-08-29

Family

ID=10800283

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709618T Expired - Fee Related DE69709618T2 (de) 1996-09-20 1997-09-02 Synergistisches immunosuppressives eine 2, 2'-bi-1h-pyrrolverbindung enthaltendes mittel

Country Status (20)

Country Link
US (1) US6291509B1 (de)
EP (1) EP0866701B1 (de)
JP (1) JP2000501118A (de)
KR (1) KR19990067692A (de)
AR (1) AR009086A1 (de)
AT (1) ATE211909T1 (de)
AU (1) AU4383197A (de)
BR (1) BR9706790A (de)
CA (1) CA2238043A1 (de)
DE (1) DE69709618T2 (de)
EA (1) EA000925B1 (de)
ES (1) ES2174288T3 (de)
GB (1) GB9619706D0 (de)
HU (1) HUP9901988A3 (de)
MX (1) MX9803920A (de)
NO (1) NO982282L (de)
NZ (1) NZ330655A (de)
PL (1) PL326759A1 (de)
WO (1) WO1998011894A1 (de)
ZA (1) ZA978187B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0867701A1 (de) 1997-03-28 1998-09-30 Interuniversitair Microelektronica Centrum Vzw Herstellungsverfahren eines infrarotempfindlichen Strahlungsdetektors, insbesondere eines infrarotempfindlichen Bolometers
AU4565000A (en) 1999-05-10 2000-11-21 Novartis Ag Organic compounds
US20040014987A1 (en) 2000-01-26 2004-01-22 Gemin X Biotechnologies Inc. Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases
US6407244B1 (en) 2000-01-26 2002-06-18 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
ATE378329T1 (de) 2001-07-18 2007-11-15 Gemin X Biotechnologies Inc Verbindungen vom pyrroltyp, zusammensetzungen und verfahren zur behandlung von krebs, zur behandlung von virenerkrankungen und zur unterdrückung der immunreaktion
KR100674222B1 (ko) * 2005-07-11 2007-01-24 한국생명공학연구원 세라시아 마르세센스 ｂ-1231 ｋｃｔｃ 0386ｂｐ로부터분리한 프로디지오신을 유효성분으로 포함한 급성이식편대숙주병의 예방 및 치료용 조성물
CN103387529B (zh) * 2013-07-30 2016-03-30 中国农业科学院烟草研究所 抗tmv的三吡咯环类化合物及其制备方法和用途
WO2017177216A1 (en) * 2016-04-08 2017-10-12 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Prodigiosin analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326284D0 (en) * 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation

Also Published As

Publication number Publication date
ES2174288T3 (es) 2002-11-01
CA2238043A1 (en) 1998-03-26
EA199800464A1 (ru) 1999-02-25
ZA978187B (en) 1998-03-03
JP2000501118A (ja) 2000-02-02
EA000925B1 (ru) 2000-06-26
BR9706790A (pt) 1999-06-01
NO982282D0 (no) 1998-05-19
PL326759A1 (en) 1998-10-26
AU4383197A (en) 1998-04-14
US6291509B1 (en) 2001-09-18
DE69709618D1 (de) 2002-02-21
HUP9901988A2 (hu) 1999-10-28
EP0866701A1 (de) 1998-09-30
EP0866701B1 (de) 2002-01-16
NZ330655A (en) 2000-01-28
MX9803920A (es) 1998-09-30
KR19990067692A (ko) 1999-08-25
AR009086A1 (es) 2000-03-08
WO1998011894A1 (en) 1998-03-26
HUP9901988A3 (en) 2000-09-28
NO982282L (no) 1998-07-20
ATE211909T1 (de) 2002-02-15
GB9619706D0 (en) 1996-11-06

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT

8339 Ceased/non-payment of the annual fee