DE69637771D1 - Eine verbesserte immobilisierte penicillin g acylase - Google Patents

Eine verbesserte immobilisierte penicillin g acylase

Info

Publication number
DE69637771D1
DE69637771D1 DE69637771T DE69637771T DE69637771D1 DE 69637771 D1 DE69637771 D1 DE 69637771D1 DE 69637771 T DE69637771 T DE 69637771T DE 69637771 T DE69637771 T DE 69637771T DE 69637771 D1 DE69637771 D1 DE 69637771D1
Authority
DE
Germany
Prior art keywords
acylase
immobilized penicillin
improved immobilized
beta
lactam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637771T
Other languages
English (en)
Inventor
Vroom Erik De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centrient Pharmaceuticals Netherlands BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE69637771D1 publication Critical patent/DE69637771D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69637771T 1995-07-18 1996-07-16 Eine verbesserte immobilisierte penicillin g acylase Expired - Lifetime DE69637771D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US147795P 1995-07-18 1995-07-18
EP95201979 1995-07-18
PCT/EP1996/003253 WO1997004086A1 (en) 1995-07-18 1996-07-16 An improved immobilized penicillin g acylase

Publications (1)

Publication Number Publication Date
DE69637771D1 true DE69637771D1 (de) 2009-01-22

Family

ID=26139505

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637771T Expired - Lifetime DE69637771D1 (de) 1995-07-18 1996-07-16 Eine verbesserte immobilisierte penicillin g acylase

Country Status (9)

Country Link
EP (1) EP0839192B1 (de)
JP (1) JP2001527381A (de)
CN (2) CN1165616C (de)
AT (1) ATE417100T1 (de)
AU (1) AU6659296A (de)
DE (1) DE69637771D1 (de)
DK (1) DK0839192T3 (de)
ES (1) ES2318851T3 (de)
WO (1) WO1997004086A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8021398A (en) * 1997-06-10 1998-12-30 Gist-Brocades B.V. Application of reducing sulphur compounds during enzymatic preparation of beta-lactam compounds
NL1009814C2 (nl) * 1998-08-06 2000-02-08 Dsm Nv Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
CN1109746C (zh) * 1998-11-10 2003-05-28 同济医科大学 一种固定化酶载体
DE10256656A1 (de) * 2002-12-03 2004-06-17 Röhm GmbH & Co. KG Verfahren zur Herstellung von Cephalexin
ITMI20030042A1 (it) * 2003-01-14 2004-07-15 Univ Degli Studi Trieste Processo di sintesi enzimatica di antibiotici b lattamici.
HUE036242T2 (hu) 2003-07-03 2018-06-28 Dsm Sinochem Pharm Nl Bv Eljárás cefradin elõállítására
BRPI0621278A2 (pt) 2005-12-28 2011-12-06 Dsm Ip Assests Bv acilases mutantes
CZ300467B6 (cs) 2007-01-31 2009-05-27 Mikrobiologický ústav AV CR, v.v.i. Sekvence nukleotidu o velikosti 2646 bp, kódující penicilinacylázu, nové konstrukty rekombinantní nukleové kyseliny a rekombinantní mikroorganismy nesoucí tuto sekvenci
EP2121960B1 (de) * 2007-03-09 2011-06-01 DSM IP Assets B.V. Verfahren zur Herstellung von beta-Lactam-Verbindungen
BRPI0922510B8 (pt) 2008-12-23 2021-05-25 Dsm Ip Assests Bv penicilina g acilase procariótica mutante
CN102656274B (zh) 2009-12-14 2014-10-15 中化帝斯曼制药有限公司荷兰公司 生产头孢拉定的方法
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters
EP2614066B1 (de) 2010-09-07 2017-11-29 DSM Sinochem Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von cephalosporinen
CN103635585A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 用青霉素g酰化酶制备3’-硫代头孢菌素的方法
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途
WO2013057197A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the formylation of cefamandole
WO2013057196A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of cefamandole nafate
CN102645503B (zh) * 2012-05-04 2014-04-02 联邦制药(内蒙古)有限公司 一种酶法制备阿莫西林中残留蛋白质的检测方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
WO2017186864A1 (en) 2016-04-27 2017-11-02 Sandoz Ag Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum
CN110343734B (zh) * 2019-06-14 2021-03-23 浙江工业大学 一种l-草铵膦化学酶法生产方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8301373A (nl) * 1983-04-19 1984-11-16 Tno Geimmobiliseerde biokatalysatoren.
GB2149816B (en) * 1983-11-14 1987-06-10 Kansai Paint Co Ltd Process for producing granular fixed enzymes or/microorganism strains
DK336987D0 (da) * 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
PT83746B (pt) * 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
DK589389D0 (da) * 1989-11-23 1989-11-23 Novo Nordisk As Immobiliseret enzympraeparat
EP0569462A1 (de) * 1991-01-25 1993-11-18 Novo Nordisk A/S Verfahren zum trennen von zwei feststoffkomponenten
EP0618979A1 (de) * 1991-12-19 1994-10-12 Gist-Brocades B.V. Verbesserte methode zur herstellung von bestimmten -g(b)-lactam-antibiotika

Also Published As

Publication number Publication date
EP0839192B1 (de) 2008-12-10
CN1190990A (zh) 1998-08-19
JP2001527381A (ja) 2001-12-25
WO1997004086A1 (en) 1997-02-06
CN1572873A (zh) 2005-02-02
DK0839192T3 (da) 2009-04-06
ES2318851T3 (es) 2009-05-01
CN1165616C (zh) 2004-09-08
EP0839192A1 (de) 1998-05-06
AU6659296A (en) 1997-02-18
ATE417100T1 (de) 2008-12-15
MX9800406A (es) 1998-09-30

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