HUE036242T2 - Eljárás cefradin elõállítására - Google Patents

Eljárás cefradin elõállítására

Info

Publication number
HUE036242T2
HUE036242T2 HUE04740631A HUE04740631A HUE036242T2 HU E036242 T2 HUE036242 T2 HU E036242T2 HU E04740631 A HUE04740631 A HU E04740631A HU E04740631 A HUE04740631 A HU E04740631A HU E036242 T2 HUE036242 T2 HU E036242T2
Authority
HU
Hungary
Prior art keywords
cephradine
preparation
Prior art date
Application number
HUE04740631A
Other languages
English (en)
Inventor
Carlos Lenhardt
Harold Moody
Van Dooren
Dennis Heemskerk
Anja Gerarda Margaretha Hogenboom
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of HUE036242T2 publication Critical patent/HUE036242T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HUE04740631A 2003-07-03 2004-07-01 Eljárás cefradin elõállítására HUE036242T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03077102 2003-07-03
EP03104445 2003-11-28

Publications (1)

Publication Number Publication Date
HUE036242T2 true HUE036242T2 (hu) 2018-06-28

Family

ID=33566322

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE04740631A HUE036242T2 (hu) 2003-07-03 2004-07-01 Eljárás cefradin elõállítására

Country Status (9)

Country Link
US (1) US7588913B2 (hu)
EP (1) EP1641933B1 (hu)
BR (1) BRPI0412302A (hu)
DK (1) DK1641933T3 (hu)
HR (1) HRP20180435T1 (hu)
HU (1) HUE036242T2 (hu)
LT (1) LT1641933T (hu)
SI (1) SI1641933T1 (hu)
WO (1) WO2005003367A2 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2367940T1 (en) * 2008-12-23 2018-04-30 Dsm Sinochem Pharmaceuticals Netherlands B.V. Mutated penicillin G acylase
CN102656274B (zh) 2009-12-14 2014-10-15 中化帝斯曼制药有限公司荷兰公司 生产头孢拉定的方法
CN103667418B (zh) * 2013-12-18 2015-03-25 华北制药河北华民药业有限责任公司 高活性β-内酰胺抗生素合成用酶的高通量筛选方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485819A (en) 1968-07-02 1969-12-23 Squibb & Sons Inc Alpha-amino-cyclohexadienylalkylene-penicillins and cephalosporins
US3819620A (en) * 1972-06-01 1974-06-25 Squibb & Sons Inc 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacet-amido)desacetoxycephalosporanic acid dihydrate
JPS51133488A (en) 1975-05-14 1976-11-19 Shionogi & Co Ltd Process for producing antibiotics enzymatically
IT1065387B (it) * 1976-12-16 1985-02-25 Dobfar Spa Proccedimento per la preparazione di cefalosporine
US5034522A (en) 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
US5278157A (en) * 1989-07-10 1994-01-11 Gema, S.A. Stable cephradine hydrate
ES2023560A6 (es) 1989-07-10 1992-01-16 Gema Sa Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
ES2139923T3 (es) * 1994-07-18 2000-02-16 Dsm Nv Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.
ATE417100T1 (de) * 1995-07-18 2008-12-15 Dsm Ip Assets Bv Eine verbesserte immobilisierte penicillin g acylase
AU8021398A (en) 1997-06-10 1998-12-30 Gist-Brocades B.V. Application of reducing sulphur compounds during enzymatic preparation of beta-lactam compounds
AU1234999A (en) * 1997-11-10 1999-05-31 Gist-Brocades B.V. Crystallization of beta-lactam compounds
NL1007828C2 (nl) 1997-12-18 1999-06-21 Dsm Nv Complexen van beta-lactam antibiotica en 1-naftol.
EP0997199A1 (en) 1998-10-26 2000-05-03 Dsm N.V. Method for separation of solid compounds in suspension
EP1456370A2 (en) * 2001-12-27 2004-09-15 DSM IP Assets B.V. Process for the preparation of a beta-lactam antibiotic with mutated penicillin acylase
EP1458727B1 (en) 2001-12-27 2005-08-31 DSM IP Assets B.V. Process for the stabilization of an acidic aqueous phase comprising cephradine

Also Published As

Publication number Publication date
DK1641933T3 (en) 2018-03-26
EP1641933A2 (en) 2006-04-05
WO2005003367A3 (en) 2005-05-26
HRP20180435T1 (hr) 2018-04-20
SI1641933T1 (en) 2018-04-30
US20060189802A1 (en) 2006-08-24
US7588913B2 (en) 2009-09-15
EP1641933B1 (en) 2017-12-20
WO2005003367A2 (en) 2005-01-13
LT1641933T (lt) 2018-04-10
BRPI0412302A (pt) 2006-06-13

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