DE69637444D1 - Imide als PDE III, PDE IV und TNF Inhibitoren - Google Patents

Imide als PDE III, PDE IV und TNF Inhibitoren

Info

Publication number
DE69637444D1
DE69637444D1 DE69637444T DE69637444T DE69637444D1 DE 69637444 D1 DE69637444 D1 DE 69637444D1 DE 69637444 T DE69637444 T DE 69637444T DE 69637444 T DE69637444 T DE 69637444T DE 69637444 D1 DE69637444 D1 DE 69637444D1
Authority
DE
Germany
Prior art keywords
lower alkyl
alkoxy
unsubstituted
substituted
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69637444T
Other languages
English (en)
Other versions
DE69637444T2 (de
Inventor
George W Muller
Mary Shire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of DE69637444D1 publication Critical patent/DE69637444D1/de
Application granted granted Critical
Publication of DE69637444T2 publication Critical patent/DE69637444T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE69637444T 1995-12-26 1996-12-24 Imide als PDE III, PDE IV und TNF Inhibitoren Expired - Fee Related DE69637444T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US578738 1995-12-26
US08/578,738 US5728844A (en) 1995-08-29 1995-12-26 Immunotherapeutic agents

Publications (2)

Publication Number Publication Date
DE69637444D1 true DE69637444D1 (de) 2008-04-03
DE69637444T2 DE69637444T2 (de) 2009-03-05

Family

ID=24314105

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69632595T Expired - Fee Related DE69632595T2 (de) 1995-12-26 1996-12-24 Imide als pde iii, pde iv und tnf inhibitoren
DE69637444T Expired - Fee Related DE69637444T2 (de) 1995-12-26 1996-12-24 Imide als PDE III, PDE IV und TNF Inhibitoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69632595T Expired - Fee Related DE69632595T2 (de) 1995-12-26 1996-12-24 Imide als pde iii, pde iv und tnf inhibitoren

Country Status (22)

Country Link
US (1) US5728844A (de)
EP (2) EP0874819B1 (de)
JP (1) JP4159109B2 (de)
KR (1) KR100450005B1 (de)
CN (1) CN1092640C (de)
AT (2) ATE386719T1 (de)
AU (1) AU723331B2 (de)
CA (1) CA2241688A1 (de)
CZ (1) CZ299090B6 (de)
DE (2) DE69632595T2 (de)
DK (2) DK0874819T3 (de)
ES (2) ES2222487T3 (de)
FI (1) FI981437A (de)
HK (2) HK1017620A1 (de)
HU (1) HUP9901780A3 (de)
IL (1) IL125086A (de)
NZ (1) NZ326578A (de)
PL (1) PL327585A1 (de)
PT (2) PT874819E (de)
RU (1) RU2174512C2 (de)
SK (1) SK88898A3 (de)
WO (1) WO1997023457A1 (de)

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* Cited by examiner, † Cited by third party
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AU723331B2 (en) 2000-08-24
DK0874819T3 (da) 2004-09-06
HUP9901780A3 (en) 2001-01-29
ATE267806T1 (de) 2004-06-15
JP4159109B2 (ja) 2008-10-01
EP0874819A1 (de) 1998-11-04
WO1997023457A1 (en) 1997-07-03
PT874819E (pt) 2004-10-29
EP0874819B1 (de) 2004-05-26
CZ299090B6 (cs) 2008-04-23
DE69632595D1 (de) 2004-07-01
HUP9901780A2 (hu) 1999-10-28
FI981437A0 (fi) 1996-12-24
SK88898A3 (en) 1998-12-02
CN1206405A (zh) 1999-01-27
IL125086A0 (en) 1999-01-26
IL125086A (en) 2002-11-10
RU2174512C2 (ru) 2001-10-10
KR100450005B1 (ko) 2005-01-15
US5728844A (en) 1998-03-17
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NZ326578A (en) 1999-10-28
HK1017620A1 (en) 1999-11-26
EP1468991A1 (de) 2004-10-20
EP1468991B1 (de) 2008-02-20
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JP2000502350A (ja) 2000-02-29
CZ202598A3 (cs) 2000-01-12
HK1072250A1 (en) 2005-08-19
FI981437A (fi) 1998-08-25
CA2241688A1 (en) 1997-07-03
KR19990076785A (ko) 1999-10-15
PT1468991E (pt) 2008-05-16
DE69632595T2 (de) 2005-06-23
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DK1468991T3 (da) 2008-06-16
PL327585A1 (en) 1998-12-21

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