GB1475513A - Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them - Google Patents

Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Info

Publication number
GB1475513A
GB1475513A GB2739274A GB2739274A GB1475513A GB 1475513 A GB1475513 A GB 1475513A GB 2739274 A GB2739274 A GB 2739274A GB 2739274 A GB2739274 A GB 2739274A GB 1475513 A GB1475513 A GB 1475513A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
benzylamine derivatives
lower alkyl
derivatives process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2739274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB2739274A priority Critical patent/GB1475513A/en
Priority to CA229,350A priority patent/CA1062265A/en
Priority to DE19752526965 priority patent/DE2526965A1/en
Priority to IE1361/75A priority patent/IE41382B1/en
Priority to SE7507018A priority patent/SE7507018L/en
Priority to FI751825A priority patent/FI751825A/fi
Priority to DK274375AA priority patent/DK136313B/en
Priority to JP50074996A priority patent/JPS5231341B2/ja
Priority to ZA00753943A priority patent/ZA753943B/en
Priority to AT471675A priority patent/AT342046B/en
Priority to AU82246/75A priority patent/AU497501B2/en
Priority to BE157510A priority patent/BE830442A/en
Priority to CH801275A priority patent/CH597206A5/xx
Priority to FR7519164A priority patent/FR2275207A1/en
Priority to SU7502145925A priority patent/SU578880A3/en
Priority to HU75SI1474A priority patent/HU173390B/en
Priority to ES438757A priority patent/ES438757A1/en
Priority to NL7507422A priority patent/NL7507422A/en
Priority to DK141377A priority patent/DK138742B/en
Priority to DK141477A priority patent/DK141477A/en
Publication of GB1475513A publication Critical patent/GB1475513A/en
Priority to AT402777A priority patent/AT349464B/en
Priority to SE7900681A priority patent/SE7900681L/en
Priority to CA332,309A priority patent/CA1078869A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1475513 Oxazolines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 20 June 1975 [20 June 1974] 27392/74 Heading C2C Novel compounds of Formula I in which X is a hydrogen or halogen atom or a trifluoromethyl radical, R 1 is a lower alkyl radical or a lower cycloalkyl radical, R 2 is a hydrogen atom or a lower alkyl radical, and R 3 and R 4 , which may be the same or different, are hydrogen atoms or lower alkyl radicals or together form an alkylene group having from 3 to 6 carbon atoms where "lower" denotes group containing up to 6 carbon atoms on salts thereof are prepared by cyclization of a compound of Formula II #-Haloethyl urens of Formula II above are prepared by reacting a compound of Formula III with a compound of formula Starting materials of Formula III are obtained by reduction of an oxime formed from an R 1 COPh(X)CF 3 ketone or by reaction of cyanogen bromide with the alcohol obtained by reduction of such a ketone. Pharmaceutical compositions in conventional forms for buccil, rectal, sublingual or parenteral administration and having anti-hypertensive activity comprises an above novel compound and a carrier or diluent.
GB2739274A 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them Expired GB1475513A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB2739274A GB1475513A (en) 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them
CA229,350A CA1062265A (en) 1974-06-20 1975-06-13 Process of preparation of new benzylamines
DE19752526965 DE2526965A1 (en) 1974-06-20 1975-06-16 BENZYLAMINE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND
IE1361/75A IE41382B1 (en) 1974-06-20 1975-06-17 Benzylamine derivatives process for their production and pharmaceutical compositions containing them
SE7507018A SE7507018L (en) 1974-06-20 1975-06-18 WAY TO PRODUCE NEW BENZYLAMINES.
FI751825A FI751825A (en) 1974-06-20 1975-06-18
DK274375AA DK136313B (en) 1974-06-20 1975-06-18 Analogous process for the preparation of N-substituted m-trifluoromethylbenzylamines.
BE157510A BE830442A (en) 1974-06-20 1975-06-19 NEW BENZYLAMINES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING
ZA00753943A ZA753943B (en) 1974-06-20 1975-06-19 Novel benzylamines, a process for making them and pharmaceutical compositions
AT471675A AT342046B (en) 1974-06-20 1975-06-19 METHOD FOR PRODUCING NEW N-BENZYLAMINOOXAZOLINES
AU82246/75A AU497501B2 (en) 1974-06-20 1975-06-19 Benzylamines
JP50074996A JPS5231341B2 (en) 1974-06-20 1975-06-19
CH801275A CH597206A5 (en) 1974-06-20 1975-06-19
FR7519164A FR2275207A1 (en) 1974-06-20 1975-06-19 NEW BENZYLAMINES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING
SU7502145925A SU578880A3 (en) 1974-06-20 1975-06-19 Method of preparing benzilaminooxazolines or their salts or their optical isomers
HU75SI1474A HU173390B (en) 1974-06-20 1975-06-19 Process for producing new benzylamine derivatives
ES438757A ES438757A1 (en) 1974-06-20 1975-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them
NL7507422A NL7507422A (en) 1974-06-20 1975-06-20 PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH BLOOD PRESSURE-LOWERING ACTION, SUCH MEDICINAL PRODUCT AND A PROCESS FOR PREPARING THE ACTIVE COMPOUNDS.
DK141377A DK138742B (en) 1974-06-20 1977-03-31 Process for the preparation of 2-aminooxazoline derivatives.
DK141477A DK141477A (en) 1974-06-20 1977-03-31 M-TRIFLUOROMETHYLBENZYLAMINE COMPOUNDS FOR USE AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF N-SUBSTITUTED M-TRIFLUOROMETHYLBENZYLAMINES
AT402777A AT349464B (en) 1974-06-20 1977-06-07 PROCESS FOR THE PRODUCTION OF NEW N-BENZYLAMINO-OXAZOLINES
SE7900681A SE7900681L (en) 1974-06-20 1979-01-25 SUBSTITUTED TRIFLUOROMETHYL BENZYLCARBAMIDES FOR USE AS INTERMEDIATE PRODUCTS FOR THE PREPARATION OF NITROGEN-SUBSTITUTED TRIFLUOROMETHYL BENZYLAMINES AND METHODS OF PREPARING URBAN
CA332,309A CA1078869A (en) 1974-06-20 1979-07-20 Process for the preparation of novel benzylamines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2739274A GB1475513A (en) 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1475513A true GB1475513A (en) 1977-06-01

Family

ID=10258850

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2739274A Expired GB1475513A (en) 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Country Status (18)

Country Link
JP (1) JPS5231341B2 (en)
AT (1) AT342046B (en)
AU (1) AU497501B2 (en)
BE (1) BE830442A (en)
CA (1) CA1062265A (en)
CH (1) CH597206A5 (en)
DE (1) DE2526965A1 (en)
DK (1) DK136313B (en)
ES (1) ES438757A1 (en)
FI (1) FI751825A (en)
FR (1) FR2275207A1 (en)
GB (1) GB1475513A (en)
HU (1) HU173390B (en)
IE (1) IE41382B1 (en)
NL (1) NL7507422A (en)
SE (2) SE7507018L (en)
SU (1) SU578880A3 (en)
ZA (1) ZA753943B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951247A1 (en) * 1978-12-20 1980-07-03 Science Union & Cie N-SUBSTITUTED TRIFLUORAETHYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358890A1 (en) * 1976-05-24 1978-02-17 Science Union & Cie NEW ARYL TRIFLUOROETHYLAMINES, THEIR METHODS OF OBTAINING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING
JPS53105752U (en) * 1977-01-31 1978-08-25
JPS5495252A (en) * 1978-01-11 1979-07-27 Oki Electric Ind Co Ltd Thermal printer
JPS57136755U (en) * 1981-02-20 1982-08-26
AUPP020297A0 (en) * 1997-11-05 1997-11-27 University Of Melbourne, The A novel receptor, and compounds which bind thereto

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951247A1 (en) * 1978-12-20 1980-07-03 Science Union & Cie N-SUBSTITUTED TRIFLUORAETHYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT

Also Published As

Publication number Publication date
AU8224675A (en) 1976-12-23
SE7900681L (en) 1979-01-25
HU173390B (en) 1979-04-28
SE7507018L (en) 1975-12-22
AU497501B2 (en) 1978-12-14
AT342046B (en) 1978-03-10
SU578880A3 (en) 1977-10-30
DE2526965A1 (en) 1976-01-02
IE41382B1 (en) 1979-12-19
FI751825A (en) 1975-12-21
ES438757A1 (en) 1977-03-16
FR2275207A1 (en) 1976-01-16
CA1062265A (en) 1979-09-11
BE830442A (en) 1975-12-19
IE41382L (en) 1975-12-20
ATA471675A (en) 1977-07-15
CH597206A5 (en) 1978-03-31
FR2275207B1 (en) 1979-08-10
NL7507422A (en) 1975-12-23
DK136313B (en) 1977-09-26
JPS5231341B2 (en) 1977-08-13
DK136313C (en) 1978-02-20
DK274375A (en) 1975-12-21
ZA753943B (en) 1976-06-30
JPS5116662A (en) 1976-02-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee