IE41382B1 - Benzylamine derivatives process for their production and pharmaceutical compositions containing them - Google Patents

Benzylamine derivatives process for their production and pharmaceutical compositions containing them

Info

Publication number
IE41382B1
IE41382B1 IE1361/75A IE136175A IE41382B1 IE 41382 B1 IE41382 B1 IE 41382B1 IE 1361/75 A IE1361/75 A IE 1361/75A IE 136175 A IE136175 A IE 136175A IE 41382 B1 IE41382 B1 IE 41382B1
Authority
IE
Ireland
Prior art keywords
formula
compound
lower alkyl
radical
pharmaceutical compositions
Prior art date
Application number
IE1361/75A
Other versions
IE41382L (en
Original Assignee
Science Union & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union & Cie filed Critical Science Union & Cie
Publication of IE41382L publication Critical patent/IE41382L/en
Publication of IE41382B1 publication Critical patent/IE41382B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

1475513 Oxazolines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 20 June 1975 [20 June 1974] 27392/74 Heading C2C Novel compounds of Formula I in which X is a hydrogen or halogen atom or a trifluoromethyl radical, R 1 is a lower alkyl radical or a lower cycloalkyl radical, R 2 is a hydrogen atom or a lower alkyl radical, and R 3 and R 4 , which may be the same or different, are hydrogen atoms or lower alkyl radicals or together form an alkylene group having from 3 to 6 carbon atoms where "lower" denotes group containing up to 6 carbon atoms on salts thereof are prepared by cyclization of a compound of Formula II #-Haloethyl urens of Formula II above are prepared by reacting a compound of Formula III with a compound of formula Starting materials of Formula III are obtained by reduction of an oxime formed from an R 1 COPh(X)CF 3 ketone or by reaction of cyanogen bromide with the alcohol obtained by reduction of such a ketone. Pharmaceutical compositions in conventional forms for buccil, rectal, sublingual or parenteral administration and having anti-hypertensive activity comprises an above novel compound and a carrier or diluent. [GB1475513A]
IE1361/75A 1974-06-20 1975-06-17 Benzylamine derivatives process for their production and pharmaceutical compositions containing them IE41382B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2739274A GB1475513A (en) 1974-06-20 1974-06-20 Benzylamine derivatives process for science union et cie benzylamine derivatives process for their production and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IE41382L IE41382L (en) 1975-12-20
IE41382B1 true IE41382B1 (en) 1979-12-19

Family

ID=10258850

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1361/75A IE41382B1 (en) 1974-06-20 1975-06-17 Benzylamine derivatives process for their production and pharmaceutical compositions containing them

Country Status (18)

Country Link
JP (1) JPS5231341B2 (en)
AT (1) AT342046B (en)
AU (1) AU497501B2 (en)
BE (1) BE830442A (en)
CA (1) CA1062265A (en)
CH (1) CH597206A5 (en)
DE (1) DE2526965A1 (en)
DK (1) DK136313B (en)
ES (1) ES438757A1 (en)
FI (1) FI751825A (en)
FR (1) FR2275207A1 (en)
GB (1) GB1475513A (en)
HU (1) HU173390B (en)
IE (1) IE41382B1 (en)
NL (1) NL7507422A (en)
SE (2) SE7507018L (en)
SU (1) SU578880A3 (en)
ZA (1) ZA753943B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358890A1 (en) * 1976-05-24 1978-02-17 Science Union & Cie NEW ARYL TRIFLUOROETHYLAMINES, THEIR METHODS OF OBTAINING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING
JPS53105752U (en) * 1977-01-31 1978-08-25
JPS5495252A (en) * 1978-01-11 1979-07-27 Oki Electric Ind Co Ltd Thermal printer
FR2444673A1 (en) * 1978-12-20 1980-07-18 Science Union & Cie NOVEL TRIFLUOROETHYLAMINES, PROCESSES FOR OBTAINING SAME AND THEIR USE AS MEDICAMENTS
JPS57136755U (en) * 1981-02-20 1982-08-26
AUPP020297A0 (en) * 1997-11-05 1997-11-27 University Of Melbourne, The A novel receptor, and compounds which bind thereto

Also Published As

Publication number Publication date
AU8224675A (en) 1976-12-23
GB1475513A (en) 1977-06-01
AT342046B (en) 1978-03-10
ES438757A1 (en) 1977-03-16
FR2275207A1 (en) 1976-01-16
DE2526965A1 (en) 1976-01-02
FR2275207B1 (en) 1979-08-10
BE830442A (en) 1975-12-19
JPS5231341B2 (en) 1977-08-13
CH597206A5 (en) 1978-03-31
SE7900681L (en) 1979-01-25
DK274375A (en) 1975-12-21
SE7507018L (en) 1975-12-22
NL7507422A (en) 1975-12-23
IE41382L (en) 1975-12-20
SU578880A3 (en) 1977-10-30
CA1062265A (en) 1979-09-11
DK136313B (en) 1977-09-26
ZA753943B (en) 1976-06-30
JPS5116662A (en) 1976-02-10
FI751825A (en) 1975-12-21
AU497501B2 (en) 1978-12-14
ATA471675A (en) 1977-07-15
DK136313C (en) 1978-02-20
HU173390B (en) 1979-04-28

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