DE69623223D1 - Methode zur massenproduktion von taxol mittels semi-kontinuierlicher kultur - Google Patents

Methode zur massenproduktion von taxol mittels semi-kontinuierlicher kultur

Info

Publication number
DE69623223D1
DE69623223D1 DE69623223T DE69623223T DE69623223D1 DE 69623223 D1 DE69623223 D1 DE 69623223D1 DE 69623223 T DE69623223 T DE 69623223T DE 69623223 T DE69623223 T DE 69623223T DE 69623223 D1 DE69623223 D1 DE 69623223D1
Authority
DE
Germany
Prior art keywords
taxol
semi
mass production
continuous culture
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69623223T
Other languages
English (en)
Other versions
DE69623223T2 (de
Inventor
Hyung-Kyoon Choi
Tom Lee Adams
Roy William Stahlhut
Sang-Ic Kim
Jeong-Hwan Yun
Bong-Kyu Song
Jin-Hyun Kim
Jun-Seog Song
Seung-Suh Hong
Hyun-Soo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Genex Corp
Original Assignee
Samyang Genex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19413178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69623223(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samyang Genex Corp filed Critical Samyang Genex Corp
Application granted granted Critical
Publication of DE69623223D1 publication Critical patent/DE69623223D1/de
Publication of DE69623223T2 publication Critical patent/DE69623223T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epoxy Compounds (AREA)
DE69623223T 1995-04-27 1996-04-27 Methode zur massenproduktion von taxol mittels semi-kontinuierlicher kultur Revoked DE69623223T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019950010204A KR960037826A (ko) 1995-04-27 1995-04-27 택서스속 식물세포의 반연속식 배양방법
PCT/KR1996/000060 WO1996034110A1 (en) 1995-04-27 1996-04-27 A method for mass production of taxol by semi-continuous culture

Publications (2)

Publication Number Publication Date
DE69623223D1 true DE69623223D1 (de) 2002-10-02
DE69623223T2 DE69623223T2 (de) 2003-04-30

Family

ID=19413178

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69623223T Revoked DE69623223T2 (de) 1995-04-27 1996-04-27 Methode zur massenproduktion von taxol mittels semi-kontinuierlicher kultur
DE69635873T Expired - Lifetime DE69635873T2 (de) 1995-04-27 1996-04-27 Verfahren zur Massenproduktion von Taxol mittels Induktion

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69635873T Expired - Lifetime DE69635873T2 (de) 1995-04-27 1996-04-27 Verfahren zur Massenproduktion von Taxol mittels Induktion

Country Status (8)

Country Link
US (1) US5871979A (de)
EP (2) EP1164197B1 (de)
JP (2) JP3066873B2 (de)
KR (1) KR960037826A (de)
CN (2) CN1084390C (de)
AU (1) AU5516696A (de)
DE (2) DE69623223T2 (de)
WO (1) WO1996034110A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR20100070388A (ko) 1996-05-24 2010-06-25 디에프비 바이오테크 인코포레이티드 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
WO2006129988A1 (en) * 2005-06-03 2006-12-07 Samyang Genex Corporation Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medicum
EP2414509B1 (de) 2009-04-03 2015-09-23 DianaPlantSciences S.A.S. Herstellung und extraktion von procyanidinen aus pflanzenzellkulturen
CN101696436B (zh) * 2009-10-30 2011-09-28 广东科伦药业有限公司 培养红豆杉植物细胞生产紫杉醇的专用培养基
CN103237457A (zh) 2010-10-04 2013-08-07 戴安娜植物科学有限公司 从植物细胞培养物产生和提取原花青素
CN105349592B (zh) * 2015-12-09 2018-11-27 天津艾赛博生物技术有限公司 代谢互补的植物细胞系混种培养生产次级代谢产物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3539180A1 (de) * 1985-11-05 1987-05-07 Consortium Elektrochem Ind Aureobasidium-pullulans-stamm, herstellungsverfahren und verwendung
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
JPH05507629A (ja) * 1991-02-12 1993-11-04 新日本製鐵株式会社 イチイの組織培養によるタキソールの生産方法
US5344775A (en) * 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
WO1993019585A1 (en) * 1992-04-01 1993-10-14 Union Camp Corporation Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
WO1995014103A1 (fr) * 1993-11-15 1995-05-26 Mitsui Petrochemical Industries, Ltd. Procede de production de diterpene de taxane et procede de recolte de cellules de culture capables de produire du diterpene de taxane a haut rendement

Also Published As

Publication number Publication date
JP2000197497A (ja) 2000-07-18
JPH10504726A (ja) 1998-05-12
EP0769064B1 (de) 2002-08-28
CN1084390C (zh) 2002-05-08
CN1153533A (zh) 1997-07-02
DE69635873D1 (de) 2006-05-04
AU5516696A (en) 1996-11-18
JP3331204B2 (ja) 2002-10-07
DE69635873T2 (de) 2006-11-23
CN1184322C (zh) 2005-01-12
EP1164197B1 (de) 2006-03-08
DE69623223T2 (de) 2003-04-30
EP0769064A1 (de) 1997-04-23
JP3066873B2 (ja) 2000-07-17
CN1394961A (zh) 2003-02-05
EP1164197A1 (de) 2001-12-19
WO1996034110A1 (en) 1996-10-31
KR960037826A (ko) 1996-11-19
US5871979A (en) 1999-02-16

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation