DE69621598D1 - Suksdorfinanaloge, diese enthaltende mittel sowie verfahren zu deren herstellung und verwendung - Google Patents

Suksdorfinanaloge, diese enthaltende mittel sowie verfahren zu deren herstellung und verwendung

Info

Publication number
DE69621598D1
DE69621598D1 DE69621598T DE69621598T DE69621598D1 DE 69621598 D1 DE69621598 D1 DE 69621598D1 DE 69621598 T DE69621598 T DE 69621598T DE 69621598 T DE69621598 T DE 69621598T DE 69621598 D1 DE69621598 D1 DE 69621598D1
Authority
DE
Germany
Prior art keywords
alkyl
acyl
compounds
ocf3
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69621598T
Other languages
English (en)
Other versions
DE69621598T2 (de
Inventor
Kuo-Hsiung Lee
Mark Cosentino
Lan Xie
Mark Manak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
VI Technologies Inc
Original Assignee
University of North Carolina at Chapel Hill
Panacos Pharmaceuticals Inc
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, Panacos Pharmaceuticals Inc, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Publication of DE69621598D1 publication Critical patent/DE69621598D1/de
Application granted granted Critical
Publication of DE69621598T2 publication Critical patent/DE69621598T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69621598T 1995-02-21 1996-02-21 Suksdorfinanaloge, diese enthaltende mittel sowie verfahren zu deren herstellung und verwendung Expired - Fee Related DE69621598T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/392,558 US5637589A (en) 1993-10-29 1995-02-21 Suksdorfin, analogs, compositions thereof, and methods for making and using thereof
PCT/US1996/002441 WO1996025930A1 (en) 1995-02-21 1996-02-21 Suksdorfin analogs, compositions thereof, and methods for making and using thereof

Publications (2)

Publication Number Publication Date
DE69621598D1 true DE69621598D1 (de) 2002-07-11
DE69621598T2 DE69621598T2 (de) 2003-08-14

Family

ID=23551064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621598T Expired - Fee Related DE69621598T2 (de) 1995-02-21 1996-02-21 Suksdorfinanaloge, diese enthaltende mittel sowie verfahren zu deren herstellung und verwendung

Country Status (9)

Country Link
US (3) US5637589A (de)
EP (1) EP0810861B1 (de)
AT (1) ATE218338T1 (de)
AU (1) AU4993496A (de)
CA (1) CA2213519C (de)
DE (1) DE69621598T2 (de)
ES (1) ES2177767T3 (de)
PT (1) PT810861E (de)
WO (1) WO1996025930A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IN190036B (de) * 1998-05-29 2003-05-31 Council Scient Ind Res
WO1999066936A1 (en) * 1998-06-24 1999-12-29 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US6274635B1 (en) 1999-03-22 2001-08-14 Immugen Pharmaceuticals Inc. Alkylated resorcinol derivatives for the treatment of immune diseases
PT1230232E (pt) 1999-11-05 2004-07-30 Cytovia Inc 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao
KR100365293B1 (ko) * 2000-04-17 2002-12-18 한국과학기술연구원 알릴화된 방향족 화합물 및 피라노쿠마린 화합물의 제조방법
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6768007B2 (en) 2001-03-13 2004-07-27 Panacos Pharmaceuticals, Inc. Substituted 3′,4′-di-O-camphanoyl-(+)-cis-khellactone analogs, compositions thereof, and methods for using thereof
US7015328B2 (en) * 2001-05-16 2006-03-21 Cytovia, Inc. Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6858607B1 (en) 2001-05-16 2005-02-22 Cytovia, Inc. 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
ES2337558T3 (es) * 2001-05-16 2010-04-27 Cytovia, Inc. 4-h-cromenos sustituidos y analagos como activadores de caspasas e inductores de apoptosis y uso como agentes anticancerigenos.
CN1652766A (zh) * 2002-03-18 2005-08-10 免疫力药品有限公司 间苯二酚和大麻素的局部制剂及其施用方法
AU2003241482A1 (en) * 2002-05-16 2003-12-02 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN100349887C (zh) * 2002-05-16 2007-11-21 西托维亚公司 取代的4－芳基－4h－吡咯并[2,3－h]色烯和类似物及其药物组合物和用途
US20040162337A1 (en) * 2003-01-30 2004-08-19 Fong Wang Fun Chemical compounds having therapeutic activities in treating cancer
WO2006026853A1 (en) * 2004-09-07 2006-03-16 Bioniche Life Sciences Inc. Prickly ash preparations and uses thereof as antiviral agents
TW200837074A (en) 2006-11-03 2008-09-16 Panacos Pharmaceuticals Inc Extended triterpene derivatives
CN101407522A (zh) * 2007-10-12 2009-04-15 中国人民解放军军事医学科学院毒物药物研究所 邪蒿素及其衍生物的制备方法
US20090111836A1 (en) * 2007-10-31 2009-04-30 City University Of Hong Kong Angular Pyranocoumarins, Process for Preparation and Uses Thereof
CN111184715B (zh) * 2020-02-25 2022-11-08 中山大学附属第七医院(深圳) 佛手苷内酯在制备hiv-1潜伏感染逆转剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980699A (en) * 1957-12-20 1961-04-18 S B Penick And Company Dihydropyranocoumarin derivatives and process for their production
US5089634A (en) * 1984-08-20 1992-02-18 Georgia Tech Research Corporation Isocoumarins with cationic substituents
US5324648A (en) * 1987-04-28 1994-06-28 Georgia Tech Research Corporation Substituted isocoumarins as serine protease inhibitors and anti-inflammatory agents
JPH03503635A (ja) * 1988-03-01 1991-08-15 ジ・アップジョン・カンパニー ヒトにおいて逆転写酵素を抑制するクマリン類
US5177073A (en) * 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
JPH03227923A (ja) * 1990-01-30 1991-10-08 Sawai Seiyaku Kk ひと免疫不全ウイルス疾患処置剤
CA2098609A1 (en) * 1990-12-28 1992-06-29 Raymond T. Bartus Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
EP0533902A1 (de) * 1991-04-10 1993-03-31 Octamer, Inc. Verfahren zur Hemmung der Retroviral Replikation
HU219914B (hu) * 1992-09-21 2001-09-28 BIOGAL Gyógyszergyár Rt. Eljárás flavíliumszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
WO1994014789A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
AU8132094A (en) * 1994-04-29 1995-11-29 Biotech Research Laboratories Khellactone derivatives and related compounds, process for their preparation and their use as antiviral and immunostimulating agents

Also Published As

Publication number Publication date
AU4993496A (en) 1996-09-11
CA2213519C (en) 2009-01-06
WO1996025930A1 (en) 1996-08-29
EP0810861A4 (de) 1998-07-08
DE69621598T2 (de) 2003-08-14
ATE218338T1 (de) 2002-06-15
EP0810861B1 (de) 2002-06-05
US5637589A (en) 1997-06-10
US5847165A (en) 1998-12-08
ES2177767T3 (es) 2002-12-16
CA2213519A1 (en) 1996-08-29
US5726204A (en) 1998-03-10
EP0810861A1 (de) 1997-12-10
PT810861E (pt) 2002-11-29

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, CHAPE

Owner name: V.I. TECHNOLOGIES, INC. (N.D.GES.D. STAATES DELAWA

8339 Ceased/non-payment of the annual fee