DE69610792T2 - Inhibitoren mit zweifacher Wirkung, die 1,2-Diazepin enthalten - Google Patents

Inhibitoren mit zweifacher Wirkung, die 1,2-Diazepin enthalten

Info

Publication number
DE69610792T2
DE69610792T2 DE69610792T DE69610792T DE69610792T2 DE 69610792 T2 DE69610792 T2 DE 69610792T2 DE 69610792 T DE69610792 T DE 69610792T DE 69610792 T DE69610792 T DE 69610792T DE 69610792 T2 DE69610792 T2 DE 69610792T2
Authority
DE
Germany
Prior art keywords
diazepine
double
inhibitors containing
acting inhibitors
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69610792T
Other languages
English (en)
Other versions
DE69610792D1 (de
Inventor
Denis E Ryono
Chong-Qing Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69610792D1 publication Critical patent/DE69610792D1/de
Publication of DE69610792T2 publication Critical patent/DE69610792T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69610792T 1995-06-07 1996-05-28 Inhibitoren mit zweifacher Wirkung, die 1,2-Diazepin enthalten Expired - Fee Related DE69610792T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47404195A 1995-06-07 1995-06-07

Publications (2)

Publication Number Publication Date
DE69610792D1 DE69610792D1 (de) 2000-12-07
DE69610792T2 true DE69610792T2 (de) 2001-06-13

Family

ID=23881962

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69610792T Expired - Fee Related DE69610792T2 (de) 1995-06-07 1996-05-28 Inhibitoren mit zweifacher Wirkung, die 1,2-Diazepin enthalten

Country Status (11)

Country Link
US (1) US5635504A (de)
EP (1) EP0747392B1 (de)
JP (1) JPH08337527A (de)
AT (1) ATE197306T1 (de)
AU (1) AU696673B2 (de)
CA (1) CA2178355A1 (de)
DE (1) DE69610792T2 (de)
DK (1) DK0747392T3 (de)
ES (1) ES2151977T3 (de)
GR (1) GR3035239T3 (de)
PT (1) PT747392E (de)

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US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6340752B1 (en) 1998-01-06 2002-01-22 Bristol-Myers Squibb Co. Deprotection and recrystallization processes
JP4499917B2 (ja) * 1998-03-09 2010-07-14 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−１β変換酵素のインヒビターとしての１，２−ジアゼパン誘導体
WO2001055074A1 (fr) 2000-01-25 2001-08-02 Kaneka Corporation Processus de production d'acide carboxylique optiquement actif substitue en position 2
EP1138671B1 (de) * 2000-03-30 2004-09-01 Ajinomoto Co., Inc. Verfahren zur Herstellung von aromatischen Acylthiocarbonsäurederivaten
EP1275642A4 (de) * 2000-04-21 2004-12-08 Kaneka Corp Ein verfahren zur kristallisation von 2-acethylthio-3-phenyl-propansäure
NL1015714C2 (nl) * 2000-07-14 2002-01-15 Dsm Nv Werkwijze voor het kristalliseren van enantiomeer verrijkt 2-acetylthio-3-fenylpropaanzuur.
JP4718534B2 (ja) * 2007-11-09 2011-07-06 カルピス株式会社 Ｆｉｓｃｈｅｒ比低下抑制剤
CA2772877A1 (en) * 2009-09-01 2011-03-10 Lz Therapeutics, Inc. Treatment of glaucoma and other retinopathies with gangliosides
EP2473615B1 (de) 2009-09-01 2016-04-06 LZ Therapeutics, Inc. Herstellung von GM1 durch Zellkulturen (nicht vom Rind oder Schwein)
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US9556467B2 (en) 2012-01-20 2017-01-31 Garnet Bio Therapeutics, Inc. Methods of ganglioside production
CN102805751B (zh) * 2012-08-27 2014-07-02 澳门科技大学 治疗心脑血管疾病的药物组合物及其制备方法
EP3672939A1 (de) 2017-08-21 2020-07-01 Celgene Corporation Verfahren zur herstellung von (s)-tert-butyl 4,5-diamino-5-oxopentanoat
CN109111371B (zh) * 2018-09-27 2021-08-06 江西万里药业有限公司 一种肼基乙酸乙酯盐酸盐的制备方法

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FR2358891A1 (fr) * 1976-07-22 1978-02-17 Yamanouchi Pharma Co Ltd Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires
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Also Published As

Publication number Publication date
GR3035239T3 (en) 2001-04-30
PT747392E (pt) 2001-02-28
JPH08337527A (ja) 1996-12-24
EP0747392B1 (de) 2000-11-02
AU696673B2 (en) 1998-09-17
AU5476096A (en) 1996-12-19
DE69610792D1 (de) 2000-12-07
ES2151977T3 (es) 2001-01-16
US5635504A (en) 1997-06-03
EP0747392A1 (de) 1996-12-11
DK0747392T3 (da) 2001-01-29
CA2178355A1 (en) 1996-12-08
ATE197306T1 (de) 2000-11-15

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