DE69535530D1 - Impfstoff und Antitoxine zur Behandlung und Vorbeugung von C. Difficile Krankheiten - Google Patents

Impfstoff und Antitoxine zur Behandlung und Vorbeugung von C. Difficile Krankheiten

Info

Publication number
DE69535530D1
DE69535530D1 DE69535530T DE69535530T DE69535530D1 DE 69535530 D1 DE69535530 D1 DE 69535530D1 DE 69535530 T DE69535530 T DE 69535530T DE 69535530 T DE69535530 T DE 69535530T DE 69535530 D1 DE69535530 D1 DE 69535530D1
Authority
DE
Germany
Prior art keywords
antitoxins
difficile
treatment
humans
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535530T
Other languages
English (en)
Inventor
James A Williams
Nisha V Padhye
Bruce S Thalley
Douglas C Stafford
Joseph R Firca
John A Kink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Ophidian Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/405,496 external-priority patent/US5919665A/en
Priority claimed from US08/480,604 external-priority patent/US5736139A/en
Application filed by Ophidian Pharmaceuticals Inc filed Critical Ophidian Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69535530D1 publication Critical patent/DE69535530D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE69535530T 1994-10-24 1995-10-23 Impfstoff und Antitoxine zur Behandlung und Vorbeugung von C. Difficile Krankheiten Expired - Lifetime DE69535530D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32915494A 1994-10-24 1994-10-24
US08/405,496 US5919665A (en) 1989-10-31 1995-03-16 Vaccine for clostridium botulinum neurotoxin
US42271195A 1995-04-14 1995-04-14
US08/480,604 US5736139A (en) 1989-10-31 1995-06-07 Treatment of Clostridium difficile induced disease

Publications (1)

Publication Number Publication Date
DE69535530D1 true DE69535530D1 (de) 2007-08-16

Family

ID=27502393

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535530T Expired - Lifetime DE69535530D1 (de) 1994-10-24 1995-10-23 Impfstoff und Antitoxine zur Behandlung und Vorbeugung von C. Difficile Krankheiten

Country Status (17)

Country Link
US (1) US6290960B1 (de)
EP (2) EP1041149B8 (de)
JP (2) JP2002514886A (de)
CN (1) CN1176658A (de)
AT (1) ATE366312T1 (de)
AU (1) AU709586B2 (de)
BR (1) BR9509903A (de)
CA (1) CA2203504A1 (de)
CZ (1) CZ296806B6 (de)
DE (1) DE69535530D1 (de)
FI (1) FI971732A (de)
HU (1) HUT78048A (de)
MX (1) MX9702955A (de)
NO (1) NO323305B1 (de)
NZ (2) NZ337543A (de)
PL (1) PL320214A1 (de)
WO (1) WO1996012802A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214787B1 (en) * 1993-09-21 2007-05-08 United States Of America As Represented By The Secretary Of The Army Recombinant vaccine against botulinum neurotoxin
GB9508204D0 (en) 1995-04-21 1995-06-07 Speywood Lab Ltd A novel agent able to modify peripheral afferent function
US7192596B2 (en) 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
US8012491B2 (en) 1996-08-23 2011-09-06 Syntaxin, Ltd. Recombinant toxin fragments
GB9617671D0 (en) 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
WO1998008540A1 (en) * 1996-08-28 1998-03-05 Ophidian Pharmaceuticals, Inc. Multivalent vaccine for clostridium botulinum neurotoxin
JP2001500730A (ja) * 1996-09-10 2001-01-23 ヘンリー エム ジャクソン ファンデーション フォージ アドバンスメント オブ ミリタリー メディシン ヒスチジン―タグ付き志賀毒素およびトキソイド、該毒素およびトキソイドとの融合タンパク質ならびにそれらの精製及び調製方法
WO1998023763A1 (en) * 1996-11-29 1998-06-04 The General Hospital Corporation Heterologous antigens in live cell v. cholerae strains
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
EP1000155A1 (de) * 1997-06-20 2000-05-17 QUEEN MARY & WESTFIELD COLLEGE Immunogene fragmente des toxins a aus clostridium difficile
DE19739685A1 (de) 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
GB9721189D0 (en) 1997-10-08 1997-12-03 Speywood Lab The Limited Analgesic conjugates
AU754270B2 (en) 1997-10-20 2002-11-07 Sanofi Pasteur Biologics, Llc Passive immunization against clostridium difficile disease
US6051239A (en) * 1997-10-20 2000-04-18 Thomas Jefferson University Compositions and methods for systemic delivery of oral vaccines and therapeutic agents
US6969520B2 (en) * 1997-10-20 2005-11-29 Acambis Inc. Active immunization against clostridium difficile disease
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
EP1097165A4 (de) * 1998-07-13 2001-09-12 Parkash S Gill Inhibitoren der angiogenese und des tumorwachstums
US20040071736A1 (en) 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
GB9818548D0 (en) 1998-08-25 1998-10-21 Microbiological Res Authority Treatment of mucas hypersecretion
GB9907429D0 (en) 1999-03-31 1999-05-26 Microbiological Res Authority Modulation of C-fibre activity
US6733760B1 (en) 1999-04-09 2004-05-11 Techlab, Inc. Recombinant toxin A/toxin B vaccine against Clostridium difficile
JP2002542169A (ja) * 1999-04-09 2002-12-10 テクラブ， インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン
EP1057895A1 (de) * 1999-06-04 2000-12-06 Lohmann Animal Health GmbH & Co. KG Fusionsprotein das das Fragment B des Shigatoxins enthält, dieses enthaltende (Impf-)Stoffzusammensetzung und Verfahren zu dessen Herstellung
FR2796385A1 (fr) * 1999-07-16 2001-01-19 Inst Nat Sante Rech Med Methode de production d'anticorps dans le jaune d'oeuf et utilisation des anticorps ainsi obtenus
GB9921592D0 (en) 1999-09-13 1999-11-17 Microbiological Res Authority Preparation of highly pure toxin fragments
US20080038274A1 (en) 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
UA79735C2 (uk) * 2000-08-10 2007-07-25 Глаксосмітклайн Байолоджікалз С.А. Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах
EP1427531B1 (de) 2001-09-11 2016-10-19 Iquum, Inc. Probenbehälter
US20040086532A1 (en) * 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
US7718421B2 (en) 2003-02-05 2010-05-18 Iquum, Inc. Sample processing
US9701737B2 (en) * 2003-02-19 2017-07-11 Camas, Incorporated Immunogen adherence and method of making and using same
EP1766093B1 (de) 2004-02-06 2011-06-15 University of Massachusetts Antikörper gegen clostridium difficile-toxine und ihre verwendung
WO2006017749A2 (en) * 2004-08-04 2006-02-16 Allergan, Inc. Optimizing expression of active botulinum toxin type a
NZ555339A (en) * 2004-11-24 2010-03-26 Techlab Inc Device and method for detection of analytes
GB0426397D0 (en) * 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
WO2007146139A2 (en) * 2006-06-08 2007-12-21 Cornell Research Foundation, Inc. Codon-optimized dna molecules encoding the receptor binding domains of clostridium difficile toxins a and b
CN100564527C (zh) * 2006-10-23 2009-12-02 中国人民解放军军事医学科学院生物工程研究所 A型肉毒毒素受体结合区Hc基因及其编码蛋白与应用
JP2008169142A (ja) * 2007-01-11 2008-07-24 Osaka Prefecture Univ 食中毒菌に対する抗体の産生方法
JP5305427B2 (ja) * 2007-01-11 2013-10-02 公立大学法人大阪府立大学 インフルエンザウイルスに対する抗体の産生方法
US9802988B2 (en) 2009-05-20 2017-10-31 University Of Maryland, Baltimore Engineered type IV pilin of Clostridium difficile
EP2432500A4 (de) 2009-05-20 2014-03-26 Univ Maryland Manipuliertes typ-iv-pilin von clostridium difficile
EP2519257A4 (de) * 2009-12-02 2014-10-15 Univ Tufts Atoxische rekombinante holotoxine aus clostridium difficile als immunogene
GB0921288D0 (en) * 2009-12-04 2010-01-20 Health Prot Agency Therapies for preventing or suppressing clostridium difficile infection
PL2753352T5 (pl) * 2010-09-03 2022-10-17 Valneva Austria Gmbh Izolowany polipeptyd białek toksyny a i toksyny b z c. difficile i jego zastosowania
GB201016742D0 (en) * 2010-10-05 2010-11-17 Health Prot Agency Clostridium difficile antigens
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
CN102181457B (zh) * 2011-03-21 2012-07-04 王世霞 密码子优化的艰难梭菌外毒素b氨基端基因序列及其核酸疫苗
BR122019017005B1 (pt) 2011-04-22 2022-03-29 Wyeth Llc Composições que se relacionam a uma toxina de clostridium difficile mutante
PL3138916T3 (pl) * 2011-05-27 2019-11-29 Glaxosmithkline Biologicals Sa Kompozycja immunogenna
US20150071958A1 (en) * 2011-11-30 2015-03-12 Board Of Trustees Of Michigan State University Immunological composition for clostridium difficile
SG11201402375VA (en) 2011-12-08 2014-10-30 Novartis Ag Clostridium difficile toxin-based vaccine
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
JP6290918B2 (ja) 2012-12-05 2018-03-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
CN103865938B (zh) * 2012-12-16 2016-10-05 山东国际生物科技园发展有限公司 艰难梭菌外毒素a羧基端序列密码子优化基因片段、表达载体构建方法及其表达蛋白的应用
WO2014159510A1 (en) 2013-03-12 2014-10-02 Yale University Compositions and methods for identifying secretory antibody-bound microbes
BE1022949B1 (fr) 2014-06-25 2016-10-21 Glaxosmithkline Biologicals S.A. Composition immunogene
EP3453396A1 (de) * 2014-08-28 2019-03-13 Yale University Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen oder -leiden
EP3307239B1 (de) 2015-06-12 2020-09-16 Vaxart, Inc. Formulierungen zur freisetzung von rsv- und norovirus-antigenen im dünndarm
JP6855469B2 (ja) * 2015-10-16 2021-04-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 消化器標的療法のための処方物を調製するための工程
JP6964623B2 (ja) * 2017-03-29 2021-11-10 バルネバ オーストリア ジーエムビーエイチ Ｃ．ディフィシルの毒素ａおよび毒素ｂタンパク質の単離ポリペプチドならびにその使用
JP6612807B2 (ja) * 2017-03-29 2019-11-27 バルネバ オーストリア ジーエムビーエイチ Ｃ．ディフィシルの毒素ａおよび毒素ｂタンパク質の単離ポリペプチドならびにその使用
CN108822211B (zh) * 2018-06-05 2019-12-24 中国人民解放军军事科学院军事医学研究院 一种制备a、b、e、f型四价肉毒抗毒素的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550019A (en) * 1978-03-22 1985-10-29 South Africa Inventions Development Corporation Manufacture and use of fowl egg antibodies
ES2052496T3 (es) 1985-11-25 1994-07-16 Ghen Corp Sustancia que contiene anticuerpo especifico obtenida de huevos y metodo para su produccion y uso.
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5736139A (en) * 1989-10-31 1998-04-07 Ochidian Pharmaceuticals, Inc. Treatment of Clostridium difficile induced disease
US5601823A (en) * 1989-10-31 1997-02-11 Ophidian Pharmaceuticals, Inc. Avian antitoxins to clostridium difficle toxin A
US5196193A (en) * 1989-10-31 1993-03-23 Ophidian Pharmaceuticals, Inc. Antivenoms and methods for making antivenoms
US5268295A (en) * 1991-05-31 1993-12-07 W. Alton Jones Cell Science Center, Inc. Mammalian adipocyte protein p154, nucleic acids coding therefor and uses thereof
GB9120306D0 (en) * 1991-09-24 1991-11-06 Graham Herbert K Method and compositions for the treatment of cerebral palsy
JP4102432B2 (ja) * 1992-09-01 2008-06-18 メルク パテント ゲーエムベーハー 杉花粉由来のアレルゲン性蛋白質及びペプチド
JPH06192118A (ja) * 1992-09-28 1994-07-12 Wisconsin Alumni Res Found ボツリヌス毒素を含む異常に過敏な筋運動障害の治療用薬剤組成物およびその製造方法
JPH06192296A (ja) * 1992-10-28 1994-07-12 Chiba Pref Gov 治療用医薬品としての結晶ａ型ボツリヌス毒素の製造法。
US5480972A (en) * 1992-10-30 1996-01-02 The University Of Melbourne Allergenic proteins from Johnson grass pollen

Also Published As

Publication number Publication date
EP0796326A1 (de) 1997-09-24
HUT78048A (hu) 1999-07-28
CZ125097A3 (cs) 1998-03-18
FI971732A (fi) 1997-06-23
CA2203504A1 (en) 1996-05-02
ATE366312T1 (de) 2007-07-15
EP1041149A3 (de) 2001-05-02
EP0796326A4 (de) 2000-01-19
WO1996012802A9 (en) 1999-09-16
EP1041149A2 (de) 2000-10-04
AU709586B2 (en) 1999-09-02
FI971732A0 (fi) 1997-04-23
CZ296806B6 (cs) 2006-06-14
EP1041149B8 (de) 2007-10-03
NO971868L (no) 1997-06-24
JP3914484B2 (ja) 2007-05-16
AU3968395A (en) 1996-05-15
MX9702955A (es) 1998-07-31
EP1041149B1 (de) 2007-07-04
BR9509903A (pt) 1997-11-25
JP2002514886A (ja) 2002-05-21
WO1996012802A1 (en) 1996-05-02
NZ337543A (en) 2002-06-28
PL320214A1 (en) 1997-09-15
CN1176658A (zh) 1998-03-18
NO971868D0 (no) 1997-04-23
US6290960B1 (en) 2001-09-18
NZ295998A (en) 1999-10-28
JP2003137897A (ja) 2003-05-14
NO323305B1 (no) 2007-03-05

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Owner name: ALLERGAN, INC., IRVINE, CALIF., US

8332 No legal effect for de