DE69531831D1 - Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren - Google Patents

Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren

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Publication number
DE69531831D1
DE69531831D1 DE69531831T DE69531831T DE69531831D1 DE 69531831 D1 DE69531831 D1 DE 69531831D1 DE 69531831 T DE69531831 T DE 69531831T DE 69531831 T DE69531831 T DE 69531831T DE 69531831 D1 DE69531831 D1 DE 69531831D1
Authority
DE
Germany
Prior art keywords
nucleic acids
nucleic acid
genetic changes
high turnover
detecting sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69531831T
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English (en)
Other versions
DE69531831T2 (de
Inventor
Anthony P Shuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/281,940 external-priority patent/US5589330A/en
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE69531831D1 publication Critical patent/DE69531831D1/de
Application granted granted Critical
Publication of DE69531831T2 publication Critical patent/DE69531831T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69531831T 1994-07-28 1995-07-28 Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren Expired - Lifetime DE69531831T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US281940 1994-07-28
US08/281,940 US5589330A (en) 1994-07-28 1994-07-28 High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides
US08/485,885 US5849483A (en) 1994-07-28 1995-06-07 High throughput screening method for sequences or genetic alterations in nucleic acids
US485885 1995-06-07
PCT/US1995/010346 WO1996003529A1 (en) 1994-07-28 1995-07-28 High throughput screening method for sequences or genetic alterations in nucleic acids

Publications (2)

Publication Number Publication Date
DE69531831D1 true DE69531831D1 (de) 2003-10-30
DE69531831T2 DE69531831T2 (de) 2004-07-15

Family

ID=26961166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69531831T Expired - Lifetime DE69531831T2 (de) 1994-07-28 1995-07-28 Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren

Country Status (8)

Country Link
US (1) US5849483A (de)
EP (1) EP0777750B1 (de)
JP (1) JPH10506267A (de)
AT (1) ATE250671T1 (de)
AU (1) AU697642B2 (de)
CA (1) CA2195880A1 (de)
DE (1) DE69531831T2 (de)
WO (1) WO1996003529A1 (de)

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EP0789781A1 (de) * 1995-09-15 1997-08-20 Genzyme Corporation Untersuchungsverfahren mit hohem umsatz für sequenzen und genetischen abweichungen in nukleinsäuren
US6110676A (en) * 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
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US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
PT1471926E (pt) 1999-06-01 2011-03-11 Baylor College Medicine Composições e métodos para a utilização terapêutica de uma sequência associada a atonal
US20030219765A1 (en) * 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
AU758744B2 (en) * 2000-10-31 2003-03-27 F. Hoffmann-La Roche Ag Methods for the analysis of non-proteinaceous components using a protease from a bacillus strain
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US20060099224A1 (en) 2002-08-12 2006-05-11 David Kirn Methods and compositions concerning poxviruses and cancer
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US20060147938A1 (en) * 2002-11-14 2006-07-06 Third Wave Technologies, Inc. CFTR allele detection assays
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
CA2574610A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
AU2005284822B2 (en) 2004-09-14 2011-03-24 Regents Of The University Of Colorado Method for treatment with bucindolol based on genetic targeting
WO2006065598A2 (en) * 2004-12-13 2006-06-22 Geneohm Sciences, Inc. Fluidic cartridges for electrochemical detection of dna
US9180149B2 (en) 2005-09-07 2015-11-10 Sillajen Biotherapeutics, Inc. Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP2029777B1 (de) * 2006-05-31 2017-03-08 Sequenom, Inc. Verfahren und zusammensetzungen zur nukleinsäureextraktion aus einer probe
AU2007257162A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
CA2921048C (en) 2006-09-15 2018-06-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
WO2008098142A2 (en) 2007-02-08 2008-08-14 Sequenom, Inc. Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
EP2079839A4 (de) 2007-03-05 2009-11-18 Cancer Care Ontario Abschätzung des kolorektalkarzinomrisikos
CA2680588A1 (en) 2007-03-26 2008-10-02 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP2195452B1 (de) 2007-08-29 2012-03-14 Sequenom, Inc. Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP2276858A4 (de) 2008-03-26 2011-10-05 Sequenom Inc Durch restriktionsendonuklease verbesserter nachweis polymorpher sequenzen
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2370568B1 (de) 2008-12-10 2017-07-19 Dana-Farber Cancer Institute, Inc. Mek mutanten mit resistenz gegen mek inhibitoren
EP3514244B1 (de) 2009-04-03 2021-07-07 Sequenom, Inc. Verfahren für die herstellung von nukleinsäuren
US20130005592A1 (en) 2009-09-10 2013-01-03 Board Of Regents Of The University Of Texas System Methods and compositions for predicting cancer therapy response
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
KR101838472B1 (ko) 2009-09-14 2018-03-15 신라젠(주) 종양 용해 백시니아 바이러스 병용 암 치료요법
MX337062B (es) 2009-12-10 2016-02-11 Ottawa Hospital Res Inst Rabdovirus oncolítico.
EP3088532B1 (de) 2009-12-22 2019-10-30 Sequenom, Inc. Verfahren und kits zur identifizierung von aneuploidie
EP2515899B1 (de) 2009-12-23 2016-05-25 ARCA biopharma, Inc. Verfahren und zusammensetzungen für herz-kreislauf-erkrankungen und -leiden
CA2789696C (en) 2010-02-25 2017-11-07 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
WO2011156588A1 (en) 2010-06-09 2011-12-15 Dana-Farber Cancer Institute, Inc. A mek 1 mutation conferring resistance to raf and mek inhibitors
KR20120054882A (ko) * 2010-11-22 2012-05-31 엘지전자 주식회사 표적 핵산 검출 장치
CN103429258B (zh) 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
US9057107B2 (en) 2011-03-08 2015-06-16 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
CN103717750B (zh) 2011-04-29 2017-03-08 塞昆纳姆股份有限公司 少数核酸物质的定量
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
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EP3757210B1 (de) 2012-03-02 2022-08-24 Sequenom, Inc. Verfahren zur anreicherung von krebsnukleinsäure aus einer biologischen probe
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
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Also Published As

Publication number Publication date
ATE250671T1 (de) 2003-10-15
AU697642B2 (en) 1998-10-15
AU3365095A (en) 1996-02-22
DE69531831T2 (de) 2004-07-15
JPH10506267A (ja) 1998-06-23
WO1996003529A1 (en) 1996-02-08
US5849483A (en) 1998-12-15
EP0777750B1 (de) 2003-09-24
EP0777750A1 (de) 1997-06-11
CA2195880A1 (en) 1996-02-08
EP0777750A4 (de) 2001-08-16

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