ATE250671T1 - Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren - Google Patents
Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäurenInfo
- Publication number
- ATE250671T1 ATE250671T1 AT95930171T AT95930171T ATE250671T1 AT E250671 T1 ATE250671 T1 AT E250671T1 AT 95930171 T AT95930171 T AT 95930171T AT 95930171 T AT95930171 T AT 95930171T AT E250671 T1 ATE250671 T1 AT E250671T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- conversion rate
- high conversion
- rate method
- genetic changes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/281,940 US5589330A (en) | 1994-07-28 | 1994-07-28 | High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides |
| US08/485,885 US5849483A (en) | 1994-07-28 | 1995-06-07 | High throughput screening method for sequences or genetic alterations in nucleic acids |
| PCT/US1995/010346 WO1996003529A1 (en) | 1994-07-28 | 1995-07-28 | High throughput screening method for sequences or genetic alterations in nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250671T1 true ATE250671T1 (de) | 2003-10-15 |
Family
ID=26961166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95930171T ATE250671T1 (de) | 1994-07-28 | 1995-07-28 | Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5849483A (de) |
| EP (1) | EP0777750B1 (de) |
| JP (1) | JPH10506267A (de) |
| AT (1) | ATE250671T1 (de) |
| AU (1) | AU697642B2 (de) |
| CA (1) | CA2195880A1 (de) |
| DE (1) | DE69531831T2 (de) |
| WO (1) | WO1996003529A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1382386A3 (de) * | 1992-02-19 | 2004-12-01 | The Public Health Research Institute Of The City Of New York, Inc. | Neue Ordnungen für Oligonukleotide und ihr Nutzen zum Sortieren, Isolieren, Sequenzierung und Manipulieren von Nukleinsäuren |
| US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
| EP0789781A1 (de) * | 1995-09-15 | 1997-08-20 | Genzyme Corporation | Untersuchungsverfahren mit hohem umsatz für sequenzen und genetischen abweichungen in nukleinsäuren |
| US6110676A (en) * | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| US6962778B1 (en) | 1997-09-25 | 2005-11-08 | Boston Probes, Inc. | Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| US6703228B1 (en) | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
| EP1001037A3 (de) * | 1998-09-28 | 2003-10-01 | Whitehead Institute For Biomedical Research | Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus |
| DE60045350D1 (de) | 1999-06-01 | 2011-01-20 | Baylor College Medicine | Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz |
| US20030219765A1 (en) * | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| AU758744B2 (en) * | 2000-10-31 | 2003-03-27 | F. Hoffmann-La Roche Ag | Methods for the analysis of non-proteinaceous components using a protease from a bacillus strain |
| US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
| EP2269619A1 (de) | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | Verfahren und Zusammensetzungen in Bezug auf Pockenviren und Krebs |
| CA2505758C (en) * | 2002-11-14 | 2012-01-10 | Third Wave Technologies, Inc. | Cftr allele detection assays |
| US20060147938A1 (en) * | 2002-11-14 | 2006-07-06 | Third Wave Technologies, Inc. | CFTR allele detection assays |
| EP2112229A3 (de) | 2002-11-25 | 2009-12-02 | Sequenom, Inc. | Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen |
| US20080199480A1 (en) * | 2004-07-22 | 2008-08-21 | Sequenom, Inc. | Methods for Identifying Risk of Type II Diabetes and Treatments Thereof |
| CA2581086C (en) | 2004-09-14 | 2023-11-07 | The Regents Of The University Of Colorado, A Body Corporate | Method for treatment with bucindolol based on genetic targeting |
| WO2006065598A2 (en) * | 2004-12-13 | 2006-06-22 | Geneohm Sciences, Inc. | Fluidic cartridges for electrochemical detection of dna |
| CA2621982C (en) | 2005-09-07 | 2017-11-28 | Jennerex Biotherapeutics Ulc | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| US8679741B2 (en) * | 2006-05-31 | 2014-03-25 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| US8153369B2 (en) | 2006-06-05 | 2012-04-10 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| CN102026645B (zh) | 2006-09-15 | 2016-01-27 | 渥太华医院研究机构 | 溶瘤弹状病毒 |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| WO2008098142A2 (en) | 2007-02-08 | 2008-08-14 | Sequenom, Inc. | Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification |
| AU2008222563A1 (en) | 2007-03-05 | 2008-09-12 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| WO2008118988A1 (en) | 2007-03-26 | 2008-10-02 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| ATE549419T1 (de) | 2007-08-29 | 2012-03-15 | Sequenom Inc | Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion |
| AU2009223671B2 (en) | 2008-03-11 | 2014-11-27 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| AU2009228312B2 (en) | 2008-03-26 | 2015-05-21 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異 |
| EP3211095B1 (de) | 2009-04-03 | 2019-01-02 | Sequenom, Inc. | Zusammensetzungen und verfahren für die herstellung von nukleinsäuren |
| US20130005592A1 (en) | 2009-09-10 | 2013-01-03 | Board Of Regents Of The University Of Texas System | Methods and compositions for predicting cancer therapy response |
| WO2011032088A1 (en) | 2009-09-11 | 2011-03-17 | Arca Biopharma, Inc. | Polymorphisms in the pde3a gene |
| ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
| AU2010329551B2 (en) | 2009-12-10 | 2016-02-11 | Turnstone Limited Partnership | Oncolytic rhabdovirus |
| EP3660165B1 (de) | 2009-12-22 | 2023-01-04 | Sequenom, Inc. | Verfahren und kits zur identifizierung von aneuploidie |
| DK2515899T3 (en) | 2009-12-23 | 2016-08-15 | Arca Biopharma Inc | METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS |
| MX360932B (es) | 2010-02-25 | 2018-11-21 | Dana Farber Cancer Inst Inc | Mutaciones del protooncogen de serina/treonina-proteina cinasa b-raf (braf) que confieren resistencia a los inhibidores del protooncogen de serina/treonina-proteina cinasa b-raf. |
| US20130143911A1 (en) | 2010-06-09 | 2013-06-06 | Dana-Farber Cancer Institute, Inc. | MEK1 Mutation Conferring Resistance to RAF and MEK Inhibitors |
| KR20120054882A (ko) * | 2010-11-22 | 2012-05-31 | 엘지전자 주식회사 | 표적 핵산 검출 장치 |
| CN103429258B (zh) | 2011-01-04 | 2016-03-09 | 新罗杰公司 | 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性 |
| AU2012226530B2 (en) | 2011-03-08 | 2016-12-01 | King Abdullah University Of Science And Technology | Molecular biomarker set for early detection of ovarian cancer |
| AU2012249531B2 (en) | 2011-04-29 | 2017-06-29 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| WO2012167382A1 (en) | 2011-06-08 | 2012-12-13 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Compositions and methods for glioblastoma treatment |
| KR102035877B1 (ko) | 2011-11-14 | 2019-10-23 | 알파시그마 에스.피.에이. | 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 |
| EP2820129A1 (de) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US20140093873A1 (en) | 2012-07-13 | 2014-04-03 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US9896728B2 (en) | 2013-01-29 | 2018-02-20 | Arcticrx Ltd. | Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD) |
| RU2684211C2 (ru) | 2013-02-21 | 2019-04-04 | Тёрнстоун Лимитед Партнершип | Композиция вакцины |
| EP2971100A1 (de) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primer zur analyse der dna-methylierung |
| WO2014183023A1 (en) | 2013-05-09 | 2014-11-13 | Trustees Of Boston University | Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease |
| CN107318267B (zh) | 2013-08-12 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 用于治疗补体相关的病症的组合物和方法 |
| MX2016010237A (es) | 2014-02-08 | 2017-04-27 | Genentech Inc | Metodos de tratamiento de enfermedad de alzheimer. |
| EP3736344A1 (de) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| EP3224362A4 (de) | 2014-11-26 | 2018-06-06 | The Regents of The University of California | Therapeutische zusammensetzungen mit transkriptionsfaktoren sowie verfahren zur herstellung und verwendung davon |
| US9789087B2 (en) | 2015-08-03 | 2017-10-17 | Thomas Jefferson University | PAR4 inhibitor therapy for patients with PAR4 polymorphism |
| US20190211098A1 (en) | 2017-12-22 | 2019-07-11 | Genentech, Inc. | Use of pilra binding agents for treatment of a disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| GB8810400D0 (en) * | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| JPH05236997A (ja) * | 1992-02-28 | 1993-09-17 | Hitachi Ltd | ポリヌクレオチド捕捉用チップ |
| US5470705A (en) * | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
| DE69322266T2 (de) * | 1992-04-03 | 1999-06-02 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
-
1995
- 1995-06-07 US US08/485,885 patent/US5849483A/en not_active Expired - Lifetime
- 1995-07-28 AU AU33650/95A patent/AU697642B2/en not_active Expired
- 1995-07-28 AT AT95930171T patent/ATE250671T1/de not_active IP Right Cessation
- 1995-07-28 DE DE69531831T patent/DE69531831T2/de not_active Expired - Lifetime
- 1995-07-28 WO PCT/US1995/010346 patent/WO1996003529A1/en active IP Right Grant
- 1995-07-28 CA CA002195880A patent/CA2195880A1/en not_active Abandoned
- 1995-07-28 EP EP95930171A patent/EP0777750B1/de not_active Expired - Lifetime
- 1995-07-28 JP JP8506020A patent/JPH10506267A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2195880A1 (en) | 1996-02-08 |
| AU697642B2 (en) | 1998-10-15 |
| WO1996003529A1 (en) | 1996-02-08 |
| DE69531831T2 (de) | 2004-07-15 |
| EP0777750B1 (de) | 2003-09-24 |
| US5849483A (en) | 1998-12-15 |
| AU3365095A (en) | 1996-02-22 |
| EP0777750A1 (de) | 1997-06-11 |
| JPH10506267A (ja) | 1998-06-23 |
| DE69531831D1 (de) | 2003-10-30 |
| EP0777750A4 (de) | 2001-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |