DE69526102D1 - Verwendung von [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2.] oct-3-yl) acetonitril zur hemmung der amyloid-beta-a4-bildung bei der alzheimerschen krankheit - Google Patents
Verwendung von [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2.] oct-3-yl) acetonitril zur hemmung der amyloid-beta-a4-bildung bei der alzheimerschen krankheitInfo
- Publication number
- DE69526102D1 DE69526102D1 DE69526102T DE69526102T DE69526102D1 DE 69526102 D1 DE69526102 D1 DE 69526102D1 DE 69526102 T DE69526102 T DE 69526102T DE 69526102 T DE69526102 T DE 69526102T DE 69526102 D1 DE69526102 D1 DE 69526102D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- alzheimer
- disease
- pct
- acetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421472A GB9421472D0 (en) | 1994-10-25 | 1994-10-25 | Novel methods |
PCT/EP1995/004082 WO1996012486A1 (en) | 1994-10-25 | 1995-10-17 | Use of [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta a4 formation in alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69526102D1 true DE69526102D1 (de) | 2002-05-02 |
DE69526102T2 DE69526102T2 (de) | 2002-10-31 |
Family
ID=10763350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69526102T Expired - Fee Related DE69526102T2 (de) | 1994-10-25 | 1995-10-17 | Verwendung von [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2.] oct-3-yl) acetonitril zur hemmung der amyloid-beta-a4-bildung bei der alzheimerschen krankheit |
Country Status (22)
Country | Link |
---|---|
US (1) | US5891887A (de) |
EP (1) | EP0786998B1 (de) |
JP (1) | JPH10509697A (de) |
KR (1) | KR100393365B1 (de) |
CN (1) | CN1085529C (de) |
AT (1) | ATE214926T1 (de) |
AU (1) | AU698695B2 (de) |
BG (1) | BG101500A (de) |
BR (1) | BR9509433A (de) |
CZ (1) | CZ287370B6 (de) |
DE (1) | DE69526102T2 (de) |
DK (1) | DK0786998T3 (de) |
ES (1) | ES2173977T3 (de) |
GB (1) | GB9421472D0 (de) |
HK (1) | HK1002057A1 (de) |
HU (1) | HUT77007A (de) |
NO (1) | NO312055B1 (de) |
NZ (1) | NZ295155A (de) |
PT (1) | PT786998E (de) |
SK (1) | SK50497A3 (de) |
WO (1) | WO1996012486A1 (de) |
ZA (1) | ZA958946B (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU751607B2 (en) * | 1995-07-29 | 2002-08-22 | Smithkline Beecham Plc | Method of treatment of dementia |
GB9619074D0 (en) * | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Composition |
DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
IL138192A0 (en) * | 1998-03-11 | 2001-11-25 | Smithkline Beecham Plc | Controlled release oral dosage forms |
GB9815383D0 (en) * | 1998-07-15 | 1998-09-16 | Smithkline Beecham Plc | Novel method of treatment |
US6245884B1 (en) * | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
US7816149B2 (en) * | 2004-03-29 | 2010-10-19 | Applied Photonics Worldwide, Inc. | Nanobioprocessor for protein and cell therapy |
GB0428170D0 (en) * | 2004-12-23 | 2005-01-26 | Biopartners Ltd | Mono and Combination Therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2219636T3 (es) * | 1989-04-13 | 2004-12-01 | Beecham Group P.L.C. | Nuevos compuestos. |
US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
JPH0725786A (ja) * | 1990-05-16 | 1995-01-27 | Univ Rockefeller | アルツハイマー病を伴うアミロイドーシスの治療 |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
MX9300875A (es) * | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
WO1994009370A1 (en) * | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Release of alzheimer amyloid precursor stimulated by activation of muscarinic acetylcholine receptors |
GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
-
1994
- 1994-10-25 GB GB9421472A patent/GB9421472D0/en active Pending
-
1995
- 1995-10-17 ES ES95936515T patent/ES2173977T3/es not_active Expired - Lifetime
- 1995-10-17 CN CN95196837A patent/CN1085529C/zh not_active Expired - Fee Related
- 1995-10-17 CZ CZ19971251A patent/CZ287370B6/cs not_active IP Right Cessation
- 1995-10-17 WO PCT/EP1995/004082 patent/WO1996012486A1/en active IP Right Grant
- 1995-10-17 SK SK504-97A patent/SK50497A3/sk unknown
- 1995-10-17 DK DK95936515T patent/DK0786998T3/da active
- 1995-10-17 NZ NZ295155A patent/NZ295155A/en unknown
- 1995-10-17 US US08/836,013 patent/US5891887A/en not_active Expired - Fee Related
- 1995-10-17 AT AT95936515T patent/ATE214926T1/de not_active IP Right Cessation
- 1995-10-17 JP JP8513628A patent/JPH10509697A/ja not_active Ceased
- 1995-10-17 EP EP95936515A patent/EP0786998B1/de not_active Expired - Lifetime
- 1995-10-17 BR BR9509433A patent/BR9509433A/pt not_active Application Discontinuation
- 1995-10-17 AU AU38431/95A patent/AU698695B2/en not_active Ceased
- 1995-10-17 PT PT95936515T patent/PT786998E/pt unknown
- 1995-10-17 DE DE69526102T patent/DE69526102T2/de not_active Expired - Fee Related
- 1995-10-17 HU HU9701815A patent/HUT77007A/hu unknown
- 1995-10-17 KR KR1019970702700A patent/KR100393365B1/ko not_active IP Right Cessation
- 1995-10-23 ZA ZA958946A patent/ZA958946B/xx unknown
-
1997
- 1997-04-24 NO NO19971899A patent/NO312055B1/no not_active IP Right Cessation
- 1997-05-20 BG BG101500A patent/BG101500A/xx unknown
-
1998
- 1998-02-05 HK HK98100893A patent/HK1002057A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0786998A1 (de) | 1997-08-06 |
AU3843195A (en) | 1996-05-15 |
GB9421472D0 (en) | 1994-12-07 |
MX9703077A (es) | 1997-07-31 |
HK1002057A1 (en) | 1998-07-31 |
ZA958946B (en) | 1996-08-20 |
CN1085529C (zh) | 2002-05-29 |
WO1996012486A1 (en) | 1996-05-02 |
DE69526102T2 (de) | 2002-10-31 |
PT786998E (pt) | 2002-09-30 |
NO971899D0 (no) | 1997-04-24 |
CZ287370B6 (en) | 2000-11-15 |
AU698695B2 (en) | 1998-11-05 |
SK50497A3 (en) | 1997-09-10 |
ES2173977T3 (es) | 2002-11-01 |
NZ295155A (en) | 2000-07-28 |
HUT77007A (hu) | 1998-03-02 |
BG101500A (en) | 1998-01-30 |
KR100393365B1 (ko) | 2003-12-18 |
BR9509433A (pt) | 1997-09-16 |
JPH10509697A (ja) | 1998-09-22 |
CZ125197A3 (en) | 1997-07-16 |
EP0786998B1 (de) | 2002-03-27 |
DK0786998T3 (da) | 2002-07-15 |
ATE214926T1 (de) | 2002-04-15 |
CN1170365A (zh) | 1998-01-14 |
US5891887A (en) | 1999-04-06 |
NO971899L (no) | 1997-04-24 |
KR970706816A (ko) | 1997-12-01 |
NO312055B1 (no) | 2002-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MINSTER PHARMACEUTICALS PLC, SAFFRON WALDEN, GB |
|
8339 | Ceased/non-payment of the annual fee |