HK1002057A1 - Use of [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta a4 formation in alzheimer's disease - Google Patents
Use of [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta a4 formation in alzheimer's diseaseInfo
- Publication number
- HK1002057A1 HK1002057A1 HK98100893A HK98100893A HK1002057A1 HK 1002057 A1 HK1002057 A1 HK 1002057A1 HK 98100893 A HK98100893 A HK 98100893A HK 98100893 A HK98100893 A HK 98100893A HK 1002057 A1 HK1002057 A1 HK 1002057A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alpha
- alzheimer
- disease
- pct
- acetonitrile
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9421472A GB9421472D0 (en) | 1994-10-25 | 1994-10-25 | Novel methods |
| PCT/EP1995/004082 WO1996012486A1 (en) | 1994-10-25 | 1995-10-17 | Use of [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta a4 formation in alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1002057A1 true HK1002057A1 (en) | 1998-07-31 |
Family
ID=10763350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98100893A HK1002057A1 (en) | 1994-10-25 | 1998-02-05 | Use of [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta a4 formation in alzheimer's disease |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5891887A (xx) |
| EP (1) | EP0786998B1 (xx) |
| JP (1) | JPH10509697A (xx) |
| KR (1) | KR100393365B1 (xx) |
| CN (1) | CN1085529C (xx) |
| AT (1) | ATE214926T1 (xx) |
| AU (1) | AU698695B2 (xx) |
| BG (1) | BG101500A (xx) |
| BR (1) | BR9509433A (xx) |
| CZ (1) | CZ287370B6 (xx) |
| DE (1) | DE69526102T2 (xx) |
| DK (1) | DK0786998T3 (xx) |
| ES (1) | ES2173977T3 (xx) |
| GB (1) | GB9421472D0 (xx) |
| HK (1) | HK1002057A1 (xx) |
| HU (1) | HUT77007A (xx) |
| NO (1) | NO312055B1 (xx) |
| NZ (1) | NZ295155A (xx) |
| PT (1) | PT786998E (xx) |
| SK (1) | SK50497A3 (xx) |
| WO (1) | WO1996012486A1 (xx) |
| ZA (1) | ZA958946B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU751607B2 (en) * | 1995-07-29 | 2002-08-22 | Smithkline Beecham Plc | Method of treatment of dementia |
| GB9619074D0 (en) * | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Composition |
| DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
| CA2323177A1 (en) * | 1998-03-11 | 1999-09-16 | Susan Marie Milosovich | Composition |
| GB9815383D0 (en) * | 1998-07-15 | 1998-09-16 | Smithkline Beecham Plc | Novel method of treatment |
| US6245884B1 (en) * | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
| US7816149B2 (en) * | 2004-03-29 | 2010-10-19 | Applied Photonics Worldwide, Inc. | Nanobioprocessor for protein and cell therapy |
| GB0428170D0 (en) * | 2004-12-23 | 2005-01-26 | Biopartners Ltd | Mono and Combination Therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0392803T3 (da) * | 1989-04-13 | 2004-10-18 | Beecham Group Plc | Hidtil ukendte forbindelser |
| US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
| JPH0725786A (ja) * | 1990-05-16 | 1995-01-27 | Univ Rockefeller | アルツハイマー病を伴うアミロイドーシスの治療 |
| MX9300875A (es) * | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
| WO1994009370A1 (en) * | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Release of alzheimer amyloid precursor stimulated by activation of muscarinic acetylcholine receptors |
| GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
-
1994
- 1994-10-25 GB GB9421472A patent/GB9421472D0/en active Pending
-
1995
- 1995-10-17 AU AU38431/95A patent/AU698695B2/en not_active Ceased
- 1995-10-17 DK DK95936515T patent/DK0786998T3/da active
- 1995-10-17 DE DE69526102T patent/DE69526102T2/de not_active Expired - Fee Related
- 1995-10-17 EP EP95936515A patent/EP0786998B1/en not_active Expired - Lifetime
- 1995-10-17 JP JP8513628A patent/JPH10509697A/ja not_active Ceased
- 1995-10-17 CZ CZ19971251A patent/CZ287370B6/cs not_active IP Right Cessation
- 1995-10-17 CN CN95196837A patent/CN1085529C/zh not_active Expired - Fee Related
- 1995-10-17 KR KR1019970702700A patent/KR100393365B1/ko not_active IP Right Cessation
- 1995-10-17 SK SK504-97A patent/SK50497A3/sk unknown
- 1995-10-17 NZ NZ295155A patent/NZ295155A/en unknown
- 1995-10-17 WO PCT/EP1995/004082 patent/WO1996012486A1/en active IP Right Grant
- 1995-10-17 US US08/836,013 patent/US5891887A/en not_active Expired - Fee Related
- 1995-10-17 BR BR9509433A patent/BR9509433A/pt not_active Application Discontinuation
- 1995-10-17 HU HU9701815A patent/HUT77007A/hu unknown
- 1995-10-17 AT AT95936515T patent/ATE214926T1/de not_active IP Right Cessation
- 1995-10-17 PT PT95936515T patent/PT786998E/pt unknown
- 1995-10-17 ES ES95936515T patent/ES2173977T3/es not_active Expired - Lifetime
- 1995-10-23 ZA ZA958946A patent/ZA958946B/xx unknown
-
1997
- 1997-04-24 NO NO19971899A patent/NO312055B1/no not_active IP Right Cessation
- 1997-05-20 BG BG101500A patent/BG101500A/xx unknown
-
1998
- 1998-02-05 HK HK98100893A patent/HK1002057A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO312055B1 (no) | 2002-03-11 |
| EP0786998A1 (en) | 1997-08-06 |
| NO971899D0 (no) | 1997-04-24 |
| DE69526102T2 (de) | 2002-10-31 |
| SK50497A3 (en) | 1997-09-10 |
| DK0786998T3 (da) | 2002-07-15 |
| CZ287370B6 (en) | 2000-11-15 |
| AU698695B2 (en) | 1998-11-05 |
| BR9509433A (pt) | 1997-09-16 |
| MX9703077A (es) | 1997-07-31 |
| CN1085529C (zh) | 2002-05-29 |
| CN1170365A (zh) | 1998-01-14 |
| AU3843195A (en) | 1996-05-15 |
| GB9421472D0 (en) | 1994-12-07 |
| WO1996012486A1 (en) | 1996-05-02 |
| HUT77007A (hu) | 1998-03-02 |
| NO971899L (no) | 1997-04-24 |
| ATE214926T1 (de) | 2002-04-15 |
| NZ295155A (en) | 2000-07-28 |
| DE69526102D1 (de) | 2002-05-02 |
| ZA958946B (en) | 1996-08-20 |
| KR970706816A (ko) | 1997-12-01 |
| KR100393365B1 (ko) | 2003-12-18 |
| JPH10509697A (ja) | 1998-09-22 |
| EP0786998B1 (en) | 2002-03-27 |
| CZ125197A3 (en) | 1997-07-16 |
| US5891887A (en) | 1999-04-06 |
| BG101500A (en) | 1998-01-30 |
| PT786998E (pt) | 2002-09-30 |
| ES2173977T3 (es) | 2002-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20061017 |