DE69523611D1 - Neues verfahren für die produktion von biologisch aktivem protein (tgf) - Google Patents

Neues verfahren für die produktion von biologisch aktivem protein (tgf)

Info

Publication number
DE69523611D1
DE69523611D1 DE69523611T DE69523611T DE69523611D1 DE 69523611 D1 DE69523611 D1 DE 69523611D1 DE 69523611 T DE69523611 T DE 69523611T DE 69523611 T DE69523611 T DE 69523611T DE 69523611 D1 DE69523611 D1 DE 69523611D1
Authority
DE
Germany
Prior art keywords
tgf
biologically active
new method
active protein
producing biologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69523611T
Other languages
English (en)
Other versions
DE69523611T2 (de
Inventor
Nico Cerletti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69523611D1 publication Critical patent/DE69523611D1/de
Application granted granted Critical
Publication of DE69523611T2 publication Critical patent/DE69523611T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69523611T 1994-07-25 1995-07-12 Neues verfahren für die produktion von biologisch aktivem protein (tgf) Expired - Lifetime DE69523611T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810439 1994-07-25
PCT/EP1995/002719 WO1996003433A1 (en) 1994-07-25 1995-07-12 New process for the production of biologically active protein

Publications (2)

Publication Number Publication Date
DE69523611D1 true DE69523611D1 (de) 2001-12-06
DE69523611T2 DE69523611T2 (de) 2002-06-20

Family

ID=8218293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523611T Expired - Lifetime DE69523611T2 (de) 1994-07-25 1995-07-12 Neues verfahren für die produktion von biologisch aktivem protein (tgf)

Country Status (19)

Country Link
US (1) US7057016B2 (de)
EP (1) EP0779896B1 (de)
JP (2) JPH11505404A (de)
KR (1) KR100394532B1 (de)
AT (1) ATE207934T1 (de)
AU (1) AU699879B2 (de)
CA (1) CA2194578A1 (de)
DE (1) DE69523611T2 (de)
DK (1) DK0779896T3 (de)
ES (1) ES2166402T3 (de)
FI (1) FI118385B (de)
HU (1) HU222829B1 (de)
IL (1) IL114702A (de)
NO (1) NO317730B1 (de)
NZ (1) NZ290374A (de)
PT (1) PT779896E (de)
TW (1) TW517059B (de)
WO (1) WO1996003433A1 (de)
ZA (1) ZA956139B (de)

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US6084076A (en) * 1995-12-21 2000-07-04 Ajinomoto Co., Inc. Method of refolding human activin A
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US20030134292A1 (en) * 2001-10-30 2003-07-17 Farchaus Joseph W. Thermostable DNA polymerases and methods of making same
FR2871061B1 (fr) * 2004-06-04 2007-08-10 Coletica Sa Principe actif capable d'induire la transformation du tgbf- latent inactif en tgfb actif
US7572474B2 (en) 2005-06-01 2009-08-11 Mead Johnson Nutrition Company Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) * 2008-10-24 2011-12-13 Mead Johnson Nutrition Company Nutritional composition with improved digestibility
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
WO2007033082A2 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (dmso)
CA2622204C (en) 2005-09-12 2016-10-11 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (dmso) or related compounds, or odors associated with same
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
GB0604966D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
US8986769B2 (en) * 2008-10-24 2015-03-24 Mead Johnson Nutrition Company Methods for preserving endogenous TGF-β
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
JP5947721B2 (ja) 2009-10-30 2016-07-06 アベラ ファーマスーティカルズ インコーポレイテッド 変形性関節症を治療するためのジメチルスルホキシド(dmso)およびメチルスルホニルメタン(msm)製剤
US10647777B2 (en) * 2014-05-28 2020-05-12 Genzyme Corporation Methods of controlling the formation of disulfide bonds in protein solutions
JP2016183118A (ja) * 2015-03-25 2016-10-20 東ソー株式会社 増殖因子前駆体のリフォールディング方法
CA3048735A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides, compositions, and methods thereof
TW202330579A (zh) * 2021-10-11 2023-08-01 高等教育聯邦系統 匹茲堡大學 經工程改造TGF-β單體及使用方法
GB2616476A (en) * 2022-03-11 2023-09-13 Multus Biotechnology Ltd Recombinant transforming growth factor beta 3 in yeast

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051985B2 (de) * 1980-11-07 1989-12-27 International Institute Of Cellular And Molecular Pathology (Icp) Immunologischer Test von Proteinen
GR79124B (de) 1982-12-22 1984-10-02 Genentech Inc
US4620948A (en) 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DE3587022T2 (de) 1984-02-17 1993-06-17 Genentech Inc Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren.
US4572798A (en) 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4731440A (en) 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
IL78197A (en) 1985-03-22 1991-07-18 Genentech Inc Nucleic acid encoding tgf-beta and its uses
GB8508340D0 (en) 1985-03-29 1985-05-09 Creighton T E Production of protein
EP0208539A3 (de) 1985-07-11 1988-08-03 Repligen Corporation In Falten gelegte Proteine, durch Disulfid gebunden
US5453363A (en) 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
JPH0759598B2 (ja) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 ヒトインスリン様成長因子▲i▼の製造法
NZ222168A (en) 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
KR890700031A (ko) 1986-11-17 1989-03-02 예안 크라메르 한스 루돌프 하우스 신규한 t-세포 억압 인자의 제조 및 그것의 용도
FI100106B (fi) 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US4931548A (en) 1987-01-30 1990-06-05 Techne Corporation Heterodimer form of transforming growth factor-beta
IL86090A (en) 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
DE3855986T2 (de) 1987-05-11 1998-02-05 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US5162507A (en) 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
US4985544A (en) 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
US5061786A (en) * 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
US5144006A (en) * 1991-06-13 1992-09-01 The Rockefeller University Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
TW440566B (en) * 1994-07-25 2001-06-16 Novartis Ag Novel process for the production of biologically active dimeric protein

Also Published As

Publication number Publication date
JPH11505404A (ja) 1999-05-21
FI970258A (fi) 1997-01-22
AU699879B2 (en) 1998-12-17
NO970326L (no) 1997-01-24
IL114702A (en) 2005-03-20
EP0779896A1 (de) 1997-06-25
JP2007082554A (ja) 2007-04-05
TW517059B (en) 2003-01-11
DK0779896T3 (da) 2002-02-18
ATE207934T1 (de) 2001-11-15
IL114702A0 (en) 1995-11-27
FI118385B (fi) 2007-10-31
NZ290374A (en) 1998-07-28
CA2194578A1 (en) 1996-02-08
JP4354980B2 (ja) 2009-10-28
ES2166402T3 (es) 2002-04-16
ZA956139B (en) 1996-03-07
DE69523611T2 (de) 2002-06-20
PT779896E (pt) 2002-03-28
EP0779896B1 (de) 2001-10-31
US7057016B2 (en) 2006-06-06
AU3109695A (en) 1996-02-22
NO317730B1 (no) 2004-12-13
US20020115834A1 (en) 2002-08-22
HU222829B1 (hu) 2003-11-28
KR100394532B1 (ko) 2003-10-22
WO1996003433A1 (en) 1996-02-08
FI970258A0 (fi) 1997-01-22
HUT76667A (en) 1997-10-28
NO970326D0 (no) 1997-01-24

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