DE69523611D1 - Neues verfahren für die produktion von biologisch aktivem protein (tgf) - Google Patents
Neues verfahren für die produktion von biologisch aktivem protein (tgf)Info
- Publication number
- DE69523611D1 DE69523611D1 DE69523611T DE69523611T DE69523611D1 DE 69523611 D1 DE69523611 D1 DE 69523611D1 DE 69523611 T DE69523611 T DE 69523611T DE 69523611 T DE69523611 T DE 69523611T DE 69523611 D1 DE69523611 D1 DE 69523611D1
- Authority
- DE
- Germany
- Prior art keywords
- tgf
- biologically active
- new method
- active protein
- producing biologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94810439 | 1994-07-25 | ||
PCT/EP1995/002719 WO1996003433A1 (en) | 1994-07-25 | 1995-07-12 | New process for the production of biologically active protein |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69523611D1 true DE69523611D1 (de) | 2001-12-06 |
DE69523611T2 DE69523611T2 (de) | 2002-06-20 |
Family
ID=8218293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69523611T Expired - Lifetime DE69523611T2 (de) | 1994-07-25 | 1995-07-12 | Neues verfahren für die produktion von biologisch aktivem protein (tgf) |
Country Status (19)
Country | Link |
---|---|
US (1) | US7057016B2 (de) |
EP (1) | EP0779896B1 (de) |
JP (2) | JPH11505404A (de) |
KR (1) | KR100394532B1 (de) |
AT (1) | ATE207934T1 (de) |
AU (1) | AU699879B2 (de) |
CA (1) | CA2194578A1 (de) |
DE (1) | DE69523611T2 (de) |
DK (1) | DK0779896T3 (de) |
ES (1) | ES2166402T3 (de) |
FI (1) | FI118385B (de) |
HU (1) | HU222829B1 (de) |
IL (1) | IL114702A (de) |
NO (1) | NO317730B1 (de) |
NZ (1) | NZ290374A (de) |
PT (1) | PT779896E (de) |
TW (1) | TW517059B (de) |
WO (1) | WO1996003433A1 (de) |
ZA (1) | ZA956139B (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6084076A (en) * | 1995-12-21 | 2000-07-04 | Ajinomoto Co., Inc. | Method of refolding human activin A |
DE10026713A1 (de) * | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
US20030134292A1 (en) * | 2001-10-30 | 2003-07-17 | Farchaus Joseph W. | Thermostable DNA polymerases and methods of making same |
FR2871061B1 (fr) * | 2004-06-04 | 2007-08-10 | Coletica Sa | Principe actif capable d'induire la transformation du tgbf- latent inactif en tgfb actif |
US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
US8075934B2 (en) * | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
WO2007033082A2 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
CA2622204C (en) | 2005-09-12 | 2016-10-11 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (dmso) or related compounds, or odors associated with same |
WO2007033180A1 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds |
GB0604966D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
US8986769B2 (en) * | 2008-10-24 | 2015-03-24 | Mead Johnson Nutrition Company | Methods for preserving endogenous TGF-β |
BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
JP5947721B2 (ja) | 2009-10-30 | 2016-07-06 | アベラ ファーマスーティカルズ インコーポレイテッド | 変形性関節症を治療するためのジメチルスルホキシド(dmso)およびメチルスルホニルメタン(msm)製剤 |
US10647777B2 (en) * | 2014-05-28 | 2020-05-12 | Genzyme Corporation | Methods of controlling the formation of disulfide bonds in protein solutions |
JP2016183118A (ja) * | 2015-03-25 | 2016-10-20 | 東ソー株式会社 | 増殖因子前駆体のリフォールディング方法 |
CA3048735A1 (en) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides, compositions, and methods thereof |
TW202330579A (zh) * | 2021-10-11 | 2023-08-01 | 高等教育聯邦系統 匹茲堡大學 | 經工程改造TGF-β單體及使用方法 |
GB2616476A (en) * | 2022-03-11 | 2023-09-13 | Multus Biotechnology Ltd | Recombinant transforming growth factor beta 3 in yeast |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0051985B2 (de) * | 1980-11-07 | 1989-12-27 | International Institute Of Cellular And Molecular Pathology (Icp) | Immunologischer Test von Proteinen |
GR79124B (de) | 1982-12-22 | 1984-10-02 | Genentech Inc | |
US4620948A (en) | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
DE3587022T2 (de) | 1984-02-17 | 1993-06-17 | Genentech Inc | Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren. |
US4572798A (en) | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US4731440A (en) | 1985-02-22 | 1988-03-15 | Monsanto Company | Method of somatotropin solubilization using dimethylsulfone and naturation |
IL78197A (en) | 1985-03-22 | 1991-07-18 | Genentech Inc | Nucleic acid encoding tgf-beta and its uses |
GB8508340D0 (en) | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
EP0208539A3 (de) | 1985-07-11 | 1988-08-03 | Repligen Corporation | In Falten gelegte Proteine, durch Disulfid gebunden |
US5453363A (en) | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
JPH0759598B2 (ja) * | 1986-02-14 | 1995-06-28 | 藤沢薬品工業株式会社 | ヒトインスリン様成長因子▲i▼の製造法 |
NZ222168A (en) | 1986-10-20 | 1991-05-28 | Oncogene Science Inc | Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions |
KR890700031A (ko) | 1986-11-17 | 1989-03-02 | 예안 크라메르 한스 루돌프 하우스 | 신규한 t-세포 억압 인자의 제조 및 그것의 용도 |
FI100106B (fi) | 1986-12-05 | 1997-09-30 | Novartis Ag | Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi |
US4931548A (en) | 1987-01-30 | 1990-06-05 | Techne Corporation | Heterodimer form of transforming growth factor-beta |
IL86090A (en) | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
DE3855986T2 (de) | 1987-05-11 | 1998-02-05 | Chiron Corp | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen |
US5162507A (en) | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
AU626524B2 (en) * | 1987-05-29 | 1992-08-06 | Bristol-Myers Squibb Company | Cloning and expression of simian transforming growth factor- beta 1 |
US4985544A (en) | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
US5061786A (en) * | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5843463A (en) * | 1990-12-21 | 1998-12-01 | Antexbiologics, Inc. | Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae |
US5144006A (en) * | 1991-06-13 | 1992-09-01 | The Rockefeller University | Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides |
AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
TW440566B (en) * | 1994-07-25 | 2001-06-16 | Novartis Ag | Novel process for the production of biologically active dimeric protein |
-
1995
- 1995-07-11 TW TW084107189A patent/TW517059B/zh not_active IP Right Cessation
- 1995-07-12 AT AT95926858T patent/ATE207934T1/de not_active IP Right Cessation
- 1995-07-12 HU HU9700211A patent/HU222829B1/hu not_active IP Right Cessation
- 1995-07-12 AU AU31096/95A patent/AU699879B2/en not_active Ceased
- 1995-07-12 EP EP95926858A patent/EP0779896B1/de not_active Expired - Lifetime
- 1995-07-12 WO PCT/EP1995/002719 patent/WO1996003433A1/en active IP Right Grant
- 1995-07-12 PT PT95926858T patent/PT779896E/pt unknown
- 1995-07-12 JP JP8505401A patent/JPH11505404A/ja not_active Withdrawn
- 1995-07-12 DK DK95926858T patent/DK0779896T3/da active
- 1995-07-12 ES ES95926858T patent/ES2166402T3/es not_active Expired - Lifetime
- 1995-07-12 CA CA002194578A patent/CA2194578A1/en not_active Abandoned
- 1995-07-12 KR KR1019970700477A patent/KR100394532B1/ko not_active IP Right Cessation
- 1995-07-12 DE DE69523611T patent/DE69523611T2/de not_active Expired - Lifetime
- 1995-07-12 NZ NZ290374A patent/NZ290374A/en not_active IP Right Cessation
- 1995-07-24 ZA ZA956139A patent/ZA956139B/xx unknown
- 1995-07-24 IL IL11470295A patent/IL114702A/xx not_active IP Right Cessation
-
1997
- 1997-01-22 FI FI970258A patent/FI118385B/fi active IP Right Grant
- 1997-01-24 NO NO19970326A patent/NO317730B1/no not_active IP Right Cessation
-
2001
- 2001-03-20 US US09/813,271 patent/US7057016B2/en not_active Expired - Fee Related
-
2006
- 2006-11-09 JP JP2006304238A patent/JP4354980B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH11505404A (ja) | 1999-05-21 |
FI970258A (fi) | 1997-01-22 |
AU699879B2 (en) | 1998-12-17 |
NO970326L (no) | 1997-01-24 |
IL114702A (en) | 2005-03-20 |
EP0779896A1 (de) | 1997-06-25 |
JP2007082554A (ja) | 2007-04-05 |
TW517059B (en) | 2003-01-11 |
DK0779896T3 (da) | 2002-02-18 |
ATE207934T1 (de) | 2001-11-15 |
IL114702A0 (en) | 1995-11-27 |
FI118385B (fi) | 2007-10-31 |
NZ290374A (en) | 1998-07-28 |
CA2194578A1 (en) | 1996-02-08 |
JP4354980B2 (ja) | 2009-10-28 |
ES2166402T3 (es) | 2002-04-16 |
ZA956139B (en) | 1996-03-07 |
DE69523611T2 (de) | 2002-06-20 |
PT779896E (pt) | 2002-03-28 |
EP0779896B1 (de) | 2001-10-31 |
US7057016B2 (en) | 2006-06-06 |
AU3109695A (en) | 1996-02-22 |
NO317730B1 (no) | 2004-12-13 |
US20020115834A1 (en) | 2002-08-22 |
HU222829B1 (hu) | 2003-11-28 |
KR100394532B1 (ko) | 2003-10-22 |
WO1996003433A1 (en) | 1996-02-08 |
FI970258A0 (fi) | 1997-01-22 |
HUT76667A (en) | 1997-10-28 |
NO970326D0 (no) | 1997-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
R082 | Change of representative |
Ref document number: 779896 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |