DE69508029T2 - Oxim-Derivate, deren Herstellung und deren therapeutische Anwendung - Google Patents

Oxim-Derivate, deren Herstellung und deren therapeutische Anwendung

Info

Publication number
DE69508029T2
DE69508029T2 DE69508029T DE69508029T DE69508029T2 DE 69508029 T2 DE69508029 T2 DE 69508029T2 DE 69508029 T DE69508029 T DE 69508029T DE 69508029 T DE69508029 T DE 69508029T DE 69508029 T2 DE69508029 T2 DE 69508029T2
Authority
DE
Germany
Prior art keywords
chem
alkyl
hydrogen
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69508029T
Other languages
English (en)
Other versions
DE69508029D1 (de
Inventor
Hiroaki Yanagisawa
Takashi Fujita
Koichi Fujimoto
Takao Yoshioka
Kunio Wada
Minoru Oguchi
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69508029D1 publication Critical patent/DE69508029D1/de
Publication of DE69508029T2 publication Critical patent/DE69508029T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69508029T 1994-10-07 1995-10-09 Oxim-Derivate, deren Herstellung und deren therapeutische Anwendung Expired - Fee Related DE69508029T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24387694 1994-10-07
JP13678895 1995-06-02

Publications (2)

Publication Number Publication Date
DE69508029D1 DE69508029D1 (de) 1999-04-08
DE69508029T2 true DE69508029T2 (de) 1999-10-21

Family

ID=26470291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69508029T Expired - Fee Related DE69508029T2 (de) 1994-10-07 1995-10-09 Oxim-Derivate, deren Herstellung und deren therapeutische Anwendung

Country Status (21)

Country Link
US (3) US5703096A (de)
EP (1) EP0708098B1 (de)
KR (1) KR100250175B1 (de)
CN (1) CN1056840C (de)
AT (1) ATE177088T1 (de)
AU (1) AU688573B2 (de)
CA (1) CA2159938A1 (de)
CZ (1) CZ261095A3 (de)
DE (1) DE69508029T2 (de)
DK (1) DK0708098T3 (de)
ES (1) ES2132536T3 (de)
FI (1) FI954763A (de)
GR (1) GR3030207T3 (de)
HK (1) HK1011974A1 (de)
HU (1) HUT72642A (de)
IL (1) IL115536A (de)
MX (1) MX9504261A (de)
NO (1) NO305954B1 (de)
NZ (1) NZ280181A (de)
RU (1) RU2122998C1 (de)
TW (1) TW400329B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038427A1 (fr) * 1995-06-02 1996-12-05 Sankyo Company, Limited Derives d'oxyimino aromatiques
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
EP0783888A1 (de) * 1995-12-26 1997-07-16 Sankyo Company Limited Verwendung von Troglitazone und verwandten Thiazolidinedionen zur Herstellung eines Medikaments für die Behandlung und Vorbeugung der Osteoporose
IL120443A (en) * 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
NZ332136A (en) * 1996-04-04 1999-08-30 Sankyo Co Phenylalkylcarboxylic acid derivatives useful for treating hyperglycemia
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
BR9711098B1 (pt) * 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
WO1998020871A1 (fr) * 1996-11-08 1998-05-22 Nippon Chemiphar Co., Ltd. Agent diminuant la graisse viscerale
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
US6019229A (en) * 1997-12-18 2000-02-01 Fleetguard, Inc. Self-centering, floating retainer for spin-on filter
DE69919156T2 (de) 1998-05-11 2005-11-03 Takeda Pharmaceutical Co. Ltd. Oxyiminoalkansäure derivate mit hypoglykämischer und hypolipidemischer wirkung
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
ATE466861T1 (de) * 1999-04-07 2010-05-15 Daiichi Sankyo Co Ltd Aminderivate
WO2001034579A1 (fr) * 1999-11-10 2001-05-17 Takeda Chemical Industries, Ltd. Derives d'acide alcoxyiminoalcanoique
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
JP4690402B2 (ja) 2004-07-28 2011-06-01 エフ．ホフマン−ラ ロシュ アーゲー １１−β−ＨＳＤ１インヒビターとしてのアリール−ピリジン誘導体

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
EP0295828A1 (de) * 1987-06-13 1988-12-21 Beecham Group Plc Chemische Verbindungen
US4728739A (en) * 1987-06-15 1988-03-01 American Home Products Corporation Hypoglycemic thiazolidinediones
SG59988A1 (en) * 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
DE69106714T2 (de) * 1990-08-23 1995-05-11 Pfizer Hypoglykämische hydroxyharnstoffderivate.
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JPH08143568A (ja) * 1994-11-22 1996-06-04 Terumo Corp ピリドピリミジン誘導体及びそれを含有する医薬組成物
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3929512B2 (ja) * 1995-06-02 2007-06-13 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法

Also Published As

Publication number Publication date
CZ261095A3 (en) 1996-04-17
HU9502925D0 (en) 1995-11-28
EP0708098B1 (de) 1999-03-03
TW400329B (en) 2000-08-01
EP0708098A1 (de) 1996-04-24
IL115536A0 (en) 1996-01-19
AU3307695A (en) 1996-05-02
NZ280181A (en) 1996-11-26
GR3030207T3 (en) 1999-08-31
FI954763A0 (fi) 1995-10-06
AU688573B2 (en) 1998-03-12
HUT72642A (en) 1996-05-28
ATE177088T1 (de) 1999-03-15
KR100250175B1 (ko) 2000-05-01
HK1011974A1 (en) 1999-07-23
NO305954B1 (no) 1999-08-23
NO953990D0 (no) 1995-10-06
DK0708098T3 (da) 1999-10-04
CA2159938A1 (en) 1996-04-08
CN1143639A (zh) 1997-02-26
US5703096A (en) 1997-12-30
FI954763A (fi) 1996-04-08
CN1056840C (zh) 2000-09-27
DE69508029D1 (de) 1999-04-08
NO953990L (no) 1996-04-09
MX9504261A (es) 1997-01-31
US5780490A (en) 1998-07-14
KR960014124A (ko) 1996-05-22
RU2122998C1 (ru) 1998-12-10
ES2132536T3 (es) 1999-08-16
US5972959A (en) 1999-10-26
IL115536A (en) 1999-07-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee