DE69427997T2 - Hybrider mensch/tier faktor viii - Google Patents
Hybrider mensch/tier faktor viiiInfo
- Publication number
- DE69427997T2 DE69427997T2 DE69427997T DE69427997T DE69427997T2 DE 69427997 T2 DE69427997 T2 DE 69427997T2 DE 69427997 T DE69427997 T DE 69427997T DE 69427997 T DE69427997 T DE 69427997T DE 69427997 T2 DE69427997 T2 DE 69427997T2
- Authority
- DE
- Germany
- Prior art keywords
- human
- factor viii
- animal
- subunits
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/212,133 US5663060A (en) | 1992-04-07 | 1994-03-11 | Hybrid human/animal factor VIII |
PCT/US1994/013200 WO1995024427A1 (en) | 1994-03-11 | 1994-11-15 | Hybrid human/animal factor viii |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69427997D1 DE69427997D1 (de) | 2001-09-20 |
DE69427997T2 true DE69427997T2 (de) | 2002-04-04 |
Family
ID=22789694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427997T Expired - Fee Related DE69427997T2 (de) | 1994-03-11 | 1994-11-15 | Hybrider mensch/tier faktor viii |
Country Status (11)
Country | Link |
---|---|
US (1) | US5663060A (de) |
EP (1) | EP0749444B1 (de) |
JP (1) | JP3406607B2 (de) |
AT (1) | ATE204298T1 (de) |
AU (1) | AU693837B2 (de) |
CA (1) | CA2185327A1 (de) |
DE (1) | DE69427997T2 (de) |
DK (1) | DK0749444T3 (de) |
ES (1) | ES2161278T3 (de) |
PT (1) | PT749444E (de) |
WO (1) | WO1995024427A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
AT403438B (de) * | 1996-05-24 | 1998-02-25 | Immuno Ag | Pharmazeutische präparation mit faktor viii prokoagulationsaktivität und vwf-bindungsaktivität |
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6340740B1 (en) * | 1997-08-26 | 2002-01-22 | Thomas Jefferson University | Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use |
US6432628B1 (en) | 1997-08-26 | 2002-08-13 | Thomas Jefferson University | Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use |
CA2343916A1 (en) | 1998-09-21 | 2000-03-30 | Genetics Institute, Inc. | Methods of downmodulating the immune response to therapeutic proteins |
JP2002526059A (ja) * | 1998-09-23 | 2002-08-20 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 31個のヒト分泌タンパク質 |
EP1144594A1 (de) | 1998-11-24 | 2001-10-17 | Regents Of The University Of Minnesota | Transgenische zirkulierende endothelzellen |
AU2001292861A1 (en) * | 2000-09-19 | 2002-04-02 | Emory University | Modified factor VIII |
EP1351986A2 (de) * | 2001-01-12 | 2003-10-15 | The American National Red Cross | Verfahren und zusammensetzungen zur verminderung von heparansulfatproteoglykan-vermittelter entfernung von faktor viii |
EP1572889B1 (de) | 2001-10-05 | 2008-12-17 | Expression Therapeutics, LLC | Faktor-viii-polypeptide auf hohem expressionsniveau codierende nukleinsäure- und aminosäuresequenzen und verwendungsverfahren |
WO2003047507A2 (en) * | 2001-11-30 | 2003-06-12 | Emory University | Factor viii c2 domain variants |
EP1454916A1 (de) * | 2002-11-29 | 2004-09-08 | ZLB Behring GmbH | Modifizierte cDNA des Factors VIII und Derivate davon |
EP1424344A1 (de) * | 2002-11-29 | 2004-06-02 | Aventis Behring Gesellschaft mit beschränkter Haftung | Modifizierte cDNA des Factors VIII und Derivate davon |
WO2005046583A2 (en) * | 2003-10-30 | 2005-05-26 | Emory University | Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
SI1750733T1 (sl) | 2004-05-03 | 2014-03-31 | Emory University | POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B |
JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
CA2578046A1 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
US20060080848A1 (en) * | 2004-10-19 | 2006-04-20 | Lace Charles R | Wheel blade sight |
WO2006063031A2 (en) * | 2004-12-06 | 2006-06-15 | Haplomics | Allelic variants of human factor viii |
FR2913020B1 (fr) * | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
US9493545B2 (en) | 2009-02-11 | 2016-11-15 | Albumedix A/S | Albumin variants and conjugates |
EP3421491A3 (de) | 2009-10-30 | 2019-03-27 | Albumedix Ltd | Albuminvarianten |
EP2498804A4 (de) | 2009-11-13 | 2013-05-08 | Puget Sound Blood Ct | Faktor-viii-b-zellen-epitopvarianten mit reduzierter immunogenität |
US20110177107A1 (en) * | 2010-01-14 | 2011-07-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
KR101948337B1 (ko) | 2010-11-05 | 2019-02-14 | 박스알타 인코퍼레이티드 | 증가된 특이 활성도를 갖는 항혈우병 인자 viii의 신규 변이체 |
EP2780364A2 (de) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteine mit verbesserter halbwertzeit und anderen eigenschaften |
BR112014018679A2 (pt) | 2012-03-16 | 2017-07-04 | Novozymes Biopharma Dk As | variantes de albumina |
BR112015010318A2 (pt) | 2012-11-08 | 2017-08-22 | Albumedix As | Variantes de albumina |
EP2928303A4 (de) | 2012-12-07 | 2016-07-13 | Haplomics Inc | Faktor-viii-mutationsreparatur und toleranzinduktion |
CN108137674B (zh) | 2015-08-20 | 2022-12-06 | 阿尔布梅迪克斯医疗有限公司 | 白蛋白变体和缀合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
EP0218712B1 (de) * | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Neue prokoagulierungsproteine |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
US5246850A (en) * | 1990-07-31 | 1993-09-21 | Genentech, Inc. | DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells |
SE468050C (sv) * | 1991-03-15 | 1998-04-27 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
US5317010A (en) * | 1991-10-10 | 1994-05-31 | Peter K. T. Pang | Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
-
1994
- 1994-03-11 US US08/212,133 patent/US5663060A/en not_active Expired - Lifetime
- 1994-11-15 CA CA002185327A patent/CA2185327A1/en not_active Abandoned
- 1994-11-15 JP JP52343095A patent/JP3406607B2/ja not_active Expired - Fee Related
- 1994-11-15 ES ES95903119T patent/ES2161278T3/es not_active Expired - Lifetime
- 1994-11-15 EP EP95903119A patent/EP0749444B1/de not_active Expired - Lifetime
- 1994-11-15 DE DE69427997T patent/DE69427997T2/de not_active Expired - Fee Related
- 1994-11-15 DK DK95903119T patent/DK0749444T3/da active
- 1994-11-15 WO PCT/US1994/013200 patent/WO1995024427A1/en active IP Right Grant
- 1994-11-15 PT PT95903119T patent/PT749444E/pt unknown
- 1994-11-15 AT AT95903119T patent/ATE204298T1/de not_active IP Right Cessation
- 1994-11-15 AU AU12096/95A patent/AU693837B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE69427997D1 (de) | 2001-09-20 |
ES2161278T3 (es) | 2001-12-01 |
CA2185327A1 (en) | 1995-09-14 |
EP0749444A1 (de) | 1996-12-27 |
US5663060A (en) | 1997-09-02 |
AU1209695A (en) | 1995-09-25 |
ATE204298T1 (de) | 2001-09-15 |
PT749444E (pt) | 2001-11-30 |
JPH10500282A (ja) | 1998-01-13 |
WO1995024427A1 (en) | 1995-09-14 |
DK0749444T3 (da) | 2001-11-26 |
AU693837B2 (en) | 1998-07-09 |
JP3406607B2 (ja) | 2003-05-12 |
EP0749444B1 (de) | 2001-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |