ATE404684T1 - Methoden und zusammensetzungen zur transformation von zellen - Google Patents

Methoden und zusammensetzungen zur transformation von zellen

Info

Publication number
ATE404684T1
ATE404684T1 AT97928910T AT97928910T ATE404684T1 AT E404684 T1 ATE404684 T1 AT E404684T1 AT 97928910 T AT97928910 T AT 97928910T AT 97928910 T AT97928910 T AT 97928910T AT E404684 T1 ATE404684 T1 AT E404684T1
Authority
AT
Austria
Prior art keywords
cell
compositions
sequences
methods
transforming cells
Prior art date
Application number
AT97928910T
Other languages
English (en)
Inventor
Philippe Leboulch
Eric Bouhassira
Karen Westerman
Ken Julian Takekoshi
Original Assignee
Massachusetts Inst Technology
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24664451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE404684(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology, Einstein Coll Med filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE404684T1 publication Critical patent/ATE404684T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT97928910T 1996-06-14 1997-06-06 Methoden und zusammensetzungen zur transformation von zellen ATE404684T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66408496A 1996-06-14 1996-06-14
US08/743,796 US5928914A (en) 1996-06-14 1996-11-05 Methods and compositions for transforming cells

Publications (1)

Publication Number Publication Date
ATE404684T1 true ATE404684T1 (de) 2008-08-15

Family

ID=24664451

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97928910T ATE404684T1 (de) 1996-06-14 1997-06-06 Methoden und zusammensetzungen zur transformation von zellen

Country Status (8)

Country Link
US (1) US5928914A (de)
EP (1) EP0914457B1 (de)
JP (2) JP2000512150A (de)
AT (1) ATE404684T1 (de)
AU (1) AU733016B2 (de)
CA (1) CA2258007A1 (de)
DE (1) DE69738905D1 (de)
WO (1) WO1997047758A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
EP0937098B1 (de) 1995-06-07 2002-08-14 Invitrogen Corporation Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6534314B1 (en) * 1996-06-14 2003-03-18 Massachusetts Institute Of Technology Methods and compositions for transforming cells
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
WO1998048005A1 (en) 1997-04-24 1998-10-29 University Of Washington Targeted gene modification by parvoviral vectors
DE69836092T2 (de) 1997-10-24 2007-05-10 Invitrogen Corp., Carlsbad Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
NZ504510A (en) 1997-11-18 2002-10-25 Pioneer Hi Bred Int Methods and compositions for increasing efficiency of excision of a viral replicon from T-DNA that is transferred to a plant by agroinfection
US7102055B1 (en) 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
PT1034262E (pt) * 1997-11-18 2005-10-31 Pioneer Hi Bred Int Composicoes e metodos para a modificacao genetica de plantas
AU745960C (en) 1997-11-18 2003-09-18 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign DNA into eukaryoticgenomes
EP0939120A1 (de) 1998-02-27 1999-09-01 Gesellschaft für biotechnologische Forschung mbH (GBF) Methode zum marker-freien, wiederholten Austausch von DNA-Expressionskassetten im Genom von Zellen oder Bestandteilen davon
CA2348778A1 (en) * 1998-10-28 2000-05-04 University Of Washington Targeted gene modification by parvoviral vectors
DE60042969D1 (de) * 1999-03-02 2009-10-29 Life Technologies Corp Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
US6410317B1 (en) * 1999-07-14 2002-06-25 Clontech Laboratories, Inc. Recombinase-based methods for producing expression vectors and compositions for use in practicing the same
JP4664554B2 (ja) * 1999-07-14 2011-04-06 株式会社トランスジェニック トラップベクター及びこれを用いた遺伝子トラップ法
DE19941186A1 (de) * 1999-08-30 2001-03-01 Peter Droege Sequenz-spezifische DNA-Rekombination in eukaryotischen Zellen
EP1228237A1 (de) 1999-11-01 2002-08-07 Chiron Corporation Expressionsvektoren, transfektionssysteme, und verfahren zur verwendung
ATE391789T1 (de) 1999-12-10 2008-04-15 Invitrogen Corp Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
WO2001066717A2 (en) * 2000-03-03 2001-09-13 The University Of Utah Gene targeting method
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6551828B1 (en) 2000-06-28 2003-04-22 Protemation, Inc. Compositions and methods for generating expression vectors through site-specific recombination
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) * 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US20030077804A1 (en) * 2001-04-19 2003-04-24 Invitrogen Corporation Compositions and methods for recombinational cloning of nucleic acid molecules
CA2448505A1 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
PT1652920E (pt) 2001-10-01 2010-11-08 Deutsches Krebsforsch Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma
WO2003040318A2 (en) * 2001-11-02 2003-05-15 Intradigm Corporation Method and system for inducible recombinational cloning in bacterial cells
ATE347593T1 (de) 2002-01-23 2006-12-15 Univ Utah Res Found Zielgerichtete chromosomale mutagenese mit zinkfingernukleasen
US7164056B2 (en) 2002-05-03 2007-01-16 Pioneer Hi-Bred International, Inc. Gene targeting using replicating DNA molecules
US9447434B2 (en) 2002-09-05 2016-09-20 California Institute Of Technology Use of chimeric nucleases to stimulate gene targeting
TW200502390A (en) 2002-11-28 2005-01-16 Peter Droege Sequence specific DNA recombination in eukaryotic cells
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
DE602004027538D1 (de) 2003-12-01 2010-07-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2566267A1 (en) * 2005-12-09 2007-06-09 University Health Network Thymidylate kinase mutants and uses thereof
US20090068158A1 (en) * 2005-12-09 2009-03-12 Medin Jeffrey A Thymidylate kinase mutants and uses thereof
EP2514824A3 (de) 2006-03-03 2013-01-23 Amorfix Life Sciences Ltd. Verfahren und Zusammensetzungen zum Behandeln und Erkennen von missgefaltetem SOD 1-herbeigeführte Erkrankungen
EP2019860A4 (de) * 2006-05-22 2010-12-15 Hiprocell Llc Proteinproduktion mittels eukaryotischer zelllinien
CA2584494A1 (en) * 2007-03-27 2008-09-27 Jeffrey A. Medin Vector encoding therapeutic polypeptide and safety elements to clear transduced cells
US8765462B2 (en) 2007-05-04 2014-07-01 University Health Network IL-12 immunotherapy for cancer
WO2009114942A1 (en) * 2008-03-20 2009-09-24 University Health Network Thymidylate kinase fusions and uses thereof
AU2010235161B2 (en) * 2009-04-09 2015-01-22 Sangamo Therapeutics, Inc. Targeted integration into stem cells
ES2778033T3 (es) 2012-11-16 2020-08-07 Poseida Therapeutics Inc Enzimas específicas de sitio y métodos de uso
US9587237B2 (en) 2013-03-14 2017-03-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
JP2018521689A (ja) 2015-06-17 2018-08-09 ポセイダ セラピューティクス， インコーポレイテッド タンパク質をゲノム内の特定の遺伝子座に導くための組成物および方法
WO2019126578A1 (en) 2017-12-20 2019-06-27 Poseida Therapeutics, Inc. Compositions and methods for directing proteins to specific loci in the genome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (en) * 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
NZ225470A (en) * 1987-07-21 1990-06-26 Du Pont Stable and viable recombinant viral vectors
US5252479A (en) * 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
EP0626999A4 (en) * 1992-01-24 1997-04-09 Life Technologies Inc Modulation of enzyme activities in the -i(in vivo) cloning of dna.
FR2737731B1 (fr) * 1995-08-07 1997-10-10 Pasteur Institut Sequence de retroelements naturels ou synthetiques ayant pour fonction de permettre l'insertion de sequences nucleotidiques dans une cellule eucaryote
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells

Also Published As

Publication number Publication date
AU733016B2 (en) 2001-05-03
JP2010063463A (ja) 2010-03-25
EP0914457B1 (de) 2008-08-13
HK1020752A1 (en) 2000-05-19
US5928914A (en) 1999-07-27
AU3306297A (en) 1998-01-07
DE69738905D1 (de) 2008-09-25
JP5765547B2 (ja) 2015-08-19
CA2258007A1 (en) 1997-12-18
WO1997047758A1 (en) 1997-12-18
JP2000512150A (ja) 2000-09-19
EP0914457A1 (de) 1999-05-12

Similar Documents

Publication Publication Date Title
DE69738905D1 (de) Methoden und zusammensetzungen zur transformation von zellen
Lee et al. Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination
ES2901074T3 (es) Métodos y composiciones para modificaciones genéticas objetivo y métodos de uso
ATE296356T1 (de) Methode zur spezifischen integration von genen in säugetierzellen durch homologe rekombination, und vektoren zu deren durchführung
DE69427997D1 (de) Hybrider mensch/tier faktor viii
WO1999015682A3 (en) Gene silencing materials and methods
BR9814669A (pt) Método para a integração de dna estranho emgenomas eucarióticos
DK0506945T3 (da) Fremgangsmåde til genoverførsel under anvendelse af retrotransposoner
TR199903234T2 (xx) Erkek doku tercih edilen d�zenleyici b�lge ve kullan�m�.
ATE222289T1 (de) Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte
WO2002088353A3 (en) Method for the stable inversion of dna sequence by site-specific recombination and dna vectors and transgenic cells thereof
DK0973928T3 (da) DNA-baseret transposonsystem til indføring af nukleinsyre i DNA i en celle
ATE280239T1 (de) Homologe rekombination in eukaryotischen zellen mit inaktiviertem fehlpaarungsreparatur-system
TR199802503A2 (xx) Endojen gen aktivasyonu i�in h�crelerin optimizasyonu.
ATE526818T1 (de) Gentechnisch hergestellte wasserlinse
Henningfeld et al. A model for topoisomerase I-mediated insertions and deletions with duplex DNA substrates containing branches, nicks, and gaps
EA199800324A1 (ru) Улучшенное встраивание экзогенной днк, введенной в эукариостические клетки
WO2000031246A3 (en) Methods for the preparation by in vivo recombination of nucleic acid and polypeptide libraries and uses thereof
ATE295888T1 (de) Genfallen-konstrukt zur identifizierung und isolierung von genen
WO2002000871A3 (de) Verfahren zur einbringung von nukleinsäuren und anderen biologisch aktiven molekülen in der kern höherer eukaryontischer zellen mit hilfe elektrischen stroms
TR200001046T2 (tr) Homolog rekombinasyonda pozitif-negatif seçimi.
WO2001079471A3 (en) Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
WO2000036113A3 (en) Extending graft survival by heme oxygenase-i expression induced immunomodulation
CA2102594A1 (en) Gene manipulation and expression using genomic elements
West Protein-DNA interactions in genetic recombination

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties